Superfamily : 81338 [ Aquaporin-like ]
Class : Membrane and cell surface proteins and peptides
Fold : Aquaporin-like
# of Members : 7
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1ldfa-  (   6 )           tlkgqciaEflGTglLIffGVgcvAalkVaga-----------
d2f2ba-  (   1 )         mvsltkrciAEfiGTfiLVffGAGsaAvtlmiAsggtspnpfnig
d2o9ga1  (   1 )            mfrklaAEsfGTfwLVfgGSGsavlaagfp------------
d3c02a-  (   8 )            svrefiGEflGTfvLMflGEgatAnfhTtg-l----------
d3cn5a-  (  32 )    lk---lwsfwrAaiaEfiATllFLyiTVatvIghske--tvv--------
d3d9sa1  (   2 )    kkevcsvaFlkAvfAEflATliFVffGLgsaL---kwps-----------
d6f7ha-  (  18 )          sllarqclaEflGVfvlMlltQgavAqAvTsget----------
                            aaaaaaaaaaaaaaaaaaaaaaaaaaa               

                             60        70        80        90        100 
d1ldfa-  (  38 )    ------sfgqweisvifGlgvAmAiylTagvSgAHLnPAvTiAlwlfacf
d2f2ba-  (  46 )    IgllgglgdwvaIGlaFGfaiaaSiyalgniSgChINPAVTiGlwsVkkf
d2o9ga1  (  31 )    ---elgi-gfagVAlaFGltvltmafavghiSgGHFNPAVTiGlwaGgrf
d3c02a-  (  40 )    ------sgdwyklClgwGlAvffGIlvSAklSgAhLNlAVSiGlssInkf
d3cn5a-  (  69 )    ---cgsv-gllgiAwaFGgmIfvLVyctagiSGGHINPAVTfGLflarkV
d3d9sa1  (  38 )    -----alPtilqiAlaFGlaiGtLaqalgpvSgGhInPAITlAllvGnqi
d6f7ha-  (  52 )    ------kgnfftmflagSlAvtiAiyvGgnVsgAHLnPAFSlAMCivgrL
                             aaaaaaaaaaaaaaaaaaa         aaaaaaaaa    

                             110       120       130       140       150 
d1ldfa-  (  82 )    dkrkvipFivsQvaGAfcaAalVyglyynlFfdfeqthhivrgsveSvdL
d2f2ba-  (  96 )    pgrevvpYiiaQllGAafGSfifLqcagi----------------gAAtv
d2o9ga1  (  77 )    pakevvgYviaQvvgGivAAalLyliAsg-------------ktgfdAaa
d3c02a-  (  84 )    dl-kipvYffAQllGAfvGTstVyglyhgfisn-------------skIp
d3cn5a-  ( 115 )    ellrAlvYmiaQclGAicGVglVkaf-mk----------------gpYnq
d3d9sa1  (  83 )    SllrAffYvaaQlvGAiaGAgiLygvAp----------------lnArg-
d6f7ha-  (  96 )    pwvklpiYilvQllSAfcASgaTyvlyhdaLqnyTg--gnltVtgpke-T
                        aaaaaaaaaaaaaaaaaaaaaa                     a  

                             160       170       180       190       200 
d1ldfa-  ( 132 )    AgTFSTyPnp---hinfvqAfavEmvITaiLMglilalt-ddgngvprg-
d2f2ba-  ( 130 )    GgLgATaPfp---gisywqAmlaEvvgTflLMitiMgiavd---erapk-
d2o9ga1  ( 114 )    sgFaSNGyghSpggysmlsAlvvElvlSagFLlvIHg-atD---kfapa-
d3c02a-  ( 121 )    qfaWETsrnp---sisltgAffnEliLTGiLLlviLvVv-denicgkfhi
d3cn5a-  ( 148 )    fgGgANsVal---gynkgtAlgaEiigTfvLVytVFs-atd---pkrsAr
d3d9sa1  ( 116 )    -nLavNalnn---nttqgqAmvvElilTfqlAlciFa-Std---srr---
d6f7ha-  ( 143 )    AsIFAtyPap---yLslnnGfldQvlGTgmLIvglLail-drrnkgvpa-
                                    aaaaaaaaaaaaaaaaaaaaa a           

                             210       220       230       240       250 
d1ldfa-  ( 177 )    pl-----apllIGlliAvIgasmgplTgTAmnPArDfGPKvfAwlagWgn
d2f2ba-  ( 173 )    -----gfaGiiiGltvAgIIttlGniSgSSLNPARTfGPYlNDmifAgtd
d2o9ga1  ( 160 )    -----gfapiaiGlactlIHliSIpvTnTSVNPARStAVAifQg-----g
d3c02a-  ( 167 )    lk-----lSsvVgliilcIGitfGgnTgFALnPSrDlGSRflSliayg--
d3cn5a-  ( 191 )    dshVpiLaplpIGfaVfmvHlaTipiTgTGINPARSfGAAvif----nsn
d3d9sa1  ( 155 )    -tspvgspalsiGlsVtlGHlvGiyfTgCSMNPARSfGPAvvm----nrf
d6f7ha-  ( 188 )    gl-----ePvvVgmlilaLGlsmGanCgiPLnPArDlGPRlfTyvagWgp
                           aaaaaaaaaaaaaaaaaaaa     aaaaaaaaaaa       

                             260       270       280       290       300 
d1ldfa-  ( 222 )    vAftGgrdipYflVPlfGPivGAivgAfayrkligrhl            
d2f2ba-  ( 218 )    -lwn------yysIYviGPivGAvlAAltyqylts               
d2o9ga1  ( 200 )    wAle------qlwFFwvVPivGGiiGGliyrtlle-kr            
d3c02a-  ( 211 )    dTftkdn--fYfwVPlvAPcvGSvvfCqfYdkvicplvdla         
d3cn5a-  ( 237 )    kVwd------DqwIFwvGPfiGAavAAayHqyvlraaa            
d3d9sa1  ( 200 )    s--p------ahwVFwvGPivGAvlAAilYfyllfpnslslservaiikg
d6f7ha-  ( 233 )    eVfsagn--gWwwVPvvAPlvGAtvGTatyqllvalhh            
                                 aaaaaaaaaaaaaaaaaaa                  

                        
d1ldfa-                 
d2f2ba-                 
d2o9ga1                 
d3c02a-                 
d3cn5a-                 
d3d9sa1  ( 242 )    tyep
d6f7ha-
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Glycerol uptake facilitator protein GlpFAquaporin-likeEscherichia coli [TaxId: 562]view
automated matchesautomated matchesMethanothermobacter marburgensis [TaxId: 79929]view
Aquaporin ZAquaporin-likeEscherichia coli [TaxId: 562]view
automated matchesautomated matchesPlasmodium falciparumview
automated matchesautomated matchesSpinach (Spinacia oleracea) [TaxId: 3562]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300
- - - - - - - T L K G Q C I A E F L G T G L L I F F G V G C V A A L K V A G A - - - - - - - - - - - - - - - - - S F G Q W E I S V I F G L G V A M A I Y L T A G V S G A H L N P A V T I A L W L F A C F D K R K V I P F I V S Q V A G A F C A A A L V Y G L Y Y N L F F D F E Q T H H I V R G S V E S V D L A G T F S T Y P N P - - - H I N F V Q A F A V E M V I T A I L M G L I L A L T - D D G N G V P R G - P L - - - - - A P L L I G L L I A V I G A S M G P L T G T A M N P A R D F G P K V F A W L A G W G N V A F T G G R D I P Y F L V P L F G P I V G A I V G A F A Y R K L I G R H L - - - - - - - - - - - - - - - -
- - - - - M V S L T K R C I A E F I G T F I L V F F G A G S A A V T L M I A S G G T S P N P F N I G I G L L G G L G D W V A I G L A F G F A I A A S I Y A L G N I S G C H I N P A V T I G L W S V K K F P G R E V V P Y I I A Q L L G A A F G S F I F L Q C A G I - - - - - - - - - - - - - - - - G A A T V G G L G A T A P F P - - - G I S Y W Q A M L A E V V G T F L L M I T I M G I A V D - - - E R A P K - - - - - - G F A G I I I G L T V A G I I T T L G N I S G S S L N P A R T F G P Y L N D M I F A G T D - L W N - - - - - - Y Y S I Y V I G P I V G A V L A A L T Y Q Y L T S - - - - - - - - - - - - - - - - - - -
- - - - - - - - M F R K L A A E S F G T F W L V F G G S G S A V L A A G F P - - - - - - - - - - - - - - - E L G I - G F A G V A L A F G L T V L T M A F A V G H I S G G H F N P A V T I G L W A G G R F P A K E V V G Y V I A Q V V G G I V A A A L L Y L I A S G - - - - - - - - - - - - - K T G F D A A A S G F A S N G Y G H S P G G Y S M L S A L V V E L V L S A G F L L V I H G - A T D - - - K F A P A - - - - - - G F A P I A I G L A C T L I H L I S I P V T N T S V N P A R S T A V A I F Q G - - - - - G W A L E - - - - - - Q L W F F W V V P I V G G I I G G L I Y R T L L E - K R - - - - - - - - - - - - - - - -
- - - - - - - - S V R E F I G E F L G T F V L M F L G E G A T A N F H T T G - L - - - - - - - - - - - - - - - - S G D W Y K L C L G W G L A V F F G I L V S A K L S G A H L N L A V S I G L S S I N K F D L - K I P V Y F F A Q L L G A F V G T S T V Y G L Y H G F I S N - - - - - - - - - - - - - S K I P Q F A W E T S R N P - - - S I S L T G A F F N E L I L T G I L L L V I L V V V - D E N I C G K F H I L K - - - - - L S S V V G L I I L C I G I T F G G N T G F A L N P S R D L G S R F L S L I A Y G - - D T F T K D N - - F Y F W V P L V A P C V G S V V F C Q F Y D K V I C P L V D L A - - - - - - - - - - - - -
L K - - - L W S F W R A A I A E F I A T L L F L Y I T V A T V I G H S K E - - T V V - - - - - - - - - - - C G S V - G L L G I A W A F G G M I F V L V Y C T A G I S G G H I N P A V T F G L F L A R K V E L L R A L V Y M I A Q C L G A I C G V G L V K A F - M K - - - - - - - - - - - - - - - - G P Y N Q F G G G A N S V A L - - - G Y N K G T A L G A E I I G T F V L V Y T V F S - A T D - - - P K R S A R D S H V P I L A P L P I G F A V F M V H L A T I P I T G T G I N P A R S F G A A V I F - - - - N S N K V W D - - - - - - D Q W I F W V G P F I G A A V A A A Y H Q Y V L R A A A - - - - - - - - - - - - - - - -
K K E V C S V A F L K A V F A E F L A T L I F V F F G L G S A L - - - K W P S - - - - - - - - - - - - - - - - A L P T I L Q I A L A F G L A I G T L A Q A L G P V S G G H I N P A I T L A L L V G N Q I S L L R A F F Y V A A Q L V G A I A G A G I L Y G V A P - - - - - - - - - - - - - - - - L N A R G - - N L A V N A L N N - - - N T T Q G Q A M V V E L I L T F Q L A L C I F A - S T D - - - S R R - - - - T S P V G S P A L S I G L S V T L G H L V G I Y F T G C S M N P A R S F G P A V V M - - - - N R F S - - P - - - - - - A H W V F W V G P I V G A V L A A I L Y F Y L L F P N S L S L S E R V A I I K G T Y E P
- - - - - - S L L A R Q C L A E F L G V F V L M L L T Q G A V A Q A V T S G E T - - - - - - - - - - - - - - - - K G N F F T M F L A G S L A V T I A I Y V G G N V S G A H L N P A F S L A M C I V G R L P W V K L P I Y I L V Q L L S A F C A S G A T Y V L Y H D A L Q N Y T G - - G N L T V T G P K E - T A S I F A T Y P A P - - - Y L S L N N G F L D Q V L G T G M L I V G L L A I L - D R R N K G V P A - G L - - - - - E P V V V G M L I L A L G L S M G A N C G I P L N P A R D L G P R L F T Y V A G W G P E V F S A G N - - G W W W V P V V A P L V G A T V G T A T Y Q L L V A L H H - - - - - - - - - - - - - - - -

 

 

 

 

 

Member Chain UniProtKB GO term
d1ldfa_ A P0AER0 GO:0005372
d1ldfa_ A P0AER0 GO:0005886
d1ldfa_ A P0AER0 GO:0006833
d1ldfa_ A P0AER0 GO:0015168
d1ldfa_ A P0AER0 GO:0015254
d1ldfa_ A P0AER0 GO:0015267
d1ldfa_ A P0AER0 GO:0015791
d1ldfa_ A P0AER0 GO:0015793
d1ldfa_ A P0AER0 GO:0016020
d1ldfa_ A P0AER0 GO:0055085
d1ldfa_ A P0AER0 GO:0071288
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in