Superfamily : 57535 [ Complement control module/SCR domain ]
Class : Small proteins
Fold : Complement control module/SCR domain
# of Members : 32
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1elva2  ( 343 )       dÇgi-PesienGkvedp----e-----stlfgsvIrYtÇeepyyyme
d1h03p1  (   5 )      ksÇpn-pgeIrnGqIdvp---------ggilfgatIsFsÇnt-gyklf
d1h03p2  (  67 )      iyÇpa-PpqidnGiIqge----rd----hYgyrqsVtYaÇnk-gftmi
d1hcca-  (   1 )    eglpÇks-PpeishGvvahm--------sdsYqygeevtYkÇfe-gfgid
d1hfia-  (   1 )    ekipÇsq-PpqiehGtinss-----rssqesyahgtklsYtÇeg-gfris
d1ly2a1  (   2 )       sÇgs-PppIlnGrisyy----st----pIavgtvIrYsÇsg-tfrli
d1ly2a2  (  67 )    kyssÇpe-P-iVpgGykirg----st----pYrhgdsVtFaÇkt-nfsmn
d1ok3a1  (   3 )       dÇgl-PpdVpnAqpal-----e--grtsFpedtvItYkçee-sfvki
d1ok3a2  (  65 )       sÇev-PtrlnsAslkq-----pyitqnyFpvgtvVeYeçrp-gyrre
d1ppqa1  ( 961 )      ksÇkt-ppdpvngmvhvi---------tdiqvgsritYsÇtt-ghrli
d1q3xa2  ( 363 )      idÇgp-PddLpsGrveyi----tgp--gvttykAvIqYsÇe-tfytmk
d1rida1  (   1 )      cÇtip-srpinMkfknsv----etdananynigdtieYlçlp-gyrkq
d1rida3  ( 127 )      vkÇqsP-psIsnGrhngy----edfy----tdgsvVtysÇns-gysli
d1rida4  ( 185 )      vkÇph-Ptisn-Gylss-----gfkrsysy--nDNvdFkÇky-gykls
d1srza1  (  96 )     vriÇsksyltlenGkvflt----ggdl--paldgArveFrÇdp-dfhlv
d2mcza1  (   1 )       qÇna-PewlpfAr----ptqltdef--efpigtylnYeÇrp------
d2o39c1  (   1 )        Çee-PptfeaMelig-----k--pkpyYeigervdYkçkk-gyfyi
d2o39c2  (  63 )      etÇpy-irdplnGqAvpa----n----gtyefgyqMhFiÇne-gyyli
d2ok5a4  (   9 )     qgsÇslegVeIkggsfrll----qe-g-------qaLeYvÇps-gfyPy
d2z3qb1  (   1 )      itÇpp-PmsvehAdiwV-----k-----syslysrErYiÇns-gfkrk
d3erba1  (   3 )       sÇpq-nVnIsggtftls----hg-w----apgSlLtYsÇpq-glyps
d3erba2  (  68 )       rÇpa-pvsfenGiytp-----r---lgsYpvggnVsfeÇed-gfilr
d3erba3  ( 129 )      ghÇpn-PgislgAvrtg-----f-----rfghgdkVrYrÇss-nlvlt
d3gova1  ( 298 )     gneÇpl--qppvhGkIeps----qa----kyffkdqVlVsÇdt-gykVl
d3op8a1  ( 244 )       sÇkl-pvkkatvvyqgervkiqekfkngMlhgdkvsFFÇknk-----
d5ubmb1  ( 289 )    gpmpÇpk--edtpnsvwepa----ka----kYvfrdvVqitÇld-gfeVv
d6v06a1  (   1 )     grtÇpk-PddlpfStVvpl----kt----fYepgeeItYsçkp-gyvSr
d6v06a3  ( 121 )      iiÇpp-PsiptfAtlrvy----kpsagnnSlyrdtAvFeçlp-qhamf
d6v06a4  ( 184 )      vkÇpf-PsrpdnGfvnyp----a---kptLyykdkAtFgÇhd-gysld
                                  bbb                   bbbbbb     bb 

                             60        70        80        90        100 
d1elva2  ( 382 )    ------ggGeYhÇag-----ngswv----NevlgpelPkÇvpv       
d1h03p1  (  42 )    ------gstsSfÇlis-g-ssvqws---------dplPeÇre        
d1h03p2  ( 105 )    ------gehsIyÇtvnn--deGews---------gppPeÇrg        
d1hcca-  (  41 )    ------gpaiAkÇl------gekWs----------hpPsÇi         
d1hfia-  (  44 )    ------eenettÇy------mGkWs----------sppqÇe         
d1ly2a1  (  39 )    ------geksLlÇitkdk-vdGtwd---------kpaPkÇeyf-------
d1ly2a2  ( 106 )    ------gnksVwÇqa-----nnmwG--------ptrlPtÇvs        
d1ok3a1  (  41 )    pg----ekdsViÇlk-----gsqws--------dIe-eFÇnr        
d1ok3a2  ( 105 )    ps----lspkltÇlq-----nlkws--------tav-eFÇkk        
d1ppqa1  ( 998 )    ------GhssAeÇilsg--ntAhWs---------tkppiÇqrip      
d1q3xa2  ( 405 )    ------vndGYvÇea-----dgfwT----sg--ekslPvÇepvcglsar 
d1rida1  (  43 )    k----mgpiyAkÇtg------tgwt---------lf-nqÇik        
d1rida3  ( 165 )    gn------sgvlÇ-s-----ggewsDp----------ptÇq-i       
d1rida4  ( 223 )    ------gsssStçspg-----ntwk---------pelPkÇvr        
d1srza1  ( 138 )    ------gssrSvÇs------qgqWs---------tpkPhÇqvn       
d2mcza1  (  35 )    --gysgrpfsiiÇlk-----nsvWtgakdrÇrr                 
d2o39c1  (  38 )    pp----lathTiÇdr-----nhtwl--------pvsddAÇyr        
d2o39c2  ( 101 )    ------geeilyÇelk-g-svAiWs---------gkpPiÇekv       
d2ok5a4  (  45 )    Pv------qtrtÇrs-----tgsWstLktqdqktvrkAeÇrai       
d2z3qb1  (  37 )    ag----tsslTeÇvlnkatnvAhWt--------tps-LkÇirdpalvhqr
d3erba1  (  39 )    p-------asrlÇks-----sgqWqtp---------kAvÇkpv       
d3erba2  ( 105 )    ------GspvrqÇrp-----ngmwd---------getAvÇdnga      
d3erba3  ( 165 )    ------gssereÇqg-----ngvWs---------gtePiÇrqpysyd--f
d3gova1  ( 337 )    kdnvemdtfqIeÇlk-----dgtWs---------n-iptÇkiv       
d3op8a1  ( 285 )    -ekkÇSytedaqÇi------dgtievpk-çfkehss-----lafwktdas
d5ubmb1  ( 333 )    ----gatsfyStÇqs-----nGkws---------nsklkÇqpv       
d6v06a1  (  40 )    -----ggmrkfiÇpl-----tGlwp---------intLkÇtp        
d6v06a3  ( 163 )    ------gndtItÇtt-----hgnWt----------klPeÇre        
d6v06a4  ( 223 )    ------gpeeIeÇtk-----lgnWs---------a-mPsÇka        
                             bbb                           bb         

                         
d1elva2                  
d1h03p1                  
d1h03p2                  
d1hcca-                  
d1hfia-                  
d1ly2a1  (  66 )    ----n
d1ly2a2                  
d1ok3a1                  
d1ok3a2                  
d1ppqa1                  
d1q3xa2                  
d1rida1                  
d1rida3                  
d1rida4                  
d1srza1                  
d2mcza1                  
d2o39c1                  
d2o39c2                  
d2ok5a4                  
d2z3qb1  (  74 )    papps
d3erba1                  
d3erba2                  
d3erba3  ( 193 )    pedva
d3gova1                  
d3op8a1  ( 322 )    dvkpç
d5ubmb1                  
d6v06a1                  
d6v06a3                  
d6v06a4
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Complement C1S protease domainComplement control module/SCR domainHuman (Homo sapiens) [TaxId: 9606]view
Complement decay-accelerating factor (Daf, CD55)Complement control module/SCR domainHuman (Homo sapiens) [TaxId: 9606]view
Complement decay-accelerating factor (Daf, CD55)Complement control module/SCR domainHuman (Homo sapiens) [TaxId: 9606]view
Factor H, 15th and 16th modulesComplement control module/SCR domainHuman (Homo sapiens) [TaxId: 9606]view
Factor H, 15th and 16th modulesComplement control module/SCR domainHuman (Homo sapiens) [TaxId: 9606]view
Complement receptor 2, cr2Complement control module/SCR domainHuman (Homo sapiens) [TaxId: 9606]view
Complement receptor 2, cr2Complement control module/SCR domainHuman (Homo sapiens) [TaxId: 9606]view
Complement decay-accelerating factor (Daf, CD55)Complement control module/SCR domainHuman (Homo sapiens) [TaxId: 9606]view
Complement decay-accelerating factor (Daf, CD55)Complement control module/SCR domainHuman (Homo sapiens) [TaxId: 9606]view
Complement receptor 1, cr1Complement control module/SCR domainHuman (Homo sapiens) [TaxId: 9606]view
Mannan-binding lectin serine protease 2 (MASP-2) domainsComplement control module/SCR domainHuman (Homo sapiens) [TaxId: 9606]view
Complement control proteinComplement control module/SCR domainVaccinia virus [TaxId: 10245]view
Complement control proteinComplement control module/SCR domainVaccinia virus [TaxId: 10245]view
Complement control proteinComplement control module/SCR domainVaccinia virus [TaxId: 10245]view
GABA-B receptor 1Complement control module/SCR domainNorway rat (Rattus norvegicus) [TaxId: 10116]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
CD46 (membrane cofactor protein, MCP)Complement control module/SCR domainHuman (Homo sapiens) [TaxId: 9606]view
CD46 (membrane cofactor protein, MCP)Complement control module/SCR domainHuman (Homo sapiens) [TaxId: 9606]view
Complement factor BComplement control module/SCR domainHuman (Homo sapiens) [TaxId: 9606]view
Interleukin-15 receptor subunit alphaComplement control module/SCR domainHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
beta2-glycoprotein IComplement control module/SCR domainHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
Domain ID Name
d6yiob26yio B:92-164
d1zjka21zjk A:311-363
d6yiob16yio B:1-61
FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100
- - - D C G I - P E S I E N G K V E D P - - - - E - - - - - S T L F G S V I R Y T C E E P Y Y Y M E - - - - - - G G G E Y H C A G - - - - - N G S W V - - - - N E V L G P E L P K C V P V - - - - - - - - - - - -
- - K S C P N - P G E I R N G Q I D V P - - - - - - - - - G G I L F G A T I S F S C N T - G Y K L F - - - - - - G S T S S F C L I S - G - S S V Q W S - - - - - - - - - D P L P E C R E - - - - - - - - - - - - -
- - I Y C P A - P P Q I D N G I I Q G E - - - - R D - - - - H Y G Y R Q S V T Y A C N K - G F T M I - - - - - - G E H S I Y C T V N N - - D E G E W S - - - - - - - - - G P P P E C R G - - - - - - - - - - - - -
E G L P C K S - P P E I S H G V V A H M - - - - - - - - S D S Y Q Y G E E V T Y K C F E - G F G I D - - - - - - G P A I A K C L - - - - - - G E K W S - - - - - - - - - - H P P S C I - - - - - - - - - - - - - -
E K I P C S Q - P P Q I E H G T I N S S - - - - - R S S Q E S Y A H G T K L S Y T C E G - G F R I S - - - - - - E E N E T T C Y - - - - - - M G K W S - - - - - - - - - - S P P Q C E - - - - - - - - - - - - - -
- - - S C G S - P P P I L N G R I S Y Y - - - - S T - - - - P I A V G T V I R Y S C S G - T F R L I - - - - - - G E K S L L C I T K D K - V D G T W D - - - - - - - - - K P A P K C E Y F - - - - - - - - - - - N
K Y S S C P E - P - I V P G G Y K I R G - - - - S T - - - - P Y R H G D S V T F A C K T - N F S M N - - - - - - G N K S V W C Q A - - - - - N N M W G - - - - - - - - P T R L P T C V S - - - - - - - - - - - - -
- - - D C G L - P P D V P N A Q P A L - - - - - E - - G R T S F P E D T V I T Y K C E E - S F V K I P G - - - - E K D S V I C L K - - - - - G S Q W S - - - - - - - - D I E - E F C N R - - - - - - - - - - - - -
- - - S C E V - P T R L N S A S L K Q - - - - - P Y I T Q N Y F P V G T V V E Y E C R P - G Y R R E P S - - - - L S P K L T C L Q - - - - - N L K W S - - - - - - - - T A V - E F C K K - - - - - - - - - - - - -
- - K S C K T - P P D P V N G M V H V I - - - - - - - - - T D I Q V G S R I T Y S C T T - G H R L I - - - - - - G H S S A E C I L S G - - N T A H W S - - - - - - - - - T K P P I C Q R I P - - - - - - - - - - -
- - I D C G P - P D D L P S G R V E Y I - - - - T G P - - G V T T Y K A V I Q Y S C E - T F Y T M K - - - - - - V N D G Y V C E A - - - - - D G F W T - - - - S G - - E K S L P V C E P V C G L S A R - - - - - -
- - C C T I P - S R P I N M K F K N S V - - - - E T D A N A N Y N I G D T I E Y L C L P - G Y R K Q K - - - - M G P I Y A K C T G - - - - - - T G W T - - - - - - - - - L F - N Q C I K - - - - - - - - - - - - -
- - V K C Q S P - P S I S N G R H N G Y - - - - E D F Y - - - - T D G S V V T Y S C N S - G Y S L I G N - - - - - - S G V L C - S - - - - - G G E W S D P - - - - - - - - - - P T C Q - I - - - - - - - - - - - -
- - V K C P H - P T I S N - G Y L S S - - - - - G F K R S Y S Y - - N D N V D F K C K Y - G Y K L S - - - - - - G S S S S T C S P G - - - - - N T W K - - - - - - - - - P E L P K C V R - - - - - - - - - - - - -
- V R I C S K S Y L T L E N G K V F L T - - - - G G D L - - P A L D G A R V E F R C D P - D F H L V - - - - - - G S S R S V C S - - - - - - Q G Q W S - - - - - - - - - T P K P H C Q V N - - - - - - - - - - - -
- - - Q C N A - P E W L P F A R - - - - P T Q L T D E F - - E F P I G T Y L N Y E C R P - - - - - - - - G Y S G R P F S I I C L K - - - - - N S V W T G A K D R C R R - - - - - - - - - - - - - - - - - - - - - -
- - - - C E E - P P T F E A M E L I G - - - - - K - - P K P Y Y E I G E R V D Y K C K K - G Y F Y I P P - - - - L A T H T I C D R - - - - - N H T W L - - - - - - - - P V S D D A C Y R - - - - - - - - - - - - -
- - E T C P Y - I R D P L N G Q A V P A - - - - N - - - - G T Y E F G Y Q M H F I C N E - G Y Y L I - - - - - - G E E I L Y C E L K - G - S V A I W S - - - - - - - - - G K P P I C E K V - - - - - - - - - - - -
- Q G S C S L E G V E I K G G S F R L L - - - - Q E - G - - - - - - - Q A L E Y V C P S - G F Y P Y P V - - - - - - Q T R T C R S - - - - - T G S W S T L K T Q D Q K T V R K A E C R A I - - - - - - - - - - - -
- - I T C P P - P M S V E H A D I W V - - - - - K - - - - - S Y S L Y S R E R Y I C N S - G F K R K A G - - - - T S S L T E C V L N K A T N V A H W T - - - - - - - - T P S - L K C I R D P A L V H Q R P A P P S
- - - S C P Q - N V N I S G G T F T L S - - - - H G - W - - - - A P G S L L T Y S C P Q - G L Y P S P - - - - - - - A S R L C K S - - - - - S G Q W Q T P - - - - - - - - - K A V C K P V - - - - - - - - - - - -
- - - R C P A - P V S F E N G I Y T P - - - - - R - - - L G S Y P V G G N V S F E C E D - G F I L R - - - - - - G S P V R Q C R P - - - - - N G M W D - - - - - - - - - G E T A V C D N G A - - - - - - - - - - -
- - G H C P N - P G I S L G A V R T G - - - - - F - - - - - R F G H G D K V R Y R C S S - N L V L T - - - - - - G S S E R E C Q G - - - - - N G V W S - - - - - - - - - G T E P I C R Q P Y S Y D - - F P E D V A
- G N E C P L - - Q P P V H G K I E P S - - - - Q A - - - - K Y F F K D Q V L V S C D T - G Y K V L K D N V E M D T F Q I E C L K - - - - - D G T W S - - - - - - - - - N - I P T C K I V - - - - - - - - - - - -
- - - S C K L - P V K K A T V V Y Q G E R V K I Q E K F K N G M L H G D K V S F F C K N K - - - - - - E K K C S Y T E D A Q C I - - - - - - D G T I E V P K - C F K E H S S - - - - - L A F W K T D A S D V K P C
G P M P C P K - - E D T P N S V W E P A - - - - K A - - - - K Y V F R D V V Q I T C L D - G F E V V - - - - G A T S F Y S T C Q S - - - - - N G K W S - - - - - - - - - N S K L K C Q P V - - - - - - - - - - - -
- G R T C P K - P D D L P F S T V V P L - - - - K T - - - - F Y E P G E E I T Y S C K P - G Y V S R - - - - - G G M R K F I C P L - - - - - T G L W P - - - - - - - - - I N T L K C T P - - - - - - - - - - - - -
- - I I C P P - P S I P T F A T L R V Y - - - - K P S A G N N S L Y R D T A V F E C L P - Q H A M F - - - - - - G N D T I T C T T - - - - - H G N W T - - - - - - - - - - K L P E C R E - - - - - - - - - - - - -
- - V K C P F - P S R P D N G F V N Y P - - - - A - - - K P T L Y Y K D K A T F G C H D - G Y S L D - - - - - - G P E E I E C T K - - - - - L G N W S - - - - - - - - - A - M P S C K A - - - - - - - - - - - - -

 

 

 

 

 

Member Chain UniProtKB GO term
d1elva2 A P09871 GO:0004252
d1elva2 A P09871 GO:0006508
d1q3xa2 A O00187 GO:0004252
d1q3xa2 A O00187 GO:0006508
d2ok5a4 A P00751 GO:0004252
d2ok5a4 A P00751 GO:0005576
d2ok5a4 A P00751 GO:0006508
d2ok5a4 A P00751 GO:0006956
d2z3qb1 B P40933 GO:0035723
d2z3qb1 B P40933 GO:0042010
d2z3qb1 B Q13261 GO:0035723
d2z3qb1 B Q13261 GO:0042010
d2z3qb1 B P40933 GO:0035723
d2z3qb1 B P40933 GO:0042010
d2z3qb1 B Q13261 GO:0035723
d2z3qb1 B Q13261 GO:0042010
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in