Superfamily : 56854 [ Bcl-2 inhibitors of programmed cell death ]
Class : Membrane and cell surface proteins and peptides
Fold : Toxins' membrane translocation domains
# of Members : 13
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1ddba-  (   1 )    mdsevsngsglGakhitdllvfgFlqssGctrqelevlGrelpvqAywea
d1k3ka-  (   1 )          mdedvlpgevlaiegiFMacGl----------------------
d1ohua-  (  72 )          dwe-eprLdIegFVVDYFthrirqngewf---------------
d1q59a1  (   1 )          m-----aystreillAlcirdSrvHGn-g---------------
d2vofa1  (   2 )             aeselhIhsLAehYLqyVlqvp----afe------------
d3bl2a-  (   5 )              ksgtyWatLItaFLktVSkve-----eldcvd--------
d4bd8a-  (  11 )       ggptsseqimktgalllqgFiqdRagrda------------------
d5vx1a1  (  23 )           seeqVaqdTeeVFrSYVfyrHqqeqeaegvaapADpeMvt---
d5wdda-  (  21 )       s--ptdkeLVsqAkaLCrdYInsrlira----gvsws----------
d6h1na1  (   5 )           mscwlreqtlllAedYisfCsgiq----q--------------
d6udva-  ( 172 )              dlyrqSleIIsrYLreqAtga----kdtkpMgr-------
d6v4ma-  (   6 )       w--dnelsgintsvsLAaDYVYmrLate----gfvfgirs-------
                                   aaaaaaaaaaaaa                      

                             60        70        80        90        100 
d1ddba-  (  51 )    dledelqtdgsqasrsfnqgriepdsesqeeiihniArhlAqiGdemdhn
d1k3ka-  (  23 )    -------------nepe----------ylyhpllsPiklyitglmrdke-
d1ohua-  ( 101 )    -------------gapg-lps----------gvqpeHervgtifekkha-
d1q59a1  (  24 )    -------------tlhpvlelaaretplrlspedtvvlrYhvlleeiie-
d2vofa1  (  30 )    --------------------------------psqAcrVLqrvAfsvQe-
d3bl2a-  (  32 )    ------------------------------saVlvdVskIitlTqefrr-
d4bd8a-  (  55 )    --------------------------------stklseslkriGdelds-
d5vx1a1  (  63 )    ---------------------------lplqpsstmGqVGrqLAiigdd-
d5wdda-  (  62 )    ------------------------------gklaeVsaiLlrlGdeley-
d6h1na1  (  30 )    ------------------------------tppsesAeAMrylAkemEq-
d6udva-  ( 202 )    ----------------------------sgatSrkAleTLrrvGdgvQr-
d6v4ma-  (  41 )    ----------------------------svrApirLCdaMflMCdlFer-
                                                      aaaaaaaaaaaaa   

                             110       120       130       140       150 
d1ddba-  ( 101 )    iqptlvrqlAaqFmngslseedkrnClAkAldevktaf---prdMenDka
d1k3ka-  (  49 )    ---slFeamlan------vrFhsttgidqlglsmlqvsgdgnmnwgrAla
d1ohua-  ( 129 )    ---enFetfSeqLla----vpIsfslYqdvVrtVgn------psygrLiG
d1q59a1  (  60 )    ---rnsetFtetwnrfithtehvdldfnsvFleifhr---gdpslGrAlA
d2vofa1  (  48 )    --venlksylddf---hVsidtAriiFnqv-ekefedg---iinWgrIVt
d3bl2a-  (  51 )    hydsvyradygp------aLknWkrdLsklFtslFvd----vinsgrIvg
d4bd8a-  (  73 )    -nmeLqrmia--------avdtsprvffrVaadmfsdg---nfnwgrvVa
d5vx1a1  (  85 )    inrrydseFqtmLqhaqPtaenAyeyFtkiAtslFes----ginwgrVvA
d5wdda-  (  81 )    irpnvyrnIarqlnIslhsetvVtdaFlavAaqiFta----gitwgkVVs
d6h1na1  (  49 )    qhrtkfrslSqeFld--tçgadpskçlqsvMrelvgdg---kMnWgrvvs
d6udva-  ( 223 )    nhetafqgmlrkldI--kned-dVkslsrvmihvFsdg---vtnWgrIVt
d6v4ma-  (  63 )    fhdryIapLknaclgisad--mdmrmFfsALdsvFss----giswsrIVA
                       aaaaaaa             aaaaaaaaaaa          aaaaaa

                             160       170       180       190       200 
d1ddba-  ( 148 )    MliMtMllAkkvAs-hap-sllrdvFhttvnFinqnlfSYvrnlvrnemd
d1k3ka-  (  90 )    iltFGSfvAqklsn----ephlrdFAlavlPayAyeAigpqwfrarGgwr
d1ohua-  ( 174 )    LiSFGGfVAAkesv---elqgqvrnLfvyTSlFIktri--nWrsWddftl
d1q59a1  ( 104 )    WmAWcMhaCrtlccnqstpyyvvdlsvrgMleaSegld--gwihqqggWs
d2vofa1  (  92 )    IFAfGGVLLkkLe-------say-kVSsFVAefI-n-nTgewi-qnggwe
d3bl2a-  (  91 )    FFDvGrYVCeevlcpgsw-tedHelLndcMthfFiennLmnhFple    
d4bd8a-  ( 113 )    lfYFaSklvlkalstk---vpelirtimgwtldflrerllgwiqdqggwd
d5vx1a1  ( 131 )    LLgFGYRLALhVyq-hgl-tgfLgqVTrFVvdFMlhhsIArwIaqrggWv
d5wdda-  ( 127 )    LYAVAAgLAvdCvr-haq-pamvhtIVdcLGefVrk-tLvtwLkrrgGWa
d6h1na1  (  94 )    iFtFtGvlAsells-rg--eegs-rlAetiAdYlGg-ekqdwlvenggWe
d6udva-  ( 267 )    lISfgAfVAkhLkt-inq-escIepLAesITdVLVr-tkrdwLvkqrgWd
d6v4ma-  ( 108 )    MYAFAGsVAlaCAr-qgr-rqtViaIpewImlYMrr-aIapwIhanggwd
                    aaaaaaaaaaa           aaaaaaaaaaaaa     aaaa      

                             210  
d1ddba-                           
d1k3ka-  ( 136 )    -glkayctqvlt  
d1ohua-  ( 228 )    -gqkedyeaea   
d1q59a1  ( 152 )    -tliednip-g   
d2vofa1  ( 142 )    dgFikkfe      
d3bl2a-                           
d4bd8a-  ( 160 )    -glls--yfgtptw
d5vx1a1  ( 179 )    -aAln--------l
d5wdda-  ( 174 )    -dItkcvv      
d6h1na1  ( 142 )    -GFcrffhna    
d6udva-  ( 314 )    -gFveffhvedleg
d6v4ma-  ( 155 )    -sFIfSqdvlngnh
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Proapoptotic molecule BidBcl-2 inhibitors of programmed cell deathMouse (Mus musculus) [TaxId: 10090]view
Bcl-2 homologBcl-2 inhibitors of programmed cell deathKaposi's sarcoma-associated herpesvirus [TaxId: 37296]view
Apoptosis regulator ced-9Bcl-2 inhibitors of programmed cell deathNematode (Caenorhabditis elegans) [TaxId: 6239]view
Early antigen protein RBcl-2 inhibitors of programmed cell deathEpstein-Barr virus [TaxId: 10376]view
automated matchesautomated matchesMouse (Mus musculus) [TaxId: 10090]view
Bcl-2 homolog V-bcl-2Bcl-2 inhibitors of programmed cell deathMurid herpesvirus 4 [TaxId: 33708]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesChicken (Gallus gallus) [TaxId: 9031]view
automated matchesautomated matchesZebrafish (Danio rerio) [TaxId: 7955]view
EAT/MCL-1 (Myeloid cell leukemia sequence 1)Bcl-2 inhibitors of programmed cell deathHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesTrichuris suis [TaxId: 68888]view
Domain ID Name
d7jgwa17jgw A:1-196
FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210
M D S E V S N G S G L G A K H I T D L L V F G F L Q S S G C T R Q E L E V L G R E L P V Q A Y W E A D L E D E L Q T D G S Q A S R S F N Q G R I E P D S E S Q E E I I H N I A R H L A Q I G D E M D H N I Q P T L V R Q L A A Q F M N G S L S E E D K R N C L A K A L D E V K T A F - - - P R D M E N D K A M L I M T M L L A K K V A S - H A P - S L L R D V F H T T V N F I N Q N L F S Y V R N L V R N E M D - - - - - - - - - - - - - -
- - - - - - M D E D V L P G E V L A I E G I F M A C G L - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - N E P E - - - - - - - - - - Y L Y H P L L S P I K L Y I T G L M R D K E - - - - S L F E A M L A N - - - - - - V R F H S T T G I D Q L G L S M L Q V S G D G N M N W G R A L A I L T F G S F V A Q K L S N - - - - E P H L R D F A L A V L P A Y A Y E A I G P Q W F R A R G G W R - G L K A Y C T Q V L T - -
- - - - - - D W E - E P R L D I E G F V V D Y F T H R I R Q N G E W F - - - - - - - - - - - - - - - - - - - - - - - - - - - - G A P G - L P S - - - - - - - - - - G V Q P E H E R V G T I F E K K H A - - - - E N F E T F S E Q L L A - - - - V P I S F S L Y Q D V V R T V G N - - - - - - P S Y G R L I G L I S F G G F V A A K E S V - - - E L Q G Q V R N L F V Y T S L F I K T R I - - N W R S W D D F T L - G Q K E D Y E A E A - - -
- - - - - - M - - - - - A Y S T R E I L L A L C I R D S R V H G N - G - - - - - - - - - - - - - - - - - - - - - - - - - - - - T L H P V L E L A A R E T P L R L S P E D T V V L R Y H V L L E E I I E - - - - R N S E T F T E T W N R F I T H T E H V D L D F N S V F L E I F H R - - - G D P S L G R A L A W M A W C M H A C R T L C C N Q S T P Y Y V V D L S V R G M L E A S E G L D - - G W I H Q Q G G W S - T L I E D N I P - G - - -
- - - - - - - - - A E S E L H I H S L A E H Y L Q Y V L Q V P - - - - A F E - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - P S Q A C R V L Q R V A F S V Q E - - - V E N L K S Y L D D F - - - H V S I D T A R I I F N Q V - E K E F E D G - - - I I N W G R I V T I F A F G G V L L K K L E - - - - - - - S A Y - K V S S F V A E F I - N - N T G E W I - Q N G G W E D G F I K K F E - - - - - -
- - - - - - - - - - K S G T Y W A T L I T A F L K T V S K V E - - - - - E L D C V D - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - S A V L V D V S K I I T L T Q E F R R - H Y D S V Y R A D Y G P - - - - - - A L K N W K R D L S K L F T S L F V D - - - - V I N S G R I V G F F D V G R Y V C E E V L C P G S W - T E D H E L L N D C M T H F F I E N N L M N H F P L E - - - - - - - - - - - - - - - - - -
- - - G G P T S S E Q I M K T G A L L L Q G F I Q D R A G R D A - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - S T K L S E S L K R I G D E L D S - - N M E L Q R M I A - - - - - - - - A V D T S P R V F F R V A A D M F S D G - - - N F N W G R V V A L F Y F A S K L V L K A L S T K - - - V P E L I R T I M G W T L D F L R E R L L G W I Q D Q G G W D - G L L S - - Y F G T P T W
- - - - - - - S E E Q V A Q D T E E V F R S Y V F Y R H Q Q E Q E A E G V A A P A D P E M V T - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - L P L Q P S S T M G Q V G R Q L A I I G D D - I N R R Y D S E F Q T M L Q H A Q P T A E N A Y E Y F T K I A T S L F E S - - - - G I N W G R V V A L L G F G Y R L A L H V Y Q - H G L - T G F L G Q V T R F V V D F M L H H S I A R W I A Q R G G W V - A A L N - - - - - - - - L
- - - S - - P T D K E L V S Q A K A L C R D Y I N S R L I R A - - - - G V S W S - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - G K L A E V S A I L L R L G D E L E Y - I R P N V Y R N I A R Q L N I S L H S E T V V T D A F L A V A A Q I F T A - - - - G I T W G K V V S L Y A V A A G L A V D C V R - H A Q - P A M V H T I V D C L G E F V R K - T L V T W L K R R G G W A - D I T K C V V - - - - - -
- - - - - - - M S C W L R E Q T L L L A E D Y I S F C S G I Q - - - - Q - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - T P P S E S A E A M R Y L A K E M E Q - Q H R T K F R S L S Q E F L D - - T C G A D P S K C L Q S V M R E L V G D G - - - K M N W G R V V S I F T F T G V L A S E L L S - R G - - E E G S - R L A E T I A D Y L G G - E K Q D W L V E N G G W E - G F C R F F H N A - - - -
- - - - - - - - - - D L Y R Q S L E I I S R Y L R E Q A T G A - - - - K D T K P M G R - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - S G A T S R K A L E T L R R V G D G V Q R - N H E T A F Q G M L R K L D I - - K N E D - D V K S L S R V M I H V F S D G - - - V T N W G R I V T L I S F G A F V A K H L K T - I N Q - E S C I E P L A E S I T D V L V R - T K R D W L V K Q R G W D - G F V E F F H V E D L E G
- - - W - - D N E L S G I N T S V S L A A D Y V Y M R L A T E - - - - G F V F G I R S - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - S V R A P I R L C D A M F L M C D L F E R - F H D R Y I A P L K N A C L G I S A D - - M D M R M F F S A L D S V F S S - - - - G I S W S R I V A M Y A F A G S V A L A C A R - Q G R - R Q T V I A I P E W I M L Y M R R - A I A P W I H A N G G W D - S F I F S Q D V L N G N H

 

 

 

 

 

Member Chain UniProtKB GO term
d1ddba_ A P70444 GO:0001836
d1ddba_ A P70444 GO:0005515
d1ddba_ A P70444 GO:0005737
d1ddba_ A P70444 GO:0005739
d1ddba_ A P70444 GO:0005741
d1ddba_ A P70444 GO:0005829
d1ddba_ A P70444 GO:0006626
d1ddba_ A P70444 GO:0006915
d1ddba_ A P70444 GO:0006974
d1ddba_ A P70444 GO:0010918
d1ddba_ A P70444 GO:0016020
d1ddba_ A P70444 GO:0031334
d1ddba_ A P70444 GO:0031625
d1ddba_ A P70444 GO:0031966
d1ddba_ A P70444 GO:0035556
d1ddba_ A P70444 GO:0042129
d1ddba_ A P70444 GO:0042770
d1ddba_ A P70444 GO:0042775
d1ddba_ A P70444 GO:0042981
d1ddba_ A P70444 GO:0043065
d1ddba_ A P70444 GO:0050678
d1ddba_ A P70444 GO:0065003
d1ddba_ A P70444 GO:0090150
d1ddba_ A P70444 GO:0090200
d1ddba_ A P70444 GO:0097191
d1ddba_ A P70444 GO:0097284
d1ddba_ A P70444 GO:0097345
d1ddba_ A P70444 GO:0097435
d1ddba_ A P70444 GO:1902108
d1ddba_ A P70444 GO:1902230
d1ddba_ A P70444 GO:2000045
d1ddba_ A P70444 GO:2000271
d1ddba_ A P70444 GO:2001235
d1ddba_ A P70444 GO:2001238
d1ddba_ A P70444 GO:2001244
d1k3ka_ A Q76RI8 GO:0042981
d1ohua_ A P41958 GO:0042981
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in