Superfamily : 56349 [ DNA breaking-rejoining enzymes ]
Class : Alpha and beta proteins (a+b)
Fold : DNA breaking-rejoining enzymes
# of Members : 7
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1a0pa2  ( 111 )                    kdLseaqVerLlqaPli-d---qpleLRDkAMLe
d1a41a-  (  81 )             nakrdriFvrVynvmkrIncfInknisstds-nYqlAVfML
d1ae9a-  ( 177 )                   rsrLtadeYlkIyqaAes-------spcWLrlAMe
d1f44a2  ( 130 )     r----------akqAlaFertdFdqVrslmensd---rcqdirNLAFLG
d1k4ta2  ( 431 )    pssrikgekdwqkYetArrLkkcvdkIrnqYredWkskemkvrQrAVALy
d1p4ea2  ( 136 )     gnshskkmlkaLlsegesiweITekILnsFeytsrf-tktkTlyQFLFL
d5c6ka-  ( 162 )                   tgyLtqeeialLlaaLd----------gdNkkIAi
                                        aaaaaaaaaa            aaaaaaaa

                             60        70        80        90        100 
d1a0pa2  ( 141 )    VLyaTGLr------------vseLvgLtmsdIsl-----rq--gVVrVig
d1a41a-  ( 123 )    MeTmf----------------fglltlnIi----spdeI-Ifvgvsefvv
d1ae9a-  ( 205 )    LAVVTGQr------------vgDLCeMkwsdiv------dg--yLyVeQs
d1f44a2  ( 166 )    IAynTLLr------------iaeIArIrvkdIsrt---dgg--rMlIhig
d1k4ta2  ( 481 )    FIDklALragnekeegetadtvgCCsLrvehInlhpeld-gqeyVVeFdf
d1p4ea2  ( 184 )    ATFINCGr------------fsDIkNVdPksFklv-qNkyLgVIIqClVt
d5c6ka-  ( 187 )    LClsTGAr------------wgEAarLkaenIi------hn--rVtFvkt
                    aaaaa               aaaa    333bb           bbbb  

                             110       120       130       140       150 
d1a0pa2  ( 172 )    --kgnkerlVPLg---eeA----vywLetYlehGrp--wLlngvsidvLF
d1a41a-  ( 177 )    h----------sn---------rlypLlkLtds----------speefLF
d1ae9a-  ( 235 )    --ktgvkIAIptaLhIdaLgIs-MeTldkCkeiLg-----------gtII
d1f44a2  ( 199 )    -----rGvekaLs---lgV----TklVerWisvSgV--ad---dpnnyLF
d1k4ta2  ( 530 )    lgkdsiryynkVp---------VekrVFkNLqlFme-----nkqpeddLF
d1p4ea2  ( 221 )    eTktsvsRhIYFFsArgr--IdPLvyLDeFLrnsepvlKrvnr-------
d5c6ka-  ( 217 )    --ktNkprtVpIs----------eavakmIadnkr-----------gfLF
                           bbbb             aaaaaaa                   

                             160       170       180       190       200 
d1a0pa2  ( 211 )    Psq------raq---qMtrqtFwhrIkhYAvlAg--Id-----sekLsph
d1a41a-  ( 201 )    n--------------kls--vcikqfg--Ir--------------kdlrt
d1ae9a-  ( 273 )    Ast---------rreplssgtVsryFmrArkaSglsfg------dpPtFh
d1f44a2  ( 240 )    CrVrkngvaapsatsqlstraLegIFeaThrliygakddsgqrylaWsgh
d1k4ta2  ( 566 )    d--------------rLnTgiLnkhLqdlme--------------gLtAk
d1p4ea2  ( 262 )    ---tgnsssnkqeyQLLkdnlvrsYnkaLkknapypIFaik---nGpksh
d5c6ka-  ( 244 )    p------------------dadyprFrrtMkaikpdLp------mgqAth
                                        aaaaaaaaaaa                   

                             210       220       230       240       250 
d1a0pa2  ( 245 )    vLrhaFAthLLnhgadLrvVqmllsdlsttqIYt-h-------VateRlr
d1a41a-  ( 225 )    YgvnytFLynFwtnVksis----------------plpspkkLIalTikq
d1ae9a-  ( 309 )    eLrsLSarlYqi--------------sFaqhLlGh-----------fddr
d1f44a2  ( 290 )    SArVGAArdmara---------gvsipeImqaGgwt-------nvniVmn
d1k4ta2  ( 588 )    vFrtYnaSitLqqqLkelTapd------------enipaKilsYnrANra
d1p4ea2  ( 306 )    IGrhLMtsfLsmk----------gLteLtnvVGnfsdkqitaIpdhYFAL
d5c6ka-  ( 270 )    ALRhSfAThfMi---------nggsiitLqriLGht-------rieqTmv
                    aaaaaaaaaaaa                aaaaa           aaaaaa

                             260       270       280       290       300 
d1a0pa2  ( 289 )    qlhq                                              
d1a41a-  ( 259 )    Taevvg--------htPsiskrayMatTIleMvkd--nfldvVskTtfde
d1ae9a-  ( 347 )    grewdkIe------------i                             
d1f44a2  ( 324 )    fIrnldse------------tgamvrlledg-------------------
d1k4ta2  ( 626 )    VAilCnhqrappkqialgtSklnLDPRITVaWCkkwgVpiekIYnktqre
d1p4ea2  ( 358 )    VSryyaydpiskeMialkdetnpieewqhieqlkgsaeGsirYpaWngiI
d5c6ka-  ( 304 )    Yahfapey------------lqdaislnplrgg-----------------
                    a                        aa                       

                             310   
d1a0pa2                            
d1a41a-  ( 300 )    FlsiVvdhVs     
d1ae9a-                            
d1f44a2  ( 343 )    --------------d
d1k4ta2  ( 751 )    kFawAidmadedyeF
d1p4ea2  ( 408 )    sqeVLdyLSsyinrr
d5c6ka-  ( 325 )    -------------te
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Recombinase XerDLambda integrase-like, catalytic coreEscherichia coli [TaxId: 562]view
Eukaryotic DNA topoisomerase I, catalytic coreEukaryotic DNA topoisomerase I, catalytic coreVaccinia virus [TaxId: 10245]view
Integrase (Int)Lambda integrase-like, catalytic coreBacteriophage lambda [TaxId: 10710]view
Cre recombinaseLambda integrase-like, catalytic coreBacteriophage P1 [TaxId: 10678]view
Eukaryotic DNA topoisomerase I, catalytic coreEukaryotic DNA topoisomerase I, catalytic coreHuman (Homo sapiens) [TaxId: 9606]view
Flp recombinaseLambda integrase-like, catalytic coreBaker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]view
Integrase (Int)Lambda integrase-like, catalytic coreEnterobacteria phage [TaxId: 10679]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310
- - - - - - - - - - - - - - - - K D L S E A Q V E R L L Q A P L I - D - - - Q P L E L R D K A M L E V L Y A T G L R - - - - - - - - - - - - V S E L V G L T M S D I S L - - - - - R Q - - G V V R V I G - - K G N K E R L V P L G - - - E E A - - - - V Y W L E T Y L E H G R P - - W L L N G V S I D V L F P S Q - - - - - - R A Q - - - Q M T R Q T F W H R I K H Y A V L A G - - I D - - - - - S E K L S P H V L R H A F A T H L L N H G A D L R V V Q M L L S D L S T T Q I Y T - H - - - - - - - V A T E R L R Q L H Q - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - N A K R D R I F V R V Y N V M K R I N C F I N K N I S S T D S - N Y Q L A V F M L M E T M F - - - - - - - - - - - - - - - - F G L L T L N I I - - - - S P D E I - I F V G V S E F V V H - - - - - - - - - - S N - - - - - - - - - R L Y P L L K L T D S - - - - - - - - - - S P E E F L F N - - - - - - - - - - - - - - K L S - - V C I K Q F G - - I R - - - - - - - - - - - - - - K D L R T Y G V N Y T F L Y N F W T N V K S I S - - - - - - - - - - - - - - - - P L P S P K K L I A L T I K Q T A E V V G - - - - - - - - H T P S I S K R A Y M A T T I L E M V K D - - N F L D V V S K T T F D E F L S I V V D H V S - - - - -
- - - - - - - - - - - - - - - R S R L T A D E Y L K I Y Q A A E S - - - - - - - S P C W L R L A M E L A V V T G Q R - - - - - - - - - - - - V G D L C E M K W S D I V - - - - - - D G - - Y L Y V E Q S - - K T G V K I A I P T A L H I D A L G I S - M E T L D K C K E I L G - - - - - - - - - - - G T I I A S T - - - - - - - - - R R E P L S S G T V S R Y F M R A R K A S G L S F G - - - - - - D P P T F H E L R S L S A R L Y Q I - - - - - - - - - - - - - - S F A Q H L L G H - - - - - - - - - - - F D D R G R E W D K I E - - - - - - - - - - - - I - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- R - - - - - - - - - - A K Q A L A F E R T D F D Q V R S L M E N S D - - - R C Q D I R N L A F L G I A Y N T L L R - - - - - - - - - - - - I A E I A R I R V K D I S R T - - - D G G - - R M L I H I G - - - - - R G V E K A L S - - - L G V - - - - T K L V E R W I S V S G V - - A D - - - D P N N Y L F C R V R K N G V A A P S A T S Q L S T R A L E G I F E A T H R L I Y G A K D D S G Q R Y L A W S G H S A R V G A A R D M A R A - - - - - - - - - G V S I P E I M Q A G G W T - - - - - - - N V N I V M N F I R N L D S E - - - - - - - - - - - - T G A M V R L L E D G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - D
P S S R I K G E K D W Q K Y E T A R R L K K C V D K I R N Q Y R E D W K S K E M K V R Q R A V A L Y F I D K L A L R A G N E K E E G E T A D T V G C C S L R V E H I N L H P E L D - G Q E Y V V E F D F L G K D S I R Y Y N K V P - - - - - - - - - V E K R V F K N L Q L F M E - - - - - N K Q P E D D L F D - - - - - - - - - - - - - - R L N T G I L N K H L Q D L M E - - - - - - - - - - - - - - G L T A K V F R T Y N A S I T L Q Q Q L K E L T A P D - - - - - - - - - - - - E N I P A K I L S Y N R A N R A V A I L C N H Q R A P P K Q I A L G T S K L N L D P R I T V A W C K K W G V P I E K I Y N K T Q R E K F A W A I D M A D E D Y E F
- G N S H S K K M L K A L L S E G E S I W E I T E K I L N S F E Y T S R F - T K T K T L Y Q F L F L A T F I N C G R - - - - - - - - - - - - F S D I K N V D P K S F K L V - Q N K Y L G V I I Q C L V T E T K T S V S R H I Y F F S A R G R - - I D P L V Y L D E F L R N S E P V L K R V N R - - - - - - - - - - T G N S S S N K Q E Y Q L L K D N L V R S Y N K A L K K N A P Y P I F A I K - - - N G P K S H I G R H L M T S F L S M K - - - - - - - - - - G L T E L T N V V G N F S D K Q I T A I P D H Y F A L V S R Y Y A Y D P I S K E M I A L K D E T N P I E E W Q H I E Q L K G S A E G S I R Y P A W N G I I S Q E V L D Y L S S Y I N R R
- - - - - - - - - - - - - - - T G Y L T Q E E I A L L L A A L D - - - - - - - - - - G D N K K I A I L C L S T G A R - - - - - - - - - - - - W G E A A R L K A E N I I - - - - - - H N - - R V T F V K T - - K T N K P R T V P I S - - - - - - - - - - E A V A K M I A D N K R - - - - - - - - - - - G F L F P - - - - - - - - - - - - - - - - - - D A D Y P R F R R T M K A I K P D L P - - - - - - M G Q A T H A L R H S F A T H F M I - - - - - - - - - N G G S I I T L Q R I L G H T - - - - - - - R I E Q T M V Y A H F A P E Y - - - - - - - - - - - - L Q D A I S L N P L R G G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - T E

 

 

 

 

 

Member Chain UniProtKB GO term
d1a0pa2 A P0A8P8 GO:0003677
d1a0pa2 A P0A8P8 GO:0005737
d1a0pa2 A P0A8P8 GO:0006276
d1a0pa2 A P0A8P8 GO:0006310
d1a0pa2 A P0A8P8 GO:0006313
d1a0pa2 A P0A8P8 GO:0007059
d1a0pa2 A P0A8P8 GO:0009009
d1a0pa2 A P0A8P8 GO:0009037
d1a0pa2 A P0A8P8 GO:0009314
d1a0pa2 A P0A8P8 GO:0015074
d1a0pa2 A P0A8P8 GO:0048476
d1a0pa2 A P0A8P8 GO:0051301
d1a0pa2 A P0A8P8 GO:0071139
d1a0pa2 A P0A8P8 GO:0003677
d1a0pa2 A P0A8P8 GO:0005737
d1a0pa2 A P0A8P8 GO:0006276
d1a0pa2 A P0A8P8 GO:0006310
d1a0pa2 A P0A8P8 GO:0006313
d1a0pa2 A P0A8P8 GO:0007059
d1a0pa2 A P0A8P8 GO:0009009
d1a0pa2 A P0A8P8 GO:0009037
d1a0pa2 A P0A8P8 GO:0009314
d1a0pa2 A P0A8P8 GO:0015074
d1a0pa2 A P0A8P8 GO:0048476
d1a0pa2 A P0A8P8 GO:0051301
d1a0pa2 A P0A8P8 GO:0071139
d1a41a_ A P68698 GO:0003677
d1a41a_ A P68698 GO:0003917
d1a41a_ A P68698 GO:0006265
d1ae9a_ A P03700 GO:0003677
d1ae9a_ A P03700 GO:0006310
d1ae9a_ A P03700 GO:0015074
d1f44a2 A P06956 GO:0003677
d1f44a2 A P06956 GO:0006310
d1f44a2 A P06956 GO:0015074
d1f44a2 A P06956 GO:0003677
d1f44a2 A P06956 GO:0006310
d1f44a2 A P06956 GO:0015074
d1k4ta2 A P11387 GO:0003677
d1k4ta2 A P11387 GO:0003677
d1k4ta2 A P11387 GO:0003917
d1k4ta2 A P11387 GO:0003917
d1k4ta2 A P11387 GO:0005694
d1k4ta2 A P11387 GO:0005694
d1k4ta2 A P11387 GO:0006265
d1k4ta2 A P11387 GO:0006265
d1p4ea2 A P03870 GO:0003677
d1p4ea2 A P03870 GO:0003690
d1p4ea2 A P03870 GO:0003697
d1p4ea2 A P03870 GO:0005575
d1p4ea2 A P03870 GO:0006310
d1p4ea2 A P03870 GO:0008301
d1p4ea2 A P03870 GO:0009009
d1p4ea2 A P03870 GO:0015074
d1p4ea2 A P03870 GO:0042150
d1p4ea2 A P03870 GO:0003677
d1p4ea2 A P03870 GO:0003690
d1p4ea2 A P03870 GO:0003697
d1p4ea2 A P03870 GO:0005575
d1p4ea2 A P03870 GO:0006310
d1p4ea2 A P03870 GO:0008301
d1p4ea2 A P03870 GO:0009009
d1p4ea2 A P03870 GO:0015074
d1p4ea2 A P03870 GO:0042150
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in