Superfamily : 55073 [ Nucleotide cyclase ]
Class : Alpha and beta proteins (a+b)
Fold : Ferredoxin-like
# of Members : 13
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1ab8a-  ( 877 )                           lyhqsydcVCVMfAsIpdFkefytesd
d1azsa-  ( 376 )                     dmmfhkiyiqkhdnVSILfAdIegftslasq--
d1fx2a-  ( 888 )                     nnnrAPke--ptdpVTLIFTdIesstaLwaah-
d1w25a3  ( 294 )    lTglhnrryMtgqLdslVkrAtlg----gdpVSALlIdIDfFkkindtfg
d1wc1a-  (1004 )                            lrpeprlITILfSdIvgftrMsna--
d1ybta-  ( 291 )                                aerlaTIftdIvgstqhaaalg
d2w01a-  ( 435 )                            mggdrrpITILTSdLrgftstseg--
d2wz1a-  ( 412 )                            vparydnVTILfSGIvgfnafcskha
d3mr7a1  (   1 )                               errlCAILaadagysr---lern
d3r5ga-  ( 222 )                             etqrkkLTVFfSdIrgfteLsee--
d4p2fa-  ( 237 )                      eperniiadkydeASVLfAdIvgft--erass
d4wp9a1  (  54 )                                  rvvilFtdieestalnerig
d6ao9a-  ( 443 )                            takeyesVTVFfSdItnftvissr--
                                                   bbbbbbbb  aaaaa    

                             60        70        80        90        100 
d1ab8a-  ( 904 )    vnkeGleClrllneIia-dFddllskpkFsgVekIktigstYMAATgLsa
d1azsa-  ( 407 )    --ctaqelvmtlneLFa-rFdklAa--enh-ClrIkilgdcYYCVSGLpe
d1fx2a-  ( 918 )    ----pdlMpdavaaHhr-mVrsLig--ryk-CyeVktvgdsFMIASk---
d1w25a3  ( 340 )    ----hdiGdeVLreFAl-rLasnVra----iDlpCryggeeFVVIMp---
d1wc1a-  (1028 )    --lqsqgvaeLlneYlg-eMtrAVf--enq-GtvDkfvgdaIMALYGApe
d1ybta-  ( 315 )    ----ddrwrdlldnHdt-iVchEIq--rfg-GreVntagdgfvAtft---
d2w01a-  ( 459 )    --lnpeevvkVlniYfg-kMadVIt--hHg-GtiDefmgdGILVLFGApt
d2wz1a-  ( 439 )    --sgamkivnLlndLyt-rFdtlTdsrknpfVykvetvgdkYMTVSGLpe
d3mr7a1  (  23 )    ----etdvlnrqklYrrelidpAia--qag-GqiVkttgd-glArFd---
d3r5ga-  ( 245 )    --leaealtdLlnnYln-eMskiAl--kyg-GtiDkfvgdcVmVFFGDps
d4p2fa-  ( 267 )    --tapadlv-fldr-ys-aFdelVd--qhg-LekIkvsg-sYMVVSGVpr
d4wp9a1  (  74 )    -----dawvklissHdk-lvsdlv---rqs-GhvvksqgdGFMvaFa---
d6ao9a-  ( 468 )    --tstkdmmaTlnkLwl-eYdaIak--rwg-VykVetigdaYlGVTGApd
                         aaaaaaaaaaaa aaaaaa        bbbb     bbbbb    

                             110       120       130       140       150 
d1ab8a-  ( 953 )    --ipsyhIgtMVeFAyaLvgkLd----------ainkhs----------f
d1azsa-  ( 451 )    ar--adHAhcCVeMGmdMieaIs----------lvremt---g-------
d1fx2a-  ( 957 )    ------spfaAVqLAqeLQlcFlhhdWgtnaLDdsYrefEeqraegecey
d1w25a3  ( 378 )    ----dtaladAlriAerIrmhVsgspFtVahg------------------
d1wc1a-  (1072 )    emspseQVrrAIaTArqMlvaLe----------klnqgWqerglVgrneV
d1ybta-  ( 354 )    ------spsaAIaCAddIVdaVa----------al---------------
d2w01a-  ( 503 )    sq--qddAlrAVACGVeMQlaLr----------eVnqqVtglgl------
d2wz1a-  ( 488 )    pc--ihHArsIChLALdMmeiAg----------qV----------qvd-g
d3mr7a1  (  63 )    ------tAqaALrCALeIQqaqqree------------------------
d3r5ga-  ( 289 )    tqgakkdAvaAVSMGIaMrkhMk----------vLrqqWraqgit-----
d4p2fa-  ( 311 )    pr--pdhTqaLAdFALdMtnvaa----------ql----------kdprg
d4wp9a1  ( 113 )    ------rpeqAvrCGielqralrn--------------------------
d6ao9a-  ( 512 )    vv--pdHAerACnFAvdIiemIk----------sFktit---g-------
                           aaaaaaaaaaaaaaa                            

                             160       170       180       190       200 
d1ab8a-  ( 992 )    n----------------dFkLrVGINhgpViAGvig-aqkpqydIwg---
d1azsa-  ( 479 )    v----------------nVnMrVGIHSgrVhCgvlg-lrkwqfdVws---
d1fx2a-  (1001 )    tppTAhmdpevYsrlWnGLrVRVGIhTglCdIrhdevtk--gydYyg---
d1w25a3  ( 406 )    ----reml---------nVtISIGVSaTag-----------------egd
d1wc1a-  (1112 )    p----------------pVrFrCGIhQgmAvVGlfgsqersdftAig---
d1ybta-  ( 373 )    -----------------gIeVrIGIHAgeVevrda--sh--gtdVag---
d2w01a-  ( 535 )    q----------------pLeMGIGINtgeVvVgnigsekrtkygVvg---
d2wz1a-  ( 515 )    e----------------svqITIGIHtgeVvTgvig-qrmprycLfg---
d3mr7a1  (  84 )    -----------dtprkeriqyrIGINigdIvled--------gdIfg---
d3r5ga-  ( 324 )    k----------------pLeIrMGINTgyCtVGnfgadtrmdytIig---
d4p2fa-  ( 339 )    n----------------pvpLrVGLATgpVvAgvvG---sfrydVwg---
d4wp9a1  ( 132 )    -----------------airvriGiHmgrSvr---------gddlfg---
d6ao9a-  ( 540 )    e----------------sinIrIGLnSgpVtAgvl-----phwcLvg---
                                        bbbbbbbb  bbbb         bbb    

                             210       220       230       240       250 
d1ab8a-  (1022 )    ---ntvnvAs-mdstGv---ldkIqVteeTsliLqtl-----gyt-Ctcf
d1azsa-  ( 509 )    ---ndvtlAnhMEaGGk---agrIHITkaTlsyLn------gdye-vepG
d1fx2a-  (1046 )    ---rTpnmAArTESVAn---GGQVLMThaAymsLsaedrk--qId-vtal
d1w25a3  ( 426 )    tpeaLlkrAdeGvyqAkasgrnavvgkaa                     
d1wc1a-  (1143 )    ---psvniAarLqeaTa---pnsIMVSamVAqyVp------de--eIikr
d1ybta-  ( 399 )    ---vAvhIGarVcalAg---pseVLVSstVrdiva---gs--rhr-Faer
d2w01a-  ( 566 )    ---aqvnlTyrIEsyTt---GgqIFIsstTleaAg------drVh-vngn
d2wz1a-  ( 545 )    ---ntvnlTsrTEttGe---kGkINVSeyTyrcLmspensdpqFh-Lehr
d3mr7a1  ( 112 )    ---davnVAarLEaiSe---pgAICVSdiVhqiTqd--rv--sep-Ftdl
d3r5ga-  ( 355 )    ---revnlAsrLesaSe---ageILIsheTyslIk------dvI-mCrdk
d4p2fa-  ( 369 )    ---dAvnvAsrMEstDs---vgqIQVpdeVyerLk------ddFv-Lrer
d4wp9a1  ( 161 )    ---rnvaMAarvAaqAa---GgeilvSqpvrdalss------gir-fddG
d6ao9a-  ( 570 )    ---dTvntAsrmestSk---aghIHIsesTyhfIk------skFv-tqpl
                       aaaaaaaaaaa         bbb aaaaa               bb 

                             260       270       280       290 
d1ab8a-  (1075 )    V                                          
d1azsa-  ( 546 )    c----GgernayLke--hsieTflIl                 
d1fx2a-  (1087 )    gdvaLr--------gvsdpvkMyqLnTVpsRnfaalrldreyf
d1w25a3                                                        
d1wc1a-  (1179 )    efl--eLkgid------epvmTCvInpnm              
d1ybta-  ( 437 )    geqeLk--------gVpgrwrLCvlrd---------------d
d2w01a-  ( 603 )    rtv--qpkgvk------dpvvIwdVagVgepynlslaveeq  
d2wz1a-  ( 588 )    gpvs--Mkgkk------epMqVwfLsrknt----------g  
d3mr7a1  ( 151 )    glqkVk--------nitrpirVwqWvpda              
d3r5ga-  ( 392 )    gqi--aVkgfs------rpvqIyqVvdsrrdlg          
d4p2fa-  ( 406 )    ghin--v---g------gvmrtwyLigrk              
d4wp9a1  ( 200 )    revelk--------gfsgtyrlFavlas               
d6ao9a-  ( 607 )    d-------------------qtywVlgrk              
                                          bbb
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Type II adenylyl cyclase C2 domainAdenylyl and guanylyl cyclase catalytic domainNorway rat (Rattus norvegicus) [TaxId: 10116]view
Adenylyl cyclase VC1, domain C1aAdenylyl and guanylyl cyclase catalytic domainDog (Canis familiaris) [TaxId: 9615]view
Receptor-type monomeric adenylyl cyclaseAdenylyl and guanylyl cyclase catalytic domainTrypanosome (Trypanosoma brucei), different isoform [TaxId: 5691]view
Response regulator PleD, C-terminal domainGGDEF domainCaulobacter crescentus [TaxId: 155892]view
Adenylate cyclase CyaCAdenylyl and guanylyl cyclase catalytic domainSpirulina platensis [TaxId: 118562]view
automated matchesautomated matchesMycobacterium tuberculosis [TaxId: 83331]view
automated matchesautomated matchesSynechocystis sp. [TaxId: 1148]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesRuegeria pomeroyi [TaxId: 246200]view
automated matchesautomated matchesPseudomonas aeruginosa [TaxId: 287]view
automated matchesautomated matchesMycobacterium tuberculosisview
automated matchesautomated matchesMycobacterium avium [TaxId: 1764]view
automated matchesautomated matchesBlastocladiella emersonii [TaxId: 4808]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290
- - - - - - - - - - - - - - - - - - - - - - - L Y H Q S Y D C V C V M F A S I P D F K E F Y T E S D V N K E G L E C L R L L N E I I A - D F D D L L S K P K F S G V E K I K T I G S T Y M A A T G L S A - - I P S Y H I G T M V E F A Y A L V G K L D - - - - - - - - - - A I N K H S - - - - - - - - - - F N - - - - - - - - - - - - - - - - D F K L R V G I N H G P V I A G V I G - A Q K P Q Y D I W G - - - - - - N T V N V A S - M D S T G V - - - L D K I Q V T E E T S L I L Q T L - - - - - G Y T - C T C F V - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - D M M F H K I Y I Q K H D N V S I L F A D I E G F T S L A S Q - - - - C T A Q E L V M T L N E L F A - R F D K L A A - - E N H - C L R I K I L G D C Y Y C V S G L P E A R - - A D H A H C C V E M G M D M I E A I S - - - - - - - - - - L V R E M T - - - G - - - - - - - V - - - - - - - - - - - - - - - - N V N M R V G I H S G R V H C G V L G - L R K W Q F D V W S - - - - - - N D V T L A N H M E A G G K - - - A G R I H I T K A T L S Y L N - - - - - - G D Y E - V E P G C - - - - G G E R N A Y L K E - - H S I E T F L I L - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - N N N R A P K E - - P T D P V T L I F T D I E S S T A L W A A H - - - - - P D L M P D A V A A H H R - M V R S L I G - - R Y K - C Y E V K T V G D S F M I A S K - - - - - - - - - S P F A A V Q L A Q E L Q L C F L H H D W G T N A L D D S Y R E F E E Q R A E G E C E Y T P P T A H M D P E V Y S R L W N G L R V R V G I H T G L C D I R H D E V T K - - G Y D Y Y G - - - - - - R T P N M A A R T E S V A N - - - G G Q V L M T H A A Y M S L S A E D R K - - Q I D - V T A L G D V A L R - - - - - - - - G V S D P V K M Y Q L N T V P S R N F A A L R L D R E Y F
L T G L H N R R Y M T G Q L D S L V K R A T L G - - - - G D P V S A L L I D I D F F K K I N D T F G - - - - H D I G D E V L R E F A L - R L A S N V R A - - - - I D L P C R Y G G E E F V V I M P - - - - - - - D T A L A D A L R I A E R I R M H V S G S P F T V A H G - - - - - - - - - - - - - - - - - - - - - - R E M L - - - - - - - - - N V T I S I G V S A T A G - - - - - - - - - - - - - - - - - E G D T P E A L L K R A D E G V Y Q A K A S G R N A V V G K A A - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - L R P E P R L I T I L F S D I V G F T R M S N A - - - - L Q S Q G V A E L L N E Y L G - E M T R A V F - - E N Q - G T V D K F V G D A I M A L Y G A P E E M S P S E Q V R R A I A T A R Q M L V A L E - - - - - - - - - - K L N Q G W Q E R G L V G R N E V P - - - - - - - - - - - - - - - - P V R F R C G I H Q G M A V V G L F G S Q E R S D F T A I G - - - - - - P S V N I A A R L Q E A T A - - - P N S I M V S A M V A Q Y V P - - - - - - D E - - E I I K R E F L - - E L K G I D - - - - - - E P V M T C V I N P N M - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - A E R L A T I F T D I V G S T Q H A A A L G - - - - D D R W R D L L D N H D T - I V C H E I Q - - R F G - G R E V N T A G D G F V A T F T - - - - - - - - - S P S A A I A C A D D I V D A V A - - - - - - - - - - A L - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - G I E V R I G I H A G E V E V R D A - - S H - - G T D V A G - - - - - - V A V H I G A R V C A L A G - - - P S E V L V S S T V R D I V A - - - G S - - R H R - F A E R G E Q E L K - - - - - - - - G V P G R W R L C V L R D - - - - - - - - - - - - - - - D
- - - - - - - - - - - - - - - - - - - - - - - - M G G D R R P I T I L T S D L R G F T S T S E G - - - - L N P E E V V K V L N I Y F G - K M A D V I T - - H H G - G T I D E F M G D G I L V L F G A P T S Q - - Q D D A L R A V A C G V E M Q L A L R - - - - - - - - - - E V N Q Q V T G L G L - - - - - - Q - - - - - - - - - - - - - - - - P L E M G I G I N T G E V V V G N I G S E K R T K Y G V V G - - - - - - A Q V N L T Y R I E S Y T T - - - G G Q I F I S S T T L E A A G - - - - - - D R V H - V N G N R T V - - Q P K G V K - - - - - - D P V V I W D V A G V G E P Y N L S L A V E E Q - -
- - - - - - - - - - - - - - - - - - - - - - - - V P A R Y D N V T I L F S G I V G F N A F C S K H A - - S G A M K I V N L L N D L Y T - R F D T L T D S R K N P F V Y K V E T V G D K Y M T V S G L P E P C - - I H H A R S I C H L A L D M M E I A G - - - - - - - - - - Q V - - - - - - - - - - Q V D - G E - - - - - - - - - - - - - - - - S V Q I T I G I H T G E V V T G V I G - Q R M P R Y C L F G - - - - - - N T V N L T S R T E T T G E - - - K G K I N V S E Y T Y R C L M S P E N S D P Q F H - L E H R G P V S - - M K G K K - - - - - - E P M Q V W F L S R K N T - - - - - - - - - - G - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - E R R L C A I L A A D A G Y S R - - - L E R N - - - - E T D V L N R Q K L Y R R E L I D P A I A - - Q A G - G Q I V K T T G D - G L A R F D - - - - - - - - - T A Q A A L R C A L E I Q Q A Q Q R E E - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - D T P R K E R I Q Y R I G I N I G D I V L E D - - - - - - - - G D I F G - - - - - - D A V N V A A R L E A I S E - - - P G A I C V S D I V H Q I T Q D - - R V - - S E P - F T D L G L Q K V K - - - - - - - - N I T R P I R V W Q W V P D A - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - E T Q R K K L T V F F S D I R G F T E L S E E - - - - L E A E A L T D L L N N Y L N - E M S K I A L - - K Y G - G T I D K F V G D C V M V F F G D P S T Q G A K K D A V A A V S M G I A M R K H M K - - - - - - - - - - V L R Q Q W R A Q G I T - - - - - K - - - - - - - - - - - - - - - - P L E I R M G I N T G Y C T V G N F G A D T R M D Y T I I G - - - - - - R E V N L A S R L E S A S E - - - A G E I L I S H E T Y S L I K - - - - - - D V I - M C R D K G Q I - - A V K G F S - - - - - - R P V Q I Y Q V V D S R R D L G - - - - - - - - - -
- - - - - - - - - - - - - - - - - - E P E R N I I A D K Y D E A S V L F A D I V G F T - - E R A S S - - T A P A D L V - F L D R - Y S - A F D E L V D - - Q H G - L E K I K V S G - S Y M V V S G V P R P R - - P D H T Q A L A D F A L D M T N V A A - - - - - - - - - - Q L - - - - - - - - - - K D P R G N - - - - - - - - - - - - - - - - P V P L R V G L A T G P V V A G V V G - - - S F R Y D V W G - - - - - - D A V N V A S R M E S T D S - - - V G Q I Q V P D E V Y E R L K - - - - - - D D F V - L R E R G H I N - - V - - - G - - - - - - G V M R T W Y L I G R K - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - R V V I L F T D I E E S T A L N E R I G - - - - - D A W V K L I S S H D K - L V S D L V - - - R Q S - G H V V K S Q G D G F M V A F A - - - - - - - - - R P E Q A V R C G I E L Q R A L R N - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A I R V R I G I H M G R S V R - - - - - - - - - G D D L F G - - - - - - R N V A M A A R V A A Q A A - - - G G E I L V S Q P V R D A L S S - - - - - - G I R - F D D G R E V E L K - - - - - - - - G F S G T Y R L F A V L A S - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - T A K E Y E S V T V F F S D I T N F T V I S S R - - - - T S T K D M M A T L N K L W L - E Y D A I A K - - R W G - V Y K V E T I G D A Y L G V T G A P D V V - - P D H A E R A C N F A V D I I E M I K - - - - - - - - - - S F K T I T - - - G - - - - - - - E - - - - - - - - - - - - - - - - S I N I R I G L N S G P V T A G V L - - - - - P H W C L V G - - - - - - D T V N T A S R M E S T S K - - - A G H I H I S E S T Y H F I K - - - - - - S K F V - T Q P L D - - - - - - - - - - - - - - - - - - - Q T Y W V L G R K - - - - - - - - - - - - - -

 

 

 

 

 

Member Chain UniProtKB GO term
d1ab8a_ A P26769 GO:0009190
d1ab8a_ A P26769 GO:0016849
d1ab8a_ A P26769 GO:0035556
d1azsa_ A P30803 GO:0009190
d1azsa_ A P30803 GO:0016849
d1azsa_ A P30803 GO:0035556
d1azsa_ A P26769 GO:0009190
d1azsa_ A P26769 GO:0016849
d1azsa_ A P26769 GO:0035556
d1azsa_ A P04896 GO:0009190
d1azsa_ A P04896 GO:0016849
d1azsa_ A P04896 GO:0035556
d1fx2a_ A Q99279 GO:0009190
d1fx2a_ A Q99279 GO:0035556
d1w25a3 A B8GZM2 GO:0000160
d1w25a3 A B8GZM2 GO:0005525
d1w25a3 A B8GZM2 GO:0005737
d1w25a3 A B8GZM2 GO:0005886
d1w25a3 A B8GZM2 GO:0016740
d1w25a3 A B8GZM2 GO:0030154
d1w25a3 A B8GZM2 GO:0043709
d1w25a3 A B8GZM2 GO:0046872
d1w25a3 A B8GZM2 GO:0052621
d1w25a3 A B8GZM2 GO:1902201
d1w25a3 A B8GZM2 GO:0000160
d1w25a3 A B8GZM2 GO:0005525
d1w25a3 A B8GZM2 GO:0005737
d1w25a3 A B8GZM2 GO:0005886
d1w25a3 A B8GZM2 GO:0016740
d1w25a3 A B8GZM2 GO:0030154
d1w25a3 A B8GZM2 GO:0043709
d1w25a3 A B8GZM2 GO:0046872
d1w25a3 A B8GZM2 GO:0052621
d1w25a3 A B8GZM2 GO:1902201
d1w25a3 A B8GZM2 GO:0000160
d1w25a3 A B8GZM2 GO:0005525
d1w25a3 A B8GZM2 GO:0005737
d1w25a3 A B8GZM2 GO:0005886
d1w25a3 A B8GZM2 GO:0016740
d1w25a3 A B8GZM2 GO:0030154
d1w25a3 A B8GZM2 GO:0043709
d1w25a3 A B8GZM2 GO:0046872
d1w25a3 A B8GZM2 GO:0052621
d1w25a3 A B8GZM2 GO:1902201
d1wc1a_ A O32393 GO:0009190
d1wc1a_ A O32393 GO:0035556
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in