Superfamily : 53790 [ Tetrapyrrole methylase ]
Class : Alpha and beta proteins (a/b)
Fold : Tetrapyrrole methylase
# of Members : 8
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1cbfa1  (  21 )      mkLyIIGAGPgd---pdlItvkGlklLqqAdVVLYadslVs------q
d1ve2a1  (   1 )    mrGkVYLVGAGFGg---pehLtlkAlrVLevAevVLhd-rlVh------p
d1wdea-  (   6 )    eaVtLlLVGWgyap-----gqtleAldaVrrAdvVyVEsytpgsswL-yk
d1wyza1  (   2 )     etALYlLpvtlgdtpleqvlpsynteIIrgIrhFIVe------dvrsAr
d2bb3a1  (   2 )        iwIVGSGtçr----gqtterAkeiierAeVIyGs--------rrAL
d2z6ra-  (   2 )       vLyFIGLGlyd---erdItvkGleiAkkCdyVFAEfytslMagTtlg
d3ndca1  (   1 )      MtVhFIGAGPGa---adlItirGrdlIasCpVCLyagslVp------e
d6pr1a3  ( 216 )      geVVLVGAGpgd---aglLtlkGlqqIqqAdIVVyd-rlVs------d
                        bbbbb             aaaaaaaaa  bbbb            a

                             60        70        80        90        100 
d1cbfa1  (  60 )    dLIakSkp----gAevlkT--agmhleemvgtMldrMregkmVVrVhtgd
d1ve2a1  (  41 )    gVlalAk------gelvpv--k-tpqeaitarLiaLAregrvVARLKgGd
d1wdea-  (  52 )    sVveaAge----arVveAs--rrdLeersreivsra-l-davVAVVTagd
d1wyza1  (  45 )    rfLkkVdreididsltFypLnkhtspedIsgyLkplag--gasGvIse--
d2bb3a1  (  36 )    eLAgvvdds----rAriLrsfk---gdeirr-IeeGre--reVAVIstgd
d2z6ra-  (  46 )    rIqrlIgk-----eIrvLs--redVelnFeniVLplAk-endVAFLTPgd
d3ndca1  (  40 )    aLlahCpp----gAkivnT--apmsldaiIdtIaeAhaagqdVARLhsgd
d6pr1a3  ( 254 )    dImnlVar----dAdrvfV--g-vpqeeINqiLlreAqkgkrVVRLKggd
                    aaa           bbbb       aaaaaaa aaaa     bbbbb   

                             110       120       130       140       150 
d1cbfa1  ( 104 )    PamygaimeQmvlLkregVdIeiVpGvtsVfaAaaaAeaeLtipdltqtv
d1ve2a1  (  89 )    PmvfgrGgeEalaLrragIpfevVpGvtsAvgALsalgLpLthrglArsf
d1wdea-  (  94 )    P-vattHssLaaeAleagVaVryipGvsgvqaArga-TLsf-----yrFg
d1wyza1  (  99 )    ----dpgadVvaiAqrqklkvipLvGPssiilSv-aSgFng-----qs-f
d2bb3a1  (  77 )    P-vaglgrvlreia--edveikiepAiSsVqvAlarlkvdl-----se-V
d2z6ra-  (  88 )    PlvattHaelrirAkragVeSyvihApsiysaVgiT-gLhi-----ykfg
d3ndca1  (  84 )    LsiwsamgeQlrrLralnIpydvTpGvpsfaaAaatLgaeLtlpgvaqsv
d6pr1a3  ( 304 )    PfifgrGgeEletLchagipfsvVpGitaAsGCsaySgIplthrdyAqsv
                          aaaaaaaaaa    bbbb    aaaaaaaa             b

                             160       170       180       190       200 
d1cbfa1  ( 154 )    iltrAegr---tpVpe-fekLtdlAkh----kCTIALfl-----------
d1ve2a1  ( 139 )    avatghd--palplp-----------r----adTLVLlm-----------
d1wdea-  ( 139 )    gtVtLpGpwrgvtPisvArrIYlnLça----glHTTAlLdvd-ergvqLs
d1wyza1  ( 139 )    afhgyLpiepg----erakkLktLEqrVyaesqTQLFiet--------py
d2bb3a1  ( 119 )    avvdcf-----------daeltelLky-----rhLLIlAd--------sh
d2z6ra-  ( 132 )    ksatVaypegnwfptsYYdvIkeNaer----glHTLLfLdikaekrmyMt
d3ndca1  ( 134 )    ilTrtsGr--asampa-getLenfArt----gaVLAIhl-----------
d6pr1a3  ( 354 )    rlvtGhlk-tggeld-----wenLAae----kQTLVFym-----------
                    bbbb                aaaaa        bbbbb            

                             210       220       230       240       250 
d1cbfa1  ( 185 )    SStlTkkVmkeFinAg-------WsedTpVVVVykAtwp-dekivrtt-V
d1ve2a1  ( 167 )    ------glkerLler--------fppetpLAlLArVgwp-geavrlgr-V
d1wdea-  ( 184 )    PgqGVslLLeADreYAreagapaLLarLPSVLVe-AgaggghrVlYwssL
d1wyza1  ( 177 )    rNhkiedIlqnCrp------------qTkLCIAanItce-gefiqtrt-V
d2bb3a1  ( 149 )    --fplerLg-----------------krrVvLLEnLç-e-geriregn-A
d2z6ra-  ( 178 )    AneAMelLlkVedmk----kggvFtddtlVVVLArAgsl-nptirAGy-V
d3ndca1  ( 166 )    SVhVLdeVvqkLvph--------ygedCpVAIVWraswp-dqrvvrat-L
d6pr1a3  ( 383 )    GlnqAatIqekLiafg-------mqadmpVALVEnGTsv-kQrVvhgv-L
                         aaaaaaaa               bbbbbb        bbbbbb  

                             260       270       280       290       300 
d1cbfa1  ( 226 )    kdLddaMrtngIrkqAMILAg-----wALdp                   
d1ve2a1  ( 201 )    edLpglge--glpspalLVVG-----kVVglYge-------------llp
d1wdea-  ( 233 )    erLSta---dveggvYsIVIPArLsgvEewlLAaaSgqrrpLeydrsVye
d1wyza1  ( 214 )    kdWk----ghipkipCiFLLyk                            
d2bb3a1  ( 178 )    dsi------eLesdyTIIFVerev                          
d2z6ra-  ( 222 )    kdLIre---dFgdppHILIVPgklhivEAeyLVeiAgApreilrvn----
d3ndca1  ( 206 )    atLqtslGaeler-tALILVG-----rSLatedf                
d6pr1a3  ( 424 )    tqLgelAq--qVespALIIVG-----rVVaLrdk-------------lnw
                                   bbbbb                              

                             310  
d1cbfa1                           
d1ve2a1  ( 232 )    dhgl          
d1wdea-  ( 280 )    tVeeNçkkgvYepv
d1wyza1                           
d2bb3a1                           
d2z6ra-  ( 265 )    -------------v
d3ndca1                           
d6pr1a3  ( 454 )    fsnh
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Cobalt precorrin-4 methyltransferase CbiFTetrapyrrole methylaseBacillus megaterium [TaxId: 1404]view
Uroporphyrin-III C-methyltransferase (SUMT, UROM, CobA)Tetrapyrrole methylaseThermus thermophilus [TaxId: 274]view
Diphthine synthase, DphBTetrapyrrole methylaseAeropyrum pernix [TaxId: 56636]view
Putative methytransferase BT4190Tetrapyrrole methylaseBacteroides thetaiotaomicron [TaxId: 818]view
Precorrin-6y methylase CbiETetrapyrrole methylaseArchaeoglobus fulgidus [TaxId: 2234]view
Diphthine synthase, DphBTetrapyrrole methylasePyrococcus horikoshii [TaxId: 53953]view
automated matchesautomated matchesRhodobacter capsulatus [TaxId: 272942]view
automated matchesTetrapyrrole methylaseSalmonella typhimurium [TaxId: 90371]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310
- - M K L Y I I G A G P G D - - - P D L I T V K G L K L L Q Q A D V V L Y A D S L V S - - - - - - Q D L I A K S K P - - - - G A E V L K T - - A G M H L E E M V G T M L D R M R E G K M V V R V H T G D P A M Y G A I M E Q M V L L K R E G V D I E I V P G V T S V F A A A A A A E A E L T I P D L T Q T V I L T R A E G R - - - T P V P E - F E K L T D L A K H - - - - K C T I A L F L - - - - - - - - - - - S S T L T K K V M K E F I N A G - - - - - - - W S E D T P V V V V Y K A T W P - D E K I V R T T - V K D L D D A M R T N G I R K Q A M I L A G - - - - - W A L D P - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
M R G K V Y L V G A G F G G - - - P E H L T L K A L R V L E V A E V V L H D - R L V H - - - - - - P G V L A L A K - - - - - - G E L V P V - - K - T P Q E A I T A R L I A L A R E G R V V A R L K G G D P M V F G R G G E E A L A L R R A G I P F E V V P G V T S A V G A L S A L G L P L T H R G L A R S F A V A T G H D - - P A L P L P - - - - - - - - - - - R - - - - A D T L V L L M - - - - - - - - - - - - - - - - - G L K E R L L E R - - - - - - - - F P P E T P L A L L A R V G W P - G E A V R L G R - V E D L P G L G E - - G L P S P A L L V V G - - - - - K V V G L Y G E - - - - - - - - - - - - - L L P D H G L - - - - - - - - - -
E A V T L L L V G W G Y A P - - - - - G Q T L E A L D A V R R A D V V Y V E S Y T P G S S W L - Y K S V V E A A G E - - - - A R V V E A S - - R R D L E E R S R E I V S R A - L - D A V V A V V T A G D P - V A T T H S S L A A E A L E A G V A V R Y I P G V S G V Q A A R G A - T L S F - - - - - Y R F G G T V T L P G P W R G V T P I S V A R R I Y L N L C A - - - - G L H T T A L L D V D - E R G V Q L S P G Q G V S L L L E A D R E Y A R E A G A P A L L A R L P S V L V E - A G A G G G H R V L Y W S S L E R L S T A - - - D V E G G V Y S I V I P A R L S G V E E W L L A A A S G Q R R P L E Y D R S V Y E T V E E N C K K G V Y E P V
- E T A L Y L L P V T L G D T P L E Q V L P S Y N T E I I R G I R H F I V E - - - - - - D V R S A R R F L K K V D R E I D I D S L T F Y P L N K H T S P E D I S G Y L K P L A G - - G A S G V I S E - - - - - - D P G A D V V A I A Q R Q K L K V I P L V G P S S I I L S V - A S G F N G - - - - - Q S - F A F H G Y L P I E P G - - - - E R A K K L K T L E Q R V Y A E S Q T Q L F I E T - - - - - - - - P Y R N H K I E D I L Q N C R P - - - - - - - - - - - - Q T K L C I A A N I T C E - G E F I Q T R T - V K D W K - - - - G H I P K I P C I F L L Y K - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - I W I V G S G T C R - - - - G Q T T E R A K E I I E R A E V I Y G S - - - - - - - - R R A L E L A G V V D D S - - - - R A R I L R S F K - - - G D E I R R - I E E G R E - - R E V A V I S T G D P - V A G L G R V L R E I A - - E D V E I K I E P A I S S V Q V A L A R L K V D L - - - - - S E - V A V V D C F - - - - - - - - - - - D A E L T E L L K Y - - - - - R H L L I L A D - - - - - - - - S H - - F P L E R L G - - - - - - - - - - - - - - - - - K R R V V L L E N L C - E - G E R I R E G N - A D S I - - - - - - E L E S D Y T I I F V E R E V - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - V L Y F I G L G L Y D - - - E R D I T V K G L E I A K K C D Y V F A E F Y T S L M A G T T L G R I Q R L I G K - - - - - E I R V L S - - R E D V E L N F E N I V L P L A K - E N D V A F L T P G D P L V A T T H A E L R I R A K R A G V E S Y V I H A P S I Y S A V G I T - G L H I - - - - - Y K F G K S A T V A Y P E G N W F P T S Y Y D V I K E N A E R - - - - G L H T L L F L D I K A E K R M Y M T A N E A M E L L L K V E D M K - - - - K G G V F T D D T L V V V L A R A G S L - N P T I R A G Y - V K D L I R E - - - D F G D P P H I L I V P G K L H I V E A E Y L V E I A G A P R E I L R V N - - - - - - - - - - - - - - - - - V
- - M T V H F I G A G P G A - - - A D L I T I R G R D L I A S C P V C L Y A G S L V P - - - - - - E A L L A H C P P - - - - G A K I V N T - - A P M S L D A I I D T I A E A H A A G Q D V A R L H S G D L S I W S A M G E Q L R R L R A L N I P Y D V T P G V P S F A A A A A T L G A E L T L P G V A Q S V I L T R T S G R - - A S A M P A - G E T L E N F A R T - - - - G A V L A I H L - - - - - - - - - - - S V H V L D E V V Q K L V P H - - - - - - - - Y G E D C P V A I V W R A S W P - D Q R V V R A T - L A T L Q T S L G A E L E R - T A L I L V G - - - - - R S L A T E D F - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - G E V V L V G A G P G D - - - A G L L T L K G L Q Q I Q Q A D I V V Y D - R L V S - - - - - - D D I M N L V A R - - - - D A D R V F V - - G - V P Q E E I N Q I L L R E A Q K G K R V V R L K G G D P F I F G R G G E E L E T L C H A G I P F S V V P G I T A A S G C S A Y S G I P L T H R D Y A Q S V R L V T G H L K - T G G E L D - - - - - W E N L A A E - - - - K Q T L V F Y M - - - - - - - - - - - G L N Q A A T I Q E K L I A F G - - - - - - - M Q A D M P V A L V E N G T S V - K Q R V V H G V - L T Q L G E L A Q - - Q V E S P A L I I V G - - - - - R V V A L R D K - - - - - - - - - - - - - L N W F S N H - - - - - - - - - -

 

 

 

 

 

Member Chain UniProtKB GO term
d1ve2a1 A Q53WA2 GO:0004851
d1ve2a1 A Q53WA2 GO:0006779
d1ve2a1 A Q53WA2 GO:0008168
d1ve2a1 A Q53WA2 GO:0019354
d1ve2a1 A Q53WA2 GO:0032259
d1ve2a1 A Q53WA2 GO:0004851
d1ve2a1 A Q53WA2 GO:0006779
d1ve2a1 A Q53WA2 GO:0008168
d1ve2a1 A Q53WA2 GO:0019354
d1ve2a1 A Q53WA2 GO:0032259
d1wdea_ A Q9YDI2 GO:0004164
d1wdea_ A Q9YDI2 GO:0008168
d1wdea_ A Q9YDI2 GO:0017183
d1wdea_ A Q9YDI2 GO:0032259
d1wdea_ A Q9YDI2 GO:0004164
d1wdea_ A Q9YDI2 GO:0008168
d1wdea_ A Q9YDI2 GO:0017183
d1wdea_ A Q9YDI2 GO:0032259
d1wyza1 A Q8A031 GO:0008168
d1wyza1 A Q8A031 GO:0008168
d2bb3a1 A O29536 GO:0008168
d2bb3a1 A O29536 GO:0008276
d2bb3a1 A O29536 GO:0009236
d2bb3a1 A O29536 GO:0032259
d2bb3a1 A O29536 GO:0008168
d2bb3a1 A O29536 GO:0008276
d2bb3a1 A O29536 GO:0009236
d2bb3a1 A O29536 GO:0032259
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in