BASE   PART 1   PART 2  
Superfamily : 53697 [ SIS domain ]
Class : Alpha and beta proteins (a/b)
Fold : SIS domain
# of Members : 7
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1m3sa1  (   1 )                          mtteyvaeilnelhnSaa--yis-----
d1nria-  (   9 )    lstliTeqrNpnSvdidrqstleivrlneedklVplaies---Cl-----
d1vima1  (   2 )                            lrflevvseHiknlrn--hid-----
d1wiwa-  (   2 )                       rdLdreetylvDrtgLaleLrdLvgtgpvPg
d2i2wa-  (   1 )                      myqdlirnelneaaeTlanFlkddani-----
d2yvaa-  (   1 )                       mqerikacftesiqtqiaAae--alp-----
d5lu5a-  (   3 )                     nreltyitnsiaeaqrVmaaMladerll-----
                                            aaaaaaaaaaaaaaaa          

                             60        70        80        90        100 
d1m3sa1  (  23 )    ------------neadqLAdhIlsSh------qIFTAGag----------
d1nria-  (  52 )    ------------pqislAveqIvqafqq--gGrLIYIGag----------
d1vima1  (  21 )    ------------letvgeMilIdsar------SIFViGag----------
d1wiwa-  (  33 )    eaYpgphAAlGygEGqfAAlLSglpdwgeegTLFlLEGGydlgeaAgaae
d2i2wa-  (  28 )    ------------haIqrAAvlLAdsFka--ggkVLSCGng----------
d2yvaa-  (  25 )    ------------daisrAamtLvqsLln--gnkILCCGng----------
d5lu5a-  (  31 )    ------------atvrkVAdaCiaSiaq--ggkVLLAGng----------
                                aaaaaaaaaaaa         bbbb             

                             110       120       130       140       150 
d1m3sa1  (  46 )    ---------------------rsglmAksFAmrLmhMg------fnAhiv
d1nria-  (  78 )    ---------------------tsGrlGvldaseCpptfgvs-tevkGiIA
d1vima1  (  44 )    ---------------------rsgyiAkaFamrLmHLg------ytVyvv
d1wiwa-  (  86 )    tgrArvVrVGfrpgVevhIppspLApYrYlrFLLlATgreevlrs----V
d2i2wa-  (  54 )    ---------------------gShcDAmhFAeeLtgryrenrpgyPAiaI
d2yvaa-  (  51 )    ---------------------tSaaNAqhFaaSMinrfeteRpslpAiAL
d5lu5a-  (  57 )    ---------------------gSaadAqhIagqFvsrfafdRpgLpAvAL
                                         aaaaaaaaaaaaaaa          bbb 

                             160       170       180       190       200 
d1m3sa1  (  69 )    gei----------------------ltp-plaegDLVIIGsgsGetksli
d1nria-  ( 107 )    ggecAirhp--vegaedntkaVlndLqsihFsknDVLVGIaasgrtpYVi
d1vima1  (  67 )    get----------------------vtp-ritdqDVLVGISgsGettsVv
d1wiwa-  ( 132 )    deALleErrrLgpevpveeNpAKflAytLl---erlPLFYSPl--frpLE
d2i2wa-  (  83 )    sdvshiscv--g-ndfGfndiFsryVea-vGregDVLLGIStsGnsaNVi
d2yvaa-  (  80 )    Ntdnvvlta--iandrlhdevYAkqVra-lGhagDVLLAIstrGnsrdIv
d5lu5a-  (  86 )    Ttdtsilta--IgndygyekLFsrqVqa-lGnegDVLIGYstsGkspNIl
                                          aaaaaa       bbbbb      aaaa

                             210       220       230       240       250 
d1m3sa1  (  96 )    htAakAkslhGiVAALTinpeSsIGk---------qA---dLiIrMPGsp
d1nria-  ( 155 )    aGLqyAkslgAlTIsIASNpkse-ae---------iA---diaIeTiVgp
d1vima1  (  94 )    niSkkAkdigSkLVAVTgkrdSsLAk---------mA---dvvMvVkgkm
d1wiwa-  ( 177 )    gavqtLFarVAkslSltPppsAlefFlvglearheqGdplAAVLLGpgee
d2i2wa-  ( 129 )    kAIaaArekgMkVITLTGkdGgkMag---------tA---dieIrVph--
d2yvaa-  ( 127 )    kAVeAAvtrdMtIVALTGydGgeLag---------lLgpqdVeIrIps--
d5lu5a-  ( 133 )    aAFreAkakgMtCVGFTGnrGgeMre---------lC---dllLeVps--
                    aaaaaaaa   bbbbbb      aa                bbbb     

                             260       270       280       290       300 
d1m3sa1  ( 134 )    ----kdyktiqpm----------gsLfeqTLllfYdaVilkLmekkglds
d1nria-  ( 193 )    Eil------tgss----------rlKSGtAQk-VLn-LTtaSillgkcye
d1vima1  ( 133 )    qerdeilsqlApl----------gtMFelTAmiFLdaLvaeImmqkhlt-
d1wiwa-  ( 227 )    aalAkeiLesrVdalaevpAtganrLAqVALwYrAWTAYYLALLyGvdPg
d2i2wa-  ( 165 )    fgy--------------------adrIqeIHikVIhiLIqlIekeMvk  
d2yvaa-  ( 166 )    hr---------------------sarIqeMHmlTVncLCdlIDntlfph 
d5lu5a-  ( 169 )    ad---------------------tpkIqeGHlvLGhiVCglVEhsifg  
                                            aaaaaaaaaaaaaaaaaaaaa     

                             310       320     
d1m3sa1  ( 175 )    etmfthhanle                
d1nria-  ( 228 )    nlvdvqasneklkaravrivqatdcnk
d1vima1  ( 172 )    edlearhavle                
d1wiwa-  ( 279 )    dhglle                     
d2i2wa-                                        
d2yvaa-                                        
d5lu5a-
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Hypothetical protein YckFmono-SIS domainBacillus subtilis [TaxId: 1423]view
Hypothetical protein HI0754mono-SIS domainHaemophilus influenzae [TaxId: 727]view
Hypothetical protein AF1796mono-SIS domainArchaeoglobus fulgidus [TaxId: 2234]view
Glucose-6-phosphate isomerase-like protein TTHA1346double-SIS domainThermus thermophilus [TaxId: 274]view
automated matchesautomated matchesEscherichia coli [TaxId: 562]view
automated matchesmono-SIS domainEscherichia coli [TaxId: 562]view
automated matchesautomated matchesBurkholderia pseudomallei [TaxId: 272560]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320
- - - - - - - - - - - - - - - - - - - - - - M T T E Y V A E I L N E L H N S A A - - Y I S - - - - - - - - - - - - - - - - - N E A D Q L A D H I L S S H - - - - - - Q I F T A G A G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - R S G L M A K S F A M R L M H M G - - - - - - F N A H I V G E I - - - - - - - - - - - - - - - - - - - - - - L T P - P L A E G D L V I I G S G S G E T K S L I H T A A K A K S L H G I V A A L T I N P E S S I G K - - - - - - - - - Q A - - - D L I I R M P G S P - - - - K D Y K T I Q P M - - - - - - - - - - G S L F E Q T L L L F Y D A V I L K L M E K K G L D S E T M F T H H A N L E - - - - - - - - - - - - - - - -
L S T L I T E Q R N P N S V D I D R Q S T L E I V R L N E E D K L V P L A I E S - - - C L - - - - - - - - - - - - - - - - - P Q I S L A V E Q I V Q A F Q Q - - G G R L I Y I G A G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - T S G R L G V L D A S E C P P T F G V S - T E V K G I I A G G E C A I R H P - - V E G A E D N T K A V L N D L Q S I H F S K N D V L V G I A A S G R T P Y V I A G L Q Y A K S L G A L T I S I A S N P K S E - A E - - - - - - - - - I A - - - D I A I E T I V G P E I L - - - - - - T G S S - - - - - - - - - - R L K S G T A Q K - V L N - L T T A S I L L G K C Y E N L V D V Q A S N E K L K A R A V R I V Q A T D C N K
- - - - - - - - - - - - - - - - - - - - - - - - L R F L E V V S E H I K N L R N - - H I D - - - - - - - - - - - - - - - - - L E T V G E M I L I D S A R - - - - - - S I F V I G A G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - R S G Y I A K A F A M R L M H L G - - - - - - Y T V Y V V G E T - - - - - - - - - - - - - - - - - - - - - - V T P - R I T D Q D V L V G I S G S G E T T S V V N I S K K A K D I G S K L V A V T G K R D S S L A K - - - - - - - - - M A - - - D V V M V V K G K M Q E R D E I L S Q L A P L - - - - - - - - - - G T M F E L T A M I F L D A L V A E I M M Q K H L T - E D L E A R H A V L E - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - R D L D R E E T Y L V D R T G L A L E L R D L V G T G P V P G E A Y P G P H A A L G Y G E G Q F A A L L S G L P D W G E E G T L F L L E G G Y D L G E A A G A A E T G R A R V V R V G F R P G V E V H I P P S P L A P Y R Y L R F L L L A T G R E E V L R S - - - - V D E A L L E E R R R L G P E V P V E E N P A K F L A Y T L L - - - E R L P L F Y S P L - - F R P L E G A V Q T L F A R V A K S L S L T P P P S A L E F F L V G L E A R H E Q G D P L A A V L L G P G E E A A L A K E I L E S R V D A L A E V P A T G A N R L A Q V A L W Y R A W T A Y Y L A L L Y G V D P G D H G L L E - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - M Y Q D L I R N E L N E A A E T L A N F L K D D A N I - - - - - - - - - - - - - - - - - H A I Q R A A V L L A D S F K A - - G G K V L S C G N G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - G S H C D A M H F A E E L T G R Y R E N R P G Y P A I A I S D V S H I S C V - - G - N D F G F N D I F S R Y V E A - V G R E G D V L L G I S T S G N S A N V I K A I A A A R E K G M K V I T L T G K D G G K M A G - - - - - - - - - T A - - - D I E I R V P H - - F G Y - - - - - - - - - - - - - - - - - - - - A D R I Q E I H I K V I H I L I Q L I E K E M V K - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - M Q E R I K A C F T E S I Q T Q I A A A E - - A L P - - - - - - - - - - - - - - - - - D A I S R A A M T L V Q S L L N - - G N K I L C C G N G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - T S A A N A Q H F A A S M I N R F E T E R P S L P A I A L N T D N V V L T A - - I A N D R L H D E V Y A K Q V R A - L G H A G D V L L A I S T R G N S R D I V K A V E A A V T R D M T I V A L T G Y D G G E L A G - - - - - - - - - L L G P Q D V E I R I P S - - H R - - - - - - - - - - - - - - - - - - - - - S A R I Q E M H M L T V N C L C D L I D N T L F P H - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - N R E L T Y I T N S I A E A Q R V M A A M L A D E R L L - - - - - - - - - - - - - - - - - A T V R K V A D A C I A S I A Q - - G G K V L L A G N G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - G S A A D A Q H I A G Q F V S R F A F D R P G L P A V A L T T D T S I L T A - - I G N D Y G Y E K L F S R Q V Q A - L G N E G D V L I G Y S T S G K S P N I L A A F R E A K A K G M T C V G F T G N R G G E M R E - - - - - - - - - L C - - - D L L L E V P S - - A D - - - - - - - - - - - - - - - - - - - - - T P K I Q E G H L V L G H I V C G L V E H S I F G - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

 

 

 

 

 

Member Chain UniProtKB GO term
d1nria_ A P44862 GO:0006040
d1nria_ A P44862 GO:0009254
d1nria_ A P44862 GO:0016803
d1nria_ A P44862 GO:0016829
d1nria_ A P44862 GO:0016835
d1nria_ A P44862 GO:0046348
d1nria_ A P44862 GO:0097173
d1nria_ A P44862 GO:0097175
d1nria_ A P44862 GO:0097367
d1nria_ A P44862 GO:1901135
d1nria_ A P44862 GO:0006040
d1nria_ A P44862 GO:0009254
d1nria_ A P44862 GO:0016803
d1nria_ A P44862 GO:0016829
d1nria_ A P44862 GO:0016835
d1nria_ A P44862 GO:0046348
d1nria_ A P44862 GO:0097173
d1nria_ A P44862 GO:0097175
d1nria_ A P44862 GO:0097367
d1nria_ A P44862 GO:1901135
d1wiwa_ A Q5SIM3 GO:0004347
d1wiwa_ A Q5SIM3 GO:0004476
d1wiwa_ A Q5SIM3 GO:0005975
d1wiwa_ A Q5SIM3 GO:0097367
d1wiwa_ A Q5SIM3 GO:1901135
d1wiwa_ A Q5SIM3 GO:0004347
d1wiwa_ A Q5SIM3 GO:0004476
d1wiwa_ A Q5SIM3 GO:0005975
d1wiwa_ A Q5SIM3 GO:0097367
d1wiwa_ A Q5SIM3 GO:1901135
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in