BASE   PART 1   PART 2  
Superfamily : 53659 [ Isocitrate/Isopropylmalate dehydrogenase-like ]
Class : Alpha and beta proteins (a/b)
Fold : Isocitrate/Isopropylmalate dehydrogenase-like
# of Members : 6
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1u7na-  (   2 )                     kIAVdAggdnApqAIVeGV-lAkqdfpdieFqL
d1vmia1  (  -3 )    alraIierceLalraparVVFPdAl---dqrVLkAAqyLhqq-glAtPiL
d4atya-  (  11 )                raMtVALAIgDPNGiGPEIAVkAAa-------qmpIvL
d4e4ra1  (   2 )    a-dllnvLkdkLsgknVkIVLPeGe---derVLtAAtqLqat-dyVtPIV
d6e85a1  (   1 )                mskmIAVTMGDPAGIGPEIIIkSLAe--gaLsgapVVV
d6xmya1  (   1 )                 mnPLLISSGEPAGIGPdLCLa-LAe-----tdlpVVI
                                     bbb         aaaaaa            bbb

                             60        70        80        90        100 
d1u7na-  (  36 )    YgkeaeIkkyit----deknItiihtdekia---------sddepvkAIr
d1vmia1  (  45 )    VanpfeLq-fa-shgvad-glqvidPhg-nl---------areefahrWl
d4atya-  (  59 )    FGDAfVIrrYArqccl---mlrlvp---------saidMvdv--asLpae
d4e4ra1  (  47 )    LgdetkVqslAqklnldisnIelinPat-se---------lkaeLVqsFv
d6e85a1  (  37 )    VGCaqTLrrIlalniTprAeLriIdhPaeAsfspatINVIde--pLsdpq
d6xmya1  (  32 )    LGdlslLeaRAseLn-lsIkfleysphqsfkkkagyLtVwpv--pCaa--
                    b  aaaaa             bb                           

                             110       120       130       140       150 
d1u7na-  (  73 )    -------------rkktAsVlAAqAVkngeAdAIFsAg-----------n
d1vmia1  (  86 )    arag-tpp--dalekLtdp-lFAAAVsAgkadVcIAGNl---------ss
d4atya-  ( 106 )    afvpGeVaaaAGtATlaYVsaALraAragqVdAVIACPhSetAi-aSg--
d4e4ra1  (  87 )    errkgkTteeqAqelLnnvnyFGTLVyagkAdGLVSGAah-------sTg
d6e85a1  (  85 )    gLrpgevqaqAGdLAfrCIrrATalAlegaVaAIATApLnkeALhlagha
d6xmya1  (  77 )    pVisgelnpqNAaYVmeLLtlGAslCskgeFsALVTAPVhkanInaagit
                               aaaa     aaa         bbbb              

                             160       170       180       190       200 
d1u7na-  ( 100 )    tgAllAaGlfiVgrIknVerpGlsTlpvgepdkGFdlDlgana------d
d1vmia1  ( 127 )    tanvl-aglriIglqpg-ctlSSIfLlPqsgpAlGfADCsvvp------q
d4atya-  ( 157 )    -agypgfVAheMgmp--aeDVYlLLIGg---glrIVHATlhegiasAlar
d4e4ra1  ( 131 )    d-Tvr-pAlqIIktkpgVsrTSGIfFikgd-eqyIfGDCainp------e
d6e85a1  ( 135 )    ypghteLLahlTqt----tdyAmVlYte---kLKVIHItthislrqFldt
d6xmya1  ( 127 )    FtghTefFadffev----etvVMMLACs---qmkVALVtthlplrmVpda
                       aa aaaaa          bbbbb        bbb             

                             210       220       230       240       250 
d1u7na-  ( 147 )    NkpeHLvqYAvLGsfyAekvrnvqnPrVGLLnng-----------tGsel
d1vmia1  ( 173 )    PtaaqLAdIAlaSAtWr-aITge-ePrVAl-SfSSn----gsarhpcVan
d4atya-  ( 201 )    LdqrHVerAAraAvqALqlMga--hPvVGLMGInphAGegglfgrdDidi
d4e4ra1  ( 173 )    LdsqgLaeIaVESAksa-lsFg--dPkVAL-SfSTk----gsaksddVtk
d6e85a1  ( 178 )    LnqprIetVIgVAdrFLrrv-gyprPrIAVAGVnphaGenglfgdeEiri
d6xmya1  ( 170 )    IssllIikVIqqLhhSLkhdfgiqsPkINVAGLnphaGesGylgreEiei
                      aaaaaaaaaaaaaaa a        bb                aaaa 

                             260       270       280       290       300 
d1u7na-  ( 190 )    tkkAfelLaade-----tInFvgnVeareLln--------------gvAd
d1vmia1  ( 218 )    vqqAt-iVr-rap----klvVdgELqfdAAfvp-vAa-kApaSpLqGkAn
d4atya-  ( 250 )    TepVArkLrd-------dmtVigPqgadlLltnp-------------dId
d4e4ra1  ( 217 )    vqeavklAqqkaeeekleAiIDGEFqfdAAivpgvAekkApgakLqGdAn
d6e85a1  ( 227 )    VapAVaamrak------gveVtgpcppdtVfmqCh----------egmyd
d6xmya1  ( 220 )    ItpALntLknq------gidVlGplpadtMFitnh----------inhCd
                    aaaaaaaaa           b     aaaa                    

                             310       320       330       340       350 
d1u7na-  ( 221 )    VVVt-dGftGnavlksiegtansllktailsgalllknalhgkdedyskh
d1vmia1  ( 264 )    V-VfpsleaGnigykiaqrl---------------------ggyra----
d4atya-  ( 281 )    VFVAMyhdqGhipVklrag-----------------------------rh
d4e4ra1  ( 267 )    VFvfpsleaGnigykiaqrl---------------------ggyda----
d6e85a1  ( 261 )    MVVAMyhdqGhipLkllgf-----------------------------yd
d6xmya1  ( 254 )    AyVAMyhdqGLpvLkyagf-----------------------------ne
                    bbb   aaaaaaaaaaaa                                

                             360       370       380       390       400 
d1u7na-  ( 282 )    GgavLfGLkapVIkThg----------aTgpdaVryTIrqIhtletqvVp
d1vmia1  ( 289 )    VGpLIqGlaap-HdLsr----------gCsvqeIieLAlVAAVp      
d4atya-  ( 302 )    SaaLsIgAgVLFSsVghgSgfdiAgtlladpapLlgaIrLVttGtvla  
d4e4ra1  ( 292 )    vGpVlQGLnspVNdLsr----------gCsiedVynlSFITAAqal    
d6e85a1  ( 282 )    gvnITAgLpfiRTsAdhgTafdiAWtGkaksesMatSIelAmhIAqe   
d6xmya1  ( 275 )    AVnITLgLpiiRTSVDhgTalelAGknkanpgSMlaAVkmAkdmalt   
                      bbbb     bbb                 aaaaaaaaaaa        

                           
d1u7na-  ( 323 )    qLveyye
d1vmia1                    
d4atya-                    
d4e4ra1                    
d6e85a1                    
d6xmya1
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Fatty acid/phospholipid synthesis protein PlsXPlsX-likeEnterococcus faecalis [TaxId: 1351]view
Ethanolamine utilization protein EutDPhosphotransacetylaseEscherichia coli [TaxId: 562]view
automated matchesautomated matchesBurkholderia xenovorans [TaxId: 266265]view
automated matchesPhosphotransacetylaseStaphylococcus aureus [TaxId: 282458]view
automated matchesautomated matchesKlebsiella pneumoniae [TaxId: 72407]view
automated matchesautomated matchesLegionella pneumophila [TaxId: 272624]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400
- - - - - - - - - - - - - - - - - K I A V D A G G D N A P Q A I V E G V - L A K Q D F P D I E F Q L Y G K E A E I K K Y I T - - - - D E K N I T I I H T D E K I A - - - - - - - - - S D D E P V K A I R - - - - - - - - - - - - - R K K T A S V L A A Q A V K N G E A D A I F S A G - - - - - - - - - - - N T G A L L A A G L F I V G R I K N V E R P G L S T L P V G E P D K G F D L D L G A N A - - - - - - D N K P E H L V Q Y A V L G S F Y A E K V R N V Q N P R V G L L N N G - - - - - - - - - - - T G S E L T K K A F E L L A A D E - - - - - T I N F V G N V E A R E L L N - - - - - - - - - - - - - - G V A D V V V T - D G F T G N A V L K S I E G T A N S L L K T A I L S G A L L L K N A L H G K D E D Y S K H G G A V L F G L K A P V I K T H G - - - - - - - - - - A T G P D A V R Y T I R Q I H T L E T Q V V P Q L V E Y Y E
A L R A I I E R C E L A L R A P A R V V F P D A L - - - D Q R V L K A A Q Y L H Q Q - G L A T P I L V A N P F E L Q - F A - S H G V A D - G L Q V I D P H G - N L - - - - - - - - - A R E E F A H R W L A R A G - T P P - - D A L E K L T D P - L F A A A V S A G K A D V C I A G N L - - - - - - - - - S S T A N V L - A G L R I I G L Q P G - C T L S S I F L L P Q S G P A L G F A D C S V V P - - - - - - Q P T A A Q L A D I A L A S A T W R - A I T G E - E P R V A L - S F S S N - - - - G S A R H P C V A N V Q Q A T - I V R - R A P - - - - K L V V D G E L Q F D A A F V P - V A A - K A P A S P L Q G K A N V - V F P S L E A G N I G Y K I A Q R L - - - - - - - - - - - - - - - - - - - - - G G Y R A - - - - V G P L I Q G L A A P - H D L S R - - - - - - - - - - G C S V Q E I I E L A L V A A V P - - - - - - - - - - - - -
- - - - - - - - - - - - R A M T V A L A I G D P N G I G P E I A V K A A A - - - - - - - Q M P I V L F G D A F V I R R Y A R Q C C L - - - M L R L V P - - - - - - - - - S A I D M V D V - - A S L P A E A F V P G E V A A A A G T A T L A Y V S A A L R A A R A G Q V D A V I A C P H S E T A I - A S G - - - A G Y P G F V A H E M G M P - - A E D V Y L L L I G G - - - G L R I V H A T L H E G I A S A L A R L D Q R H V E R A A R A A V Q A L Q L M G A - - H P V V G L M G I N P H A G E G G L F G R D D I D I T E P V A R K L R D - - - - - - - D M T V I G P Q G A D L L L T N P - - - - - - - - - - - - - D I D V F V A M Y H D Q G H I P V K L R A G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - R H S A A L S I G A G V L F S S V G H G S G F D I A G T L L A D P A P L L G A I R L V T T G T V L A - - - - - - - - -
A - D L L N V L K D K L S G K N V K I V L P E G E - - - D E R V L T A A T Q L Q A T - D Y V T P I V L G D E T K V Q S L A Q K L N L D I S N I E L I N P A T - S E - - - - - - - - - L K A E L V Q S F V E R R K G K T T E E Q A Q E L L N N V N Y F G T L V Y A G K A D G L V S G A A H - - - - - - - S T G D - T V R - P A L Q I I K T K P G V S R T S G I F F I K G D - E Q Y I F G D C A I N P - - - - - - E L D S Q G L A E I A V E S A K S A - L S F G - - D P K V A L - S F S T K - - - - G S A K S D D V T K V Q E A V K L A Q Q K A E E E K L E A I I D G E F Q F D A A I V P G V A E K K A P G A K L Q G D A N V F V F P S L E A G N I G Y K I A Q R L - - - - - - - - - - - - - - - - - - - - - G G Y D A - - - - V G P V L Q G L N S P V N D L S R - - - - - - - - - - G C S I E D V Y N L S F I T A A Q A L - - - - - - - - - - -
- - - - - - - - - - - - M S K M I A V T M G D P A G I G P E I I I K S L A E - - G A L S G A P V V V V G C A Q T L R R I L A L N I T P R A E L R I I D H P A E A S F S P A T I N V I D E - - P L S D P Q G L R P G E V Q A Q A G D L A F R C I R R A T A L A L E G A V A A I A T A P L N K E A L H L A G H A Y P G H T E L L A H L T Q T - - - - T D Y A M V L Y T E - - - K L K V I H I T T H I S L R Q F L D T L N Q P R I E T V I G V A D R F L R R V - G Y P R P R I A V A G V N P H A G E N G L F G D E E I R I V A P A V A A M R A K - - - - - - G V E V T G P C P P D T V F M Q C H - - - - - - - - - - E G M Y D M V V A M Y H D Q G H I P L K L L G F - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Y D G V N I T A G L P F I R T S A D H G T A F D I A W T G K A K S E S M A T S I E L A M H I A Q E - - - - - - - - - -
- - - - - - - - - - - - - M N P L L I S S G E P A G I G P D L C L A - L A E - - - - - T D L P V V I L G D L S L L E A R A S E L N - L S I K F L E Y S P H Q S F K K K A G Y L T V W P V - - P C A A - - P V I S G E L N P Q N A A Y V M E L L T L G A S L C S K G E F S A L V T A P V H K A N I N A A G I T F T G H T E F F A D F F E V - - - - E T V V M M L A C S - - - Q M K V A L V T T H L P L R M V P D A I S S L L I I K V I Q Q L H H S L K H D F G I Q S P K I N V A G L N P H A G E S G Y L G R E E I E I I T P A L N T L K N Q - - - - - - G I D V L G P L P A D T M F I T N H - - - - - - - - - - I N H C D A Y V A M Y H D Q G L P V L K Y A G F - - - - - - - - - - - - - - - - - - - - - - - - - - - - - N E A V N I T L G L P I I R T S V D H G T A L E L A G K N K A N P G S M L A A V K M A K D M A L T - - - - - - - - - -

 

 

 

 

 

Member Chain UniProtKB GO term
d1u7na_ A Q82ZE8 GO:0003824
d1u7na_ A Q82ZE8 GO:0005737
d1u7na_ A Q82ZE8 GO:0006633
d1u7na_ A Q82ZE8 GO:0006644
d1u7na_ A Q82ZE8 GO:0008654
d1u7na_ A Q82ZE8 GO:0016740
d1u7na_ A Q82ZE8 GO:0016747
d1u7na_ A Q82ZE8 GO:0043811
d1u7na_ A Q82ZE8 GO:0003824
d1u7na_ A Q82ZE8 GO:0005737
d1u7na_ A Q82ZE8 GO:0006633
d1u7na_ A Q82ZE8 GO:0006644
d1u7na_ A Q82ZE8 GO:0008654
d1u7na_ A Q82ZE8 GO:0016740
d1u7na_ A Q82ZE8 GO:0016747
d1u7na_ A Q82ZE8 GO:0043811
d1u7na_ A Q82ZE8 GO:0003824
d1u7na_ A Q82ZE8 GO:0005737
d1u7na_ A Q82ZE8 GO:0006633
d1u7na_ A Q82ZE8 GO:0006644
d1u7na_ A Q82ZE8 GO:0008654
d1u7na_ A Q82ZE8 GO:0016740
d1u7na_ A Q82ZE8 GO:0016747
d1u7na_ A Q82ZE8 GO:0043811
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in