Superfamily : 52788 [ Phosphotyrosine protein phosphatases I ]
Class : Alpha and beta proteins (a/b)
Fold : Phosphotyrosine protein phosphatases I-like
# of Members : 13
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1jf8a-  (   2 )    dkktIYFIStGNsarSQMAeGwGkeiLg-----egwnVySAGieth----
d1u2pa-  (   4 )    p-lhVTFVCtgNiCRSPMAekMFaqqLrhrglgdaVrVtSAGtgnw---h
d1y1la-  (   1 )       kVLFVCihNTARSVMAeaLFnamAk------swkAeSAGvekae---
d2gi4a1  (   1 )     mkkilFiClgniCRSPMaefiMkdlvkkanlekeffinsAGtsGe---h
d2myna-  (   1 )     mkkvMFvCkrnSCrSqMAEGFAktlGa-----gkiavtSCGless----
d3jvia1  (   1 )      mkLLFVClgNicrSPAAeAVMkkVIqnhhlte-yiCdSAGTcsh----
d3rh0a-  (   1 )     mksVLFV-vgNggkSQMAaaLAqkyAs-----dsveIhSAGtkpaq---
d3rofa1  (   1 )     mvdvAFvClgniCRSPMAeAiMrqrlkdrni-hdikvhSrGtgSw---n
d4etna1  (   1 )      mdiiFvCtgntsrSPMAealFksiAeregl--nvnVrSAGvfAs----
d5gota1  (   1 )     mkkVCFVClgNicRSPMAEFVMksiVss----dvMmIeSrATsdw---e
d6u1pa-  (   5 )     glsvLVVCtgNlcRSPmaEIilrdkirq-kl--niqVrSAGTlktg---
d7dhfa1  (   2 )     fnkILVVAvgNiCRSPTGerVLqklLp------nktVaSAGiaAeksrl
d7kh8a1  (   4 )    atksVLFVClgNiCRSPIAEAVFrklVtdqnisenWrVdSAATsgy---e
                       bbbbbb     aaaaaaaaaaaa          bbbbbb        

                             60        70        80        90        100 
d1jf8a-  (  43 )    ---gvnpkAieAMkevdIdIs-nHtsdlidndiLkqSdLVVTLcsdAdnn
d1u2pa-  (  50 )    vgscAderAagvLrahgyptd--hrAaqVgtehla-AdLLVALdrnHarl
d1y1la-  (  39 )    ---rVdetVkrLLaerglkAk-e-kPrtvdeVnlddFdlIVTVÇee--ss
d2gi4a1  (  47 )    dGeGmhyGtknKlaqlniehk-nftskkltqklCdeSdflitMDnsnfkn
d2myna-  (  41 )    ---rvhptAiamMeevgidis-gqtSdpienfnAddYdvviSlCgc----
d3jvia1  (  47 )    -gqqAdsrMrkVGksrgyqVd--siSrpVvssDFknfdyIFAMdndNyye
d3rh0a-  (  42 )    ---glnqlSveSIaevgadMs-qgipkaidpellrtVdrVVILgddA---
d3rofa1  (  46 )    lgepPhegtqkilnkhnipfd-gmiSelFeatdd--fdYivAMdqsnvdn
d4etna1  (  43 )    pngkAtphAveAlfekhial--nhvSsplteelMesAdlvlAMthqHkqi
d5gota1  (  43 )    hgnpIhsgTqsiLktyqInyditkcSkqItitdFntFdyIIGMdsdNvkn
d6u1pa-  (  49 )    -ktmPddkAlqaLqdygyhPm-vnpvqqVtqqdFieHdfIyAMdrtNlad
d7dhfa1  (  45 )    igkpAdamAieVAkencVdVe-nHqSqqLtsalCsqydLILVMekghmea
d7kh8a1  (  51 )    ignpPdyrGqsCMkrhgipMs--hvArqItkeDFatFdyILCMdesNlrd
                          aaaaaaaaa               aaaa    bbbb    aaaa

                             110       120       130       140       150 
d1jf8a-  (  89 )    Cpi-lpp----nVkkehw-------------gfddPagkewseFqrVrde
d1u2pa-  (  97 )    Lrql--gV-eaar-Vrm-LrsFdprsgthaldVedPyygdhsdFeeVFav
d1y1la-  (  82 )    çvv-Lp---Tdk-pvtrw-------------hIenPagkdegtYrrVLae
d2gi4a1  (  96 )    vlknFt--ntqnk-vlk-itdfSp--slnydevPDpwysg--nfdetyki
d2myna-  (  83 )    gvn-lppeWvtqeifedW-------------qledPdgqslevFrtvrgq
d3jvia1  (  94 )    LldrCpe-qykqk-Ifk-MvdFCtt---itteVpdPy--gekgFhrVIdI
d3rh0a-  (  85 )    qVd-mpesA--qgalerW-------------sIeepdaqgmerMriVrdq
d3rofa1  (  93 )    iksinp---nlkgqlfk-llefSn---meesdvpdPyytn--nFegvydm
d4etna1  (  91 )    iasqf-g-ryrdk-vft-lkeyvtgs---hgdvldPfggsidiYkqtRde
d5gota1  (  93 )    Lkemsqh-qwdsk-Iyl-Fre---------ggVpdPwytn--dfeeTyql
d6u1pa-  (  97 )    LldiCpa-ehknk-Lal-flskanrq---ekevpdpyrrsseffqrtall
d7dhfa1  (  94 )    LtqiA-p-eArgk-TmL-FGqwig-----qkdIpdPyrqskeaFvhAyql
d7kh8a1  (  99 )    LnrksnqvktckAkIel-LGsYDpq---kqliIedPyygndsdFetVyqQ
                                  bbb                         aaaaaaaa

                             160       
d1jf8a-  ( 121 )    IklaIekfklr        
d1u2pa-  ( 142 )    IesALpgLhdwVde-rlar
d1y1la-  ( 114 )    IeerVkklvg--e      
d2gi4a1  ( 138 )    lslACknllvflsk     
d2myna-  ( 119 )    vkervenliakis      
d3jvia1  ( 139 )    LedACenLIikLeegkLin
d3rh0a-  ( 119 )    IdnrVqalla         
d3rofa1  ( 134 )    vlsSCdnlidyivkdanlk
d4etna1  ( 134 )    leellrqlAkqlkk     
d5gota1  ( 129 )    VrkgCqdWlsrLmskey  
d6u1pa-  ( 141 )    iesgavalvdswq      
d7dhfa1  ( 135 )    IdeAAqaWakkl       
d7kh8a1  ( 145 )    CvrCCraFlekah      
                    aaaaaaaaa
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Arsenate reductase ArsCLow-molecular-weight phosphotyrosine protein phosphatasesStaphylococcus aureus [TaxId: 1280]view
automated matchesautomated matchesMycobacterium tuberculosis [TaxId: 1773]view
Arsenate reductase ArsCLow-molecular-weight phosphotyrosine protein phosphatasesArchaeoglobus fulgidus [TaxId: 2234]view
automated matchesautomated matchesCampylobacter jejuni [TaxId: 197]view
automated matchesautomated matchesSynechocystis sp. [TaxId: 1111708]view
automated matchesautomated matchesEntamoeba histolytica [TaxId: 294381]view
automated matchesautomated matchesCorynebacterium glutamicum [TaxId: 1718]view
automated matchesautomated matchesStaphylococcus aureus [TaxId: 1280]view
automated matchesautomated matchesBacillus subtilis [TaxId: 1423]view
automated matchesautomated matchesStreptococcus pyogenes [TaxId: 1314]view
automated matchesautomated matchesVibrio cholerae [TaxId: 666]view
automated matchesautomated matchesVibrio vulnificus [TaxId: 672]view
Tyrosine phosphataseLow-molecular-weight phosphotyrosine protein phosphatasesHuman (Homo sapiens) [TaxId: 9606]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160
D K K T I Y F I S T G N S A R S Q M A E G W G K E I L G - - - - - E G W N V Y S A G I E T H - - - - - - - G V N P K A I E A M K E V D I D I S - N H T S D L I D N D I L K Q S D L V V T L C S D A D N N C P I - L P P - - - - N V K K E H W - - - - - - - - - - - - - G F D D P A G K E W S E F Q R V R D E I K L A I E K F K L R - - - - - - - -
P - L H V T F V C T G N I C R S P M A E K M F A Q Q L R H R G L G D A V R V T S A G T G N W - - - H V G S C A D E R A A G V L R A H G Y P T D - - H R A A Q V G T E H L A - A D L L V A L D R N H A R L L R Q L - - G V - E A A R - V R M - L R S F D P R S G T H A L D V E D P Y Y G D H S D F E E V F A V I E S A L P G L H D W V D E - R L A R
- - - K V L F V C I H N T A R S V M A E A L F N A M A K - - - - - - S W K A E S A G V E K A E - - - - - - R V D E T V K R L L A E R G L K A K - E - K P R T V D E V N L D D F D L I V T V C E E - - S S C V V - L P - - - T D K - P V T R W - - - - - - - - - - - - - H I E N P A G K D E G T Y R R V L A E I E E R V K K L V G - - E - - - - - -
- M K K I L F I C L G N I C R S P M A E F I M K D L V K K A N L E K E F F I N S A G T S G E - - - H D G E G M H Y G T K N K L A Q L N I E H K - N F T S K K L T Q K L C D E S D F L I T M D N S N F K N V L K N F T - - N T Q N K - V L K - I T D F S P - - S L N Y D E V P D P W Y S G - - N F D E T Y K I L S L A C K N L L V F L S K - - - - -
- M K K V M F V C K R N S C R S Q M A E G F A K T L G A - - - - - G K I A V T S C G L E S S - - - - - - - R V H P T A I A M M E E V G I D I S - G Q T S D P I E N F N A D D Y D V V I S L C G C - - - - G V N - L P P E W V T Q E I F E D W - - - - - - - - - - - - - Q L E D P D G Q S L E V F R T V R G Q V K E R V E N L I A K I S - - - - - -
- - M K L L F V C L G N I C R S P A A E A V M K K V I Q N H H L T E - Y I C D S A G T C S H - - - - - G Q Q A D S R M R K V G K S R G Y Q V D - - S I S R P V V S S D F K N F D Y I F A M D N D N Y Y E L L D R C P E - Q Y K Q K - I F K - M V D F C T T - - - I T T E V P D P Y - - G E K G F H R V I D I L E D A C E N L I I K L E E G K L I N
- M K S V L F V - V G N G G K S Q M A A A L A Q K Y A S - - - - - D S V E I H S A G T K P A Q - - - - - - G L N Q L S V E S I A E V G A D M S - Q G I P K A I D P E L L R T V D R V V I L G D D A - - - Q V D - M P E S A - - Q G A L E R W - - - - - - - - - - - - - S I E E P D A Q G M E R M R I V R D Q I D N R V Q A L L A - - - - - - - - -
- M V D V A F V C L G N I C R S P M A E A I M R Q R L K D R N I - H D I K V H S R G T G S W - - - N L G E P P H E G T Q K I L N K H N I P F D - G M I S E L F E A T D D - - F D Y I V A M D Q S N V D N I K S I N P - - - N L K G Q L F K - L L E F S N - - - M E E S D V P D P Y Y T N - - N F E G V Y D M V L S S C D N L I D Y I V K D A N L K
- - M D I I F V C T G N T S R S P M A E A L F K S I A E R E G L - - N V N V R S A G V F A S - - - - P N G K A T P H A V E A L F E K H I A L - - N H V S S P L T E E L M E S A D L V L A M T H Q H K Q I I A S Q F - G - R Y R D K - V F T - L K E Y V T G S - - - H G D V L D P F G G S I D I Y K Q T R D E L E E L L R Q L A K Q L K K - - - - -
- M K K V C F V C L G N I C R S P M A E F V M K S I V S S - - - - D V M M I E S R A T S D W - - - E H G N P I H S G T Q S I L K T Y Q I N Y D I T K C S K Q I T I T D F N T F D Y I I G M D S D N V K N L K E M S Q H - Q W D S K - I Y L - F R E - - - - - - - - - G G V P D P W Y T N - - D F E E T Y Q L V R K G C Q D W L S R L M S K E Y - -
- G L S V L V V C T G N L C R S P M A E I I L R D K I R Q - K L - - N I Q V R S A G T L K T G - - - - K T M P D D K A L Q A L Q D Y G Y H P M - V N P V Q Q V T Q Q D F I E H D F I Y A M D R T N L A D L L D I C P A - E H K N K - L A L - F L S K A N R Q - - - E K E V P D P Y R R S S E F F Q R T A L L I E S G A V A L V D S W Q - - - - - -
- F N K I L V V A V G N I C R S P T G E R V L Q K L L P - - - - - - N K T V A S A G I A A E K S R L I G K P A D A M A I E V A K E N C V D V E - N H Q S Q Q L T S A L C S Q Y D L I L V M E K G H M E A L T Q I A - P - E A R G K - T M L - F G Q W I G - - - - - Q K D I P D P Y R Q S K E A F V H A Y Q L I D E A A Q A W A K K L - - - - - - -
A T K S V L F V C L G N I C R S P I A E A V F R K L V T D Q N I S E N W R V D S A A T S G Y - - - E I G N P P D Y R G Q S C M K R H G I P M S - - H V A R Q I T K E D F A T F D Y I L C M D E S N L R D L N R K S N Q V K T C K A K I E L - L G S Y D P Q - - - K Q L I I E D P Y Y G N D S D F E T V Y Q Q C V R C C R A F L E K A H - - - - - -

 

 

 

 

 

Member Chain UniProtKB GO term
d1jf8a_ A P0A006 GO:0004725
d1jf8a_ A P0A006 GO:0005737
d1jf8a_ A P0A006 GO:0016491
d1jf8a_ A P0A006 GO:0030612
d1jf8a_ A P0A006 GO:0046685
d1jf8a_ A P0A006 GO:0046872
d1y1la_ A O28910 GO:0046685
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in