Superfamily : 51351 [ Triosephosphate isomerase (TIM) ]
Class : Alpha and beta proteins (a/b)
Fold : TIM beta/alpha-barrel
# of Members : 6
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1n55a-  (   2 )    akpqpIAAANWkc--ngttasIeklVqvFne-htIsh--dVqCVVAPtfv
d2h6ra-  (   1 )        mvIVINYktyneSignrGleIAkiAe-Vse---esgItIGVAPqfv
d2jgqa-  (   2 )       tkIAMANFks--aMpifkShaYLkeLektLkpqhfd--rVFVFPdff
d3kxqa-  (   5 )      irpFIAGNWkm--ngtges-lgeLraIaagis------feALICVpat
d3taob-  (   2 )    s-rkpLIAGNWkm--nlnhyeAialVqkIafsLpdkyydrVdVAVIPpft
d5csra-  (   1 )       mytAIVNLktyreAtganFtrfMekFe-pvq----gkFeLIFSPsll
                         bbbbb         aaaaaaaaaa             bbbb    

                             60        70        80        90        100 
d1n55a-  (  47 )    hIplVqakL---rNpkYviSAqnAiak-sgaftgevSMpiLkdigVhWVI
d2h6ra-  (  44 )    DLrmIvenV------nIpVYAqHIdninpgshtghilAeaIkdcgCkGTL
d2jgqa-  (  45 )    Gllpn-------sFlhFtLGVqnAyPrdcgaftgeiTSkhLeelkIhTLL
d3kxqa-  (  50 )    LLsrAfdiLgg----nIlLGGqnChfddygpytgdiSAfmLkeagAshVI
d3taob-  (  49 )    DLrsVqtlvdgdkl-rLtYGAqdLsphdsgaytgdvSGafLaklgCsyVV
d5csra-  (  43 )    DLekAakcg------kfrFFAqHVdaepygaytghvPMdmMidlgItGSI
                     aaaaaaa         bb                  aaaaaa    bbb

                             110       120       130       140       150 
d1n55a-  (  93 )    LGHserrtyygEtdeiVAqkVSeACkqgFmVIACIGEtlqqrean--qta
d2h6ra-  (  88 )    Inhsekr----mlladieaVInkCknlgLeTIVCTnn------------i
d2jgqa-  (  88 )    IGHserrtllkEspsfLkeKFdfFksknfkIVYCIGEelttrekgfkavk
d3kxqa-  (  97 )    IGhserrtvyqEsdaiVrakVqAAwrAgLvALICVGEtl-ers----nvl
d3taob-  (  98 )    VGhserrtyhnEddalVAaKAatAlkhgLtPIVCIGEhldvreag--nhv
d5csra-  (  87 )    LNhserr----lprdtIinTLkkAskldFtIVLCVen------------a
                    b            aaaaaaaaaaaaa   bbbbbb              a

                             160       170       180       190       200 
d1n55a-  ( 141 )    kvVlsqTsaIaakLtkdaWnqVVLAYEPvwAigtgkvAtpeqAqeVHllL
d2h6ra-  ( 122 )    ntSkavAal----------sPdCIAVepp---------------evvegT
d2jgqa-  ( 138 )    efLseqLenIdln-----ypnLVVAYEPiwAigt--sAsledIyltHgfL
d3kxqa-  ( 145 )    dvLtrqLegSLP--dgAtaenIIIAYePvw--------tsadVaeVHafI
d3taob-  ( 146 )    ahNieqLrgSLagLlaeqIgsVVIAYEPvWAigtgrvAsaadAqeVCaaI
d5csra-  ( 121 )    eeAkyFrey----------ePdfIAyePrdLig-gdvsVstakpeiIedI
                    aaaaaa                bbbb                  aaaaaa

                             210       220       230       240       250 
d1n55a-  ( 191 )    rkwVsenigtdvaakLrILYGgsVn-aanAatLyakpdINGFLVggaSlk
d2h6ra-  ( 161 )    VraVkein-----kdVkVLcGagIs-gedVkaald-lgAeGVLlAsgVVk
d2jgqa-  ( 183 )    kqiLn--------qkTpLLYGgsVn-tqnAkeILgidsVdGLLIgsaSwe
d3kxqa-  ( 193 )    hhkMhsrfg--dGakIrLLyGgsVp--snAfelLstahVnGALIggaSlk
d3taob-  ( 196 )    rkeLaslAspriAdtVrVLYGGsVn-aknVgdIvaqddVdGGLVggaSld
d5csra-  ( 160 )    vkiYegt-------gTsVLVGaGIktgeDVrrSig-lgArGILvasgVVk
                    aaaa             bbb         aaaaa      bbbb      

                             260   
d1n55a-  ( 240 )    -peFrdIIdaTr   
d2h6ra-  ( 205 )    aknveeaIreLik  
d2jgqa-  ( 224 )    lenFktIisfL    
d3kxqa-  ( 241 )    aidFltICdvy    
d3taob-  ( 245 )    GehFAtLAaiAAggp
d5csra-  ( 202 )    sadptksLnsliel 
                       aaaaa
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Triosephosphate isomeraseTriosephosphate isomerase (TIM)Trypanosome (Leishmania mexicana) [TaxId: 5665]view
Triosephosphate isomeraseTriosephosphate isomerase (TIM)Methanocaldococcus jannaschii [TaxId: 243232]view
automated matchesautomated matchesHelicobacter pylori [TaxId: 85962]view
automated matchesautomated matchesBartonella henselae [TaxId: 38323]view
automated matchesautomated matchesMycobacterium tuberculosis [TaxId: 83332]view
automated matchesautomated matchesThermoplasma acidophilum [TaxId: 273075]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260
A K P Q P I A A A N W K C - - N G T T A S I E K L V Q V F N E - H T I S H - - D V Q C V V A P T F V H I P L V Q A K L - - - R N P K Y V I S A Q N A I A K - S G A F T G E V S M P I L K D I G V H W V I L G H S E R R T Y Y G E T D E I V A Q K V S E A C K Q G F M V I A C I G E T L Q Q R E A N - - Q T A K V V L S Q T S A I A A K L T K D A W N Q V V L A Y E P V W A I G T G K V A T P E Q A Q E V H L L L R K W V S E N I G T D V A A K L R I L Y G G S V N - A A N A A T L Y A K P D I N G F L V G G A S L K - P E F R D I I D A T R - - -
- - - - M V I V I N Y K T Y N E S I G N R G L E I A K I A E - V S E - - - E S G I T I G V A P Q F V D L R M I V E N V - - - - - - N I P V Y A Q H I D N I N P G S H T G H I L A E A I K D C G C K G T L I N H S E K R - - - - M L L A D I E A V I N K C K N L G L E T I V C T N N - - - - - - - - - - - - I N T S K A V A A L - - - - - - - - - - S P D C I A V E P P - - - - - - - - - - - - - - - E V V E G T V R A V K E I N - - - - - K D V K V L C G A G I S - G E D V K A A L D - L G A E G V L L A S G V V K A K N V E E A I R E L I K - -
- - - T K I A M A N F K S - - A M P I F K S H A Y L K E L E K T L K P Q H F D - - R V F V F P D F F G L L P N - - - - - - - S F L H F T L G V Q N A Y P R D C G A F T G E I T S K H L E E L K I H T L L I G H S E R R T L L K E S P S F L K E K F D F F K S K N F K I V Y C I G E E L T T R E K G F K A V K E F L S E Q L E N I D L N - - - - - Y P N L V V A Y E P I W A I G T - - S A S L E D I Y L T H G F L K Q I L N - - - - - - - - Q K T P L L Y G G S V N - T Q N A K E I L G I D S V D G L L I G S A S W E L E N F K T I I S F L - - - -
- - I R P F I A G N W K M - - N G T G E S - L G E L R A I A A G I S - - - - - - F E A L I C V P A T L L S R A F D I L G G - - - - N I L L G G Q N C H F D D Y G P Y T G D I S A F M L K E A G A S H V I I G H S E R R T V Y Q E S D A I V R A K V Q A A W R A G L V A L I C V G E T L - E R S - - - - N V L D V L T R Q L E G S L P - - D G A T A E N I I I A Y E P V W - - - - - - - - T S A D V A E V H A F I H H K M H S R F G - - D G A K I R L L Y G G S V P - - S N A F E L L S T A H V N G A L I G G A S L K A I D F L T I C D V Y - - - -
S - R K P L I A G N W K M - - N L N H Y E A I A L V Q K I A F S L P D K Y Y D R V D V A V I P P F T D L R S V Q T L V D G D K L - R L T Y G A Q D L S P H D S G A Y T G D V S G A F L A K L G C S Y V V V G H S E R R T Y H N E D D A L V A A K A A T A L K H G L T P I V C I G E H L D V R E A G - - N H V A H N I E Q L R G S L A G L L A E Q I G S V V I A Y E P V W A I G T G R V A S A A D A Q E V C A A I R K E L A S L A S P R I A D T V R V L Y G G S V N - A K N V G D I V A Q D D V D G G L V G G A S L D G E H F A T L A A I A A G G P
- - - M Y T A I V N L K T Y R E A T G A N F T R F M E K F E - P V Q - - - - G K F E L I F S P S L L D L E K A A K C G - - - - - - K F R F F A Q H V D A E P Y G A Y T G H V P M D M M I D L G I T G S I L N H S E R R - - - - L P R D T I I N T L K K A S K L D F T I V L C V E N - - - - - - - - - - - - A E E A K Y F R E Y - - - - - - - - - - E P D F I A Y E P R D L I G - G D V S V S T A K P E I I E D I V K I Y E G T - - - - - - - G T S V L V G A G I K T G E D V R R S I G - L G A R G I L V A S G V V K S A D P T K S L N S L I E L -

 

 

 

 

 

Member Chain UniProtKB GO term
d1n55a_ A P48499 GO:0004807
d1n55a_ A P48499 GO:0005737
d1n55a_ A P48499 GO:0005829
d1n55a_ A P48499 GO:0006094
d1n55a_ A P48499 GO:0006096
d1n55a_ A P48499 GO:0016853
d1n55a_ A P48499 GO:0019563
d1n55a_ A P48499 GO:0020015
d1n55a_ A P48499 GO:0046166
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in