BASE   PART 1   PART 2   PART 3   PART 4  
Superfamily : 75217 [ alpha/beta knot ]
Class : Alpha and beta proteins (a/b)
Fold : alpha/beta knot
# of Members : 6
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1k3ra2  (   1 )                                                      
d1v2xa-  (   1 )                                                      
d2v3ka-  (  25 )    pqappvLtSkdkitkRIVVLAAslethk-------------------iyv
d3aiaa1  (   2 )                  reFIFkAnkTiTssdInlkdLpg-------------
d3bbda1  (   2 )                 tynIILAkSAlElIpeeIknk--IrksrvYk----yd
d3o7ba-  (   1 )                mgSAFVFLEASLelIpqkIrghpaVradairgkrpekI
                                                                      

                             60        70        80        90        100 
d1k3ra2  (   1 )                                           mnrVdLSLFIP
d1v2xa-  (   1 )                      mrertearrrrieevLr----rRQpdLTVLLe
d2v3ka-  (  67 )    LlncddhqglLkkgrdise-arPdiTHqCLltLldspINkagkLQVYIqT
d3aiaa1  (  25 )    ------------------sCgrLdLLCrCVsdAFflshdirrdVvFYAVL
d3bbda1  (  33 )    ILDsnyhykA-ekLkdke-RGrPdIIhiSLlnILdSpINhekkLnIyIHT
d3o7ba-  (  40 )    LLddskHhtAMksLefreKrGrPdiVHqCLllLLdSp---lrdFeVyVhT
                                             aaaaaaaaa          bbbbbb

                             110       120       130       140       150 
d1k3ra2  (  12 )    DSLTaetg----------dlkikTykVVlIArAAsifgVkrIVIYhddad
d1v2xa-  (  29 )    nVh-------------------kphNLSaILrtCdaVgVleAHAv-----
d2v3ka-  ( 117 )    sr-----giLIeVnptVr-Iprtfkrfsgl-vqllhk--lsirsv-----
d3aiaa1  (  57 )    ygqpnppVCIkFvGseLkkVspdernIAifIkkALkkFeeld--------
d3bbda1  (  83 )    yd-----dkVlkInpeTr-LprnyfrfLgv-ekvLkg--ern--------
d3o7ba-  (  87 )    Ln-----geIIwVnreTr-LprnynrFvglMEkLFee--rritag-----
                                           aaaaaa   aaaa              

                             160       170       180       190       200 
d1k3ra2  (  52 )    gearFIrdILtyMdtpqylrrkvfpimreLkhVgiLpplr------tgYe
d1v2xa-  (  55 )    --nPTgg---------------------------vptfnetsggShkwVy
d2v3ka-  ( 154 )    --------------------------------------------nseekl
d3aiaa1  (  99 )    --eeqrk---------------------------dwnqStp------GIy
d3bbda1  ( 117 )    ------------------------------------------------hl
d3o7ba-  ( 124 )    ----------------------------------------------dttl
                                                                     b

                             210       220       230       240       250 
d1k3ra2  ( 167 )    VldtrrnLaeSlktv--gAdvvVAtsr--naspItsildeVktrMrgare
d1v2xa-  (  76 )    LrvHp-dLheAFrfLkergftVyAtalredArdFreV--dYtk------p
d2v3ka-  ( 160 )    LkviknpItdhLPt----kCrkVTLsf--dapvi--rVqdyIekLdddeS
d3aiaa1  ( 114 )    Vrrl--gFrnLVleKleegknIYYLhm--ngedVenV--dI-e------n
d3bbda1  ( 119 )    ik-eektLedLLnei---nAkkIAItk--tgklt--hpklLke-----yd
d3o7ba-  ( 128 )    IefkdvgLrdiVr-----gRdVLLFre--kGgrf--efseLLd----gdV
                    bb b   aaaa         bbbbb                         

                             260       270       280       290       300 
d1k3ra2  ( 213 )    AAILFgGpykgLpe---IdAd--IwVnTlpgqctetvrTeeaVlaTLsvF
d1v2xa-  ( 117 )    TAVLFGAekwgVseeAlalAd--gaIkipmlgmvqslnvsvaAavILfeA
d2v3ka-  ( 202 )    ICVFVgAargkdn-fAdeyV----dekVGLs-nyp-lsasvaCskFchGa
d3aiaa1  ( 151 )    pVFIIgdhi-gIgeeDerfLdeikAkrIsLs-ple-lhANhcItiIHnvl
d3bbda1  ( 158 )    TFIigGfpygkLkInkekVf--gdikeISiy-nkg-l-AwtvCgiICysL
d3o7ba-  ( 165 )    AVCIgAfphgdffeeTlreL--gefkeVsLg-tes-ytslyvTsrVlceY
                    bbbbb                    bb           aaaaaaaaaaaa

                             310       320     
d1k3ra2  ( 258 )    nmLtq                      
d1v2xa-  ( 165 )    qrqRlkaglydrprLdpelyqkVladW
d2v3ka-  ( 246 )    edAwni                     
d3aiaa1  ( 198 )    dkk                        
d3bbda1  ( 204 )    sf                         
d3o7ba-  ( 211 )    ervra                      
                    aa
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Hypothetical protein MTH1 (MT0001), dimerisation domainHypothetical protein MTH1 (MT0001), dimerisation domainMethanobacterium thermoautotrophicum [TaxId: 145262]view
tRNA (Gm18) methyltransferase TrmHSpoU-like RNA 2'-O ribose methyltransferaseThermus thermophilus [TaxId: 274]view
Essential for mitotic growth 1, EMG1EMG1/NEP1-likeBaker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]view
automated matchesautomated matchesMethanocaldococcus jannaschii [TaxId: 2190]view
Ribosome biogenesis protein NEP1EMG1/NEP1-likeMethanococcus jannaschii [TaxId: 2190]view
automated matchesautomated matchesArchaeoglobus fulgidus [TaxId: 2234]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M N R V D L S L F I P D S L T A E T G - - - - - - - - - - D L K I K T Y K V V L I A R A A S I F G V K R I V I Y H D D A D G E A R F I R D I L T Y M D T P Q Y L R R K V F P I M R E L K H V G I L P P L R - - - - - - T G Y E V L D T R R N L A E S L K T V - - G A D V V V A T S R - - N A S P I T S I L D E V K T R M R G A R E A A I L F G G P Y K G L P E - - - I D A D - - I W V N T L P G Q C T E T V R T E E A V L A T L S V F N M L T Q - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M R E R T E A R R R R I E E V L R - - - - R R Q P D L T V L L E N V H - - - - - - - - - - - - - - - - - - - K P H N L S A I L R T C D A V G V L E A H A V - - - - - - - N P T G G - - - - - - - - - - - - - - - - - - - - - - - - - - - V P T F N E T S G G S H K W V Y L R V H P - D L H E A F R F L K E R G F T V Y A T A L R E D A R D F R E V - - D Y T K - - - - - - P T A V L F G A E K W G V S E E A L A L A D - - G A I K I P M L G M V Q S L N V S V A A A V I L F E A Q R Q R L K A G L Y D R P R L D P E L Y Q K V L A D W
P Q A P P V L T S K D K I T K R I V V L A A S L E T H K - - - - - - - - - - - - - - - - - - - I Y V L L N C D D H Q G L L K K G R D I S E - A R P D I T H Q C L L T L L D S P I N K A G K L Q V Y I Q T S R - - - - - G I L I E V N P T V R - I P R T F K R F S G L - V Q L L H K - - L S I R S V - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - N S E E K L L K V I K N P I T D H L P T - - - - K C R K V T L S F - - D A P V I - - R V Q D Y I E K L D D D E S I C V F V G A A R G K D N - F A D E Y V - - - - D E K V G L S - N Y P - L S A S V A C S K F C H G A E D A W N I - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - R E F I F K A N K T I T S S D I N L K D L P G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - S C G R L D L L C R C V S D A F F L S H D I R R D V V F Y A V L Y G Q P N P P V C I K F V G S E L K K V S P D E R N I A I F I K K A L K K F E E L D - - - - - - - - - - E E Q R K - - - - - - - - - - - - - - - - - - - - - - - - - - - D W N Q S T P - - - - - - G I Y V R R L - - G F R N L V L E K L E E G K N I Y Y L H M - - N G E D V E N V - - D I - E - - - - - - N P V F I I G D H I - G I G E E D E R F L D E I K A K R I S L S - P L E - L H A N H C I T I I H N V L D K K - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - T Y N I I L A K S A L E L I P E E I K N K - - I R K S R V Y K - - - - Y D I L D S N Y H Y K A - E K L K D K E - R G R P D I I H I S L L N I L D S P I N H E K K L N I Y I H T Y D - - - - - D K V L K I N P E T R - L P R N Y F R F L G V - E K V L K G - - E R N - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - H L I K - E E K T L E D L L N E I - - - N A K K I A I T K - - T G K L T - - H P K L L K E - - - - - Y D T F I I G G F P Y G K L K I N K E K V F - - G D I K E I S I Y - N K G - L - A W T V C G I I C Y S L S F - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - M G S A F V F L E A S L E L I P Q K I R G H P A V R A D A I R G K R P E K I L L D D S K H H T A M K S L E F R E K R G R P D I V H Q C L L L L L D S P - - - L R D F E V Y V H T L N - - - - - G E I I W V N R E T R - L P R N Y N R F V G L M E K L F E E - - R R I T A G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - D T T L I E F K D V G L R D I V R - - - - - G R D V L L F R E - - K G G R F - - E F S E L L D - - - - G D V A V C I G A F P H G D F F E E T L R E L - - G E F K E V S L G - T E S - Y T S L Y V T S R V L C E Y E R V R A - - - - - - - - - - - - - - - - - - - - - -

 

 

 

 

 

Member Chain UniProtKB GO term
d1v2xa_ A Q5SM16 GO:0000049
d1v2xa_ A Q5SM16 GO:0002938
d1v2xa_ A Q5SM16 GO:0003723
d1v2xa_ A Q5SM16 GO:0006396
d1v2xa_ A Q5SM16 GO:0008033
d1v2xa_ A Q5SM16 GO:0008168
d1v2xa_ A Q5SM16 GO:0008173
d1v2xa_ A Q5SM16 GO:0009020
d1v2xa_ A Q5SM16 GO:0030488
d1v2xa_ A Q5SM16 GO:0032259
d1v2xa_ A Q5SM16 GO:0141100
d1v2xa_ A Q5SM16 GO:0000049
d1v2xa_ A Q5SM16 GO:0002938
d1v2xa_ A Q5SM16 GO:0003723
d1v2xa_ A Q5SM16 GO:0006396
d1v2xa_ A Q5SM16 GO:0008033
d1v2xa_ A Q5SM16 GO:0008168
d1v2xa_ A Q5SM16 GO:0008173
d1v2xa_ A Q5SM16 GO:0009020
d1v2xa_ A Q5SM16 GO:0030488
d1v2xa_ A Q5SM16 GO:0032259
d1v2xa_ A Q5SM16 GO:0141100
d3bbda1 A Q57977 GO:0006364
d3bbda1 A Q57977 GO:0008168
d3bbda1 A Q57977 GO:0019843
d3bbda1 A Q57977 GO:0032259
d3bbda1 A Q57977 GO:0042254
d3bbda1 A Q57977 GO:0042803
d3bbda1 A Q57977 GO:0070037
d3bbda1 A Q57977 GO:0070475
d3bbda1 A Q57977 GO:0006364
d3bbda1 A Q57977 GO:0008168
d3bbda1 A Q57977 GO:0019843
d3bbda1 A Q57977 GO:0032259
d3bbda1 A Q57977 GO:0042254
d3bbda1 A Q57977 GO:0042803
d3bbda1 A Q57977 GO:0070037
d3bbda1 A Q57977 GO:0070475
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in