BASE   PART 1   PART 2  
Superfamily : 63748 [ Tudor/PWWP/MBT ]
Class : All beta proteins
Fold : SH3-like barrel
# of Members : 8
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1h3za-  ( 118 )                                 servnYkpgmrvltkmsg--f
d1khca-  ( 223 )                                 eYd-efgigdLVWGkikg---
d1oz2a1  ( 204 )    ecwswesyleeqkaitapvslfqdsqavthnkNgfklgmkLEGidpqhps
d1oz2a2  ( 314 )      fswsqylrstraqaapkhlf-vsqshsppPlgfqvgmklEAvdrmnps
d1wjra1  (   8 )                                  pidlitvgSliElqdsqnpf
d2l89a-  (  45 )                                 saddrlnfGdrilvkapg--y
d4rxja-  ( 958 )                                      lhykqiVwVlg-n--y
d6iipa1  (   8 )                                     eYkagdlVFAkmkg--y
                                                           bbbbb      

                             60        70        80        90        100 
d1h3za-  ( 137 )    pwwPSMvvteskMtsvArkskpkr-----agtfypviFFpnke----YlW
d1khca-  ( 244 )    swWPAmVvswaTskrqAmp------------gmRwVqWfgdgk----fse
d1oz2a1  ( 254 )    myfiLtVaevc-------------------gyrLrLhFdgy--sechdfw
d1oz2a2  ( 361 )    lVcvAsVtdvv-------------------dsrFlVhFdnw--ddtydyw
d1wjra1  (  28 )    qYWivsvienv-------------------gGrlrlryvgledtesydqw
d2l89a-  (  64 )    pwwPAlllrr-ket------kdslntnssfnvlYkvlfFpdfn----faw
d4rxja-  ( 972 )    rwwpAeIcnp--sVpniqglhdl--------gDfPVfffgsh-----dyw
d6iipa1  (  23 )    phwPArIdelpegavkppa------------nkypIfFFGthe----taf
                     bbbbbb                         bbbbbb          bb

                             110       120       130       140       150 
d1h3za-  ( 178 )    tgs--dsltpl---tseaisqflekpkp---ktaslikAYkmAqstpdld
d1khca-  ( 279 )    isa--dkLva----LG-lFsqhFnlatf---nlvsYrkAMyhTLekArvr
d1oz2a1  ( 283 )    vnAnspdIhp-----agwfek----tghklqppk-gy-------------
d1oz2a2  ( 390 )    CdpsspyIhp-----vgwCqk----qgkpltppq-dyp------------
d1wjra1  (  59 )    lfYldyrlrp-----vgwCqe----nkyrmdPpseiyplkm---------
d2l89a-  ( 103 )    vkr--nsvkpl---ldseiakflgsskr---kskelieAYeaSktppdlk
d4rxja-  (1011 )    Vhq--grVfpyvegfaegqtsint--fa---leeaakrfqelkaqresea
d6iipa1  (  57 )    lgp--kdLfp----Ykeykdkfgk--sn---krkgFneGlweIennpgv 
                    b       b        aaaa                             

                             160       170       180   
d1h3za-  ( 220 )    slsvps                             
d1khca-  ( 320 )    AgktfssspgesedqLkpMlewAhggFkptgigLp
d1oz2a1  ( 310 )    ------keee                         
d1oz2a2  ( 418 )    ------dpdn                         
d1wjra1  (  91 )    ----aseWkctlekslidAakfplpmevfkdhadl
d2l89a-  ( 145 )    eesstdle                           
d4rxja-  (1061 )    lei                                
d6iipa1
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Hypothetical protein SPBC215.07cPWWP domainFission yeast (Schizosaccharomyces pombe) [TaxId: 4896]view
DNA methyltransferase DNMT3BPWWP domainMouse (Mus musculus) [TaxId: 10090]view
Lethal(3)malignant brain tumor-like proteinMBT repeatHuman (Homo sapiens) [TaxId: 9606]view
Lethal(3)malignant brain tumor-like proteinMBT repeatHuman (Homo sapiens) [TaxId: 9606]view
Scm-like with four MBT domains protein 2, SFMBT2 (KIAA1617)MBT repeatHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesFission yeast (Schizosaccharomyces pombe) [TaxId: 4896]view
automated matchesPWWP domainHuman (Homo sapiens) [TaxId: 9606]view
automated matchesPWWP domainHuman (Homo sapiens) [TaxId: 9606]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - S E R V N Y K P G M R V L T K M S G - - F P W W P S M V V T E S K M T S V A R K S K P K R - - - - - A G T F Y P V I F F P N K E - - - - Y L W T G S - - D S L T P L - - - T S E A I S Q F L E K P K P - - - K T A S L I K A Y K M A Q S T P D L D S L S V P S - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - E Y D - E F G I G D L V W G K I K G - - - S W W P A M V V S W A T S K R Q A M P - - - - - - - - - - - - G M R W V Q W F G D G K - - - - F S E I S A - - D K L V A - - - - L G - L F S Q H F N L A T F - - - N L V S Y R K A M Y H T L E K A R V R A G K T F S S S P G E S E D Q L K P M L E W A H G G F K P T G I G L P
E C W S W E S Y L E E Q K A I T A P V S L F Q D S Q A V T H N K N G F K L G M K L E G I D P Q H P S M Y F I L T V A E V C - - - - - - - - - - - - - - - - - - - G Y R L R L H F D G Y - - S E C H D F W V N A N S P D I H P - - - - - A G W F E K - - - - T G H K L Q P P K - G Y - - - - - - - - - - - - - - - - - - - K E E E - - - - - - - - - - - - - - - - - - - - - - - - -
- - F S W S Q Y L R S T R A Q A A P K H L F - V S Q S H S P P P L G F Q V G M K L E A V D R M N P S L V C V A S V T D V V - - - - - - - - - - - - - - - - - - - D S R F L V H F D N W - - D D T Y D Y W C D P S S P Y I H P - - - - - V G W C Q K - - - - Q G K P L T P P Q - D Y P - - - - - - - - - - - - - - - - - - D P D N - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - P I D L I T V G S L I E L Q D S Q N P F Q Y W I V S V I E N V - - - - - - - - - - - - - - - - - - - G G R L R L R Y V G L E D T E S Y D Q W L F Y L D Y R L R P - - - - - V G W C Q E - - - - N K Y R M D P P S E I Y P L K M - - - - - - - - - - - - - A S E W K C T L E K S L I D A A K F P L P M E V F K D H A D L
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - S A D D R L N F G D R I L V K A P G - - Y P W W P A L L L R R - K E T - - - - - - K D S L N T N S S F N V L Y K V L F F P D F N - - - - F A W V K R - - N S V K P L - - - L D S E I A K F L G S S K R - - - K S K E L I E A Y E A S K T P P D L K E E S S T D L E - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - L H Y K Q I V W V L G - N - - Y R W W P A E I C N P - - S V P N I Q G L H D L - - - - - - - - G D F P V F F F G S H - - - - - D Y W V H Q - - G R V F P Y V E G F A E G Q T S I N T - - F A - - - L E E A A K R F Q E L K A Q R E S E A L E I - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - E Y K A G D L V F A K M K G - - Y P H W P A R I D E L P E G A V K P P A - - - - - - - - - - - - N K Y P I F F F G T H E - - - - T A F L G P - - K D L F P - - - - Y K E Y K D K F G K - - S N - - - K R K G F N E G L W E I E N N P G V - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

 

 

 

 

 

Member Chain UniProtKB GO term
d1oz2a1 A Q9Y468 GO:0005634
d1oz2a1 A Q9Y468 GO:0006355
d1oz2a1 A Q9Y468 GO:0005634
d1oz2a1 A Q9Y468 GO:0006355
d1oz2a1 A Q9Y468 GO:0005634
d1oz2a1 A Q9Y468 GO:0006355
d1oz2a1 A Q9Y468 GO:0005634
d1oz2a1 A Q9Y468 GO:0006355
d1oz2a2 A Q9Y468 GO:0005634
d1oz2a2 A Q9Y468 GO:0006355
d1oz2a2 A Q9Y468 GO:0005634
d1oz2a2 A Q9Y468 GO:0006355
d1oz2a2 A Q9Y468 GO:0005634
d1oz2a2 A Q9Y468 GO:0006355
d1oz2a2 A Q9Y468 GO:0005634
d1oz2a2 A Q9Y468 GO:0006355
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in