Superfamily : 56973 [ Aerolisin/ETX pore-forming domain ]
Class : Membrane and cell surface proteins and peptides
Fold : Aerolisin/ETX pore-forming domain
# of Members : 3
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d3c0na2  (  85 )    IptlsaldIpDGdevdVQwrLVhdsanFikPTSy--LAhyLGYAwVgGnh
d3ziwa1  (  38 )                                                      
d3zjxa1  (  15 )           asydnvdtLIekGryntkynylkrmeyypnamayf--------
                                                                      

                             60        70        80        90        100 
d3c0na2  ( 133 )    sqyvGedMdVtrdgdgWvIrGnndggçdgyrçgdKTAIkVsnFaYnLdpd
d3ziwa1  (  38 )                                                      
d3zjxa1  (  51 )    ------dvtinpg----------------------ndfyinnpkVeld--
                                                                      

                             110       120       130       140       150 
d3c0na2  ( 183 )    sfkhgdvtqsdrqlvkt--------VvgwAVNdsdtpqsgydVtLrgdTa
d3ziwa1  (  38 )          sdglyVidkgaGwIlGepSvvssqiLnpn-----etgtFsqslt
d3zjxa1  (  73 )    -----gePsmnyledvy--------vgalltNdtqqeqklsq-sftcknt
                            bbbbbb              bbbb            bbbbbb

                             160       170       180       190       200 
d3c0na2  ( 225 )    TnWsKtnty---------gLSekVtTknkfkWplvg-eTeLsIeIaanqs
d3ziwa1  (  77 )    kskevsinvnfsvgFtsefIqasVeyGfgitIg-----------------
d3zjxa1  ( 111 )    DtVtAtTth---------tVgtsqa--taftVpfnetgvsLttsYsFAnt
                    bb bb                                             

                             210       220       230       240       250 
d3c0na2  ( 265 )    WasqnGgstttslsqsvrptVparskIpVkIeLykAdIsYpYeFkAdVsY
d3ziwa1  ( 110 )    ------eqntiersvsTtAg--------------peyVyYKVYATYrkYq
d3zjxa1  ( 152 )    --------ntntnskeitanVps-QdIlVpanTtVevaylkkvnVkgnVL
                             bbbb  bb                     bbbbbbbbbb  

                             260       270       280       290       300 
d3c0na2  ( 315 )    dLtLsgFLrwggNAwythpdnrpnwnhtFvigpykdkassIryqWdkryi
d3ziwa1  ( 141 )    Airish--------------------------------------------
d3zjxa1  ( 195 )    vGqVsgsEwgepsyl-----afprdgykfs-------LsdTvn-------
                    bbbbb                                             

                             310       320       330       340       350 
d3c0na2  ( 365 )    pgevkwWdWnwTiqqnglstMqnnLArVlrpvrAGItGdFsAeSqfAgnI
d3ziwa1  ( 147 )    ----------------------------gnisDdGSIYkLtgiwlsktsa
d3zjxa1  ( 228 )    -----------------------sdnedgtInIngGnYsAvMgdeLIVkV
                                                   bbb  bbbbbbbbbbb   

                             360       370       380       390      
d3c0na2  ( 415 )    eig----------apvplgLrleIpldaqeLsglgFnnVsLsvtpaa 
d3ziwa1  ( 169 )    --dslgnIdqgslietgercVltvpstdieei                
d3zjxa1  ( 257 )    rNl-------ntnnvqeyvIpvdi-----------ivyrslsIkApgi
 

 

Domain IDNameFamilySourceDomainSTRING-DB
(Pro)aerolysin, pore-forming lobe(Pro)aerolysin, pore-forming lobeAeromonas hydrophila [TaxId: 644]view
automated matchesClostridium perfringens enterotoxin (CPE), pore-forming domainClostridium perfringens [TaxId: 1502]view
automated matchesETX/MTX2Clostridium perfringens [TaxId: 107819]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

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I P T L S A L D I P D G D E V D V Q W R L V H D S A N F I K P T S Y - - L A H Y L G Y A W V G G N H S Q Y V G E D M D V T R D G D G W V I R G N N D G G C D G Y R C G D K T A I K V S N F A Y N L D P D S F K H G D V T Q S D R Q L V K T - - - - - - - - V V G W A V N D S D T P Q S G Y D V T L R G D T A T N W S K T N T Y - - - - - - - - - G L S E K V T T K N K F K W P L V G - E T E L S I E I A A N Q S W A S Q N G G S T T T S L S Q S V R P T V P A R S K I P V K I E L Y K A D I S Y P Y E F K A D V S Y D L T L S G F L R W G G N A W Y T H P D N R P N W N H T F V I G P Y K D K A S S I R Y Q W D K R Y I P G E V K W W D W N W T I Q Q N G L S T M Q N N L A R V L R P V R A G I T G D F S A E S Q F A G N I E I G - - - - - - - - - - A P V P L G L R L E I P L D A Q E L S G L G F N N V S L S V T P A A -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - S D G L Y V I D K G A G W I L G E P S V V S S Q I L N P N - - - - - E T G T F S Q S L T K S K E V S I N V N F S V G F T S E F I Q A S V E Y G F G I T I G - - - - - - - - - - - - - - - - - - - - - - - E Q N T I E R S V S T T A G - - - - - - - - - - - - - - P E Y V Y Y K V Y A T Y R K Y Q A I R I S H - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - G N I S D D G S I Y K L T G I W L S K T S A - - D S L G N I D Q G S L I E T G E R C V L T V P S T D I E E I - - - - - - - - - - - - - - - -
- - - - - - - A S Y D N V D T L I E K G R Y N T K Y N Y L K R M E Y Y P N A M A Y F - - - - - - - - - - - - - - D V T I N P G - - - - - - - - - - - - - - - - - - - - - - N D F Y I N N P K V E L D - - - - - - - G E P S M N Y L E D V Y - - - - - - - - V G A L L T N D T Q Q E Q K L S Q - S F T C K N T D T V T A T T T H - - - - - - - - - T V G T S Q A - - T A F T V P F N E T G V S L T T S Y S F A N T - - - - - - - - N T N T N S K E I T A N V P S - Q D I L V P A N T T V E V A Y L K K V N V K G N V L V G Q V S G S E W G E P S Y L - - - - - A F P R D G Y K F S - - - - - - - L S D T V N - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - S D N E D G T I N I N G G N Y S A V M G D E L I V K V R N L - - - - - - - N T N N V Q E Y V I P V D I - - - - - - - - - - - I V Y R S L S I K A P G I

 

 

 

 

 

Member Chain UniProtKB GO term
d3c0na2 A P09167 GO:0005576
d3c0na2 A P09167 GO:0016020
d3c0na2 A P09167 GO:0020002
d3c0na2 A P09167 GO:0035821
d3c0na2 A P09167 GO:0042802
d3c0na2 A P09167 GO:0090729
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in