Superfamily : 56959 [ Leukocidin-like ]
Class : Membrane and cell surface proteins and peptides
Fold : Leukocidin-like
# of Members : 7
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1uuna-  (   1 )                          gldnelslvDgqdrtLtVqQwdTfLngv
d4i0na-  (  45 )                sGeiig--keAikytssdtash-gWkAtLsGtFIeDp-
d4iyaa-  (   2 )               nnienIgdgAeVvkrtedtssdkwgVtQnIqFDFVkDk-
d6rhvg-  (  18 )                        tkmytrtattsdsqknitqslqFnFltep-
d6rhvh-  (  37 )              pd---diGkngkitkrtetvydektnilqnlqFDFidDp-
d6u2sa-  (   1 )         aqhitpvsekkVddkItlykTtAtSdndklnIsQiLtFNFIkDk-
d7ahla-  (   1 )    adsdiniktgtt---digsnttvktgdlvtydkengMhKkVfysFidDk-
                                          bbbbbbbbbb    bbbbbbbbbbb   

                             60        70        80        90        100 
d1uuna-  (  29 )    fpldrnr---ltreWfHsGrAkYiVagpgadeFeGtLeLGYqigFp----
d4i0na-  (  83 )    ----hsdkKTALLnLegfIpSdkqifgsk---yyGkMkWPetYrInVkSa
d4iyaa-  (  41 )    -----ynkdALILkMqgfInSkTtyynykntdhiKAMrWPFqYNIGLkTn
d6rhvg-  (  47 )    ----nydkEtvfikAkgtigSglrildpngywn-StlrWPGSYsvsiqnv
d6rhvh-  (  73 )    ----tydknvllvkKqGsihSnlkFeshkeeknSnwlkYPSEYHvDFqvk
d6u2sa-  (  45 )    ----sydkDTLVLkAagnInSgYkkpnpk-dynySqFyWGGkYnVsVsSe
d7ahla-  (  47 )    ----nhnkklLvIrTkgtIaGqYvys--eegan-SGLaWPSaFkVqLqL-
                           bbbbbbbbbbbbb   bb         bbbbbbbbbbbbbbb 

                             110       120       130       140       150 
d1uuna-  (  72 )    -----------------wslgvginfsytt--pniliddGditrppfGln
d4i0na-  ( 126 )    dvnnn-IIanSIPkntidkkdVsnsIgYsiggn-----------------
d4iyaa-  (  86 )    d--pnVdLinyLPknkidsvnVsqtLGYnigGnfnsgpstg----gng--
d6rhvg-  (  92 )    ddnnntnvtdfapknqdesrevkytygyk---tggdfsi---------lt
d6rhvh-  ( 119 )    -rnrkteildqlpknkistakvdstfsys---sggkfds---------tg
d6u2sa-  (  90 )    -sndaVnVvdyAPknqneefqVqqtLgYsygGdInisn-------glg--
d7ahla-  (  91 )    pdnEvAqIsdyyprnsidtkeymstltyg---fngnvtgdd----tgkig
                          bbbbbb        bbbbbbbbb   bb                

                             160       170       180       190       200 
d1uuna-  ( 103 )    svitpnlfpgvsisadlgnGpg----------------------------
d4i0na-  ( 159 )    ------isvvntIsYeQpdFrTiqrkd--anlASWdIkFv--etkdg--y
d4iyaa-  ( 128 )    -----sfnysktIsYnQqnYiSeveh-qnsksVqWGIkAnsFitsl--gm
d6rhvg-  ( 134 )    gnitkesnysetisyqqpsYrtlldqstshkGvGWkveAhlinnmg-hdH
d6rhvh-  ( 157 )    igrtssnsysktisynqqnYdtiASgknnnwhvHWSviAndlkYgg-evk
d6u2sa-  ( 135 )    -----sksfsetInYkQesYrTtidrktnhksIGWGVeAhkImnngwgpy
d7ahla-  ( 134 )    gliganvsightlkyvqpdFktiLe-sptdkkVGWkViFnnMvnqnwgpy
                            bbbbbb     bbbbb       bbbbbbbb  bbb    bb

                             210       220       230       240       250 
d1uuna-  ( 125 )    --------------------------------------------------
d4i0na-  ( 213 )    nid--syha-iyGNqLFMksrly-----nnGdNFtd-ddLstLIsgGFsP
d4iyaa-  ( 171 )    sGh--d-------pnLFVg-ykpys--qnprdYFvpdneLPpLVhsGFnP
d6rhvg-  ( 183 )    trqltndsdnrtkSEiFSltrngnlw---AkdnFtpkdkMpvtvseGfnP
d6rhvh-  ( 206 )    nRnde---------llFyr-ntriAtvenpelSFAskyrYPalvrsGfnP
d6u2sa-  ( 180 )    gRd--sydp-tygNeLFLggrqsss---nAGqNFLpthqMplLArgnFnP
d7ahla-  ( 183 )    drd--swnp-vyGnqLFMktrngsmk---AadnFLdpnkAsslLssGfsP
                                                 333    333  aaaa bb  

                             260       270       280       290       300 
d1uuna-  ( 125 )    ---------------------iqevatfsvdvsgaeggvavsnahgtvtg
d4i0na-  ( 256 )    nMALALtApkna--keSvIiVeYqRfDndYiLnwet--t--qWrGtNlSs
d4iyaa-  ( 209 )    SFIATVSHekgsg-dtSeFeItYGRnMDVThAtt-h--ygnsaLGsRihn
d6rhvg-  ( 230 )    eFlAvMSHdkkd-kgkSqFvvhYkRsMDeFkidwnrhgfwGyWSGenhvd
d6rhvh-  ( 246 )    eFltYlSneksn--ektqFevtYtRnqDilKnrPgi----hyApPilekn
d6u2sa-  ( 224 )    eFISVLSHkqndt-kkSkIkVtYqReMDrYTNqwnr--l--hWvGnNykn
d7ahla-  ( 227 )    dFaTvItMdrkaskqqTnIdVIYERvrDDYqLhwts----tnWkGtntkd
                     bbbbbbbb      bbbbbbbbbbbbbbbbbb         bbbbbbbb

                             310       320       330    
d1uuna-  ( 154 )    AaggVlLrPFArLiAstgdsvtTygepwnMn     
d4i0na-  ( 301 )    --t-seyneFFkInWq----dhIeyyl         
d4iyaa-  ( 259 )    afvnrnYtVkYeVnWt----hIvghn          
d6rhvg-  ( 279 )    kke-eklSAlYevdWkthnvkfvkvln         
d6rhvh-  ( 290 )    kdG-qrlivtYevdWknktvkvvdkySddnapykeg
d6u2sa-  ( 269 )    qNt-VtFtStYeVdWqnhtVkLigtdsketnpgv  
d7ahla-  ( 273 )    kwt-drSserYkIdWekeeMtn              
                    bbb bbbbbbbbbb     bb
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Porin MspAPorin MspAMycobacterium smegmatis [TaxId: 1772]view
automated matchesautomated matchesClostridium perfringens [TaxId: 1502]view
automated matchesautomated matchesStaphylococcus phage [TaxId: 71366]view
automated matchesautomated matchesStaphylococcus aureus [TaxId: 1280]view
automated matchesautomated matchesStaphylococcus aureus [TaxId: 1280]view
automated matchesLeukocidin (pore-forming toxin)Staphylococcus aureus [TaxId: 282459]view
Alpha-hemolysinLeukocidin (pore-forming toxin)Staphylococcus aureus [TaxId: 1280]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330
- - - - - - - - - - - - - - - - - - - - - - G L D N E L S L V D G Q D R T L T V Q Q W D T F L N G V F P L D R N R - - - L T R E W F H S G R A K Y I V A G P G A D E F E G T L E L G Y Q I G F P - - - - - - - - - - - - - - - - - - - - - W S L G V G I N F S Y T T - - P N I L I D D G D I T R P P F G L N S V I T P N L F P G V S I S A D L G N G P G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - I Q E V A T F S V D V S G A E G G V A V S N A H G T V T G A A G G V L L R P F A R L I A S T G D S V T T Y G E P W N M N - - - - -
- - - - - - - - - - - - S G E I I G - - K E A I K Y T S S D T A S H - G W K A T L S G T F I E D P - - - - - H S D K K T A L L N L E G F I P S D K Q I F G S K - - - Y Y G K M K W P E T Y R I N V K S A D V N N N - I I A N S I P K N T I D K K D V S N S I G Y S I G G N - - - - - - - - - - - - - - - - - - - - - - - I S V V N T I S Y E Q P D F R T I Q R K D - - A N L A S W D I K F V - - E T K D G - - Y N I D - - S Y H A - I Y G N Q L F M K S R L Y - - - - - N N G D N F T D - D D L S T L I S G G F S P N M A L A L T A P K N A - - K E S V I I V E Y Q R F D N D Y I L N W E T - - T - - Q W R G T N L S S - - T - S E Y N E F F K I N W Q - - - - D H I E Y Y L - - - - - - - - -
- - - - - - - - - - - N N I E N I G D G A E V V K R T E D T S S D K W G V T Q N I Q F D F V K D K - - - - - - Y N K D A L I L K M Q G F I N S K T T Y Y N Y K N T D H I K A M R W P F Q Y N I G L K T N D - - P N V D L I N Y L P K N K I D S V N V S Q T L G Y N I G G N F N S G P S T G - - - - G N G - - - - - - - S F N Y S K T I S Y N Q Q N Y I S E V E H - Q N S K S V Q W G I K A N S F I T S L - - G M S G H - - D - - - - - - - P N L F V G - Y K P Y S - - Q N P R D Y F V P D N E L P P L V H S G F N P S F I A T V S H E K G S G - D T S E F E I T Y G R N M D V T H A T T - H - - Y G N S A L G S R I H N A F V N R N Y T V K Y E V N W T - - - - H I V G H N - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - T K M Y T R T A T T S D S Q K N I T Q S L Q F N F L T E P - - - - - N Y D K E T V F I K A K G T I G S G L R I L D P N G Y W N - S T L R W P G S Y S V S I Q N V D D N N N T N V T D F A P K N Q D E S R E V K Y T Y G Y K - - - T G G D F S I - - - - - - - - - L T G N I T K E S N Y S E T I S Y Q Q P S Y R T L L D Q S T S H K G V G W K V E A H L I N N M G - H D H T R Q L T N D S D N R T K S E I F S L T R N G N L W - - - A K D N F T P K D K M P V T V S E G F N P E F L A V M S H D K K D - K G K S Q F V V H Y K R S M D E F K I D W N R H G F W G Y W S G E N H V D K K E - E K L S A L Y E V D W K T H N V K F V K V L N - - - - - - - - -
- - - - - - - - - - P D - - - D I G K N G K I T K R T E T V Y D E K T N I L Q N L Q F D F I D D P - - - - - T Y D K N V L L V K K Q G S I H S N L K F E S H K E E K N S N W L K Y P S E Y H V D F Q V K - R N R K T E I L D Q L P K N K I S T A K V D S T F S Y S - - - S G G K F D S - - - - - - - - - T G I G R T S S N S Y S K T I S Y N Q Q N Y D T I A S G K N N N W H V H W S V I A N D L K Y G G - E V K N R N D E - - - - - - - - - L L F Y R - N T R I A T V E N P E L S F A S K Y R Y P A L V R S G F N P E F L T Y L S N E K S N - - E K T Q F E V T Y T R N Q D I L K N R P G I - - - - H Y A P P I L E K N K D G - Q R L I V T Y E V D W K N K T V K V V D K Y S D D N A P Y K E G
- - - - - A Q H I T P V S E K K V D D K I T L Y K T T A T S D N D K L N I S Q I L T F N F I K D K - - - - - S Y D K D T L V L K A A G N I N S G Y K K P N P K - D Y N Y S Q F Y W G G K Y N V S V S S E - S N D A V N V V D Y A P K N Q N E E F Q V Q Q T L G Y S Y G G D I N I S N - - - - - - - G L G - - - - - - - S K S F S E T I N Y K Q E S Y R T T I D R K T N H K S I G W G V E A H K I M N N G W G P Y G R D - - S Y D P - T Y G N E L F L G G R Q S S S - - - N A G Q N F L P T H Q M P L L A R G N F N P E F I S V L S H K Q N D T - K K S K I K V T Y Q R E M D R Y T N Q W N R - - L - - H W V G N N Y K N Q N T - V T F T S T Y E V D W Q N H T V K L I G T D S K E T N P G V - -
A D S D I N I K T G T T - - - D I G S N T T V K T G D L V T Y D K E N G M H K K V F Y S F I D D K - - - - - N H N K K L L V I R T K G T I A G Q Y V Y S - - E E G A N - S G L A W P S A F K V Q L Q L - P D N E V A Q I S D Y Y P R N S I D T K E Y M S T L T Y G - - - F N G N V T G D D - - - - T G K I G G L I G A N V S I G H T L K Y V Q P D F K T I L E - S P T D K K V G W K V I F N N M V N Q N W G P Y D R D - - S W N P - V Y G N Q L F M K T R N G S M K - - - A A D N F L D P N K A S S L L S S G F S P D F A T V I T M D R K A S K Q Q T N I D V I Y E R V R D D Y Q L H W T S - - - - T N W K G T N T K D K W T - D R S S E R Y K I D W E K E E M T N - - - - - - - - - - - - - -

 

 

 

 

 

Member Chain UniProtKB GO term
d1uuna_ A A0QR29 GO:0005576
d1uuna_ A A0QR29 GO:0006826
d1uuna_ A A0QR29 GO:0009279
d1uuna_ A A0QR29 GO:0015288
d1uuna_ A A0QR29 GO:0046930
d1uuna_ A A0QR29 GO:0055085
d7ahla_ A P09616 GO:0001897
d7ahla_ A P09616 GO:0005515
d7ahla_ A P09616 GO:0005576
d7ahla_ A P09616 GO:0031640
d7ahla_ A P09616 GO:0035821
d7ahla_ A P09616 GO:0042802
d7ahla_ A P09616 GO:0051715
d7ahla_ A P09616 GO:0090729
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in