Superfamily : 56712 [ Prokaryotic type I DNA topoisomerase ]
Class : Multi-domain proteins (alpha and beta)
Fold : Prokaryotic type I DNA topoisomerase
# of Members : 3
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1gkub3  ( 499 )    qefdlikpALFIVesptKArQISrffgkpsvkvldgAvVyeipmqkyvLm
d1i7da-  (   1 )           mrLFIAekpsLAraIAdvLpk-phrkgd--gfieCg---ngqV
d1mw9x-  (   2 )          gkaLVIVespaKaktInkyLg-------------------sdyv
                            bbbbb  aaaaaaaa                         bb

                             60        70        80        90        100 
d1gkub3  ( 549 )    VTASighVvdLitn----rgfhGVlvn----grfvpvyasikdnsrsrie
d1i7da-  (  38 )    VTwCighLLeqAqPdaydsryarwnladLPIvPekwqlqprps-vtkqln
d1mw9x-  (  27 )    VksSvghIrdLptergalvnrMGVdPwhnWe----ahyevlpg-kekvvs
                    bbb     bb                            bb     aaaaa

                             110       120       130       140       150 
d1gkub3  ( 615 )    ALrklAhdAefVIVGTdPdteGEKIAwDLknlLs------gcgaVkRAeF
d1i7da-  (  87 )    vIkrFLheAseIVHAGDpdreGQLLVdeVLdylqLapekrqq--VqRClI
d1mw9x-  (  95 )    eLkqlAekAdhIyLATdldreGEaiAwHLrevIgg---ddar--YSRVvF
                    aaaaaaa   bbbb     aaaaaaaaaaaaa             bb   

                             160       170       180       190       200 
d1gkub3  ( 659 )    heVtrraIleALeslrdV--denlVkAqvVrrIEdrWIgfVLsqkLwerf
d1i7da-  ( 135 )    nDlnpqaVeraidrLrsnsefvplcvSAlArarAdwLYgiNMtRAYTiLG
d1mw9x-  ( 140 )    neItknaIrqaFnkpgeL--nidrVnAqQArrFMdrVVgymVspLLwkkI
                        aaaaaaaa         aaaaaaaaaaaaaaaaaaaaaaaaaaa  

                             210       220       230       240       250 
d1gkub3  ( 707 )    n----nrnLsAgRaQTlVLGwIidrfqesr--errkiAiVr-------df
d1i7da-  ( 185 )    rnagYqgvLSVgrvqTPVLGlVVrrDeeienfvakdFfeVkAhIvtpade
d1mw9x-  ( 188 )    ar-----glsAgRvqsVAVrLVVerereikafvpeefweVdAsTtTpsge
                                  aaaaaaaaaaaa         bbbbb          

                             260       270       280       290       300 
d1gkub3  ( 744 )    dlvleHdee---------------------------efdLtIklveeree
d1i7da-  ( 235 )    rFtAiWqpseacepyqdeegrLlhrplAehvvnrIsgqpAiVtsyndkre
d1mw9x-  ( 233 )    aLaLqVthqnd---kpF---rpvnkeqTqaAvslLekarYsVleredkpt
                     bbb                                   bb  bbbbbbb

                             310       320       330       340       350 
d1gkub3  ( 767 )    lrtPlpPYtTetMLsDAnrilkfsVkqTmqiAqeLFe-NgLITYHrTdst
d1i7da-  ( 285 )    sesAplPFSLSaLQieAAkrfglsaqnVldiCqkLyethkLItfPrSdcr
d1mw9x-  ( 277 )    tskPgaPFiTStLQqaAStrlgFgVkkTmmMAqrLYe-aGyITYMrtdst
                    bb       aaaaaaaaaa     aaaaaaaaaaaaa             

                             360       370       380       390       400 
d1gkub3  ( 816 )    rVsdvGqr---iAkeyLg---------ddfv---grewge---sgaheCI
d1i7da-  ( 335 )    yLPeehfagrhavmnAIsvHapdllpqpvVdpdirnrCWddkkVdahhAI
d1mw9x-  ( 326 )    nLsqdAvn---mVrgyIsdnfg-----kkYlpespnqya-------rEAI
                               aaaaaa                                 

                             410       420       430       440       450 
d1gkub3  ( 848 )    RPTrpltrddVqrliqegvlvVegLrweHfaLYdlIFrrFMASQCrpFkV
d1i7da-  ( 385 )    IPtarss------ai--------nLtenEakVYnLIARQYLMQFCpdAvF
d1mw9x-  ( 369 )    RPSdVnv--mAesLk--------dMeadAqkLYqlIWrqFVACQMtpAky
                                              aaaaaaaaaaaaaaaa     bbb

                             460       470       480       490       500 
d1gkub3  ( 898 )    vVkkysIefdgktaeeeRivrAegrAyeLyr-----avwvkneLpt----
d1i7da-  ( 421 )    rkcvIeLdIakGkFvakarfLaeaGWRtLlgskerdeendgtpLpvVakg
d1mw9x-  ( 409 )    dsttLtVgAgdFrLkArgrilrfdGwtkVmp------aledriLpaVnkg
                    bbbbbbb      bbb  bbbbb                           

                             510       520       530       540       550 
d1gkub3  ( 939 )    ---gtfrVkAevksvpkvlpFtqseIIqmMker-----------------
d1i7da-  ( 471 )    deLlCekGeVverqtqpprhFtdatLLsAMtgIArfVqdkdlkkiLratd
d1mw9x-  ( 457 )    daLtlveLtpaqhftkpparFseasLVkeLekr-----------------
                       bbbbbb   bb        aaaaaaaaa                   

                             560       570       580       590       600 
d1gkub3  ( 969 )    gIGrpstYatiVdrLfmrnYVvekygrMiPtklGidVfrfLvrryakFVs
d1i7da-  ( 521 )    GLgtEatRAgiielLfkrgFLtkkgryIhStdAGkaLfhSLp---emATr
d1mw9x-  ( 490 )    gIGrpstYasIIstIqdrgYVrvenrrFyAekmGeiVTdRLeenFrelMn
                           aaaaaaaaaa   bbb   bbbb aaaaaaaaa          

                             610       620       630       640       650 
d1gkub3  (1019 )    edrTrdLesrMdaIergeldylkALedMyaeIksid              
d1i7da-  ( 568 )    PdmTAhWesvLtqIsekqcryqdFMqplvgtLyqLIdqAkrtpvrqFrgi
d1mw9x-  ( 540 )    ydftaqmEnnLdqVAnheaewkavLdhffsdFtqqldkAekdpeegGMrp
                     aaaaaaaaaaaaaa     aaaaaaaaaaaaa                 

                       
d1gkub3                
d1i7da-  ( 618 )    vap
d1mw9x-  ( 590 )    nqm
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Topoisomerase 'domain' of reverse gyraseProkaryotic type I DNA topoisomeraseArchaeoglobus fulgidus [TaxId: 2234]view
DNA topoisomerase IIIProkaryotic type I DNA topoisomeraseEscherichia coli [TaxId: 562]view
DNA topoisomerase I, 67K N-terminal domainProkaryotic type I DNA topoisomeraseEscherichia coli [TaxId: 562]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650
Q E F D L I K P A L F I V E S P T K A R Q I S R F F G K P S V K V L D G A V V Y E I P M Q K Y V L M V T A S I G H V V D L I T N - - - - R G F H G V L V N - - - - G R F V P V Y A S I K D N S R S R I E A L R K L A H D A E F V I V G T D P D T E G E K I A W D L K N L L S - - - - - - G C G A V K R A E F H E V T R R A I L E A L E S L R D V - - D E N L V K A Q V V R R I E D R W I G F V L S Q K L W E R F N - - - - N R N L S A G R A Q T L V L G W I I D R F Q E S R - - E R R K I A I V R - - - - - - - D F D L V L E H D E E - - - - - - - - - - - - - - - - - - - - - - - - - - - E F D L T I K L V E E R E E L R T P L P P Y T T E T M L S D A N R I L K F S V K Q T M Q I A Q E L F E - N G L I T Y H R T D S T R V S D V G Q R - - - I A K E Y L G - - - - - - - - - D D F V - - - G R E W G E - - - S G A H E C I R P T R P L T R D D V Q R L I Q E G V L V V E G L R W E H F A L Y D L I F R R F M A S Q C R P F K V V V K K Y S I E F D G K T A E E E R I V R A E G R A Y E L Y R - - - - - A V W V K N E L P T - - - - - - - G T F R V K A E V K S V P K V L P F T Q S E I I Q M M K E R - - - - - - - - - - - - - - - - - G I G R P S T Y A T I V D R L F M R N Y V V E K Y G R M I P T K L G I D V F R F L V R R Y A K F V S E D R T R D L E S R M D A I E R G E L D Y L K A L E D M Y A E I K S I D - - - - - - - - - - - - - - - - -
- - - - - - - M R L F I A E K P S L A R A I A D V L P K - P H R K G D - - G F I E C G - - - N G Q V V T W C I G H L L E Q A Q P D A Y D S R Y A R W N L A D L P I V P E K W Q L Q P R P S - V T K Q L N V I K R F L H E A S E I V H A G D P D R E G Q L L V D E V L D Y L Q L A P E K R Q Q - - V Q R C L I N D L N P Q A V E R A I D R L R S N S E F V P L C V S A L A R A R A D W L Y G I N M T R A Y T I L G R N A G Y Q G V L S V G R V Q T P V L G L V V R R D E E I E N F V A K D F F E V K A H I V T P A D E R F T A I W Q P S E A C E P Y Q D E E G R L L H R P L A E H V V N R I S G Q P A I V T S Y N D K R E S E S A P L P F S L S A L Q I E A A K R F G L S A Q N V L D I C Q K L Y E T H K L I T F P R S D C R Y L P E E H F A G R H A V M N A I S V H A P D L L P Q P V V D P D I R N R C W D D K K V D A H H A I I P T A R S S - - - - - - A I - - - - - - - - N L T E N E A K V Y N L I A R Q Y L M Q F C P D A V F R K C V I E L D I A K G K F V A K A R F L A E A G W R T L L G S K E R D E E N D G T P L P V V A K G D E L L C E K G E V V E R Q T Q P P R H F T D A T L L S A M T G I A R F V Q D K D L K K I L R A T D G L G T E A T R A G I I E L L F K R G F L T K K G R Y I H S T D A G K A L F H S L P - - - E M A T R P D M T A H W E S V L T Q I S E K Q C R Y Q D F M Q P L V G T L Y Q L I D Q A K R T P V R Q F R G I V A P
- - - - - - G K A L V I V E S P A K A K T I N K Y L G - - - - - - - - - - - - - - - - - - - S D Y V V K S S V G H I R D L P T E R G A L V N R M G V D P W H N W E - - - - A H Y E V L P G - K E K V V S E L K Q L A E K A D H I Y L A T D L D R E G E A I A W H L R E V I G G - - - D D A R - - Y S R V V F N E I T K N A I R Q A F N K P G E L - - N I D R V N A Q Q A R R F M D R V V G Y M V S P L L W K K I A R - - - - - G L S A G R V Q S V A V R L V V E R E R E I K A F V P E E F W E V D A S T T T P S G E A L A L Q V T H Q N D - - - K P F - - - R P V N K E Q T Q A A V S L L E K A R Y S V L E R E D K P T T S K P G A P F I T S T L Q Q A A S T R L G F G V K K T M M M A Q R L Y E - A G Y I T Y M R T D S T N L S Q D A V N - - - M V R G Y I S D N F G - - - - - K K Y L P E S P N Q Y A - - - - - - - R E A I R P S D V N V - - M A E S L K - - - - - - - - D M E A D A Q K L Y Q L I W R Q F V A C Q M T P A K Y D S T T L T V G A G D F R L K A R G R I L R F D G W T K V M P - - - - - - A L E D R I L P A V N K G D A L T L V E L T P A Q H F T K P P A R F S E A S L V K E L E K R - - - - - - - - - - - - - - - - - G I G R P S T Y A S I I S T I Q D R G Y V R V E N R R F Y A E K M G E I V T D R L E E N F R E L M N Y D F T A Q M E N N L D Q V A N H E A E W K A V L D H F F S D F T Q Q L D K A E K D P E E G G M R P N Q M

 

 

 

 

 

Member Chain UniProtKB GO term
d1gkub3 B O29238 GO:0003676
d1gkub3 B O29238 GO:0003677
d1gkub3 B O29238 GO:0003916
d1gkub3 B O29238 GO:0003918
d1gkub3 B O29238 GO:0005524
d1gkub3 B O29238 GO:0005737
d1gkub3 B O29238 GO:0006265
d1gkub3 B O29238 GO:0006268
d1gkub3 B O29238 GO:0008094
d1gkub3 B O29238 GO:0008270
d1gkub3 B O29238 GO:0016887
d1gkub3 B O29238 GO:0046872
d1gkub3 B O29238 GO:0160097
d1i7da_ A P14294 GO:0000287
d1i7da_ A P14294 GO:0003677
d1i7da_ A P14294 GO:0003916
d1i7da_ A P14294 GO:0003917
d1i7da_ A P14294 GO:0005515
d1i7da_ A P14294 GO:0006261
d1i7da_ A P14294 GO:0006265
d1i7da_ A P14294 GO:0006281
d1i7da_ A P14294 GO:0006310
d1i7da_ A P14294 GO:0043597
d1i7da_ A P14294 GO:0046872
d1i7da_ A P14294 GO:0051304
d1i7da_ A P14294 GO:0098847
d1mw9x_ X P06612 GO:0003677
d1mw9x_ X P06612 GO:0003916
d1mw9x_ X P06612 GO:0003917
d1mw9x_ X P06612 GO:0006265
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in