Superfamily : 56542 [ Substrate-binding domain of HMG-CoA reductase ]
Class : Alpha and beta proteins (a+b)
Fold : Substrate-binding domain of HMG-CoA reductase
# of Members : 2
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1hwla2  ( 442 )    prpne---eCflsdaEiiqlvnak-hipaykLetlIetherGVsIRrqll
d4i6ya1  (   3 )     ldSrLpafrnlspaarldhIGqllgLs---------------hddvsll
                                 aaaaaaaaaa                    aaaaaaa

                             60        70        80        90        100 
d1hwla2  ( 500 )    skklsepsslqylpyrdynYslvmgaccenViGympipvgvAGpLcLdek
d4i6ya1  (  37 )    ana------------galpmdiang-mienvigtfelpyavAsnFqingr
                    a                  aaaa               bbbb   bb  b

                             110       120       130       140       150 
d1hwla2  ( 550 )    efqVPMAttegcLvasTnrGCrAIglGggAsSrvladksVvCeavIpakv
d4i6ya1  (  74 )    dvLVPLvveepsIvaaAsyMAklArangGFtTsSsaprlArAqVrItpqq
                    b  bbbb     aaaaaaaaaaaaa     bbbb    bbbbbbbb aaa

                             160       170       180       190       200 
d1hwla2  ( 717 )    VrevLkt---tTeaMievNinkNlvgsamagsiggynAhAanIVtAIYiA
d4i6ya1  ( 234 )    LetaefsGeaVIegIldayaf-AavdpyrAatH---NkgIMnGIdPLIvA
                    a          aaaaaaaaaa a a aaa          aaaaaaaaaaa

                             210       220       230       240       250 
d1hwla2  ( 764 )    CgQdaaq-nvgSsn---------CiTlMeasgptnedLyIsCtMpsIeIg
d4i6ya1  ( 280 )    TgndwraVeagAhayAcrsghygSLTtWekdn--nghLvGtLeMp-MpVg
                            aaaa             bbbbb       bbbbbbb      

                             260       270       280       290       300 
d1hwla2  ( 804 )    TvgggTn-llpqqacLqmLgVqgackdnpgenarqLArIVCGTVMAGELS
d4i6ya1  ( 327 )    lvggaTkthplAqLSlrILgVk---------taqaLAeIAVAVGLAQNLG
                             aaaaaaaaa              aaaaaaaaaaaaaaaaaa

                             
d1hwla2  ( 853 )    lMAalAag 
d4i6ya1  ( 368 )    aMralaTeg
                    aaaaaaa  

 

 

Domain IDNameFamilySourceDomainSTRING-DB
Substrate-binding domain of HMG-CoA reductaseSubstrate-binding domain of HMG-CoA reductaseHuman (Homo sapiens) [TaxId: 9606]view
Substrate-binding domain of HMG-CoA reductaseSubstrate-binding domain of HMG-CoA reductasePseudomonas mevalonii [TaxId: 32044]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300
P R P N E - - - E C F L S D A E I I Q L V N A K - H I P A Y K L E T L I E T H E R G V S I R R Q L L S K K L S E P S S L Q Y L P Y R D Y N Y S L V M G A C C E N V I G Y M P I P V G V A G P L C L D E K E F Q V P M A T T E G C L V A S T N R G C R A I G L G G G A S S R V L A D K S V V C E A V I P A K V V R E V L K T - - - T T E A M I E V N I N K N L V G S A M A G S I G G Y N A H A A N I V T A I Y I A C G Q D A A Q - N V G S S N - - - - - - - - - C I T L M E A S G P T N E D L Y I S C T M P S I E I G T V G G G T N - L L P Q Q A C L Q M L G V Q G A C K D N P G E N A R Q L A R I V C G T V M A G E L S L M A A L A A G -
- L D S R L P A F R N L S P A A R L D H I G Q L L G L S - - - - - - - - - - - - - - - H D D V S L L A N A - - - - - - - - - - - - G A L P M D I A N G - M I E N V I G T F E L P Y A V A S N F Q I N G R D V L V P L V V E E P S I V A A A S Y M A K L A R A N G G F T T S S S A P R L A R A Q V R I T P Q Q L E T A E F S G E A V I E G I L D A Y A F - A A V D P Y R A A T H - - - N K G I M N G I D P L I V A T G N D W R A V E A G A H A Y A C R S G H Y G S L T T W E K D N - - N G H L V G T L E M P - M P V G L V G G A T K T H P L A Q L S L R I L G V K - - - - - - - - - T A Q A L A E I A V A V G L A Q N L G A M R A L A T E G

 

 

 

 

 

Member Chain UniProtKB GO term
d1hwla2 A P04035 GO:0004420
d1hwla2 A P04035 GO:0004420
d1hwla2 A P04035 GO:0005789
d1hwla2 A P04035 GO:0005789
d1hwla2 A P04035 GO:0008299
d1hwla2 A P04035 GO:0008299
d1hwla2 A P04035 GO:0015936
d1hwla2 A P04035 GO:0015936
d1hwla2 A P04035 GO:0016616
d1hwla2 A P04035 GO:0016616
d1hwla2 A P04035 GO:0050661
d1hwla2 A P04035 GO:0050661
d1hwla2 A P04035 GO:0004420
d1hwla2 A P04035 GO:0004420
d1hwla2 A P04035 GO:0005789
d1hwla2 A P04035 GO:0005789
d1hwla2 A P04035 GO:0008299
d1hwla2 A P04035 GO:0008299
d1hwla2 A P04035 GO:0015936
d1hwla2 A P04035 GO:0015936
d1hwla2 A P04035 GO:0016616
d1hwla2 A P04035 GO:0016616
d1hwla2 A P04035 GO:0050661
d1hwla2 A P04035 GO:0050661