Superfamily : 56104 [ SAICAR synthase-like ]
Class : Alpha and beta proteins (a+b)
Fold : SAICAR synthase-like
# of Members : 6
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1kuta-  (   7 )                           tkivkvtg--dyAlLeFkdd-------
d1w2fa-  ( 187 )                   sWVqlAghtgsfkaAgtsglILKrCs---------
d2cnqa-  (   2 )    sitkTeLdgiLplvargk-----vrDiYevd-agtlLfVATDrISAydvi
d3nuaa1  (   1 )    mvn------qlemlyegk-----akkiyaTdkedmvIVhYkddAtafnge
d6cn2a-  (  58 )                                                      
d6ux9a1  (  35 )                                                      
                                                                      

                             60        70        80        90        100 
d1kuta-  (  36 )    ----ltgkGsiCAeTtaiL-kyLsek----------gikthlveyip---
d1w2fa-  ( 213 )    ---------epEryCLarLadaLr------------gCVPafhgvver--
d2cnqa-  (  46 )    MenSIpeKGiLLTkLSefWFkfLsn-----------dvrnHlvdiapg--
d3nuaa1  (  40 )    kkaqiesKGvLNNeITslIFemLnke----------gikTHFvekLn---
d6cn2a-  (  58 )       tssalkgAIqlGIthsVgslsq-per-dVlmqdFevvesifFpgs--
d6ux9a1  (  35 )         dpllsVLmwGVnhsIneLshvqipvmLmpddfkayskikvdnhlf
                           aaaaaaaaaaa   a                   bbbb     

                             110       120       130       140       150 
d1kuta-  (  69 )    -------------------------------------prtLkVipl----
d1w2fa-  ( 241 )    ----------------d-------------------gesyLqLqdLldgf
d2cnqa-  (  83 )    ----------------ktifdyLpakLsepkYktqLedRSlLVhkh----
d3nuaa1  (  77 )    -------------------------------------drdQlCkkV----
d6cn2a-  ( 105 )    -sTpghhgdFFktyApiAFryFRemfgirpddYlysLCnepLiel----l
d6ux9a1  (  80 )    nkenmpshFkFkEyCpmVFrnLRerFgIddqdFqnSLtrsaPlpd--gar
                                                             bb       

                             160       170       180       190       200 
d1kuta-  (  78 )    --k-fpLeVvVrlkkAgsfvrrygg-------------------------
d1w2fa-  ( 256 )    dgpCVLDCkGvRtYleeeLtkarer----------pklrkdYkklavdpe
d2cnqa-  ( 113 )    --klIpLeViVRGYItgsAwkeyvk----------tgtVHglkQpq----
d3nuaa1  (  86 )    --eiVpLeViVRnvAAgsmAkrl---------------------------
d6cn2a-  ( 160 )    fYvSsddeFiIktVqhkeAefLqtLLpgYfmnlnqNm-rtlLPkFYGLYC
d6ux9a1  ( 134 )    fhtSydkrYiIktItsedvaeMhnILkkYhqyIvechGiTlLpQFLGMYr
                            bbbbb   aaaaaaa                           

                             210       220       230       240       250 
d1kuta-  ( 101 )    -----------aegedlp----------vplVeffikdder---------
d1w2fa-  ( 299 )    aPteeehaqrAVtkpryqwrEgiSSSttlGFRIegikkadgscst-----
d2cnqa-  ( 147 )    ---------gLkeSqeFp----------epiFTPStkae-----------
d3nuaa1  ( 107 )    ---------gleegyelk----------ttvfeLsykddsl---------
d6cn2a-  ( 209 )    vqa------gnrIVVmnnllpa-----pmhlkFnLkGstykrrAspkers
d6ux9a1  ( 184 )    LnVd---gveiyVIVtrnvfShrl---sVyrkYdLkGstvareAsdkeka
                                   bb             bbbbb               

                             260       270       280       290       300 
d1kuta-  ( 121 )    -hdpv-cvdhLeil--giat--kkqAekk-eaAvkITlaLkeFFeranfe
d1w2fa-  ( 345 )    dfkttrsreqVLrvFeeFVqgdeeVLrrYlnrLqqIrdtLevSeFFrrHE
d2cnqa-  ( 170 )    -hdenispaqAael----Vg--edlSrrVaelAvkLYskCkdyAkekgII
d3nuaa1  ( 129 )    -gdplindyhAvgi--gaTt--feeLnkIyeiTakVNeiLkeaFkkqnIn
d6cn2a-  ( 254 )    -gvptykDlDFmqdmpGIlLe----hytaLrtMqrDCrvLqsf-----kI
d6ux9a1  ( 228 )    kelptlkDndFinegqkIyIdd--nnkkvFlekLkDVefLAql-----kL
                           aaaaaa           aaa   aaaaaaaaaaaa       b

                             310       320       330       340       350 
d1kuta-  ( 166 )    LwdIkYefglD---kdgnvVLgdeI-SPdtFrLrkk-----gei------
d1w2fa-  ( 395 )    VIgSSLLFVHD---hchrAgVwLId-Fg-kTtpLpd--------------
d2cnqa-  ( 213 )    IADTkFeFGid--ektneIILVdEVLTPDSSrFWnGasykvgesQdsyDk
d3nuaa1  ( 174 )    LIdFkLEFGry--n--geiLLAdEI-SPdtCrFwdatt------gekMDk
d6cn2a-  ( 298 )    mdYSLlVGihilh-----------------ggipang------eLfIGIi
d6ux9a1  ( 272 )    mdYSLlVGIHdVeraeqplapGefdpniDvYGikchenSprkeVYFMAIi
                    b  bbbbbbb                     bb                 

                             360       370       380       390     
d1kuta-  ( 201 )    -----------------fdkdvyrrdlgdplkkyrevLelCrslnsq
d1w2fa-  ( 426 )    ---------gqiLdHrrpwe--egnrEDGYLlGLdnLIgILasLaer
d2cnqa-  ( 261 )    qfL--rdwLtanklngvngvkMpqdIVdrTrakYieAyetLTgskws
d3nuaa1  ( 213 )    Drf--rrdmg------------------nvinGYreVLnrLrn    
d6cn2a-  ( 378 )    dIlsyh-----------------------rpsfyAdrFqfMcstVFr
d6ux9a1  ( 359 )    dIlthyda-------------------tvnPeqYSkrFldfIghil 
                                                  aaaaaaaaaaa
 

 

Domain IDNameFamilySourceDomainSTRING-DB
SAICAR synthaseSAICAR synthaseThermotoga maritima [TaxId: 2336]view
Inositol 1,4,5-trisphosphate 3-kinase A, IP3K AInositol polyphosphate kinase (IPK)Human (Homo sapiens) [TaxId: 9606]view
SAICAR synthaseSAICAR synthaseBaker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]view
automated matchesautomated matchesClostridium perfringens [TaxId: 195103]view
automated matchesautomated matchesZebrafish (Danio rerio) [TaxId: 7955]view
automated matchesPhosphatidylinositol phosphate kinase IIbeta, PIPK IIbetaHuman (Homo sapiens) [TaxId: 9606]view

 

No outliers

Created with Raphaëld6ux9a1d6cn2a-d1w2fa-d1kuta-d3nuaa1d2cnqa-
FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

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- - - - - - - - - - - - - - - - - - - - - - - T K I V K V T G - - D Y A L L E F K D D - - - - - - - - - - - L T G K G S I C A E T T A I L - K Y L S E K - - - - - - - - - - G I K T H L V E Y I P - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - P R T L K V I P L - - - - - - K - F P L E V V V R L K K A G S F V R R Y G G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A E G E D L P - - - - - - - - - - V P L V E F F I K D D E R - - - - - - - - - - H D P V - C V D H L E I L - - G I A T - - K K Q A E K K - E A A V K I T L A L K E F F E R A N F E L W D I K Y E F G L D - - - K D G N V V L G D E I - S P D T F R L R K K - - - - - G E I - - - - - - - - - - - - - - - - - - - - - - - F D K D V Y R R D L G D P L K K Y R E V L E L C R S L N S Q
- - - - - - - - - - - - - - - S W V Q L A G H T G S F K A A G T S G L I L K R C S - - - - - - - - - - - - - - - - - - E P E R Y C L A R L A D A L R - - - - - - - - - - - - G C V P A F H G V V E R - - - - - - - - - - - - - - - - - - D - - - - - - - - - - - - - - - - - - - G E S Y L Q L Q D L L D G F D G P C V L D C K G V R T Y L E E E L T K A R E R - - - - - - - - - - P K L R K D Y K K L A V D P E A P T E E E H A Q R A V T K P R Y Q W R E G I S S S T T L G F R I E G I K K A D G S C S T - - - - - D F K T T R S R E Q V L R V F E E F V Q G D E E V L R R Y L N R L Q Q I R D T L E V S E F F R R H E V I G S S L L F V H D - - - H C H R A G V W L I D - F G - K T T P L P D - - - - - - - - - - - - - - - - - - - - - - - G Q I L D H R R P W E - - E G N R E D G Y L L G L D N L I G I L A S L A E R
S I T K T E L D G I L P L V A R G K - - - - - V R D I Y E V D - A G T L L F V A T D R I S A Y D V I M E N S I P E K G I L L T K L S E F W F K F L S N - - - - - - - - - - - D V R N H L V D I A P G - - - - - - - - - - - - - - - - - - K T I F D Y L P A K L S E P K Y K T Q L E D R S L L V H K H - - - - - - K L I P L E V I V R G Y I T G S A W K E Y V K - - - - - - - - - - T G T V H G L K Q P Q - - - - - - - - - - - - - G L K E S Q E F P - - - - - - - - - - E P I F T P S T K A E - - - - - - - - - - - - H D E N I S P A Q A A E L - - - - V G - - E D L S R R V A E L A V K L Y S K C K D Y A K E K G I I I A D T K F E F G I D - - E K T N E I I L V D E V L T P D S S R F W N G A S Y K V G E S Q D S Y D K Q F L - - R D W L T A N K L N G V N G V K M P Q D I V D R T R A K Y I E A Y E T L T G S K W S
M V N - - - - - - Q L E M L Y E G K - - - - - A K K I Y A T D K E D M V I V H Y K D D A T A F N G E K K A Q I E S K G V L N N E I T S L I F E M L N K E - - - - - - - - - - G I K T H F V E K L N - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - D R D Q L C K K V - - - - - - E I V P L E V I V R N V A A G S M A K R L - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - G L E E G Y E L K - - - - - - - - - - T T V F E L S Y K D D S L - - - - - - - - - - G D P L I N D Y H A V G I - - G A T T - - F E E L N K I Y E I T A K V N E I L K E A F K K Q N I N L I D F K L E F G R Y - - N - - G E I L L A D E I - S P D T C R F W D A T T - - - - - - G E K M D K D R F - - R R D M G - - - - - - - - - - - - - - - - - - N V I N G Y R E V L N R L R N - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - T S S A L K G A I Q L G I T H S V G S L S Q - P E R - D V L M Q D F E V V E S I F F P G S - - - S T P G H H G D F F K T Y A P I A F R Y F R E M F G I R P D D Y L Y S L C N E P L I E L - - - - L F Y V S S D D E F I I K T V Q H K E A E F L Q T L L P G Y F M N L N Q N M - R T L L P K F Y G L Y C V Q A - - - - - - G N R I V V M N N L L P A - - - - - P M H L K F N L K G S T Y K R R A S P K E R S - G V P T Y K D L D F M Q D M P G I L L E - - - - H Y T A L R T M Q R D C R V L Q S F - - - - - K I M D Y S L L V G I H I L H - - - - - - - - - - - - - - - - - G G I P A N G - - - - - - E L F I G I I D I L S Y H - - - - - - - - - - - - - - - - - - - - - - - R P S F Y A D R F Q F M C S T V F R
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - D P L L S V L M W G V N H S I N E L S H V Q I P V M L M P D D F K A Y S K I K V D N H L F N K E N M P S H F K F K E Y C P M V F R N L R E R F G I D D Q D F Q N S L T R S A P L P D - - G A R F H T S Y D K R Y I I K T I T S E D V A E M H N I L K K Y H Q Y I V E C H G I T L L P Q F L G M Y R L N V D - - - G V E I Y V I V T R N V F S H R L - - - S V Y R K Y D L K G S T V A R E A S D K E K A K E L P T L K D N D F I N E G Q K I Y I D D - - N N K K V F L E K L K D V E F L A Q L - - - - - K L M D Y S L L V G I H D V E R A E Q P L A P G E F D P N I D V Y G I K C H E N S P R K E V Y F M A I I D I L T H Y D A - - - - - - - - - - - - - - - - - - - T V N P E Q Y S K R F L D F I G H I L -

 

 

 

 

 

 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in