BASE   PART 1   PART 2   PART 3  
Superfamily : 55874 [ ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase ]
Class : Alpha and beta proteins (a+b)
Fold : ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
# of Members : 4
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1b63a2  (   1 )       mpiq------vlppqlaNqiaAgevVe--------------------
d1q1da1  (   7 )    sasdkyq------kisqlehIlkrpdtyIgsvetqeqlqwiydedcmien
d2hkja3  (  10 )                  lspaefFkrnpelaGFpn-----------------p
d3t0ha-  (  16 )           evetfaFqaeiaqlMsliin-------tfys------------
                                    aaaaaaa  aa                       

                             60        70        80        90        100 
d1b63a2  (  22 )    -----rPasVVkeLVenSLda--------------gAtrIdIdIe----r
d1q1da1  (  54 )    vtIVpGLfkIFdeILvnAadnkvrdp---------sMkrIdVnIhae---
d2hkja3  (  29 )    ---arALyQTVrELIenSLdaTdvhg---------ilPnIkItIdlidda
d3t0ha-  (  40 )    -nkeiFlrelisnSsdaldkiryeSltdpskldsgkelhinliPnkq---
                        aaaaaaaaaaaaaaaa                  bbbbbbb     

                             110       120       130       140       150 
d1b63a2  (  49 )    GGaklIrIrDnGcGikkd--------eLalaL-arhatskiaslddleai
d1q1da1  (  93 )    ---htIeVkndgkGipIeihnkeniyiPemifGhlltssnyd---ddekk
d2hkja3  (  67 )    rqiYkVnVvDnGiGippq--------eVpnaFGrVl----ys---syvnr
d3t0ha-  (  86 )    --drtltivDtGiGmtkadlinnlgtiAksgtkaFmealq-------aga
                        bbbbbb                 aaaaaa                 

                             160       170       180       190       200 
d1b63a2  (  90 )    i--slgfrgEalASISSVS------rLtLtSrtaeqqeAwqAyAeg--rd
d1q1da1  ( 137 )    v--tggrngygaKLCNIF----St-eFiLeTAdlnvgqkYvQkWen----
d2hkja3  ( 103 )    q--trgmyglgvkAAVLYSQmhqdkpIeIeTSpvnskriytFkLkIdink
d3t0ha-  ( 127 )    dismigqfgvGFYSAYlv----Ae-kvtvitkhndd-eqyaWeSsAg---
                               aaaaa         bbbbbbb      bbbbbbb     

                             210       220       230       240       250 
d1b63a2  ( 130 )    m---nvtvkpaahp---vGttleVldLFyntparrkflrtektEfnhIde
d1q1da1  ( 176 )    nMsichppkitsykkgpsytkvtFkPdltrFgmeL-----dndILgVMrr
d2hkja3  ( 151 )    nepiivergsveNtrgfhGtsvaISIp------Gd-----WpkaksrIye
d3t0ha-  ( 168 )    ---gsFtvrtdtgepmgRGtkvilhlkedqteYle---------errike
                        bbbbbbb       bbbbbbbb               aaaaaaaaa

                             260       270       280       290  
d1b63a2  ( 174 )    iIrriAlarfdVTInLshngkivrqyravpeggqkerRlgaIc 
d1q1da1  ( 222 )    rVydINgsvrdInVyln---gksLkir                 
d2hkja3  ( 190 )    yIkrtyiiTpYAeFiFkDPegnvtyyprltn-----kipkppqe
d3t0ha-  ( 206 )    ivkkhSqf-igypitlfve                         
                    aaaaaaaa    bbbb      b
 

 

Domain IDNameFamilySourceDomainSTRING-DB
DNA mismatch repair protein MutLDNA gyrase/MutL, N-terminal domainEscherichia coli [TaxId: 562]view
DNA topoisomerase IIDNA gyrase/MutL, N-terminal domainBaker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]view
Topoisomerase VI-B subunitDNA gyrase/MutL, N-terminal domainSulfolobus shibatae [TaxId: 2286]view
automated matchesHeat shock protein 90, HSP90, N-terminal domainHuman (Homo sapiens) [TaxId: 9606]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290
- - - M P I Q - - - - - - V L P P Q L A N Q I A A G E V V E - - - - - - - - - - - - - - - - - - - - - - - - - R P A S V V K E L V E N S L D A - - - - - - - - - - - - - - G A T R I D I D I E - - - - R G G A K L I R I R D N G C G I K K D - - - - - - - - E L A L A L - A R H A T S K I A S L D D L E A I I - - S L G F R G E A L A S I S S V S - - - - - - R L T L T S R T A E Q Q E A W Q A Y A E G - - R D M - - - N V T V K P A A H P - - - V G T T L E V L D L F Y N T P A R R K F L R T E K T E F N H I D E I I R R I A L A R F D V T I N L S H N G K I V R Q Y R A V P E G G Q K E R R L G A I C -
S A S D K Y Q - - - - - - K I S Q L E H I L K R P D T Y I G S V E T Q E Q L Q W I Y D E D C M I E N V T I V P G L F K I F D E I L V N A A D N K V R D P - - - - - - - - - S M K R I D V N I H A E - - - - - - H T I E V K N D G K G I P I E I H N K E N I Y I P E M I F G H L L T S S N Y D - - - D D E K K V - - T G G R N G Y G A K L C N I F - - - - S T - E F I L E T A D L N V G Q K Y V Q K W E N - - - - N M S I C H P P K I T S Y K K G P S Y T K V T F K P D L T R F G M E L - - - - - D N D I L G V M R R R V Y D I N G S V R D I N V Y L N - - - G K S L K I R - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - L S P A E F F K R N P E L A G F P N - - - - - - - - - - - - - - - - - P - - - A R A L Y Q T V R E L I E N S L D A T D V H G - - - - - - - - - I L P N I K I T I D L I D D A R Q I Y K V N V V D N G I G I P P Q - - - - - - - - E V P N A F G R V L - - - - Y S - - - S Y V N R Q - - T R G M Y G L G V K A A V L Y S Q M H Q D K P I E I E T S P V N S K R I Y T F K L K I D I N K N E P I I V E R G S V E N T R G F H G T S V A I S I P - - - - - - G D - - - - - W P K A K S R I Y E Y I K R T Y I I T P Y A E F I F K D P E G N V T Y Y P R L T N - - - - - K I P K P P Q E
- - - - - - - E V E T F A F Q A E I A Q L M S L I I N - - - - - - - T F Y S - - - - - - - - - - - - - N K E I F L R E L I S N S S D A L D K I R Y E S L T D P S K L D S G K E L H I N L I P N K Q - - - - - D R T L T I V D T G I G M T K A D L I N N L G T I A K S G T K A F M E A L Q - - - - - - - A G A D I S M I G Q F G V G F Y S A Y L V - - - - A E - K V T V I T K H N D D - E Q Y A W E S S A G - - - - - - G S F T V R T D T G E P M G R G T K V I L H L K E D Q T E Y L E - - - - - - - - - E R R I K E I V K K H S Q F - I G Y P I T L F V E - - - - - - - - - - - - - - - - - - - - - - - - -

 

 

 

 

 

Member Chain UniProtKB GO term
d1b63a2 A P23367 GO:0005524
d1b63a2 A P23367 GO:0006298
d1b63a2 A P23367 GO:0016887
d1b63a2 A P23367 GO:0030983
d1b63a2 A P23367 GO:0032300
d1b63a2 A P23367 GO:0140664
d1b63a2 A P23367 GO:0005524
d1b63a2 A P23367 GO:0006298
d1b63a2 A P23367 GO:0016887
d1b63a2 A P23367 GO:0030983
d1b63a2 A P23367 GO:0032300
d1b63a2 A P23367 GO:0140664
d2hkja3 A O05207 GO:0003676
d2hkja3 A O05207 GO:0003677
d2hkja3 A O05207 GO:0003918
d2hkja3 A O05207 GO:0005524
d2hkja3 A O05207 GO:0006265
d2hkja3 A O05207 GO:0003676
d2hkja3 A O05207 GO:0003677
d2hkja3 A O05207 GO:0003918
d2hkja3 A O05207 GO:0005524
d2hkja3 A O05207 GO:0006265
d2hkja3 A O05207 GO:0003676
d2hkja3 A O05207 GO:0003677
d2hkja3 A O05207 GO:0003918
d2hkja3 A O05207 GO:0005524
d2hkja3 A O05207 GO:0006265
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in