BASE   PART 1   PART 2   PART 3  
Superfamily : 55874 [ ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase ]
Class : Alpha and beta proteins (a+b)
Fold : ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
# of Members : 6
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1h7sa2  (  29 )                                g---------------------
d1i58a-  ( 352 )        gs--hmvpIsfVFnrFprmVrdlakkm-nkeVnfimrge-------
d1s14a-  (1027 )                                                      
d2e0aa2  ( 188 )    pshigsidpnCdVvavVqdAFecSrmlCdqyylsSPelkltqvNgkfpdq
d3cwva1  (   8 )                 ggiVenVrkrpgmyCg---------------------
d4k4oa1  (  18 )                   gleaVrkrpgmyIg---------------------
                                                                      

                             60        70        80        90        100 
d1h7sa2  (  30 )    ---qvv---l-sLsTAvkeLVenSlda----------------gAtnIdL
d1i58a-  ( 388 )    dteLd-rtfVeeIgePLlhLLrnAIdhgIEpkeeRiakgkppiGtLiLsA
d1s14a-  (1027 )        td---ttrPnhLGqeVIdnSVdeAla--------g----hAkrVdV
d2e0aa2  ( 238 )    pIhIvY--vpshLhhMLfeLFknAMraTv---ehQen--qpsltpIeViV
d3cwva1  (  24 )    ---dvg---eyGLHhLVyfLLdVAyeeArr--------g----eCrdVVL
d4k4oa1  (  32 )    ---sts---geGLHhLVweIVdnSideala--------g----fAksIqV
                                aaaaaaaaaaaaaaa                   bbbb

                             110       120       130       140       150 
d1h7sa2  (  57 )    klkdyGvdlIeVsdnGcGve----ee----nFeglTl---adltqvetFG
d1i58a-  ( 437 )    rheg-nnVVIeVeDdGrGid-------kekIirkAiekglideskAatLs
d1s14a-  (1058 )    iLhad--qSLeViDdGrGmpvdihpeegvpaVeliLc-------------
d2e0aa2  ( 281 )    vLgk-edLtIkIsdrGgGvp------------------------------
d3cwva1  (  56 )    eVggd--gSIALFCTSrtVt--------aenLvrVAtGaGFlgrppgdgW
d4k4oa1  (  64 )    IIepd--dSItViDdGrGipvgiqaktgrpaVetvFtv------------
                    bb       bbbbb                                    

                             160       170       180       190       200 
d1h7sa2  ( 106 )    frgealSSLCaLS-dVtIsTchasakvGtrLFdhnGkii---qktpyprp
d1i58a-  ( 479 )    ---dqeiLnflfvpgFst--------------------------------
d1s14a-  (1093 )    -----isvvnalSkrVeVnVrrdg--qvynIAFengekvqdlqvvgt-cg
d2e0aa2  ( 300 )    ----lriidrlfsytystap------------------------------
d3cwva1  (  96 )    GwdsmLVVSLALSsrYqVDIWadg--rQwrVmGehGhpqgegaavtpmep
d4k4oa1  ( 100 )    ---lgsSvVNALStsLdVrVykdg--kVyyQeYrrGavvddLkviee-t-
                           aaaa                                       

                             210       220       230       240       250 
d1h7sa2  ( 153 )    -----rGttvsVqqLFstlpvrhkeFqrnikkeyakvqvlhayCiisagi
d1i58a-  ( 494 )    -------------------------kevsevsggvgmdvVknvVesl-nG
d1s14a-  (1158 )    kr---ntGtsvhFwPdet---fF-dsprFsvsrLt--hvLkakAvlCpgV
d2e0aa2  ( 316 )    -----------------------tpnapLaGf-gyglPiSrlyAkyf-qg
d3cwva1  ( 144 )    mpvsaerGVrVhFvPDat---iF-evlaFdrarLs--rrCneLAalapgL
d4k4oa1  ( 163 )    -d---rhGttVhFiPDpe---iFtettvYdfdkLA--trVrelAflnrgL
                                                         aaaaaaaaa    

                             260       270       280       290 
d1h7sa2  ( 199 )    rVsCtnqlgqgkrqpvVcTgGsp-------sikeNigsVf
d1i58a-  ( 520 )    sIsIeSekdkGtkvtIrLplt                   
d1s14a-  (1199 )    eItFkDeinn--teqrwcyqd                   
d2e0aa2  ( 347 )    dLnlySlsgyGtdaiIyLkAlssesieklpvfnksafkhy
d3cwva1  ( 188 )    rVsFAdlq--rgertlwhlpg                   
d4k4oa1  ( 204 )    hIsIeDrregqedkkeyhyeg                   
                    bbbbbb      bbbbbb
 

 

Domain IDNameFamilySourceDomainSTRING-DB
DNA mismatch repair protein PMS2DNA gyrase/MutL, N-terminal domainHuman (Homo sapiens) [TaxId: 9606]view
Histidine kinase CheAHistidine kinaseThermotoga maritima [TaxId: 2336]view
Topoisomerase IV subunit BDNA gyrase/MutL, N-terminal domainEscherichia coli [TaxId: 562]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesMyxococcus xanthus [TaxId: 246197]view
automated matchesautomated matchesEnterococcus faecalis [TaxId: 226185]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290
- - - - - - - - - - - - - - - - - - - - - - - - - - - - G - - - - - - - - - - - - - - - - - - - - - - - - Q V V - - - L - S L S T A V K E L V E N S L D A - - - - - - - - - - - - - - - - G A T N I D L K L K D Y G V D L I E V S D N G C G V E - - - - E E - - - - N F E G L T L - - - A D L T Q V E T F G F R G E A L S S L C A L S - D V T I S T C H A S A K V G T R L F D H N G K I I - - - Q K T P Y P R P - - - - - R G T T V S V Q Q L F S T L P V R H K E F Q R N I K K E Y A K V Q V L H A Y C I I S A G I R V S C T N Q L G Q G K R Q P V V C T G G S P - - - - - - - S I K E N I G S V F
- - - - G S - - H M V P I S F V F N R F P R M V R D L A K K M - N K E V N F I M R G E - - - - - - - D T E L D - R T F V E E I G E P L L H L L R N A I D H G I E P K E E R I A K G K P P I G T L I L S A R H E G - N N V V I E V E D D G R G I D - - - - - - - K E K I I R K A I E K G L I D E S K A A T L S - - - D Q E I L N F L F V P G F S T - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - K E V S E V S G G V G M D V V K N V V E S L - N G S I S I E S E K D K G T K V T I R L P L T - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - T D - - - T T R P N H L G Q E V I D N S V D E A L A - - - - - - - - G - - - - H A K R V D V I L H A D - - Q S L E V I D D G R G M P V D I H P E E G V P A V E L I L C - - - - - - - - - - - - - - - - - - I S V V N A L S K R V E V N V R R D G - - Q V Y N I A F E N G E K V Q D L Q V V G T - C G K R - - - N T G T S V H F W P D E T - - - F F - D S P R F S V S R L T - - H V L K A K A V L C P G V E I T F K D E I N N - - T E Q R W C Y Q D - - - - - - - - - - - - - - - - - - -
P S H I G S I D P N C D V V A V V Q D A F E C S R M L C D Q Y Y L S S P E L K L T Q V N G K F P D Q P I H I V Y - - V P S H L H H M L F E L F K N A M R A T V - - - E H Q E N - - Q P S L T P I E V I V V L G K - E D L T I K I S D R G G G V P - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - L R I I D R L F S Y T Y S T A P - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - T P N A P L A G F - G Y G L P I S R L Y A K Y F - Q G D L N L Y S L S G Y G T D A I I Y L K A L S S E S I E K L P V F N K S A F K H Y
- - - - - - - - - - - - - G G I V E N V R K R P G M Y C G - - - - - - - - - - - - - - - - - - - - - - - - D V G - - - E Y G L H H L V Y F L L D V A Y E E A R R - - - - - - - - G - - - - E C R D V V L E V G G D - - G S I A L F C T S R T V T - - - - - - - - A E N L V R V A T G A G F L G R P P G D G W G W D S M L V V S L A L S S R Y Q V D I W A D G - - R Q W R V M G E H G H P Q G E G A A V T P M E P M P V S A E R G V R V H F V P D A T - - - I F - E V L A F D R A R L S - - R R C N E L A A L A P G L R V S F A D L Q - - R G E R T L W H L P G - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - G L E A V R K R P G M Y I G - - - - - - - - - - - - - - - - - - - - - - - - S T S - - - G E G L H H L V W E I V D N S I D E A L A - - - - - - - - G - - - - F A K S I Q V I I E P D - - D S I T V I D D G R G I P V G I Q A K T G R P A V E T V F T V - - - - - - - - - - - - - - - L G S S V V N A L S T S L D V R V Y K D G - - K V Y Y Q E Y R R G A V V D D L K V I E E - T - - D - - - R H G T T V H F I P D P E - - - I F T E T T V Y D F D K L A - - T R V R E L A F L N R G L H I S I E D R R E G Q E D K K E Y H Y E G - - - - - - - - - - - - - - - - - - -

 

 

 

 

 

Member Chain UniProtKB GO term
d1h7sa2 A P54278 GO:0005524
d1h7sa2 A P54278 GO:0006298
d1h7sa2 A P54278 GO:0016887
d1h7sa2 A P54278 GO:0030983
d1h7sa2 A P54278 GO:0032300
d1h7sa2 A P54278 GO:0140664
d1h7sa2 A P54278 GO:0005524
d1h7sa2 A P54278 GO:0006298
d1h7sa2 A P54278 GO:0016887
d1h7sa2 A P54278 GO:0030983
d1h7sa2 A P54278 GO:0032300
d1h7sa2 A P54278 GO:0140664
d1i58a_ A Q56310 GO:0016310
d1i58a_ A Q56310 GO:0016772
d1i58a_ A Q56310 GO:0016310
d1i58a_ A Q56310 GO:0016772
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in