BASE   PART 1   PART 2   PART 3  
Superfamily : 55874 [ ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase ]
Class : Alpha and beta proteins (a+b)
Fold : ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
# of Members : 7
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1bxda-  ( 290 )    tgqempmemadlnavlgeviaaesg-----yereietaly-pgsievkM-
d1id0a-  ( 335 )          relhpVaplLdnltsalnkvyqrk-gVnIsldIs--peIsFvG-
d1r62a-  ( 194 )          rvtesIhkVAerVvtlVsmelpd---nVLirdyd-psLpeLaH-
d1th8a1  (   1 )    mrnemhlqfsArsenesfArvtVaafVaql-dpt---------------m
d1ysra-  ( 299 )        ddhvpVdItdLLdrAAhdaariyp---dLdVslvpS--ptciIvG-
d2c2aa2  ( 321 )    qin---rekvdLÇdlVesAvnaikefAss-hnVnVlfesnvpçpVeAyI-
d4e01a2  ( 186 )    dfvgiictrLSPkkiIekwvdfArrlcehkygnAPrVrInghvaarfpF-
                           bbb aaaaaaaaaaaaaaa         bbb        bb  

                             60        70        80        90        100 
d1bxda-  ( 333 )    -hplsikrAvanMvvnAaryGn----------gwikvsSgtep-------
d1id0a-  ( 375 )    -eqndFveVMgNVLDnACkyCl-e---------fVeIsArqtd-------
d1r62a-  ( 234 )    -dpdqIeqVLLnIVrnAlqaLgpe-------GgeIiLrTrtafqltLhge
d1th8a1  (  35 )    delteIktVVseAVtnAIihgynndpn-----giVsIsViIed-------
d1ysra-  ( 339 )    -lpagLrlAVdnAIaNavkhggAt---------lVqLsAvssr-------
d2c2aa2  ( 366 )    -dptrIrqVLlnLLnnGVkysk---kdap--dkyVkViLdekd-------
d4e01a2  ( 235 )    -ipmpLdyILpeLLknAMraTMeshldtpynVpdVvItIannd-------
                      aaaaaaaaaaaaaaaaa              bbbbbbbbb        

                             110       120       130       140       150 
d1bxda-  ( 365 )    ---nrAwFqveDdgpGiapeqrkhlfqpfvrgdsartisgtglglaivqr
d1id0a-  ( 407 )    ---ehLyIvVeDdGpgiplskreviFdrgqrvdtlr--pgqgvglavAre
d1r62a-  ( 276 )    ryrlAArIDVeDnGpgi------------------------glglsiArn
d1th8a1  (  73 )    ---gvVhLtVrDegvGip--dieearqpl---------ersgmgftiMen
d1ysra-  ( 372 )    ---agVeIAIdDngsgVpegerqvVfer------------fslGLalVaq
d2c2aa2  ( 403 )    ---gGVlIiVednGiGipdhAkdrifeqfyrvt------g--lglaiTke
d4e01a2  ( 277 )    ---vdLiIrIsDrGgGiahkdldrvmdyhftta------gfgfglPtSra
                        bbbbbbbb                                aaaaaa

                             160       170       180       
d1bxda-  ( 412 )    ivdnHngmlelgtserGglsirAwlpvpvtraqgttkeg
d1id0a-  ( 452 )    iTeqyegkIvAgeSmlgGarmeViFGrQh          
d1r62a-  ( 322 )    lIdqhsGkIeftswp-ghtEfSVYLpirk          
d1th8a1  ( 116 )    fMd----eViVeSevnkgttvyLkk              
d1ysra-  ( 418 )    qAqlHggtAsLenSplgGarLVLrLpgps          
d2c2aa2  ( 452 )    IVelHgGrIwVeSevgkGSrffVwIpkd           
d4e01a2  ( 346 )    yAeylggsLqlqSlqgiGtdvyLrLrhid---------g
                    aaaa   bbbbbbb   bbbbbbbb
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Histidine kinase domain of the osmosensor EnvZHistidine kinaseEscherichia coli [TaxId: 562]view
Histidine kinase PhoQ domainHistidine kinaseEscherichia coli [TaxId: 562]view
Nitrogen regulation protein NtrB, C-terminal domainHistidine kinaseEscherichia coli [TaxId: 562]view
Anti-sigma factor spoIIabHistidine kinaseBacillus stearothermophilus [TaxId: 1422]view
automated matchesHistidine kinaseMycobacterium tuberculosis [TaxId: 1773]view
Sensor histidine kinase TM0853Histidine kinaseThermotoga maritima [TaxId: 2336]view
Branched-chain alpha-ketoacid dehydrogenase kinase (BCK)alpha-ketoacid dehydrogenase kinase, C-terminal domainNorway rat (Rattus norvegicus) [TaxId: 10116]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180
T G Q E M P M E M A D L N A V L G E V I A A E S G - - - - - Y E R E I E T A L Y - P G S I E V K M - - H P L S I K R A V A N M V V N A A R Y G N - - - - - - - - - - G W I K V S S G T E P - - - - - - - - - - N R A W F Q V E D D G P G I A P E Q R K H L F Q P F V R G D S A R T I S G T G L G L A I V Q R I V D N H N G M L E L G T S E R G G L S I R A W L P V P V T R A Q G T T K E G
- - - - - - R E L H P V A P L L D N L T S A L N K V Y Q R K - G V N I S L D I S - - P E I S F V G - - E Q N D F V E V M G N V L D N A C K Y C L - E - - - - - - - - - F V E I S A R Q T D - - - - - - - - - - E H L Y I V V E D D G P G I P L S K R E V I F D R G Q R V D T L R - - P G Q G V G L A V A R E I T E Q Y E G K I V A G E S M L G G A R M E V I F G R Q H - - - - - - - - - -
- - - - - - R V T E S I H K V A E R V V T L V S M E L P D - - - N V L I R D Y D - P S L P E L A H - - D P D Q I E Q V L L N I V R N A L Q A L G P E - - - - - - - G G E I I L R T R T A F Q L T L H G E R Y R L A A R I D V E D N G P G I - - - - - - - - - - - - - - - - - - - - - - - - G L G L S I A R N L I D Q H S G K I E F T S W P - G H T E F S V Y L P I R K - - - - - - - - - -
M R N E M H L Q F S A R S E N E S F A R V T V A A F V A Q L - D P T - - - - - - - - - - - - - - - M D E L T E I K T V V S E A V T N A I I H G Y N N D P N - - - - - G I V S I S V I I E D - - - - - - - - - - G V V H L T V R D E G V G I P - - D I E E A R Q P L - - - - - - - - - E R S G M G F T I M E N F M D - - - - E V I V E S E V N K G T T V Y L K K - - - - - - - - - - - - - -
- - - - D D H V P V D I T D L L D R A A H D A A R I Y P - - - D L D V S L V P S - - P T C I I V G - - L P A G L R L A V D N A I A N A V K H G G A T - - - - - - - - - L V Q L S A V S S R - - - - - - - - - - A G V E I A I D D N G S G V P E G E R Q V V F E R - - - - - - - - - - - - F S L G L A L V A Q Q A Q L H G G T A S L E N S P L G G A R L V L R L P G P S - - - - - - - - - -
Q I N - - - R E K V D L C D L V E S A V N A I K E F A S S - H N V N V L F E S N V P C P V E A Y I - - D P T R I R Q V L L N L L N N G V K Y S K - - - K D A P - - D K Y V K V I L D E K D - - - - - - - - - - G G V L I I V E D N G I G I P D H A K D R I F E Q F Y R V T - - - - - - G - - L G L A I T K E I V E L H G G R I W V E S E V G K G S R F F V W I P K D - - - - - - - - - - -
D F V G I I C T R L S P K K I I E K W V D F A R R L C E H K Y G N A P R V R I N G H V A A R F P F - - I P M P L D Y I L P E L L K N A M R A T M E S H L D T P Y N V P D V V I T I A N N D - - - - - - - - - - V D L I I R I S D R G G G I A H K D L D R V M D Y H F T T A - - - - - - G F G F G L P T S R A Y A E Y L G G S L Q L Q S L Q G I G T D V Y L R L R H I D - - - - - - - - - G

 

 

 

 

 

Member Chain UniProtKB GO term
d1bxda_ A P0AEJ4 GO:0016310
d1bxda_ A P0AEJ4 GO:0016772
d1bxda_ A P0AEJ4 GO:0016310
d1bxda_ A P0AEJ4 GO:0016772
d1id0a_ A P23837 GO:0016310
d1id0a_ A P23837 GO:0016772
d1id0a_ A P23837 GO:0016310
d1id0a_ A P23837 GO:0016772
d1r62a_ A P0AFB5 GO:0016310
d1r62a_ A P0AFB5 GO:0016772
d1r62a_ A P0AFB5 GO:0016310
d1r62a_ A P0AFB5 GO:0016772
d2c2aa2 A Q9WZV7 GO:0000155
d2c2aa2 A Q9WZV7 GO:0007165
d2c2aa2 A Q9WZV7 GO:0016310
d2c2aa2 A Q9WZV7 GO:0016772
d2c2aa2 A Q9WZV7 GO:0000155
d2c2aa2 A Q9WZV7 GO:0007165
d2c2aa2 A Q9WZV7 GO:0016310
d2c2aa2 A Q9WZV7 GO:0016772
d2c2aa2 A Q9WZV7 GO:0000155
d2c2aa2 A Q9WZV7 GO:0007165
d2c2aa2 A Q9WZV7 GO:0016310
d2c2aa2 A Q9WZV7 GO:0016772
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in