Superfamily : 55831 [ Thymidylate synthase/dCMP hydroxymethylase ]
Class : Alpha and beta proteins (a+b)
Fold : Thymidylate synthase/dCMP hydroxymethylase
# of Members : 4
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1b5ea-  (   1 )    misdsmtVeeIRlhLGlalkekdfv--vdktg-------vkTIeiigAsF
d1bkpa-  (   2 )        tqFDkqYnsiIkdIinnGisdeefdvtkWdsdgtpAhtlsviskqM
d3v8ha-  (   1 )           mkqYLdlVrtIldtGtwq--sn--g-------irtIgipgamL
d4ez8a-  (  21 )        rhgElqYlrqVehILrcGfkk--edrTg-------tGTlSvfgmqA
                           aaaaaaaaaaaaaa bbb                bbbbbbbbb

                             60        70        80        90        100 
d1b5ea-  (  42 )    vAd-----epfIFgalndeyiqrEleWYk-skslfvkdIpgetpkiwqqv
d1bkpa-  (  49 )    rFdN-seVPILTTkkVawktAIkeLLWIWqlksndVndLnmmgVhiwdqw
d3v8ha-  (  35 )    rfdLqqgFPAVTTkkLafksAIGELVGFL-rATrsAaeFralgCkvWdan
d4ez8a-  (  58 )    rYsLrdeFPLLTTkrVfwkGVLeELlwFI-kgsTnAkeLsskgVriwdan
                    bb               aaaaaaaaaaaa      aaaaa          

                             110       120       130       140       150 
d1b5ea-  (  86 )    ASs-------------kgeInsNYGwAIws------------edny----
d1bkpa-  (  98 )    kqe-------------dgtIghAyGfQLgkknrsln--------------
d3v8ha-  (  84 )    AnenaqWlanpyrr-gaddLGdVYGvQWRrwpgykvldahadaqiadAts
d4ez8a-  ( 107 )    Gs-rdfLdslgfsarqeGDLGPvYGFQWrhfgaeYk----------dMds
                                            aaaaa                     

                             160       170       180       190       200 
d1b5ea-  ( 107 )    ----------------------aqYdmClaeLgqnpdsrrGiMiYtrpsM
d1bkpa-  ( 121 )    -----------g-------ekvDqVdyLlhqLknnpssrrHiTmLwnpde
d3v8ha-  ( 133 )    rgfrivarfeggadkVlLhkaidqLrdCLdtIvrdpssrrIlFhGwNpav
d4ez8a-  ( 146 )    dys---------------gqgvdqLqkVIdtIktnpddrrIiMcAwnpkD
                                           aaaaaaaaaaa       bbb      

                             210       220       230       240       250 
d1b5ea-  ( 135 )    qfdynkdgMsdfMcTntVqYlIr-dkkInAvVnMrsNdVVfgFrndyaWQ
d1bkpa-  ( 153 )    lda-----MaltPcVyeTqWyVk-hgkLhLeVrArsNdMAlgNPfnVFQY
d3v8ha-  ( 184 )    lde-----iAlpAcHllYqFlPnvereIsLcLyIrsNdVGlgTPfnLAEG
d4ez8a-  ( 181 )    lpl-----MAlpPchalCqFyVv-ngeLsCqLyQrsGdMGlgVPfnIASY
                    333           bbbbbbbbb   bbbbbbbbbbbb    aaaaaaaa

                             260       270       280       290       300 
d1b5ea-  ( 184 )    kyVLdkLvsdLnagdstrqYkagsIiWnVgsLhVysrHfyLVdhwwktg-
d1bkpa-  ( 197 )    NVLQrMIAqVTg-------yelgeYiFnIgdChVytrHidnLkiQmereq
d3v8ha-  ( 230 )    AALLtLVGrLTg-------ysprwFTYfIgdAhIyenqldmL--Qler-p
d4ez8a-  ( 225 )    ALLTyMIAhITg-------lqpGdFvHtLGdAhIylnHiepLkiQlqrep
                    aaaaaaaaaaa         bbbbbbbbbbbbbbb333aaaaaaaa    

                             310       320       330       340       
d1b5ea-  ( 233 )    ----ethisk-----kdy                               
d1bkpa-  ( 240 )    feAPeLwinpevk---------dFydFtiddFkLinYkhgdkllFevAv
d3v8ha-  ( 273 )    f-sPrLeLarVpdyaktgyePqwLerVepsDFtLvgyrhh         
d4ez8a-  ( 268 )    rpFPkLkilrkVe---------tIddFkveDFqiegynPhptikMemav
                        bbbb                    333bbbb
 

 

Domain IDNameFamilySourceDomainSTRING-DB
dCMP hydroxymethylaseThymidylate synthase/dCMP hydroxymethylaseBacteriophage T4 [TaxId: 10665]view
Thymidylate synthaseThymidylate synthase/dCMP hydroxymethylaseBacillus subtilis [TaxId: 1423]view
automated matchesautomated matchesBurkholderia thailandensis [TaxId: 271848]view
automated matchesThymidylate synthase/dCMP hydroxymethylaseMouse (Mus musculus) [TaxId: 10090]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340
M I S D S M T V E E I R L H L G L A L K E K D F V - - V D K T G - - - - - - - V K T I E I I G A S F V A D - - - - - E P F I F G A L N D E Y I Q R E L E W Y K - S K S L F V K D I P G E T P K I W Q Q V A S S - - - - - - - - - - - - - K G E I N S N Y G W A I W S - - - - - - - - - - - - E D N Y - - - - - - - - - - - - - - - - - - - - - - - - - - A Q Y D M C L A E L G Q N P D S R R G I M I Y T R P S M Q F D Y N K D G M S D F M C T N T V Q Y L I R - D K K I N A V V N M R S N D V V F G F R N D Y A W Q K Y V L D K L V S D L N A G D S T R Q Y K A G S I I W N V G S L H V Y S R H F Y L V D H W W K T G - - - - - E T H I S K - - - - - K D Y - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - T Q F D K Q Y N S I I K D I I N N G I S D E E F D V T K W D S D G T P A H T L S V I S K Q M R F D N - S E V P I L T T K K V A W K T A I K E L L W I W Q L K S N D V N D L N M M G V H I W D Q W K Q E - - - - - - - - - - - - - D G T I G H A Y G F Q L G K K N R S L N - - - - - - - - - - - - - - - - - - - - - - - - - G - - - - - - - E K V D Q V D Y L L H Q L K N N P S S R R H I T M L W N P D E L D A - - - - - M A L T P C V Y E T Q W Y V K - H G K L H L E V R A R S N D M A L G N P F N V F Q Y N V L Q R M I A Q V T G - - - - - - - Y E L G E Y I F N I G D C H V Y T R H I D N L K I Q M E R E Q F E A P E L W I N P E V K - - - - - - - - - D F Y D F T I D D F K L I N Y K H G D K L L F E V A V
- - - - - - - M K Q Y L D L V R T I L D T G T W Q - - S N - - G - - - - - - - I R T I G I P G A M L R F D L Q Q G F P A V T T K K L A F K S A I G E L V G F L - R A T R S A A E F R A L G C K V W D A N A N E N A Q W L A N P Y R R - G A D D L G D V Y G V Q W R R W P G Y K V L D A H A D A Q I A D A T S R G F R I V A R F E G G A D K V L L H K A I D Q L R D C L D T I V R D P S S R R I L F H G W N P A V L D E - - - - - I A L P A C H L L Y Q F L P N V E R E I S L C L Y I R S N D V G L G T P F N L A E G A A L L T L V G R L T G - - - - - - - Y S P R W F T Y F I G D A H I Y E N Q L D M L - - Q L E R - P F - S P R L E L A R V P D Y A K T G Y E P Q W L E R V E P S D F T L V G Y R H H - - - - - - - - -
- - - - R H G E L Q Y L R Q V E H I L R C G F K K - - E D R T G - - - - - - - T G T L S V F G M Q A R Y S L R D E F P L L T T K R V F W K G V L E E L L W F I - K G S T N A K E L S S K G V R I W D A N G S - R D F L D S L G F S A R Q E G D L G P V Y G F Q W R H F G A E Y K - - - - - - - - - - D M D S D Y S - - - - - - - - - - - - - - - G Q G V D Q L Q K V I D T I K T N P D D R R I I M C A W N P K D L P L - - - - - M A L P P C H A L C Q F Y V V - N G E L S C Q L Y Q R S G D M G L G V P F N I A S Y A L L T Y M I A H I T G - - - - - - - L Q P G D F V H T L G D A H I Y L N H I E P L K I Q L Q R E P R P F P K L K I L R K V E - - - - - - - - - T I D D F K V E D F Q I E G Y N P H P T I K M E M A V

 

 

 

 

 

Member Chain UniProtKB GO term
d1b5ea_ A P08773 GO:0016740
d1b5ea_ A P08773 GO:0047153
d1bkpa_ A P0CI79 GO:0004799
d1bkpa_ A P0CI79 GO:0005737
d1bkpa_ A P0CI79 GO:0005829
d1bkpa_ A P0CI79 GO:0006231
d1bkpa_ A P0CI79 GO:0006235
d1bkpa_ A P0CI79 GO:0008168
d1bkpa_ A P0CI79 GO:0009165
d1bkpa_ A P0CI79 GO:0016741
d1bkpa_ A P0CI79 GO:0032259
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in