Superfamily : 55785 [ PYP-like sensor domain (PAS domain) ]
Class : Alpha and beta proteins (a+b)
Fold : Profilin-like
# of Members : 22
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1d06a-  ( 122 )                 gsh-mletedvvrardahlrsildtvpdATVVSat--
d1ll8a1  (   8 )                                           nkAiFtvDak-
d1nwza-  (   1 )                 mehvafgsedIentLakMddgqLdgLaFGAIqLdg--
d1oj5a-  ( 259 )                                          vesFmTkqdt--
d1v9ya-  (  20 )                                 giffpaleqnmmGAVlIne--
d2gj3a-  (  22 )                              llpeifrqtvehapiAiSiTdl--
d3f1pb-  ( 357 )                                       vcqptrFiSrHni--
d3nhqa1  (   5 )                      tpvtlancedepihvpgaiqphgAlVtLra--
d3zq5a1  (   2 )                attvqlsdqslrqletlaihtahliqphgLvVvLqEp-
d4cqha1  (   7 )    pffpplylgGpeit---------tncerepihipgsiqphgAlLtAdGh-
d4e04a1  (  13 )                           stcddepihipgaiqphgLlLALaa--
d4hoia1  (  28 )                                            tnfVlGnAqi
d4hqaa-  (  26 )                                           srkfIiAnArv
d4kuka1  (  20 )                                 diadlalleaemsVvFsdpsq
d4wn5a1  ( 237 )                                       g--rgaflSrHsl--
d5f68a-  ( 310 )                                            mFiSrHsg--
d5svva-  (  14 )                                         tapCGfIvtdAve
d5viqa1  (  19 )                            nceheeihlagsiqphgAlLVVSeh-
d6bafa1  (  16 )                           tncdrepihipgaiqphgVlLVLsep-
d6gg9a1  (   1 )                             minaqllqsmvdasndGiVvaekeg
d6qqha-  ( 387 )                                          meknfvisdprl
d6ywha1  (  48 )                                           asGmIvtda-g
                                                             bbbbb    

                             60        70        80        90        100 
d1d06a-  ( 156 )    -dGtIvSFNaaAvrqFgya-eeeVigqnl--riLmpe---------pyrh
d1ll8a1  (  18 )    -tteilvAndkAcgllgys-sqdligqk--ltqFFlrsd----------s
d1nwza-  (  36 )    -dGnIlqYNaaEGdItgrd-pkqvigknFF-kdvapc---------Tdsp
d1oj5a-  ( 269 )    -tgkiisidtssLraagrtgwedLvrkCiaFfqpqg------------ep
d1v9ya-  (  39 )    -ndeVmfFNpaAeklWgyk-reeVignni--dmLipr---------dlrp
d2gj3a-  (  45 )    --anIlyANraFrtiTgyg-seeVlgkn--esilsn---------gtTpr
d3f1pb-  ( 370 )    -eGiFtfvdhrCvatvgyq-pqellgkni--veFChp---------edqq
d3nhqa1  (  35 )    -dgmVlaaseniqalLgfv-As--pgsylt-qeqV--g-----------p
d3zq5a1  (  39 )    -dltIsqIsanCtgiLgrs-p-dLlgrtL--geVF--dsfqidpiq--sr
d4cqha1  (  48 )    -sGeVlqVslnAatfLgqe-ptvLrgqtL--aall----p----------
d4e04a1  (  38 )    -dmtIvaGsdnLpelTgla-igaLigrsA--adVF--d-s----------
d4hoia1  (  38 )    vdwpIvySndgFcklSgyh-raeVmqksSaCsfMyg---------elTdk
d4hqaa-  (  37 )    encaViyCndGFcelCgys-raeVmqrpCtCdfLhg---------prTqr
d4kuka1  (  45 )    pdnPMiyVsdaFlvqTgyt-leeVlgrn--crfLqg---------pdTnp
d4wn5a1  ( 248 )    -dMkFtyCddriaevAgys-pddligcsa--yeyiha---------ldsd
d5f68a-  ( 318 )    -eGkFlfIdqrAtlvIgfl-pqeIlgtsF--yeYFhn---------edia
d5svva-  (  27 )    pdqpiiyvntvFemvtgYr-aeevlgrn--crflqcrgpfakrrhplvds
d5viqa1  (  44 )    -dhrViqAsanAaefLnlg---sVlgvpL--aeId----g----------
d6bafa1  (  42 )    -gLvLthAsenApavLgns-aeqLlgapL--ghFI--e-p----------
d6gg9a1  (  26 )    ddtiLiyVNaaFeylTgys-rdeily-d--crfLqg---------d--dh
d6qqha-  ( 399 )    pdnpIifAsdsFlelTeys-reeIlgrn--crfLqg---------peTdq
d6ywha1  (  58 )    adqpIvfVnraFstiTgya-pneVlgrn--arfLqg---------pqTda
                        bbbb   aaaaa                                  

                             110       120       130       140       150 
d1d06a-  ( 193 )    ehdgylqr-ymatgekriigidrvvsGqrkdgstFpMklavgemrsgg--
d1ll8a1  (  54 )    DvveAlseehmeadghaavvFgtvvdiiSrsgekipvsvwmkrmrqer--
d1nwza-  (  74 )    eFygkFke-gvasgn---lntmfeytFdy-qmtptkVkVHMkkals----
d1oj5a-  ( 308 )    syArqLfeVt------rgtasSpsYrfilndgtmLsAhTrclcyp-----
d1v9ya-  (  76 )    ahpeyirh-nre-----------elqLekkdgskiwTrfalskvsaeg--
d2gj3a-  (  81 )    lvyqalwg-rLa----qkkpwsgvlvnrRkdktlYlAeltvaPvlne-ag
d3f1pb-  ( 407 )    llrdSFqq-vvk---lkgqvlsvmFrFrsknqewlwMrtsSftfqnpysd
d3nhqa1  (  67 )    eVlrMlee-Gltgngp-ws-nsvetrig-----ehlFdViGhsyk-----
d3zq5a1  (  81 )    ltagqis-----------slnpSkLwarvmgddfviFdGvFhrns-----
d4cqha1  (  80 )    dqwpaLqt-aL-ppgc-a--lqyatLdwpa-ag--hLsLtVhRva-----
d4e04a1  (  71 )    eThnrLti-alaepga-avGapiaVgFtMp-dgeraFnGsWhrhd-----
d4hoia1  (  78 )    dtvekVrq-TFe----nyemnsfeIlMykknrtpVwFfvkIaPirne-qd
d4hqaa-  (  77 )    raaaqIaq-ALl----gaeerkVeIAFyrkdgsCFlClVdVvPvkne-dg
d4kuka1  (  83 )    haveairq-glk----aet-ftidIlNyrkdgsafvNrlrirpiydp-eg
d4wn5a1  ( 285 )    avsksiht-lls----kgqavtgqYrflarsggylwtqtqAtvvsgrgpq
d5f68a-  ( 355 )    aLmesHkm-Vmq---vpekvtTqvYrFrckdnsyiqLqSeWrAfknpats
d5svva-  (  74 )    mvvseirk-Cid----egieFqgellnFrkdgsplmnrlrltpiygd-dd
d5viqa1  (  74 )    dLlikIlp-hldptae-gMpvavrCrI-Gn--psteYcGlMhrpp-----
d6bafa1  (  75 )    svrepLea-dLrsarL-kqlnpLkVVWrvd-gvdrfFdGiAhrhq-----
d6gg9a1  (  63 )    qGiarir--Ama----egrpcrevLrNyrkdgsaFwNelsitpvksd-fd
d6qqha-  ( 437 )    atvqkird-air----dqreitvQLiNytksgkkfwNlfhLqpmrdq-kg
d6ywha1  (  96 )    atvarlre-Aia----aarpiq-eIlNyrkdgqpFwNqlsisPvrde-tg
                    aaaaaaaa a            bbbbbb     bbbbbbbbbbb      

                             160       170 
d1d06a-  ( 240 )    -erfftgfirdlt          
d1ll8a1  ( 102 )    -rlCcvvvlepver         
d1nwza-  ( 115 )    -gdsYWVFVkrv           
d1oj5a-  ( 355 )    -qpfImGiHiIdr          
d1v9ya-  ( 123 )    -kvyylalVrd            
d2gj3a-  ( 125 )    etiyylgmHrdtselh       
d3f1pb-  ( 453 )    eieyiiCtntnvk--------ns
d3nhqa1  ( 104 )    --evFyLeFeirt-adt      
d3zq5a1  ( 115 )    -dglLvCeLepAytsdn      
d4cqha1  ( 120 )    --elLiLeFept           
d4e04a1  ( 113 )    --qlvfLeLeppqrd-v      
d4hoia1  ( 122 )    kVvlFlCtFsditafk       
d4hqaa-  ( 121 )    avimFiLnFevvme-k       
d4kuka1  ( 127 )    nlmfFAgAQnpv           
d4wn5a1  ( 331 )    s-esivCvhflis--------q 
d5f68a-  ( 401 )    eidyIiAkNsvf           
d5svva-  ( 118 )    tithiiGiqffi           
d5viqa1  ( 114 )    -eggLiIeLeragp         
d6bafa1  ( 117 )    --grLiLeLepsshr-e      
d6gg9a1  ( 108 )    qrtyfigiQkdvsvel---elae
d6qqha-  ( 481 )    elqyFiGvQldgefipnpllgld
d6ywha1  ( 140 )    nvvaFvgvDtdvta         
                       bbbbbbbb
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Histidine kinase FixL heme domainHeme-binding PAS domainRhizobium meliloti [TaxId: 382]view
N-terminal PAS domain of Pas kinaseN-terminal PAS domain of Pas kinaseHuman (Homo sapiens) [TaxId: 9606]view
Photoactive yellow protein, PYPPYP-likeMethylophilus methylotrophus, strain w3a1 [TaxId: 17]view
PAS domain of steroid receptor coactivator 1A, NCo-A1PAS domain of steroid receptor coactivator 1A, NCo-A1Mouse (Mus musculus) [TaxId: 10090]view
Direct oxygen sensor protein, DOSHeme-binding PAS domainEscherichia coli [TaxId: 562]view
automated matchesautomated matchesAzotobacter vinelandii [TaxId: 354]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
Bacteriophytochrome BphPBphP N-terminal domain-likePseudomonas aeruginosa [TaxId: 287]view
automated matchesautomated matchesSynechocystis sp. [TaxId: 1148]view
automated matchesautomated matchesDeinococcus radiodurans [TaxId: 1299]view
automated matchesautomated matchesRhodopseudomonas palustris [TaxId: 258594]view
automated matchesautomated matchesMouse (Mus musculus) [TaxId: 10090]view
automated matchesFlavin-binding PAS domainHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesDinoroseobacter shibae [TaxId: 398580]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesFruit fly (Drosophila melanogaster) [TaxId: 7227]view
automated matchesautomated matchesThale cress (Arabidopsis thaliana) [TaxId: 3702]view
automated matchesautomated matchesRhodopseudomonas palustris [TaxId: 1076]view
automated matchesautomated matchesStigmatella aurantiaca [TaxId: 378806]view
automated matchesautomated matchesPseudomonas putida [TaxId: 160488]view
automated matchesFlavin-binding PAS domainThale cress (Arabidopsis thaliana) [TaxId: 3702]view
automated matchesautomated matchesChloroflexus aggregans [TaxId: 326427]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170
- - - - - - - - - - - - - G S H - M L E T E D V V R A R D A H L R S I L D T V P D A T V V S A T - - - D G T I V S F N A A A V R Q F G Y A - E E E V I G Q N L - - R I L M P E - - - - - - - - - P Y R H E H D G Y L Q R - Y M A T G E K R I I G I D R V V S G Q R K D G S T F P M K L A V G E M R S G G - - - E R F F T G F I R D L T - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - N K A I F T V D A K - - T T E I L V A N D K A C G L L G Y S - S Q D L I G Q K - - L T Q F F L R S D - - - - - - - - - - S D V V E A L S E E H M E A D G H A A V V F G T V V D I I S R S G E K I P V S V W M K R M R Q E R - - - R L C C V V V L E P V E R - - - - - - - - -
- - - - - - - - - - - - - M E H V A F G S E D I E N T L A K M D D G Q L D G L A F G A I Q L D G - - - D G N I L Q Y N A A E G D I T G R D - P K Q V I G K N F F - K D V A P C - - - - - - - - - T D S P E F Y G K F K E - G V A S G N - - - L N T M F E Y T F D Y - Q M T P T K V K V H M K K A L S - - - - - G D S Y W V F V K R V - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - V E S F M T K Q D T - - - T G K I I S I D T S S L R A A G R T G W E D L V R K C I A F F Q P Q G - - - - - - - - - - - - E P S Y A R Q L F E V T - - - - - - R G T A S S P S Y R F I L N D G T M L S A H T R C L C Y P - - - - - - Q P F I M G I H I I D R - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - G I F F P A L E Q N M M G A V L I N E - - - N D E V M F F N P A A E K L W G Y K - R E E V I G N N I - - D M L I P R - - - - - - - - - D L R P A H P E Y I R H - N R E - - - - - - - - - - - E L Q L E K K D G S K I W T R F A L S K V S A E G - - - K V Y Y L A L V R D - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - L L P E I F R Q T V E H A P I A I S I T D L - - - - A N I L Y A N R A F R T I T G Y G - S E E V L G K N - - E S I L S N - - - - - - - - - G T T P R L V Y Q A L W G - R L A - - - - Q K K P W S G V L V N R R K D K T L Y L A E L T V A P V L N E - A G E T I Y Y L G M H R D T S E L H - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - V C Q P T R F I S R H N I - - - E G I F T F V D H R C V A T V G Y Q - P Q E L L G K N I - - V E F C H P - - - - - - - - - E D Q Q L L R D S F Q Q - V V K - - - L K G Q V L S V M F R F R S K N Q E W L W M R T S S F T F Q N P Y S D E I E Y I I C T N T N V K - - - - - - - - N S
- - - - - - - - - - - - - - - - - - T P V T L A N C E D E P I H V P G A I Q P H G A L V T L R A - - - D G M V L A A S E N I Q A L L G F V - A S - - P G S Y L T - Q E Q V - - G - - - - - - - - - - - P E V L R M L E E - G L T G N G P - W S - N S V E T R I G - - - - - E H L F D V I G H S Y K - - - - - - - E V F Y L E F E I R T - A D T - - - - - -
- - - - - - - - - - - - A T T V Q L S D Q S L R Q L E T L A I H T A H L I Q P H G L V V V L Q E P - - D L T I S Q I S A N C T G I L G R S - P - D L L G R T L - - G E V F - - D S F Q I D P I Q - - S R L T A G Q I S - - - - - - - - - - - S L N P S K L W A R V M G D D F V I F D G V F H R N S - - - - - - D G L L V C E L E P A Y T S D N - - - - - -
P F F P P L Y L G G P E I T - - - - - - - - - T N C E R E P I H I P G S I Q P H G A L L T A D G H - - S G E V L Q V S L N A A T F L G Q E - P T V L R G Q T L - - A A L L - - - - P - - - - - - - - - - D Q W P A L Q T - A L - P P G C - A - - L Q Y A T L D W P A - A G - - H L S L T V H R V A - - - - - - - E L L I L E F E P T - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - S T C D D E P I H I P G A I Q P H G L L L A L A A - - - D M T I V A G S D N L P E L T G L A - I G A L I G R S A - - A D V F - - D - S - - - - - - - - - - E T H N R L T I - A L A E P G A - A V G A P I A V G F T M P - D G E R A F N G S W H R H D - - - - - - - Q L V F L E L E P P Q R D - V - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - T N F V L G N A Q I V D W P I V Y S N D G F C K L S G Y H - R A E V M Q K S S A C S F M Y G - - - - - - - - - E L T D K D T V E K V R Q - T F E - - - - N Y E M N S F E I L M Y K K N R T P V W F F V K I A P I R N E - Q D K V V L F L C T F S D I T A F K - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - S R K F I I A N A R V E N C A V I Y C N D G F C E L C G Y S - R A E V M Q R P C T C D F L H G - - - - - - - - - P R T Q R R A A A Q I A Q - A L L - - - - G A E E R K V E I A F Y R K D G S C F L C L V D V V P V K N E - D G A V I M F I L N F E V V M E - K - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - D I A D L A L L E A E M S V V F S D P S Q P D N P M I Y V S D A F L V Q T G Y T - L E E V L G R N - - C R F L Q G - - - - - - - - - P D T N P H A V E A I R Q - G L K - - - - A E T - F T I D I L N Y R K D G S A F V N R L R I R P I Y D P - E G N L M F F A G A Q N P V - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - G - - R G A F L S R H S L - - - D M K F T Y C D D R I A E V A G Y S - P D D L I G C S A - - Y E Y I H A - - - - - - - - - L D S D A V S K S I H T - L L S - - - - K G Q A V T G Q Y R F L A R S G G Y L W T Q T Q A T V V S G R G P Q S - E S I V C V H F L I S - - - - - - - - Q -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M F I S R H S G - - - E G K F L F I D Q R A T L V I G F L - P Q E I L G T S F - - Y E Y F H N - - - - - - - - - E D I A A L M E S H K M - V M Q - - - V P E K V T T Q V Y R F R C K D N S Y I Q L Q S E W R A F K N P A T S E I D Y I I A K N S V F - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - T A P C G F I V T D A V E P D Q P I I Y V N T V F E M V T G Y R - A E E V L G R N - - C R F L Q C R G P F A K R R H P L V D S M V V S E I R K - C I D - - - - E G I E F Q G E L L N F R K D G S P L M N R L R L T P I Y G D - D D T I T H I I G I Q F F I - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - N C E H E E I H L A G S I Q P H G A L L V V S E H - - D H R V I Q A S A N A A E F L N L G - - - S V L G V P L - - A E I D - - - - G - - - - - - - - - - D L L I K I L P - H L D P T A E - G M P V A V R C R I - G N - - P S T E Y C G L M H R P P - - - - - - E G G L I I E L E R A G P - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - T N C D R E P I H I P G A I Q P H G V L L V L S E P - - G L V L T H A S E N A P A V L G N S - A E Q L L G A P L - - G H F I - - E - P - - - - - - - - - - S V R E P L E A - D L R S A R L - K Q L N P L K V V W R V D - G V D R F F D G I A H R H Q - - - - - - - G R L I L E L E P S S H R - E - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - M I N A Q L L Q S M V D A S N D G I V V A E K E G D D T I L I Y V N A A F E Y L T G Y S - R D E I L Y - D - - C R F L Q G - - - - - - - - - D - - D H Q G I A R I R - - A M A - - - - E G R P C R E V L R N Y R K D G S A F W N E L S I T P V K S D - F D Q R T Y F I G I Q K D V S V E L - - - E L A E
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M E K N F V I S D P R L P D N P I I F A S D S F L E L T E Y S - R E E I L G R N - - C R F L Q G - - - - - - - - - P E T D Q A T V Q K I R D - A I R - - - - D Q R E I T V Q L I N Y T K S G K K F W N L F H L Q P M R D Q - K G E L Q Y F I G V Q L D G E F I P N P L L G L D
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A S G M I V T D A - G A D Q P I V F V N R A F S T I T G Y A - P N E V L G R N - - A R F L Q G - - - - - - - - - P Q T D A A T V A R L R E - A I A - - - - A A R P I Q - E I L N Y R K D G Q P F W N Q L S I S P V R D E - T G N V V A F V G V D T D V T A - - - - - - - - -

 

 

 

 

 

Member Chain UniProtKB GO term
d1d06a_ A P10955 GO:0006355
d1nwza_ A P16113 GO:0006355
d1nwza_ A P16113 GO:0007602
d1nwza_ A P16113 GO:0009881
d1nwza_ A P16113 GO:0042802
d1oj5a_ A P70365 GO:0005634
d1oj5a_ A P70365 GO:0006355
d1oj5a_ A P70365 GO:0030374
d1oj5a_ A P42226 GO:0005634
d1oj5a_ A P42226 GO:0006355
d1oj5a_ A P42226 GO:0030374
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in