Superfamily : 54452 [ MHC antigen-recognition domain ]
Class : Alpha and beta proteins (a+b)
Fold : MHC antigen-recognition domain
# of Members : 18
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1a6za2  (   4 )      rshsLhYlFmGaSed-lglslFeAlGyVddqlFVfYdh---srrvepr
d1k5na2  (   1 )      gshsMryfhtSvsrpgrgeprFiTvGyVddtlFVrFdsdaasprEepr
d1kcgc-  (   9 )      dahsLwYnFtIihlprhgqqwÇeVqSqvdqknFLsYdÇgsd--kvlsm
d1lqva-  (   7 )      glqrlhmlqiSyFrdp-yhVwYqgnaslgghlThvlegpdtnTtIiql
d1t7va2  (   5 )     dgrysLtyiYtGlskhvedvpaFqAlGsLndlqFFrYnsk--drkSqpm
d1u58a2  (   8 )       esGLryaYtLvvdgtantrrçfGtGhVdgeaFVgYsn----nkThgi
d1uvqb2  (   3 )    spedfvfqfkgmçyftngterVrLVTryiynreeyArFdsd--vgvYrav
d2bc4a1  (  13 )    lq-nhtflhtvyÇqdg----spsvgLsEaydedqlffFdfs--qntrvpr
d2bc4b1  (   3 )        fvahvestçlLddagtpkdftYçisfnkdlLTçWdpe--enkMapc
d2wy3a-  (   0 )     mephsLrYnLmVlsqdsv-qsgFlAeGhldgqpFLrYdrqkr--rAkpq
d3dbxa1  (   7 )    peesqfFqLfytLlLgnv-ssTL-tGmAlLadvpIMvLd--phtwnLnic
d3g08a1  (   7 )       nytFrclqmSsFans--wsrTdsvvwLgdlqTHrws--ndsatisft
d3jvga1  (   6 )       shmlkllhfAtFqns-tsvlvgglglLgdvkmgsld--srtgni-yy
d4p5ma1  (   1 )    ikadhvstyaafVqth----rptGeFmfefdedemFyVdld--kketvwh
d4pp8c-  (   4 )         sLrÇnLtIkdptpadplwYeAkÇfvge-lilhlsniat-------
d5wl1a1  (   4 )    fqgPtsfhviqtSsFtns--twAtqgsGwlddlqihgwd--sdsgtaifl
d6a97a1  (   6 )       thtLrYnVrAhsLgse-kTqLlVlIyVdeelfLkyngdsreteplgç
d6c99a1  (   5 )        lsLlYhLtAvsspapgtpaFwVsGwLgpqqYLsYnsl---geAepc
                          bbbbbbbb         bbbbbbb  bbbbbbb        bb 

                             60        70        80        90        100 
d1a6za2  (  50 )    t-----pwss------qmw--qLqsLkgwDhm-FtvDFwtIMenHnh-sk
d1k5na2  (  49 )    A-----pWIeqE-gp-eYwdreTqickakAqt-DredLrtLlryynqsea
d1kcgc-  (  55 )    g-----hl-eeqLyatdAwgkQlemLreVGqr-LrleLadtep-------
d1lqva-  (  54 )    q-----p-lq---ep-eswartqsglqsyLlq-fHglvrlVhqertla--
d1t7va2  (  52 )    g-----lWrqve-gM-edwkqdSqlQkarEdi-FmetLkdIVeyykd-st
d1u58a2  (  51 )    g-----rwVn-----ashveeEnkeFvrQçke-LqaeLdkmqnnskVi--
d1uvqb2  (  51 )    t-----pqGrpdaeywnsqkevlegtraeldtvÇrhnyevafrgilqrr 
d2bc4a1  (  56 )    l-----pefadwAqeqg----dapaIlfdkef-çewmiqqigpkldgkip
d2bc4b1  (  47 )    efgvlnslAnvlsqhlnqkdtlmqrLrnGlqn-Çathtqpfwgsltnr  
d2wy3a-  (  47 )    g-----qwAedvLga-etwdtEtedLtenGqd-LrrTLthIkdq----kg
d3dbxa1  (  54 )    r-----pwVqitaeV-kilsfsmvGIrntirf-Mh-emTaA----gld--
d3g08a1  (  51 )    k-----pwSqGkLsn-qqweklqhmfqvyrvs-ftrdiqelvm--med--
d3jvga1  (  50 )    r-----pwLrpslpk-gdwdviessiksyvrd-fs-lvqmy----Tvp--
d4p5ma1  (  45 )    l-----eefgqa--fsf----eaqgGlaniai-lnnnlntliqrsnhtqa
d4pp8c-  (  56 )    ------------------eVçLtqpLknLCqk-Lrnkvs-----------
d5wl1a1  (  51 )    k-----pwSkGnFsd-kevaeleeifrvyifg-farevqdfAgdfqMk--
d6a97a1  (  53 )    w-----kgggnetça-rEtnnLlkVeekLrgm-MaeVInqks-q----ee
d6c99a1  (  49 )    g-----aWvwEn-q--vyw-eEttdLrike-l-FleAfkaLg-------g
                                          aaaaaaaaaa aaaaaa           

                             110       120       130       140       150 
d1a6za2  (  92 )    esHtLqViLGÇemqdn--steGyWkYgYdgqdHLeFcpdtldWrAae---
d1k5na2  (  91 )    gshtLqNmyGÇdVgpdgrllrGyhqhaYdgkdYIaLnedLssWtAad---
d1kcgc-  (  99 )    --ltLqVrMsÇeceadg-yirGsWqFsfdgrkfLlFdSnnrkWtvv----
d1lqva-  (  91 )    fpLtirCflGÇelppegsrahVfFevavngssfVSFrperAlWqadtqvt
d1t7va2  (  93 )    gshvLqGrFGCeIenn-rssgAfwkyyydgkdYIeFnkeipaWvpfd---
d1u58a2  (  88 )    gvktVqLdvgÇts-------kiekhyaydgnete----------------
d1uvqb2                                                               
d2bc4a1  (  96 )    --------------------------------------------------
d2bc4b1                                                               
d2wy3a-  (  86 )    glhsLqEirvÇeiheds-strGsRhFyyngelFLsQnLetqestvpq---
d3dbxa1  (  95 )    yprvFqihtGCklytng-trwSfvnIgEggrdLVtYels-erWvpqrs--
d3g08a1  (  94 )    ypIeiqlsaGÇmy-----as-sflhvafqgkyVVrFw--gtswqtvpgAp
d3jvga1  (  88 )    ypFvFqSsiGÇelqsng-tirTffdiayegqnFLrFnldagtWdqmqh--
d4p5ma1  (  83 )    --------------------------------------------------
d4pp8c-  (  78 )    ntphLqVtMiYpqsq--gtpsAtWeFnIsdsyfFtFytenmswrsan---
d5wl1a1  (  92 )    ypfeiqgiaGÇelhsgg-aivSflrgalggldflsvk--nasÇvpspegg
d6a97a1  (  93 )    glhtLqAtLGÇellsng-strGFWhLgydgqnfLtFdqktltWtvdg---
d6c99a1  (  86 )    gpytLqGlLGÇlgpdn--tsvptAkFaLngeeFMnFd--lgtWggdw---
                        bbbbbbb           bbbbbb   bbbbb      bb      

                             160       170       180       190     
d1a6za2  ( 138 )    -prAwpTkleWerhk-irArqnrayLerdÇPaqLqqLlelG-gvLd 
d1k5na2  ( 138 )    -taAqitqrkwea-a-rvAeqlrayLegeÇVewLrrYlenGketLqr
d1kcgc-  ( 142 )    hagArrMkekWekds-gLTtfFkmVSmrdÇksWLrdFlmhrkkrle 
d1lqva-  ( 141 )    sgvvtftlqqlnayn-rtryelrefLedtÇvqyVqkhs         
d1t7va2  ( 139 )    -pAAqitkqkweaep-vyvqrakayLeeeCPatLrkYlkySknILdr
d1u58a2  ( 128 )    -----------------------------çqkkLteYrklvlasa-v
d1uvqb2                                                            
d2bc4a1  (  96 )    ----------------------------------------------v
d2bc4b1                                                            
d2wy3a-  ( 132 )    ssrAqtlAnVtnfwkektkthyramq-adÇlqkLqrYlksg      
d3dbxa1  ( 142 )    tlLAkvMSntltdlr-avSgfl-hIFsssFpnYIlmLheeGrtdLer
d3g08a1  ( 141 )    -swldlpikvlnadq-gtSatvqmllndtçplfVrgLleaGksdLek
d3jvga1  ( 135 )    -nlSakaehlmanas-tlNeviqvlLndtçVdiLrlFiqaGkadler
d4p5ma1  (  83 )    ----------------------------------------------t
d4pp8c-  ( 134 )    -deSgvimnkWkddg-eFvkqL-fLIh-eÇsqkMdefl         
d5wl1a1  ( 139 )    -srAqkfçaliiqy--gimetvrillyetçpryllgvlnaGkadlqr
d6a97a1  ( 139 )    pst-qqnkmfwkthAP-radlVktFLddiÇpahLqrYlaslng    
d6c99a1  ( 132 )    -peAlaIsqrWqq---qaankEltFLl-sÇphrLreHl-rgrgnLew
                        aaa  aa        aa        aaaaaaaa
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Hemochromatosis protein Hfe, alpha-1 and alpha-2 domainsMHC antigen-recognition domainHuman (Homo sapiens) [TaxId: 9606]view
Class I MHC, alpha-1 and alpha-2 domainsMHC antigen-recognition domainHuman (Homo sapiens), HLA-B27 [TaxId: 9606]view
Class I MHC-related molecule Ulbp3MHC antigen-recognition domainHuman (Homo sapiens) [TaxId: 9606]view
Endothelial protein C receptorMHC antigen-recognition domainHuman (Homo sapiens) [TaxId: 9606]view
Zinc-alpha-2-glycoprotein, ZAGMHC antigen-recognition domainHuman (Homo sapiens) [TaxId: 9606]view
Immunomodulatory protein m144, alpha-1 and alpha-2 domainsMHC antigen-recognition domainMurine cytomegalovirus [TaxId: 10366]view
Class II MHC beta chain, N-terminal domainMHC antigen-recognition domainHuman (Homo sapiens), HLA-DQ6 [TaxId: 9606]view
automated matchesMHC antigen-recognition domainHuman (Homo sapiens) [TaxId: 9606]view
automated matchesMHC antigen-recognition domainHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesChicken (Gallus gallus) [TaxId: 9031]view
automated matchesautomated matchesMouse (Mus musculus) [TaxId: 10090]view
automated matchesautomated matchesChicken (Gallus gallus) [TaxId: 9031]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
NK cell ligand RAE-1 betaMHC antigen-recognition domainMouse (Mus musculus) [TaxId: 10090]view
CD1, alpha-1 and alpha-2 domainsMHC antigen-recognition domainHuman (Homo sapiens), CD1b [TaxId: 9606]view
automated matchesautomated matchesMouse (Mus musculus) [TaxId: 10090]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190
- - R S H S L H Y L F M G A S E D - L G L S L F E A L G Y V D D Q L F V F Y D H - - - S R R V E P R T - - - - - P W S S - - - - - - Q M W - - Q L Q S L K G W D H M - F T V D F W T I M E N H N H - S K E S H T L Q V I L G C E M Q D N - - S T E G Y W K Y G Y D G Q D H L E F C P D T L D W R A A E - - - - P R A W P T K L E W E R H K - I R A R Q N R A Y L E R D C P A Q L Q Q L L E L G - G V L D -
- - G S H S M R Y F H T S V S R P G R G E P R F I T V G Y V D D T L F V R F D S D A A S P R E E P R A - - - - - P W I E Q E - G P - E Y W D R E T Q I C K A K A Q T - D R E D L R T L L R Y Y N Q S E A G S H T L Q N M Y G C D V G P D G R L L R G Y H Q H A Y D G K D Y I A L N E D L S S W T A A D - - - - T A A Q I T Q R K W E A - A - R V A E Q L R A Y L E G E C V E W L R R Y L E N G K E T L Q R
- - D A H S L W Y N F T I I H L P R H G Q Q W C E V Q S Q V D Q K N F L S Y D C G S D - - K V L S M G - - - - - H L - E E Q L Y A T D A W G K Q L E M L R E V G Q R - L R L E L A D T E P - - - - - - - - - L T L Q V R M S C E C E A D G - Y I R G S W Q F S F D G R K F L L F D S N N R K W T V V - - - - H A G A R R M K E K W E K D S - G L T T F F K M V S M R D C K S W L R D F L M H R K K R L E -
- - G L Q R L H M L Q I S Y F R D P - Y H V W Y Q G N A S L G G H L T H V L E G P D T N T T I I Q L Q - - - - - P - L Q - - - E P - E S W A R T Q S G L Q S Y L L Q - F H G L V R L V H Q E R T L A - - F P L T I R C F L G C E L P P E G S R A H V F F E V A V N G S S F V S F R P E R A L W Q A D T Q V T S G V V T F T L Q Q L N A Y N - R T R Y E L R E F L E D T C V Q Y V Q K H S - - - - - - - - -
- D G R Y S L T Y I Y T G L S K H V E D V P A F Q A L G S L N D L Q F F R Y N S K - - D R K S Q P M G - - - - - L W R Q V E - G M - E D W K Q D S Q L Q K A R E D I - F M E T L K D I V E Y Y K D - S T G S H V L Q G R F G C E I E N N - R S S G A F W K Y Y Y D G K D Y I E F N K E I P A W V P F D - - - - P A A Q I T K Q K W E A E P - V Y V Q R A K A Y L E E E C P A T L R K Y L K Y S K N I L D R
- - - E S G L R Y A Y T L V V D G T A N T R R C F G T G H V D G E A F V G Y S N - - - - N K T H G I G - - - - - R W V N - - - - - A S H V E E E N K E F V R Q C K E - L Q A E L D K M Q N N S K V I - - G V K T V Q L D V G C T S - - - - - - - K I E K H Y A Y D G N E T E - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - C Q K K L T E Y R K L V L A S A - V
S P E D F V F Q F K G M C Y F T N G T E R V R L V T R Y I Y N R E E Y A R F D S D - - V G V Y R A V T - - - - - P Q G R P D A E Y W N S Q K E V L E G T R A E L D T V C R H N Y E V A F R G I L Q R R - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
L Q - N H T F L H T V Y C Q D G - - - - S P S V G L S E A Y D E D Q L F F F D F S - - Q N T R V P R L - - - - - P E F A D W A Q E Q G - - - - D A P A I L F D K E F - C E W M I Q Q I G P K L D G K I P - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - V
- - - - F V A H V E S T C L L D D A G T P K D F T Y C I S F N K D L L T C W D P E - - E N K M A P C E F G V L N S L A N V L S Q H L N Q K D T L M Q R L R N G L Q N - C A T H T Q P F W G S L T N R - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- M E P H S L R Y N L M V L S Q D S V - Q S G F L A E G H L D G Q P F L R Y D R Q K R - - R A K P Q G - - - - - Q W A E D V L G A - E T W D T E T E D L T E N G Q D - L R R T L T H I K D Q - - - - K G G L H S L Q E I R V C E I H E D S - S T R G S R H F Y Y N G E L F L S Q N L E T Q E S T V P Q - - - S S R A Q T L A N V T N F W K E K T K T H Y R A M Q - A D C L Q K L Q R Y L K S G - - - - - -
P E E S Q F F Q L F Y T L L L G N V - S S T L - T G M A L L A D V P I M V L D - - P H T W N L N I C R - - - - - P W V Q I T A E V - K I L S F S M V G I R N T I R F - M H - E M T A A - - - - G L D - - Y P R V F Q I H T G C K L Y T N G - T R W S F V N I G E G G R D L V T Y E L S - E R W V P Q R S - - T L L A K V M S N T L T D L R - A V S G F L - H I F S S S F P N Y I L M L H E E G R T D L E R
- - - N Y T F R C L Q M S S F A N S - - W S R T D S V V W L G D L Q T H R W S - - N D S A T I S F T K - - - - - P W S Q G K L S N - Q Q W E K L Q H M F Q V Y R V S - F T R D I Q E L V M - - M E D - - Y P I E I Q L S A G C M Y - - - - - A S - S F L H V A F Q G K Y V V R F W - - G T S W Q T V P G A P - S W L D L P I K V L N A D Q - G T S A T V Q M L L N D T C P L F V R G L L E A G K S D L E K
- - - S H M L K L L H F A T F Q N S - T S V L V G G L G L L G D V K M G S L D - - S R T G N I - Y Y R - - - - - P W L R P S L P K - G D W D V I E S S I K S Y V R D - F S - L V Q M Y - - - - T V P - - Y P F V F Q S S I G C E L Q S N G - T I R T F F D I A Y E G Q N F L R F N L D A G T W D Q M Q H - - - N L S A K A E H L M A N A S - T L N E V I Q V L L N D T C V D I L R L F I Q A G K A D L E R
I K A D H V S T Y A A F V Q T H - - - - R P T G E F M F E F D E D E M F Y V D L D - - K K E T V W H L - - - - - E E F G Q A - - F S F - - - - E A Q G G L A N I A I - L N N N L N T L I Q R S N H T Q A - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - T
- - - - - S L R C N L T I K D P T P A D P L W Y E A K C F V G E - L I L H L S N I A T - - - - - - - - - - - - - - - - - - - - - - - - - E V C L T Q P L K N L C Q K - L R N K V S - - - - - - - - - - - N T P H L Q V T M I Y P Q S Q - - G T P S A T W E F N I S D S Y F F T F Y T E N M S W R S A N - - - - D E S G V I M N K W K D D G - E F V K Q L - F L I H - E C S Q K M D E F L - - - - - - - - -
F Q G P T S F H V I Q T S S F T N S - - T W A T Q G S G W L D D L Q I H G W D - - S D S G T A I F L K - - - - - P W S K G N F S D - K E V A E L E E I F R V Y I F G - F A R E V Q D F A G D F Q M K - - Y P F E I Q G I A G C E L H S G G - A I V S F L R G A L G G L D F L S V K - - N A S C V P S P E G G - S R A Q K F C A L I I Q Y - - G I M E T V R I L L Y E T C P R Y L L G V L N A G K A D L Q R
- - - T H T L R Y N V R A H S L G S E - K T Q L L V L I Y V D E E L F L K Y N G D S R E T E P L G C W - - - - - K G G G N E T C A - R E T N N L L K V E E K L R G M - M A E V I N Q K S - Q - - - - E E G L H T L Q A T L G C E L L S N G - S T R G F W H L G Y D G Q N F L T F D Q K T L T W T V D G - - - P S T - Q Q N K M F W K T H A P - R A D L V K T F L D D I C P A H L Q R Y L A S L N G - - - -
- - - - L S L L Y H L T A V S S P A P G T P A F W V S G W L G P Q Q Y L S Y N S L - - - G E A E P C G - - - - - A W V W E N - Q - - V Y W - E E T T D L R I K E - L - F L E A F K A L G - - - - - - - G G P Y T L Q G L L G C L G P D N - - T S V P T A K F A L N G E E F M N F D - - L G T W G G D W - - - - P E A L A I S Q R W Q Q - - - Q A A N K E L T F L L - S C P H R L R E H L - R G R G N L E W

 

 

 

 

 

Member Chain UniProtKB GO term
d1lqva_ A Q9UNN8 GO:0038023
d1lqva_ A P04070 GO:0038023
d1t7va2 A P25311 GO:0001580
d1t7va2 A P25311 GO:0004540
d1t7va2 A P25311 GO:0005515
d1t7va2 A P25311 GO:0005576
d1t7va2 A P25311 GO:0005615
d1t7va2 A P25311 GO:0005634
d1t7va2 A P25311 GO:0006955
d1t7va2 A P25311 GO:0007155
d1t7va2 A P25311 GO:0008285
d1t7va2 A P25311 GO:0008320
d1t7va2 A P25311 GO:0009897
d1t7va2 A P25311 GO:0062023
d1t7va2 A P25311 GO:0070062
d1t7va2 A P25311 GO:0071806
d1uvqb2 B E9PMV2 GO:0006955
d1uvqb2 B E9PMV2 GO:0016020
d1uvqb2 B E9PMV2 GO:0019882
d1uvqb2 B E9PMV2 GO:0042613
d1uvqb2 B P01920 GO:0006955
d1uvqb2 B P01920 GO:0016020
d1uvqb2 B P01920 GO:0019882
d1uvqb2 B P01920 GO:0042613
d1uvqb2 B O43612 GO:0006955
d1uvqb2 B O43612 GO:0016020
d1uvqb2 B O43612 GO:0019882
d1uvqb2 B O43612 GO:0042613
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in