Superfamily : 54277 [ CAD & PB1 domains ]
Class : Alpha and beta proteins (a+b)
Fold : beta-Grasp (ubiquitin-like)
# of Members : 14
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1c9fa-  (   1 )                               mcavlrqpkcvklrAlhsackfg
d1d4ba1  (   1 )    meylsalnpsdllrsvsnissefgrrvwtsapppqrpfrvcdhkrtirkg
d1f2ri-  (   1 )                     melsrgasapdpddvrplkpCllrrnhsrdqhg
d1ip9a1  (   6 )                                stsglkttkikFyykd--difa
d1oeya1  ( 352 )                                       ytlkVhyk---ytvv
d1oeyj-  ( 235 )                                   htnwLrVyyYedtistikd
d1pqsa-  ( 778 )                                                 seift
d1wmha-  (  16 )                                      qVrVkAyyr-g-dimi
d1wmhb-  (  15 )                                      iveVkSkfd-a-efrr
d2bkfa1  (   1 )                                   mepqVtLnVtfk-n-eiqs
d2c60a1  (  43 )                                     sdVrIkFehng---rri
d2npta1  (   5 )                              algpfpamvlvIrIkip-nsgavd
d4d2ka1  (   7 )                                  r--gkrpLkIwdswrnvrkg
d4maca-  (  38 )                                  etprarpCrVStadrkvrkg
                                                       bbbbbb      bbb

                             60        70        80        90        100 
d1c9fa-  (  24 )    vaar-------scqellrkGcvrfqlpmp------gSrlclye---dGte
d1d4ba1  (  51 )    ltaa-------trqellakAletlllngv-------ltlvlee---dgta
d1f2ri-  (  34 )    vaAs-------sleelrskAcellaid----ksltpitlvlae---dGti
d1ip9a1  (  26 )    lmlkg----dttykelrskiapridtd------nF-klqtklfd-gsgee
d1oeya1  ( 365 )    ktq-----pglpysqVr-dVskkLelr----lehT-kLsYrprdsnelvp
d1oeyj-  ( 255 )    IaveedlsstpllkdLlelTrrefqr------edI-aLNyrdae-gdLvr
d1pqsa-  ( 783 )    llvek----vWnfddlimainskisnthnnnisPitkikYqded-gdfvv
d1wmha-  (  30 )    thFp-----sisfegLcneVrdmCsFd----nqlF-tMkwidee-gdpct
d1wmhb-  (  29 )    falp--rasvsgfqeFSrlLravHqip----gldV-lLgYtdah-gdllp
d2bkfa1  (  18 )    flvs--dPenttWadIeamVkvsFdLn------tI-qIkyldee-neevs
d2c60a1  (  58 )    iafsr----pV-yedVehkVttvfgq-------pL-dLhynne---lsil
d2npta1  (  31 )    wtvl-------lfrdVldvIgqvlp------eatTtAFeyeded-gdrit
d4d2ka1  (  25 )    VvVg-------tfeeLlvrGkdkLgVp----as-epVrVVlec---dgtq
d4maca-  (  58 )    ImAh-------sledLlnkVqdiLklk----d--kPfsLVlee---dGti
                    bbb         aaaaaaaaaaa              bbbb       bb

                             110       120       130       140       150 
d1c9fa-  (  58 )    vtddcFp-glp---------------ndAelllltagetwhgyvsd    
d1d4ba1  (  84 )    vdsedFfqlle---------------ddtclMvlqsgqswsp----trsg
d1f2ri-  (  70 )    vddddyFlclp---------------sntkFvAlAc------nekwtynd
d1ip9a1  (  64 )    iktdsqvsniiq--------------aklkiSvhdi              
d1oeya1  ( 405 )    l-seds-kdAwgqvk----------nycLtLwCen               
d1oeyj-  ( 297 )    LlsdedVal-vrqar---glpsqkrlFpwkLhITqk------dny-rVyn
d1pqsa-  ( 828 )    lgsdedWnvAkemlaenn---------ekflnirly              
d1wmha-  (  71 )    VssqleLeeAFrlyelnkd-------seLlIhVfp               
d1wmhb-  (  71 )    LtnddsLhrALasg----p-------pplrLlVqkr              
d2bkfa1  (  58 )    InsqgeYeeALkMAvkqg--------nqLqMqVheg              
d2c60a1  (  94 )    LknqddLdAidildrss--------sksLrIlLls               
d2npta1  (  72 )    VrsdeeMkaMlsyyystVmqqvngqieplqIfPra               
d4d2ka1  (  60 )    IedgeyFrtla---------------nntvLLLLrq------gerw    
d4maca-  (  92 )    VeteeyFqala---------------kdtmFMVllk------gqkwkpp 
                        aaaa                     bbbbb                

                      
d1c9fa-               
d1d4ba1  ( 115 )    vl
d1f2ri-  (  99 )    sd
d1ip9a1               
d1oeya1               
d1oeyj-  ( 337 )    tp
d1pqsa-               
d1wmha-               
d1wmhb-               
d2bkfa1               
d2c60a1               
d2npta1               
d4d2ka1               
d4maca-
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Caspase-activated DNase (CAD), DFF40, N-terminal domainCAD domainMouse (Mus musculus) [TaxId: 10090]view
Cell death-inducing effector B (CIDE-B), N-terminal domainCAD domainHuman (Homo sapiens) [TaxId: 9606]view
Inhibitor of caspase-activated DNase (ICAD), DFF45, N-terminal domainCAD domainMouse (Mus musculus) [TaxId: 10090]view
Bud emergence mediator Bemp1PB1 domainBaker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]view
Neutrophil cytosol factor 2 (p67phox component of NADPH oxidase)PB1 domainHuman (Homo sapiens) [TaxId: 9606]view
Neutrophil cytosol factor 4 (p40phox component of NADPH oxidase)PB1 domainHuman (Homo sapiens) [TaxId: 9606]view
Cell division control protein 24, CDC24, C-terminal domainPB1 domainBaker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]view
Protein kinase C, iota typePB1 domainHuman (Homo sapiens) [TaxId: 9606]view
Partitioning defective-6 homolog alpha, PAR-6 alphaPB1 domainHuman (Homo sapiens) [TaxId: 9606]view
Next to BRCA1 gene 1 protein, NBR1 (KIAA0049)PB1 domainHuman (Homo sapiens) [TaxId: 9606]view
Mitogen-activated protein kinase kinase kinase 3, MEKK 3PB1 domainHuman (Homo sapiens) [TaxId: 9606]view
Mitogen activated protein kinase kinase 5, Map2k5PB1 domainHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesFruit fly (Drosophila melanogaster) [TaxId: 7227]view
automated matchesautomated matchesMouse (Mus musculus) [TaxId: 10090]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150
- - - - - - - - - - - - - - - - - - - - - - - - - - - M C A V L R Q P K C V K L R A L H S A C K F G V A A R - - - - - - - S C Q E L L R K G C V R F Q L P M P - - - - - - G S R L C L Y E - - - D G T E V T D D C F P - G L P - - - - - - - - - - - - - - - N D A E L L L L T A G E T W H G Y V S D - - - - - -
M E Y L S A L N P S D L L R S V S N I S S E F G R R V W T S A P P P Q R P F R V C D H K R T I R K G L T A A - - - - - - - T R Q E L L A K A L E T L L L N G V - - - - - - - L T L V L E E - - - D G T A V D S E D F F Q L L E - - - - - - - - - - - - - - - D D T C L M V L Q S G Q S W S P - - - - T R S G V L
- - - - - - - - - - - - - - - - - M E L S R G A S A P D P D D V R P L K P C L L R R N H S R D Q H G V A A S - - - - - - - S L E E L R S K A C E L L A I D - - - - K S L T P I T L V L A E - - - D G T I V D D D D Y F L C L P - - - - - - - - - - - - - - - S N T K F V A L A C - - - - - - N E K W T Y N D S D
- - - - - - - - - - - - - - - - - - - - - - - - - - - - S T S G L K T T K I K F Y Y K D - - D I F A L M L K G - - - - D T T Y K E L R S K I A P R I D T D - - - - - - N F - K L Q T K L F D - G S G E E I K T D S Q V S N I I Q - - - - - - - - - - - - - - A K L K I S V H D I - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Y T L K V H Y K - - - Y T V V K T Q - - - - - P G L P Y S Q V R - D V S K K L E L R - - - - L E H T - K L S Y R P R D S N E L V P L - S E D S - K D A W G Q V K - - - - - - - - - - N Y C L T L W C E N - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - H T N W L R V Y Y Y E D T I S T I K D I A V E E D L S S T P L L K D L L E L T R R E F Q R - - - - - - E D I - A L N Y R D A E - G D L V R L L S D E D V A L - V R Q A R - - - G L P S Q K R L F P W K L H I T Q K - - - - - - D N Y - R V Y N T P
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - S E I F T L L V E K - - - - V W N F D D L I M A I N S K I S N T H N N N I S P I T K I K Y Q D E D - G D F V V L G S D E D W N V A K E M L A E N N - - - - - - - - - E K F L N I R L Y - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Q V R V K A Y Y R - G - D I M I T H F P - - - - - S I S F E G L C N E V R D M C S F D - - - - N Q L F - T M K W I D E E - G D P C T V S S Q L E L E E A F R L Y E L N K D - - - - - - - S E L L I H V F P - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - I V E V K S K F D - A - E F R R F A L P - - R A S V S G F Q E F S R L L R A V H Q I P - - - - G L D V - L L G Y T D A H - G D L L P L T N D D S L H R A L A S G - - - - P - - - - - - - P P L R L L V Q K R - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M E P Q V T L N V T F K - N - E I Q S F L V S - - D P E N T T W A D I E A M V K V S F D L N - - - - - - T I - Q I K Y L D E E - N E E V S I N S Q G E Y E E A L K M A V K Q G - - - - - - - - N Q L Q M Q V H E G - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - S D V R I K F E H N G - - - R R I I A F S R - - - - P V - Y E D V E H K V T T V F G Q - - - - - - - P L - D L H Y N N E - - - L S I L L K N Q D D L D A I D I L D R S S - - - - - - - - S K S L R I L L L S - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - A L G P F P A M V L V I R I K I P - N S G A V D W T V L - - - - - - - L F R D V L D V I G Q V L P - - - - - - E A T T T A F E Y E D E D - G D R I T V R S D E E M K A M L S Y Y Y S T V M Q Q V N G Q I E P L Q I F P R A - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - R - - G K R P L K I W D S W R N V R K G V V V G - - - - - - - T F E E L L V R G K D K L G V P - - - - A S - E P V R V V L E C - - - D G T Q I E D G E Y F R T L A - - - - - - - - - - - - - - - N N T V L L L L R Q - - - - - - G E R W - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - E T P R A R P C R V S T A D R K V R K G I M A H - - - - - - - S L E D L L N K V Q D I L K L K - - - - D - - K P F S L V L E E - - - D G T I V E T E E Y F Q A L A - - - - - - - - - - - - - - - K D T M F M V L L K - - - - - - G Q K W K P P - - -

 

 

 

 

 

Member Chain UniProtKB GO term
d1c9fa_ A O54788 GO:0004520
d1c9fa_ A O54788 GO:0006309
d1c9fa_ A O54788 GO:0006915
d1f2ri_ I O54788 GO:0006915
d1f2ri_ I O54786 GO:0006915
d1oeyj_ J P19878 GO:0006909
d1oeyj_ J P19878 GO:0016176
d1oeyj_ J P19878 GO:0043020
d1oeyj_ J P19878 GO:0045730
d1oeyj_ J Q15080 GO:0006909
d1oeyj_ J Q15080 GO:0016176
d1oeyj_ J Q15080 GO:0043020
d1oeyj_ J Q15080 GO:0045730
d1oeyj_ J P19878 GO:0006909
d1oeyj_ J P19878 GO:0016176
d1oeyj_ J P19878 GO:0043020
d1oeyj_ J P19878 GO:0045730
d1oeyj_ J Q15080 GO:0006909
d1oeyj_ J Q15080 GO:0016176
d1oeyj_ J Q15080 GO:0043020
d1oeyj_ J Q15080 GO:0045730
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in