Superfamily : 52972 [ ITPase-like ]
Class : Alpha and beta proteins (a/b)
Fold : Anticodon-binding domain-like
# of Members : 9
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1ex2a-  (   1 )         mtkplILAsqsprrkeLLdllq-----l-pysiivs---eveekl
d1k7ka1  (   2 )           qkVVlAtgnvgkvreLaslLd--fgl-dIvaqtdlgVdsaeet
d1u14a1  (   2 )           hqVISAttnpakiqAIlqAFeeifgegsChItpv---aveSgv
d1v7ra-  (   1 )           mkIfFItsnpgkvrEVanfLgt-fgI-eIvqlk---heypeiq
d1vp2a-  (   3 )          kltVyLAttnphkv-eIkmIap--w-M-eIlpsp-----ivved
d2amha1  (   7 )        eeirtMiIGTssafrAnVLrehFgdr-Fr-nfvllpp---dideka
d2cara1  (   1 )    maasLvgkkIVFvtgnakkleeVvqiLgdkFPC-tLvaqk---idLpeyq
d4jhca-  (   2 )           pkLILAstspwrralLeklq-----i-sFecaap----vdetp
d4oo0a-  (   8 )     aptplfqtLYLAs-sprrqeLLqqig-----V--felllprpdedaala
                             bbb    aaaaaaaa            bb            

                             60        70        80        90        100 
d1ex2a-  (  37 )    nrnfspeenVqwlAkqkAkaVadlhp-----hAiVIGAdtmvÇLd---ge
d1k7ka1  (  43 )    gl------tfieNAilkArhAAkvta------lpAIAddsgLaVdvlgga
d1u14a1  (  42 )    peqpfgseeTraGArnrVdnArrlhp-----qAdfWVAIEaGIdd-----
d1v7ra-  (  39 )    ae------kLedVVdfGIswLkgkVp------epFMIEdsGLfIeslkgf
d1vp2a-  (  42 )    ge------tfleNSvkkAvvyGk-lk------hpVMADdSgLvIyslggf
d2amha1  (  48 )    yraadpfelTesIArakMkaVlekarqh---paIALTFDqVVVkg---de
d2cara1  (  47 )    g-------epdeISiqkCqeAvrqvq------gpVLVedtCLCFnalggl
d4jhca-  (  36 )    r-desprqLVlrLAqekAqsLasryp-----dhlIIGSDqvCvLd---ge
d4oo0a-  (  56 )    lpgeaadayVrrVTvakAeaArarLvasgkpaaPVLVAdtTVTId---ga
                             aaaaaaaaaaaaa            bbbbbbbbbb      

                             110       120       130       140       150 
d1ex2a-  (  79 )    çLg-----kPq----dqeeAasMLrrLSg-----rsHsVITAVSIqA-en
d1k7ka1  (  81 )    P-giysarysgedatdqkNLqkLletk-dvpddqrqArfhCVLVyLrhae
d1u14a1  (  82 )    ------------------------------------datFSwVVIdngv-
d1v7ra-  (  77 )    P-gvyssyvyr-----tiglegIlklMega--edrrAyfkSVIGFyidg-
d1vp2a-  (  80 )    P-gvmsa-fm-eehsy-eKMrtIlkmLegkd---rrAAfVCSATFfdPve
d2amha1  (  98 )    vre-----kPl----steqCrsfIasYsg-----ggVrTVATYALCvvgt
d2cara1  (  84 )    PG-pyIkwfle-----klkpegLhqlLagf--edksAyALCTFALStGdp
d4jhca-  (  78 )    itg-----kPl----teenArlqLrkAsG-----niVtfyTGLALfnSan
d4oo0a-  ( 103 )    iLg-----kPt----daddAlamLtrLag-----reHaVlTAVAVIdasg
                                    a aaaaaaa          bbbbbbbbbbb    

                             160       170       180       190       200 
d1ex2a-  ( 114 )    --hsetfydkTeVaFwsLseeeIwtYIetkePmdkaGAYgIq----g-rG
d1k7ka1  ( 130 )    DptplvChGsWpGvItr----epagt----ggfgYDpIFfVp---segkT
d1u14a1  (  95 )    ---qrGearSatlpLp---avIldrVrqgealgpVsqytgideigrkeGa
d1v7ra-  ( 118 )    --kaykfsgvtwgrIsn----ekrgt----hgfgYDpIFIPe---gsekT
d1vp2a-  ( 125 )    -ntlisvedrVeGrIAn----eirgt----ggfgYDpFFiPd---gydkT
d2amha1  ( 134 )    e-nvlvahneTeTfFskFgddiVerTlergaCmnsaGGLVVe----deDM
d2cara1  ( 126 )    sqpVrLFrgrTsGrIv-----aprgc----qdfgwdPCFqPd---gyeqT
d4jhca-  ( 114 )    g-hlqtevEpFdVhFrhLseaeIdnYVrkehPlhcaGSFks-----g-fG
d4oo0a-  ( 139 )    e-llppaLSrSsVrFaaasrdaYvrYvetgePfgkaGAYaIq----g-rA
                        bbbbbbbbbbb                                   

                             210       220       230      
d1ex2a-  ( 157 )    alFvkkidg----dyySVMGLPiskTmralrhF     
d1k7ka1  ( 169 )    AAeL----t-eeksaiShrgqAl-lLldalrn-g    
d1u14a1  ( 140 )    iGvft----agkltrssvYyqAVilALspFhna     
d1v7ra-  ( 155 )    FAeM----tieeKNalSHRGkALkaFfewLkvnlky  
d1vp2a-  ( 163 )    FGei----p-hlKekiSHRSkAFrkLFsvLekil    
d2amha1  ( 179 )    srhvvrivg----tsyGVrgMepavVekLLsql     
d2cara1  ( 164 )    YAeM----pkaeknavShrfrALleLqeyFgs-laa  
d4jhca-  ( 158 )    itLFerlegr---DpnTLvgLPLiALcqMLrregnplm
d4oo0a-  ( 183 )    aeFIeridg----shsGIMGLPlfeTaalLrtArVaf 
                                  aa aa   aaaaaaaa
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Maf proteinMaf-likeBacillus subtilis [TaxId: 1423]view
Hypothetical protein YggVITPase (Ham1)Escherichia coli [TaxId: 562]view
Hypothetical protein YjjXYjjX-likeSalmonella typhimurium [TaxId: 90371]view
XTP pyrophosphataseITPase (Ham1)Pyrococcus horikoshii [TaxId: 53953]view
Putative inosine/xanthosine triphosphate pyrophosphatase TM0159ITPase (Ham1)Thermotoga maritima [TaxId: 2336]view
Maf homologue Tb11.01.5890Maf-likeTrypanosome (Trypanosoma brucei) [TaxId: 5691]view
Inosine triphosphate pyrophosphatase, ITPaseITPase (Ham1)Human (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesEscherichia coli K-12 [TaxId: 83333]view
automated matchesautomated matchesBurkholderia cenocepacia [TaxId: 216591]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230
- - - - - M T K P L I L A S Q S P R R K E L L D L L Q - - - - - L - P Y S I I V S - - - E V E E K L N R N F S P E E N V Q W L A K Q K A K A V A D L H P - - - - - H A I V I G A D T M V C L D - - - G E C L G - - - - - K P Q - - - - D Q E E A A S M L R R L S G - - - - - R S H S V I T A V S I Q A - E N - - H S E T F Y D K T E V A F W S L S E E E I W T Y I E T K E P M D K A G A Y G I Q - - - - G - R G A L F V K K I D G - - - - D Y Y S V M G L P I S K T M R A L R H F - - - - -
- - - - - - - Q K V V L A T G N V G K V R E L A S L L D - - F G L - D I V A Q T D L G V D S A E E T G L - - - - - - T F I E N A I L K A R H A A K V T A - - - - - - L P A I A D D S G L A V D V L G G A P - G I Y S A R Y S G E D A T D Q K N L Q K L L E T K - D V P D D Q R Q A R F H C V L V Y L R H A E D P T P L V C H G S W P G V I T R - - - - E P A G T - - - - G G F G Y D P I F F V P - - - S E G K T A A E L - - - - T - E E K S A I S H R G Q A L - L L L D A L R N - G - - - -
- - - - - - - H Q V I S A T T N P A K I Q A I L Q A F E E I F G E G S C H I T P V - - - A V E S G V P E Q P F G S E E T R A G A R N R V D N A R R L H P - - - - - Q A D F W V A I E A G I D D - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - D A T F S W V V I D N G V - - - - Q R G E A R S A T L P L P - - - A V I L D R V R Q G E A L G P V S Q Y T G I D E I G R K E G A I G V F T - - - - A G K L T R S S V Y Y Q A V I L A L S P F H N A - - - - -
- - - - - - - M K I F F I T S N P G K V R E V A N F L G T - F G I - E I V Q L K - - - H E Y P E I Q A E - - - - - - K L E D V V D F G I S W L K G K V P - - - - - - E P F M I E D S G L F I E S L K G F P - G V Y S S Y V Y R - - - - - T I G L E G I L K L M E G A - - E D R R A Y F K S V I G F Y I D G - - - K A Y K F S G V T W G R I S N - - - - E K R G T - - - - H G F G Y D P I F I P E - - - G S E K T F A E M - - - - T I E E K N A L S H R G K A L K A F F E W L K V N L K Y - -
- - - - - - K L T V Y L A T T N P H K V - E I K M I A P - - W - M - E I L P S P - - - - - I V V E D G E - - - - - - T F L E N S V K K A V V Y G K - L K - - - - - - H P V M A D D S G L V I Y S L G G F P - G V M S A - F M - E E H S Y - E K M R T I L K M L E G K D - - - R R A A F V C S A T F F D P V E - N T L I S V E D R V E G R I A N - - - - E I R G T - - - - G G F G Y D P F F I P D - - - G Y D K T F G E I - - - - P - H L K E K I S H R S K A F R K L F S V L E K I L - - - -
- - - - E E I R T M I I G T S S A F R A N V L R E H F G D R - F R - N F V L L P P - - - D I D E K A Y R A A D P F E L T E S I A R A K M K A V L E K A R Q H - - - P A I A L T F D Q V V V K G - - - D E V R E - - - - - K P L - - - - S T E Q C R S F I A S Y S G - - - - - G G V R T V A T Y A L C V V G T E - N V L V A H N E T E T F F S K F G D D I V E R T L E R G A C M N S A G G L V V E - - - - D E D M S R H V V R I V G - - - - T S Y G V R G M E P A V V E K L L S Q L - - - - -
M A A S L V G K K I V F V T G N A K K L E E V V Q I L G D K F P C - T L V A Q K - - - I D L P E Y Q G - - - - - - - E P D E I S I Q K C Q E A V R Q V Q - - - - - - G P V L V E D T C L C F N A L G G L P G - P Y I K W F L E - - - - - K L K P E G L H Q L L A G F - - E D K S A Y A L C T F A L S T G D P S Q P V R L F R G R T S G R I V - - - - - A P R G C - - - - Q D F G W D P C F Q P D - - - G Y E Q T Y A E M - - - - P K A E K N A V S H R F R A L L E L Q E Y F G S - L A A - -
- - - - - - - P K L I L A S T S P W R R A L L E K L Q - - - - - I - S F E C A A P - - - - V D E T P R - D E S P R Q L V L R L A Q E K A Q S L A S R Y P - - - - - D H L I I G S D Q V C V L D - - - G E I T G - - - - - K P L - - - - T E E N A R L Q L R K A S G - - - - - N I V T F Y T G L A L F N S A N G - H L Q T E V E P F D V H F R H L S E A E I D N Y V R K E H P L H C A G S F K S - - - - - G - F G I T L F E R L E G R - - - D P N T L V G L P L I A L C Q M L R R E G N P L M
- A P T P L F Q T L Y L A S - S P R R Q E L L Q Q I G - - - - - V - - F E L L L P R P D E D A A L A L P G E A A D A Y V R R V T V A K A E A A R A R L V A S G K P A A P V L V A D T T V T I D - - - G A I L G - - - - - K P T - - - - D A D D A L A M L T R L A G - - - - - R E H A V L T A V A V I D A S G E - L L P P A L S R S S V R F A A A S R D A Y V R Y V E T G E P F G K A G A Y A I Q - - - - G - R A A E F I E R I D G - - - - S H S G I M G L P L F E T A A L L R T A R V A F -

 

 

 

 

 

Member Chain UniProtKB GO term
d1ex2a_ A Q02169 GO:0005737
d1ex2a_ A Q02169 GO:0009117
d1ex2a_ A Q02169 GO:0016462
d1ex2a_ A Q02169 GO:0016787
d1ex2a_ A Q02169 GO:0036218
d1ex2a_ A Q02169 GO:0036221
d1ex2a_ A Q02169 GO:0047429
d1v7ra_ A O59580 GO:0000166
d1v7ra_ A O59580 GO:0005737
d1v7ra_ A O59580 GO:0009117
d1v7ra_ A O59580 GO:0009143
d1v7ra_ A O59580 GO:0009146
d1v7ra_ A O59580 GO:0016787
d1v7ra_ A O59580 GO:0017111
d1v7ra_ A O59580 GO:0035870
d1v7ra_ A O59580 GO:0036220
d1v7ra_ A O59580 GO:0036222
d1v7ra_ A O59580 GO:0046872
d1v7ra_ A O59580 GO:0047429
d1vp2a_ A Q9WY06 GO:0000166
d1vp2a_ A Q9WY06 GO:0005737
d1vp2a_ A Q9WY06 GO:0005829
d1vp2a_ A Q9WY06 GO:0009117
d1vp2a_ A Q9WY06 GO:0009143
d1vp2a_ A Q9WY06 GO:0009146
d1vp2a_ A Q9WY06 GO:0016787
d1vp2a_ A Q9WY06 GO:0017111
d1vp2a_ A Q9WY06 GO:0035870
d1vp2a_ A Q9WY06 GO:0036220
d1vp2a_ A Q9WY06 GO:0036222
d1vp2a_ A Q9WY06 GO:0046872
d1vp2a_ A Q9WY06 GO:0047429
d2cara1 A Q9BY32 GO:0000166
d2cara1 A Q9BY32 GO:0005654
d2cara1 A Q9BY32 GO:0005737
d2cara1 A Q9BY32 GO:0005829
d2cara1 A Q9BY32 GO:0006193
d2cara1 A Q9BY32 GO:0009117
d2cara1 A Q9BY32 GO:0009143
d2cara1 A Q9BY32 GO:0009204
d2cara1 A Q9BY32 GO:0016787
d2cara1 A Q9BY32 GO:0035870
d2cara1 A Q9BY32 GO:0036220
d2cara1 A Q9BY32 GO:0036222
d2cara1 A Q9BY32 GO:0042802
d2cara1 A Q9BY32 GO:0043231
d2cara1 A Q9BY32 GO:0046872
d2cara1 A Q9BY32 GO:0047429
d2cara1 A Q9BY32 GO:0051276
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in