Superfamily : 52141 [ Uracil-DNA glycosylase-like ]
Class : Alpha and beta proteins (a/b)
Fold : Uracil-DNA glycosylase-like
# of Members : 8
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1muga-  (   1 )                                                      
d1oe4a-  (  36 )               esPAdsFLkvEleLnlkLsnlvFqdpVqyvYnPLvYAwa
d1vk2a-  (   2 )                    ytreeleivserVkct------------acpLhl
d1wywa-  ( 117 )                                                    ae
d2c53a-  (  18 )    dWttfrvFlIddaWrpLMepElanplTahLlaeYnrrcq--teeVlPpre
d2hxma2  (  85 )             fgesWkkhLsgefgkpyfikLmgfvaeerk--hytVyPpph
d2q07a2  ( 244 )                                                      
d4wpka1  (   1 )     MarplselVergWaaaLepva--dqVahMgqfLraeia-agrrylPags
                                                                      

                             60        70        80        90        100 
d1muga-  (   1 )        mVedILapgLrVVFCgiNPgls-sagtgfpfAhp------------
d1oe4a-  (  75 )    PHenYVqtYCkskKeVLFLGmNPgpfGMAQTGVPfGEvnhVrdWLqIegp
d1vk2a-  (  26 )    nrtnVVvGegnldTrIVFVGeGPgee-ed-tgrPFvgr------------
d1wywa-  ( 119 )    lltktLpdiLtfnLdIVIIgiNPglm-aAykghHyPgp------------
d2c53a-  (  67 )    dVFSWTryCtPdeVrVVIIgqnPyhhpgqAhgLAfSVa------------
d2hxma2  ( 124 )    qvftWTqmcdIkdVkVVILgqdPyhgpnqAHgLCfSVqr-----------
d2q07a2  ( 244 )                                                      
d4wpka1  (  48 )    nVLrAFt-fpfdnVrVLIVGqDPyptpghAvgLSfSVap-----------
                                   bbbbb                              

                             110       120       130       140       150 
d1muga-  (  34 )    ------------------------anrFWkVIyqAg-FTdrqLk------
d1oe4a-  ( 125 )    VskpevehpkrrIrGfeCpqsevsGarFWsLFkslC-g------------
d1vk2a-  (  63 )    ------------------------aGlLteLLresg------ir------
d1wywa-  ( 156 )    ------------------------gnhFWkCLfmSg-LSevqln------
d2c53a-  ( 106 )    ----------------nv-ppppsLrnVlaAVknCyp-------------
d2hxma2  ( 163 )    ----------------pv-ppppsLenIYkELstDie------------d
d2q07a2  ( 244 )                            ryfFerAlecYkpfsdTVLLLpctar
d4wpka1  (  86 )    ----------------dvrpwprsLanIFdEYtaDlg-------------
                                               aaaaaaa                

                             160       170       180       190       200 
d1muga-  (  53 )    -----pqeAqhLl-d---yrCGVTkLvdrpt-v------qaneVs----k
d1oe4a-  ( 162 )    -------qPetFFk-----hCFVhNHCPLIFMnhsGknltPtdLpkaqrd
d1vk2a-  (  78 )    --------red---------VyICNVVKcrP-p------nnrtPt----p
d1wywa-  ( 175 )    -----hmdDhtLpgk---ygIGFTnMVerTt-p------gskdls----s
d2c53a-  ( 127 )    -amsghGcLekWA-----dGVLLLnTTLTVkrg----------aaasHs-
d2hxma2  ( 184 )    FvhpghGdLsgWAk----qGVLLLnAVLTVrah----------qansHke
d2q07a2  ( 270 )    kpyltSrtHraLrskVkVnvNEIIIssplVVPrefell--------hwse
d4wpka1  ( 107 )    yplPsnGdLtpWAq----rGVLLLnrVLTVrps----------npasHrg
                                        bbbbb                         

                             210       220       230       240       250 
d1muga-  (  83 )    qeLhaGGrkLiekIedyqPqALAILg-kqAYeqGF----sqr-gaqwgkq
d1oe4a-  ( 200 )    tLLeiCdeaLcqAVrvLgVklVIGVg-rfSeqrArkaLmae---------
d1vk2a-  ( 100 )    eEqaacghFLlaQIeiInPdVIVALg-atALsfFvd---gkvsitvrGnp
d1wywa-  ( 206 )    keFregGriLvqkLqkyqPrIAVFnG-kcIYeiFSkEvfgvkvnLefglQ
d2c53a-  ( 163 )    igWdrFVggVIrrLaar-pglVFMLWgthAqnaIp--dp-----------
d2hxma2  ( 220 )    rgWeqFTdaVvswLnqnsngLVFLLWgsyAqkkGsaIdr-----------
d2q07a2  ( 324 )    eeVsfVagwLkrFIekGgFrkVVAHVtggyrkVVerVed-----------
d4wpka1  ( 143 )    kgWeaVTecAIraLaaraapLVAILWgrdAstLkpmLaa-----------
                      aaaaaaaaaaaaaaa   bbbbb  aaaaaa                 

                             260       270       280       290       300 
d1muga-  ( 127 )    tltIg--sTqIWVLpnPsglsr--v--slekLveaYreLdqaLvv     
d1oe4a-  ( 240 )    -----gidVtVkGImhPsprnpqAnkgWegiVrgqLlel-gVlslLt   
d1vk2a-  ( 148 )    idw-lg-gkkVIPTfhPsyLlrnrsnelrriVleDIekAksfik      
d1wywa-  ( 256 )    phkIpdteTlCYVMPsSsarcaqfp--rAqDKvHyYikLkdlrdqlkgie
d2c53a-  ( 202 )    -------vHcvlkfsnPspls-kvpFgtCqhFlvAnryLet-----sisp
d2hxma2  ( 259 )    ------krHhVlqtahPsplsVyrgFfgcrHFskTnelLqk----sgkkp
d2q07a2  ( 363 )    -----eVeAeVvyTAekdvls--------deSierLkqeIesk-------
d4wpka1  ( 182 )    ------gnCvAIesphPsplsAsrgFfgsrPFsrAnelLvg----mgaep
                             bbbbb                aaaaaaaaaa          

                             310       320     
d1muga-                                        
d1oe4a-                                        
d1vk2a-                                        
d1wywa-  ( 304 )    rnmdvqevqytfdlqlAqedakkmavk
d2c53a-  ( 240 )    IdWsV                      
d2hxma2  ( 299 )    IdWkel                     
d2q07a2  ( 393 )    --------------------------g
d4wpka1  ( 222 )    IdWrLp
 

 

Domain IDNameFamilySourceDomainSTRING-DB
G:T/U mismatch-specific DNA glycosylase, MugMug-likeEscherichia coli [TaxId: 562]view
Single-strand selective monofunctional uracil-DNA glycosylase SMUG1Single-strand selective monofunctional uracil-DNA glycosylase SMUG1African clawed frog (Xenopus laevis) [TaxId: 8355]view
Thermophilic uracil-DNA glycosylaseMug-likeThermotoga maritima [TaxId: 2336]view
G/T mismatch-specific thymine DNA glycosylaseMug-likeHuman (Homo sapiens) [TaxId: 9606]view
automated matchesUracil-DNA glycosylaseHuman herpesvirus 1 [TaxId: 10298]view
Uracil-DNA glycosylaseUracil-DNA glycosylaseHuman (Homo sapiens) [TaxId: 9606]view
Uncharacterized protein AF0587AF0587 domain-likeArchaeoglobus fulgidus [TaxId: 2234]view
automated matchesautomated matchesMycobacterium tuberculosis [TaxId: 83332]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M V E D I L A P G L R V V F C G I N P G L S - S A G T G F P F A H P - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A N R F W K V I Y Q A G - F T D R Q L K - - - - - - - - - - - P Q E A Q H L L - D - - - Y R C G V T K L V D R P T - V - - - - - - Q A N E V S - - - - K Q E L H A G G R K L I E K I E D Y Q P Q A L A I L G - K Q A Y E Q G F - - - - S Q R - G A Q W G K Q T L T I G - - S T Q I W V L P N P S G L S R - - V - - S L E K L V E A Y R E L D Q A L V V - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - E S P A D S F L K V E L E L N L K L S N L V F Q D P V Q Y V Y N P L V Y A W A P H E N Y V Q T Y C K S K K E V L F L G M N P G P F G M A Q T G V P F G E V N H V R D W L Q I E G P V S K P E V E H P K R R I R G F E C P Q S E V S G A R F W S L F K S L C - G - - - - - - - - - - - - - - - - - - - Q P E T F F K - - - - - H C F V H N H C P L I F M N H S G K N L T P T D L P K A Q R D T L L E I C D E A L C Q A V R V L G V K L V I G V G - R F S E Q R A R K A L M A E - - - - - - - - - - - - - - G I D V T V K G I M H P S P R N P Q A N K G W E G I V R G Q L L E L - G V L S L L T - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - Y T R E E L E I V S E R V K C T - - - - - - - - - - - - A C P L H L N R T N V V V G E G N L D T R I V F V G E G P G E E - E D - T G R P F V G R - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A G L L T E L L R E S G - - - - - - I R - - - - - - - - - - - - - - R E D - - - - - - - - - V Y I C N V V K C R P - P - - - - - - N N R T P T - - - - P E E Q A A C G H F L L A Q I E I I N P D V I V A L G - A T A L S F F V D - - - G K V S I T V R G N P I D W - L G - G K K V I P T F H P S Y L L R N R S N E L R R I V L E D I E K A K S F I K - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A E L L T K T L P D I L T F N L D I V I I G I N P G L M - A A Y K G H H Y P G P - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - G N H F W K C L F M S G - L S E V Q L N - - - - - - - - - - - H M D D H T L P G K - - - Y G I G F T N M V E R T T - P - - - - - - G S K D L S - - - - S K E F R E G G R I L V Q K L Q K Y Q P R I A V F N G - K C I Y E I F S K E V F G V K V N L E F G L Q P H K I P D T E T L C Y V M P S S S A R C A Q F P - - R A Q D K V H Y Y I K L K D L R D Q L K G I E R N M D V Q E V Q Y T F D L Q L A Q E D A K K M A V K
D W T T F R V F L I D D A W R P L M E P E L A N P L T A H L L A E Y N R R C Q - - T E E V L P P R E D V F S W T R Y C T P D E V R V V I I G Q N P Y H H P G Q A H G L A F S V A - - - - - - - - - - - - - - - - - - - - - - - - - - - - N V - P P P P S L R N V L A A V K N C Y P - - - - - - - - - - - - - - A M S G H G C L E K W A - - - - - D G V L L L N T T L T V K R G - - - - - - - - - - A A A S H S - I G W D R F V G G V I R R L A A R - P G L V F M L W G T H A Q N A I P - - D P - - - - - - - - - - - - - - - - - - V H C V L K F S N P S P L S - K V P F G T C Q H F L V A N R Y L E T - - - - - S I S P I D W S V - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - F G E S W K K H L S G E F G K P Y F I K L M G F V A E E R K - - H Y T V Y P P P H Q V F T W T Q M C D I K D V K V V I L G Q D P Y H G P N Q A H G L C F S V Q R - - - - - - - - - - - - - - - - - - - - - - - - - - - P V - P P P P S L E N I Y K E L S T D I E - - - - - - - - - - - - D F V H P G H G D L S G W A K - - - - Q G V L L L N A V L T V R A H - - - - - - - - - - Q A N S H K E R G W E Q F T D A V V S W L N Q N S N G L V F L L W G S Y A Q K K G S A I D R - - - - - - - - - - - - - - - - - K R H H V L Q T A H P S P L S V Y R G F F G C R H F S K T N E L L Q K - - - - S G K K P I D W K E L - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - R Y F F E R A L E C Y K P F S D T V L L L P C T A R K P Y L T S R T H R A L R S K V K V N V N E I I I S S P L V V P R E F E L L - - - - - - - - H W S E E E V S F V A G W L K R F I E K G G F R K V V A H V T G G Y R K V V E R V E D - - - - - - - - - - - - - - - - E V E A E V V Y T A E K D V L S - - - - - - - - D E S I E R L K Q E I E S K - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - G
- M A R P L S E L V E R G W A A A L E P V A - - D Q V A H M G Q F L R A E I A - A G R R Y L P A G S N V L R A F T - F P F D N V R V L I V G Q D P Y P T P G H A V G L S F S V A P - - - - - - - - - - - - - - - - - - - - - - - - - - - D V R P W P R S L A N I F D E Y T A D L G - - - - - - - - - - - - - Y P L P S N G D L T P W A Q - - - - R G V L L L N R V L T V R P S - - - - - - - - - - N P A S H R G K G W E A V T E C A I R A L A A R A A P L V A I L W G R D A S T L K P M L A A - - - - - - - - - - - - - - - - - G N C V A I E S P H P S P L S A S R G F F G S R P F S R A N E L L V G - - - - M G A E P I D W R L P - - - - - - - - - - - - - - - - - - - - -

 

 

 

 

 

Member Chain UniProtKB GO term
d1muga_ A P0A9H1 GO:0000700
d1muga_ A P0A9H1 GO:0003677
d1muga_ A P0A9H1 GO:0004844
d1muga_ A P0A9H1 GO:0005737
d1muga_ A P0A9H1 GO:0006281
d1muga_ A P0A9H1 GO:0006285
d1muga_ A P0A9H1 GO:0008263
d1muga_ A P0A9H1 GO:0016787
d1muga_ A P0A9H1 GO:0043739
d1oe4a_ A Q9YGN6 GO:0006284
d1oe4a_ A Q9YGN6 GO:0017065
d1vk2a_ A Q9WYY1 GO:0004844
d1vk2a_ A Q9WYY1 GO:0006281
d1vk2a_ A Q9WYY1 GO:0016787
d1vk2a_ A Q9WYY1 GO:0046872
d1vk2a_ A Q9WYY1 GO:0051539
d2q07a2 A O29668 GO:0003723
d2q07a2 A O29668 GO:0003723
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in