Superfamily : 51069 [ Carbonic anhydrase ]
Class : All beta proteins
Fold : Carbonic anhydrase
# of Members : 13
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1y7wa-  (   3 )        nPndgydYmqhGfdWpglqeggttkypaÇsgsnQSPIdIntn---q
d3fw3a-  (   5 )        wÇYev--qassçlvPvk------WggnÇq-kdrQSPInIvtt---k
d3jxga-  (  58 )       pyways--gayGpehWvt------ssvsÇg-gshQSPIdIldh---h
d3k34a-  (   3 )       hhwgYg--khnGpehWhk------dfpiAk-gerQSPVdIdth---t
d3q31a-  (  35 )       nkfnYt--glGGplnWygld-ea--neaÇakgkhQSPivIdsa---a
d4e9ox-  (   3 )                                       qQlSPInIetk---k
d4ht2a-  (   3 )        kwtyf--gpdgensWsk------kypsÇg-gllQSPIdLhsd---i
d4twla-  (   3 )       deFsYidgnpnGPenWGnlk-pe--wetÇgkgmeQSPIqLrdn---r
d4xfwa-  (  22 )        kWdYk-nkenGPhrWdklh-kd--fevÇksgksQSPInIe-----h
d4xiwa-  (  74 )    awnygeva---------gPptwk------gvÇatgkrqSPiniplntsap
d5hpja-  (  14 )        ewsyt--gehGtehWgd----s--fatÇaegvnqtPidin-----q
d6qqma1  (  44 )                                  mçs-gyyQSPIdLktd---i
d6rqqa-  ( 140 )        hwryg--gdp---pwpr------vspaÇa-grfQSPVdIrpq---l
                                                             bb       

                             60        70        80        90        100 
d1y7wa-  (  46 )    Lme----pssRsgTsaVslnGLnvdGaqadGItLtnAkVdLeQg-MkVtF
d3fw3a-  (  38 )    Akvd------kLg-FfFsgYd---------k--qtWtVqNng-hsVmMlL
d3jxga-  (  93 )    Arvgd-----eyqeLqLdgFd--------neSsnkTwMkNtG-ktVaIlL
d3k34a-  (  38 )    Akydp-----slkpLsVs-Yd--------qAtSl--rIlNnG-haFnVeF
d3q31a-  (  74 )    idyAas------gsLkLdLp-----------ladgskLeNlg-fgLqVtl
d4e9ox-  (  15 )    Ais-------alkpLdIh-Yn----------eSkPttIqNtG-klVrInF
d4ht2a-  (  37 )    Lqyda-----sltpLeFqgYn--------LsankqflLtNnG-hsVkLnL
d4twla-  (  44 )    Vifd---q--tlgkLrrnYr-----------avdA-rLrnsg-hDVLVdF
d4xfwa-  (  59 )    yyhtqdk-----AdLqFkYa-----------askPkaVffth-htLkAsF
d4xiwa-  ( 109 )    kvd----Aem--geFdFaYgs-----------fekCdvlntghgtMqvnF
d5hpja-  (  47 )    ttqa------elaplhldYe-----------gqvt-elvnng-htiqAnl
d6qqma1  (  60 )    Stldl-----klktViIyrns--------st--etTtIqNng-hSAeVkF
d6rqqa-  ( 171 )    Aafsp-----aLrpLeLsgFq--------lpplpeLrLrNnG-hsVqLtL
                     bb            bbb                  bbbb     bbbb 

                             110       120       130       140       150 
d1y7wa-  (  91 )    dqpaanLPtIeiggtt-ksFvPiqFhFHHf------lSEHTIngihypLE
d3fw3a-  (  71 )    e----nkAsIsgGg-LpapYqAkqLhLHWSdlp-ykGSEHSldgehfaME
d3jxga-  ( 129 )    k-d---dYfVsgAg-LpgrFkAekVeFHWGhsnGsaGSEHSvngrrFpVE
d3k34a-  (  71 )    d-dsqdkAvLkgGp-LdgtYrLiqFhFHWGsld-gqGSEHtvdkkkyAAE
d3q31a-  ( 106 )    t-----nGsLtans---ktytLaqFhFHT-------pSEHhvneehfpME
d4e9ox-  (  48 )    k-----gGyIsgGf-LpneYvLssLhIYWGked-dyGSNHlidvyKySGE
d4ht2a-  (  73 )    p-s---dMhIqgl---qsrYsAtqLhLHWGnpndphGSEHTvsgqhfAAE
d4twla-  (  76 )    kg---nAGsLsinr---veYqLkrIhFHS-------pSEHeMngerFdLE
d4xfwa-  (  92 )    ep---t-NhInyrg---hdYvLdnVhFHa-------pMEFlinnktrpLS
d4xiwa-  ( 142 )    pa----gnlAfign---melellqFhFHA-------pSEHAMdgrryaME
d5hpja-  (  78 )    tg---k-ntltvdg---ktFelkqFhFHt-------pSEnylkgkqyplE
d6qqma1  (  95 )    p---rnTWFISfdgildykyEIiqMhFHWGntd-drGSEHTidgfrfPLE
d6rqqa-  ( 207 )    p-p---gLeMkLgp--greYrAlqLhLHWGaagr-pGSEHTveghrfpAE
                            bbb        bbbbbbbbb            bb      bb

                             160       170       180       190       200 
d1y7wa-  ( 134 )    LHIvMqeq------dpadvatAqLAVIGIMYky-se-----ngdaFLnsL
d3fw3a-  ( 118 )    MHIvHekep-----------edeiAVLAFLVeagt------qvnegFqpL
d3jxga-  ( 174 )    MQIFFynpddfdsFqtAisenriIGAMAIFFqvsp------rdnsaLdpI
d3k34a-  ( 118 )    LHLVHWNtky-gdfgkAvqqpdGLAVLGIFLkvg-------sakpgLqkV
d3q31a-  ( 141 )    VHFvFqta------------aketAVVGFFFqlsev----gdsvpLFdsV
d4e9ox-  (  91 )    INLVHwNkkkyssyeeAkkhddGLIIISIFLqvld------hknvyFqkI
d4ht2a-  ( 116 )    LHIvHyNsdlypdastAsnkseGLAVLAVLIemg-------sfnpsYdkI
d4twla-  ( 113 )    AQLVHeSq------------dqkrAVVSILFrfg-------raDpFLsdL
d4xfwa-  ( 128 )    AHFvHkDa------------kgrlLVLAIGFeeg-------kenpnLdpI
d4xiwa-  ( 178 )    AHlvHknk-----------stgnlAvlGiMlepggl-----iknpAlstA
d5hpja-  ( 114 )    AHFvHatd------------kgelAvvAvMFdfgp------rsnnelttl
d6qqma1  ( 141 )    GHIvSFrrqmysspseA-grpgGlAVLGIMHqivesikyeqTAFkAYnnF
d6rqqa-  ( 250 )    IHVvHLst-kyarvdeAlgrpgGLAVLAAFLeegp------eensaYeqL
                    bbbbbb                 bbbbbbbbbb              aaa

                             210       220       230       240       250 
d1y7wa-  ( 172 )    qtqIegkigdgtAsygdtgvsIdnInVktqLLPs----slkYAGYdGSlT
d3fw3a-  ( 161 )    veaL-snIppe-----msttMa-eSSLldLLpe-----eLhYFRYlGSlT
d3jxga-  ( 218 )    IhgLkgVvhhe-----ketfLd-pFiLrdLLPa----slgsYYRYtGSlT
d3k34a-  ( 161 )    VdvLdsIktkg-----ksadft-nFdPrgLlPe----sl-dYWtYpGSlT
d3q31a-  ( 175 )    FapIdnIpdag-----tsttT-gqLdFggLldhFn---rhgvYqytGSlT
d4e9ox-  ( 135 )    VnqLdsIrsan-----tsapFdsvFyLdnLlPs----kl-dYFtYlGTti
d4ht2a-  ( 159 )    FshLqhVkykg-----qeafVp-GfnIeeLLPe----rtaeYYrYrGSlT
d4twla-  ( 144 )    edfIkqFsnsqk----neinA-gvVdPnqLq--Id---dsaYYrYmGSfT
d4xfwa-  ( 159 )    LeGiqkk-----------qnf-keVaLdaFL--pk---sInYYhFnGSlT
d4xiwa-  ( 212 )    levAPe-------vplakkpSpkginPvmllPkkskagtrpFvhYpGSlt
d5hpja-  ( 146 )    lasiPskg--------qtvelkealnPadll--Pr---dreYYrFnGSlt
d6qqma1  ( 191 )    sgvLnsqfvpp-----nnstId-dInLalLLsl---LnpsrYFrYlGSlT
d6rqqa-  ( 293 )    LsrLeeIaeeg-----setqVp-GLdIsaLLPs----dfsrYFQYeGSlT
                    a                bbb                     bbbbbb   

                             260       270       280       290       300 
d1y7wa-  ( 218 )    tPgÇderVkWHVFttpreVtreQMkLFvdVTm---gAhagA---dvvNNR
d3fw3a-  ( 200 )    tptÇdekVvWTVFrepIqLhreQilAFsqkL-yYdkeqt---vsMkdNvR
d3jxga-  ( 258 )    tPpÇseiVeWIVFrrPVpISyhQLeAFY-sI-ftt---e-sveyLrnNfR
d3k34a-  ( 200 )    tPpLleCVtWIVLkepIsVsseQVlkFr-kL-Nfngege-peelMvdNwR
d3q31a-  ( 216 )    tppÇteeVmWNLStepLpLtvqgynkVkkiIk--------------yNAR
d4e9ox-  ( 175 )    --nhsAdAvWIIFptpinIhsdQLskFrtLl-sl------gphyItenyr
d4ht2a-  ( 199 )    tPpÇnptVlWTVFrnpvqIsqeQLlaLEtAL-ycthmddpspreMinNfR
d4twla-  ( 184 )    aPpÇtegIsWTVMrkVAtVsprQVlLLkqAVn-------en---AinNAR
d4xfwa-  ( 192 )    aPpÇtegVaWFVVeepleVsakQlaeIkkrMk------------nspNqR
d4xiwa-  ( 255 )    tppÇsegvdWFvFMqpikvpdsqildFmrfvG---dnk--t---yatntR
d5hpja-  ( 183 )    tPpÇsegvrWFvMqepqtSskaqteklqavMg--------------nnAR
d6qqma1  ( 232 )    tppÇtenVlWTVFidpVlItreqInlFrn-L-pYgsnekq--trMGdnfr
d6rqqa-  ( 333 )    tppÇaqgViWTVFnqtvsLsakQlhtLsdtL-wGpg-----dsrLqlNfr
                           bbbbbb   bbb aaaaaaaa                      

                             310       320      
d1y7wa-  ( 262 )    miqdlg------dreVykYny       
d3fw3a-  ( 247 )    plqqlg------qrtViks         
d3jxga-  ( 308 )    pqqaln------dRvVSks         
d3k34a-  ( 247 )    paqplk------nRqIkasfk       
d3q31a-  ( 252 )    ytQnal------gqdNll---evaaqkl
d4e9ox-  ( 221 )    npyklnd-----dteVyys         
d4ht2a-  ( 248 )    qvqkFd------erlVyTSFs---q   
d4twla-  ( 224 )    plqptn------frsVfyfeqlks    
d4xfwa-  ( 230 )    pvqpdy------ntvIikrsAeTr    
d4xiwa-  ( 297 )    plqlln------sRlveYel        
d5hpja-  ( 219 )    plqpln------arlile          
d6qqma1  ( 278 )    piqllnpidtlasrtLyrAta------g
d6rqqa-  ( 377 )    atqpln------grvIeASfp---agvd
                                    bb
 

 

Domain IDNameFamilySourceDomainSTRING-DB
automated matchesautomated matchesDunaliella salina [TaxId: 3046]view
Carbonic anhydraseCarbonic anhydraseHuman (Homo sapiens), isozyme IV [TaxId: 9606]view
automated matchesautomated matchesMouse (Mus musculus) [TaxId: 10090]view
Carbonic anhydraseCarbonic anhydraseHuman (Homo sapiens), erythrocytes, isozyme II [TaxId: 9606]view
automated matchesautomated matchesFungus (Aspergillus oryzae) [TaxId: 5062]view
automated matchesautomated matchesVaccinia virus [TaxId: 10245]view
Carbonic anhydraseCarbonic anhydraseHuman (Homo sapiens), isozyme XII [TaxId: 9606]view
automated matchesautomated matchesDioscorea japonica [TaxId: 4673]view
automated matchesautomated matchesHelicobacter pylori [TaxId: 563041]view
automated matchesautomated matchesGreen alga (Chlamydomonas reinhardtii) [TaxId: 3055]view
automated matchesautomated matchesPhotobacterium profundum [TaxId: 298386]view
automated matchesautomated matchesBlood fluke (Schistosoma mansoni) [TaxId: 6183]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320
- - - - N P N D G Y D Y M Q H G F D W P G L Q E G G T T K Y P A C S G S N Q S P I D I N T N - - - Q L M E - - - - P S S R S G T S A V S L N G L N V D G A Q A D G I T L T N A K V D L E Q G - M K V T F D Q P A A N L P T I E I G G T T - K S F V P I Q F H F H H F - - - - - - L S E H T I N G I H Y P L E L H I V M Q E Q - - - - - - D P A D V A T A Q L A V I G I M Y K Y - S E - - - - - N G D A F L N S L Q T Q I E G K I G D G T A S Y G D T G V S I D N I N V K T Q L L P S - - - - S L K Y A G Y D G S L T T P G C D E R V K W H V F T T P R E V T R E Q M K L F V D V T M - - - G A H A G A - - - D V V N N R M I Q D L G - - - - - - D R E V Y K Y N Y - - - - - - -
- - - - W C Y E V - - Q A S S C L V P V K - - - - - - W G G N C Q - K D R Q S P I N I V T T - - - K A K V D - - - - - - K L G - F F F S G Y D - - - - - - - - - K - - Q T W T V Q N N G - H S V M M L L E - - - - N K A S I S G G G - L P A P Y Q A K Q L H L H W S D L P - Y K G S E H S L D G E H F A M E M H I V H E K E P - - - - - - - - - - - E D E I A V L A F L V E A G T - - - - - - Q V N E G F Q P L V E A L - S N I P P E - - - - - M S T T M A - E S S L L D L L P E - - - - - E L H Y F R Y L G S L T T P T C D E K V V W T V F R E P I Q L H R E Q I L A F S Q K L - Y Y D K E Q T - - - V S M K D N V R P L Q Q L G - - - - - - Q R T V I K S - - - - - - - - -
- - - P Y W A Y S - - G A Y G P E H W V T - - - - - - S S V S C G - G S H Q S P I D I L D H - - - H A R V G D - - - - - E Y Q E L Q L D G F D - - - - - - - - N E S S N K T W M K N T G - K T V A I L L K - D - - - D Y F V S G A G - L P G R F K A E K V E F H W G H S N G S A G S E H S V N G R R F P V E M Q I F F Y N P D D F D S F Q T A I S E N R I I G A M A I F F Q V S P - - - - - - R D N S A L D P I I H G L K G V V H H E - - - - - K E T F L D - P F I L R D L L P A - - - - S L G S Y Y R Y T G S L T T P P C S E I V E W I V F R R P V P I S Y H Q L E A F Y - S I - F T T - - - E - S V E Y L R N N F R P Q Q A L N - - - - - - D R V V S K S - - - - - - - - -
- - - H H W G Y G - - K H N G P E H W H K - - - - - - D F P I A K - G E R Q S P V D I D T H - - - T A K Y D P - - - - - S L K P L S V S - Y D - - - - - - - - Q A T S L - - R I L N N G - H A F N V E F D - D S Q D K A V L K G G P - L D G T Y R L I Q F H F H W G S L D - G Q G S E H T V D K K K Y A A E L H L V H W N T K Y - G D F G K A V Q Q P D G L A V L G I F L K V G - - - - - - - S A K P G L Q K V V D V L D S I K T K G - - - - - K S A D F T - N F D P R G L L P E - - - - S L - D Y W T Y P G S L T T P P L L E C V T W I V L K E P I S V S S E Q V L K F R - K L - N F N G E G E - P E E L M V D N W R P A Q P L K - - - - - - N R Q I K A S F K - - - - - - -
- - - N K F N Y T - - G L G G P L N W Y G L D - E A - - N E A C A K G K H Q S P I V I D S A - - - A I D Y A A S - - - - - - G S L K L D L P - - - - - - - - - - - L A D G S K L E N L G - F G L Q V T L T - - - - - N G S L T A N S - - - K T Y T L A Q F H F H T - - - - - - - P S E H H V N E E H F P M E V H F V F Q T A - - - - - - - - - - - - A K E T A V V G F F F Q L S E V - - - - G D S V P L F D S V F A P I D N I P D A G - - - - - T S T T T - G Q L D F G G L L D H F N - - - R H G V Y Q Y T G S L T T P P C T E E V M W N L S T E P L P L T V Q G Y N K V K K I I K - - - - - - - - - - - - - - Y N A R Y T Q N A L - - - - - - G Q D N L L - - - E V A A Q K L
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Q Q L S P I N I E T K - - - K A I S - - - - - - - A L K P L D I H - Y N - - - - - - - - - - E S K P T T I Q N T G - K L V R I N F K - - - - - G G Y I S G G F - L P N E Y V L S S L H I Y W G K E D - D Y G S N H L I D V Y K Y S G E I N L V H W N K K K Y S S Y E E A K K H D D G L I I I S I F L Q V L D - - - - - - H K N V Y F Q K I V N Q L D S I R S A N - - - - - T S A P F D S V F Y L D N L L P S - - - - K L - D Y F T Y L G T T I - - N H S A D A V W I I F P T P I N I H S D Q L S K F R T L L - S L - - - - - - G P H Y I T E N Y R N P Y K L N D - - - - - D T E V Y Y S - - - - - - - - -
- - - - K W T Y F - - G P D G E N S W S K - - - - - - K Y P S C G - G L L Q S P I D L H S D - - - I L Q Y D A - - - - - S L T P L E F Q G Y N - - - - - - - - L S A N K Q F L L T N N G - H S V K L N L P - S - - - D M H I Q G L - - - Q S R Y S A T Q L H L H W G N P N D P H G S E H T V S G Q H F A A E L H I V H Y N S D L Y P D A S T A S N K S E G L A V L A V L I E M G - - - - - - - S F N P S Y D K I F S H L Q H V K Y K G - - - - - Q E A F V P - G F N I E E L L P E - - - - R T A E Y Y R Y R G S L T T P P C N P T V L W T V F R N P V Q I S Q E Q L L A L E T A L - Y C T H M D D P S P R E M I N N F R Q V Q K F D - - - - - - E R L V Y T S F S - - - Q - - -
- - - D E F S Y I D G N P N G P E N W G N L K - P E - - W E T C G K G M E Q S P I Q L R D N - - - R V I F D - - - Q - - T L G K L R R N Y R - - - - - - - - - - - A V D A - R L R N S G - H D V L V D F K G - - - N A G S L S I N R - - - V E Y Q L K R I H F H S - - - - - - - P S E H E M N G E R F D L E A Q L V H E S Q - - - - - - - - - - - - D Q K R A V V S I L F R F G - - - - - - - R A D P F L S D L E D F I K Q F S N S Q K - - - - N E I N A - G V V D P N Q L Q - - I D - - - D S A Y Y R Y M G S F T A P P C T E G I S W T V M R K V A T V S P R Q V L L L K Q A V N - - - - - - - E N - - - A I N N A R P L Q P T N - - - - - - F R S V F Y F E Q L K S - - - -
- - - - K W D Y K - N K E N G P H R W D K L H - K D - - F E V C K S G K S Q S P I N I E - - - - - H Y Y H T Q D K - - - - - A D L Q F K Y A - - - - - - - - - - - A S K P K A V F F T H - H T L K A S F E P - - - T - N H I N Y R G - - - H D Y V L D N V H F H A - - - - - - - P M E F L I N N K T R P L S A H F V H K D A - - - - - - - - - - - - K G R L L V L A I G F E E G - - - - - - - K E N P N L D P I L E G I Q K K - - - - - - - - - - - Q N F - K E V A L D A F L - - P K - - - S I N Y Y H F N G S L T A P P C T E G V A W F V V E E P L E V S A K Q L A E I K K R M K - - - - - - - - - - - - N S P N Q R P V Q P D Y - - - - - - N T V I I K R S A E T R - - - -
A W N Y G E V A - - - - - - - - - G P P T W K - - - - - - G V C A T G K R Q S P I N I P L N T S A P K V D - - - - A E M - - G E F D F A Y G S - - - - - - - - - - - F E K C D V L N T G H G T M Q V N F P A - - - - G N L A F I G N - - - M E L E L L Q F H F H A - - - - - - - P S E H A M D G R R Y A M E A H L V H K N K - - - - - - - - - - - S T G N L A V L G I M L E P G G L - - - - - I K N P A L S T A L E V A P E - - - - - - - V P L A K K P S P K G I N P V M L L P K K S K A G T R P F V H Y P G S L T T P P C S E G V D W F V F M Q P I K V P D S Q I L D F M R F V G - - - D N K - - T - - - Y A T N T R P L Q L L N - - - - - - S R L V E Y E L - - - - - - - -
- - - - E W S Y T - - G E H G T E H W G D - - - - S - - F A T C A E G V N Q T P I D I N - - - - - Q T T Q A - - - - - - E L A P L H L D Y E - - - - - - - - - - - G Q V T - E L V N N G - H T I Q A N L T G - - - K - N T L T V D G - - - K T F E L K Q F H F H T - - - - - - - P S E N Y L K G K Q Y P L E A H F V H A T D - - - - - - - - - - - - K G E L A V V A V M F D F G P - - - - - - R S N N E L T T L L A S I P S K G - - - - - - - - Q T V E L K E A L N P A D L L - - P R - - - D R E Y Y R F N G S L T T P P C S E G V R W F V M Q E P Q T S S K A Q T E K L Q A V M G - - - - - - - - - - - - - - N N A R P L Q P L N - - - - - - A R L I L E - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M C S - G Y Y Q S P I D L K T D - - - I S T L D L - - - - - K L K T V I I Y R N S - - - - - - - - S T - - E T T T I Q N N G - H S A E V K F P - - - R N T W F I S F D G I L D Y K Y E I I Q M H F H W G N T D - D R G S E H T I D G F R F P L E G H I V S F R R Q M Y S S P S E A - G R P G G L A V L G I M H Q I V E S I K Y E Q T A F K A Y N N F S G V L N S Q F V P P - - - - - N N S T I D - D I N L A L L L S L - - - L N P S R Y F R Y L G S L T T P P C T E N V L W T V F I D P V L I T R E Q I N L F R N - L - P Y G S N E K Q - - T R M G D N F R P I Q L L N P I D T L A S R T L Y R A T A - - - - - - G
- - - - H W R Y G - - G D P - - - P W P R - - - - - - V S P A C A - G R F Q S P V D I R P Q - - - L A A F S P - - - - - A L R P L E L S G F Q - - - - - - - - L P P L P E L R L R N N G - H S V Q L T L P - P - - - G L E M K L G P - - G R E Y R A L Q L H L H W G A A G R - P G S E H T V E G H R F P A E I H V V H L S T - K Y A R V D E A L G R P G G L A V L A A F L E E G P - - - - - - E E N S A Y E Q L L S R L E E I A E E G - - - - - S E T Q V P - G L D I S A L L P S - - - - D F S R Y F Q Y E G S L T T P P C A Q G V I W T V F N Q T V S L S A K Q L H T L S D T L - W G P G - - - - - D S R L Q L N F R A T Q P L N - - - - - - G R V I E A S F P - - - A G V D

 

 

 

 

 

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Contact: Prof. R. Sowdhamini - mini@ncbs.res.in