Superfamily : 50993 [ Peptidase/esterase \'gauge\' domain ]
Class : All beta proteins
Fold : 7-bladed beta-propeller
# of Members : 7
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1yr2a1  (  38 )    pp---ypaspqv-plvedhf-----gekvsdpwrwleadvrtdakVaawv
d2bkla1  (   3 )         ypatraeq-vvdtlh-----gvqvadpyrwle--dekapeVqtwm
d2hu7a1  (   9 )                                                      
d3ivma1  (   7 )       lhypvtrqge-qvdhyf-----gqavadpyrwle--ddrspeteawv
d4bcda1  (   1 )    mlsfqypdvyrdetaiqdyh-----ghkvcdpyawle--dpdseqtkafv
d5n4fa2  (   7 )    apg-nypstrrs-dhvdtyqsaskgevpvpdpyqwlees---tdevdkwt
d7ne5a1  (   2 )       mtppkaekrp-ypitth-----gdtrvddyywlrddertdpqvldyl
                                   bbbb       bbbb   3333      aaaaaaa

                             60        70        80        90        100 
d1yr2a1  (  79 )    qaqsaytaaylkql-peraalekrmkalidyerfglPqrrg-asVFYswN
d2bkla1  (  40 )    taqnaharealakf-pgrealaarfkelfytdsvstPsrrn-grfFYvrt
d2hu7a1  (   9 )                   fsivrdverlia---vekYsLqgVVdgdkLLVvGf
d3ivma1  (  46 )    kaqnavtqdylaqi-pyraaikeklaaswnyakegapfreg-ryhYffkn
d4bcda1  (  44 )    eaqnkitvpfleqc-pirglykermtelydypkysCHfkkg-kryFyFyn
d5n4fa2  (  52 )    taqadlaqsyldqn-adiqklaekfrasrnyakFsAPtlLddghwYWfyn
d7ne5a1  (  43 )    qaenaftdaalkpqqalretlyeemvarenlyfqsvpyvrh-gyryqtrf
                    aaaaaaaaaaa      aaaaaaaaaaa    bb   bbb   bbbbbbb

                             110       120       130       140       150 
d1yr2a1  ( 127 )    sglmnqsqLLVRpadap------vgtkGrvLldPntw-----ataldawa
d2bkla1  (  88 )    hkdkekaILyWrqge---------sgqekvLLdPngwskdg-tvslgtwa
d2hu7a1  (  42 )    Seg--svNAYLydgg-----------etvkLNr---------epInsVLd
d3ivma1  (  94 )    dGlqnqnVLwRqqe----------gkpaevFldPntlspdG-ttaLdqls
d4bcda1  (  92 )    tGlqnqrVLyVQdsl---------egearvFldPnilsddG-tvalrgya
d5n4fa2  ( 101 )    rglqsqsvLYrSkepalpdFskgDdnvGdvFFDPnvlaadg-sAgmvlck
d7ne5a1  (  92 )    epgneyaiyVrQpqaes--------ehwdtLIdgnqraeqrefYtlggle
                           bbbbb                bbbb 333        bbbbbb

                             160       170       180       190       200 
d1yr2a1  ( 170 )    ASddGrlLAySVqdg-gsdwrtVkFVgVadgk-----------pla-deL
d2bkla1  ( 128 )    VSwdGkkVAFAqkpn-aadeAvLhVIdVdsge-----------wskvDvI
d2hu7a1  (  70 )    PhygvgrVILVrdvskgaeqhALfkVnTs--------rpgeeqrleaVkp
d3ivma1  ( 133 )    FSrdGriLAySLsla-gsdwreIhL-dVeskq-----------ple-tpL
d4bcda1  ( 132 )    FSedGeyFAYGlSas-gsdwVtIkFMkVdgak-----------elp-dvL
d5n4fa2  ( 150 )    fSpdGkfFAYAVshl-ggdystIyVRsTsspLsqasvaqgvdgrls-DeV
d7ne5a1  ( 134 )    VSpdnqkLAVAEDfl-srrqydIrFknlsdd-----------swtd-evL
                    b     bbbbbbb       bbbbbbb                      b

                             210       220       230       240       250 
d1yr2a1  ( 207 )    kwVkfSgLaWL-gndALLYSrFaep----------lnynQ-tVwLHrLgt
d2bkla1  ( 166 )    eGGkyAtPkWtpdSkGFyYEwLptdp---sikvderpGyT-tIryHtlgt
d2hu7a1  ( 112 )    MrIl--sGVDtg--eAVVFTGate--------------drvALYAldgg-
d3ivma1  ( 170 )    kdVkfSgIsWlg-neGFFYSsYdkpdgsel---sartdqH-kVyFHrlgt
d4bcda1  ( 169 )    erVkfScMaWThdgkGMFYNaYpqqdgksdgtetstnlhQ-kLyYHvlgt
d5n4fa2  ( 198 )    kwFkfstIiWTkdSkGFLYQrYpar----------sdrnA-mMCYHkvgt
d7ne5a1  ( 171 )    enTSG-sFeWAndSaTVYYVrkha-----------ktllPyqVyrHvVgt
                    bbb     bb     bbbbbb                    bbbbbb   

                             260       270       280       290       300 
d1yr2a1  ( 253 )    pqsaDqpVfat-pelpkrgHgAsVSsdgrWVVItSsegtdpvnTVhVAr-
d2bkla1  ( 212 )    epskDtvvhe-rtgdptTfLqSdLsrdgkYLFVyilrgws-eNDVyWkrp
d2hu7a1  ( 143 )    -----glreLaLp---gfGfVsdIrg--dlIAGlGfFgg-grvSLFTSnl
d3ivma1  ( 215 )    aqedDrlvFGaipaqhHryVgAtVTeddrFLLIsAansts-gnrLyVkdl
d4bcda1  ( 218 )    dqseDilCAef-pdepkwmGgAeLSddGrYVLLsIregcdpvNrLwyCdl
d5n4fa2  ( 244 )    tqeeDiiVyqd-nehpewiYgAdTsedgkyLYLYQfkdtskkNLLwVAe-
d7ne5a1  ( 209 )    dpqlDelIyeE--qddtFyVgLekTtsdrfILIhLss-t-ttSEILlLdA
                     333 bbbb         bbbbbb     bbbbbbb       bbbbbb 

                             310       320       330       340       350 
d1yr2a1  ( 301 )    ---vtngkI-gpvtaLip-dlkaqwdfVdGvgdqLWFVSgdgAplkkIVr
d2bkla1  ( 260 )    gek--------dfrlLvk-GvgAkYeVhAwk-drFYVLTdegAprqrVFE
d2hu7a1  ( 183 )    s--------sgglrvFdsg-egsFssASIspgmkVTAGLet---aArLVt
d3ivma1  ( 264 )    sqe------naplltVQg-dldAdVsLvDNkgstLYLlTnrdApnrrLVt
d4bcda1  ( 267 )    qqesngItgiLkWvklid-nfeGeYdYVTNegtvFTFkTnrhSpnyrLIn
d5n4fa2  ( 292 )    ---ldgVksgihwrkvvn-eyaadYnIItNhgslVYIkTnlnApqykVIt
d7ne5a1  ( 255 )    dra------dstpqmFVprrkdHeYgIdhYh-qhfYIrSnkdgknFGLYq
                                 bbbb       bbbbbb   bbbbbb       bbbb

                             360       370       380       390       400 
d1yr2a1  ( 346 )    VdLsgstpr---fdtVVpesk---------dnLesVgIAg-nrLFASYih
d2bkla1  ( 300 )    VdPa--kparasWkeIvpeds--------sAsLlsVsIVgg-hLSLeYlk
d2hu7a1  ( 223 )    VdPr-------dgsvedlelpskdFssyrPtaItwLgyLpdgrLAVVArr
d3ivma1  ( 307 )    vdAa--nPgpahWrdLIperq---------qvL-tVhsGSg-yLFAeY-v
d4bcda1  ( 316 )    IdFt--dpeeskwkvlvpehe--------kdvLewVaCVrsnfLVLCylh
d5n4fa2  ( 340 )    IdLskdepe---irdfipeek--------dAkLaqVnCAneeyFVAIYkr
d7ne5a1  ( 298 )    Se----qadeaqWqtliapri--------evmLegfsLFr-dWLVVeErs
                    b            bbbb              bbbbbbbb   bbbbbbbb

                             410       420       430       440       450 
d1yr2a1  ( 383 )    dakSqVlAfdld-GkpagaVslpg-igsAsglsg-rpgdrhAYLsFssft
d2bkla1  ( 339 )    datSeVrVAtlk-Gkpvrtvqlpg-vgaAsnLmg-ledlddAYYvFtsft
d2hu7a1  ( 266 )    eg--rSAVFId--GerveAp-----qgnHgrVVlwr---gklVTsHtsls
d3ivma1  ( 344 )    datArVeQfdye-gkrvreVaLpg-lgsVsgFng-khddpALyFgFenya
d4bcda1  ( 356 )    dvkNtLqLhdlatGallkiFpL-e-vgsVvgysG-qkkdteIFYqftsfl
d5n4fa2  ( 379 )    nvkdeIyLYska-Gvqltrla-pd-fvgaAsIan-rqkqthFFLtlsgfn
d7ne5a1  ( 335 )    egltqLrQihwqsg-evkriafddptytTwlaynpepetelLrYGysSmt
                       bbbbbbb     bbbb        bbbb         bbbbbbbb  

                             460       470       480 
d1yr2a1  ( 430 )    qpatVlaLdPa---tAkTtpWEpvhlt-fdp
d2bkla1  ( 386 )    tprqIyktsVs---tgkselwakvdvp-mnp
d2hu7a1  ( 304 )    tpprIVsLp-----sge--pllegg      
d3ivma1  ( 391 )    qpptlyrFePk---sGaislyrasaAp-fkp
d4bcda1  ( 403 )    spGiIyhCdLtk-eeleprvfrevtvk-gi 
d5n4fa2  ( 425 )    tpgtIArydftapetqrfsiLrtTkvneldp
d7ne5a1  ( 384 )    tptTlyelnLd---sdervmlkqqevknftp
                       bbbbbb        bbbbb
 

 

Domain IDNameFamilySourceDomainSTRING-DB
automated matchesautomated matchesNovosphingobium capsulatum [TaxId: 13688]view
automated matchesautomated matchesMyxococcus xanthus [TaxId: 34]view
Acylamino-acid-releasing enzyme, N-terminal donainAcylamino-acid-releasing enzyme, N-terminal donainAeropyrum pernix [TaxId: 56636]view
automated matchesautomated matchesAeromonas punctata [TaxId: 648]view
Prolyl oligopeptidase, N-terminal domainProlyl oligopeptidase, N-terminal domainPig (Sus scrofa) [TaxId: 9823]view
Prolyl oligopeptidase, N-terminal domainProlyl oligopeptidase, N-terminal domainGalerina marginata [TaxId: 109633]view
automated matchesautomated matchesSerratia proteamaculans [TaxId: 28151]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480
P P - - - Y P A S P Q V - P L V E D H F - - - - - G E K V S D P W R W L E A D V R T D A K V A A W V Q A Q S A Y T A A Y L K Q L - P E R A A L E K R M K A L I D Y E R F G L P Q R R G - A S V F Y S W N S G L M N Q S Q L L V R P A D A P - - - - - - V G T K G R V L L D P N T W - - - - - A T A L D A W A A S D D G R L L A Y S V Q D G - G S D W R T V K F V G V A D G K - - - - - - - - - - - P L A - D E L K W V K F S G L A W L - G N D A L L Y S R F A E P - - - - - - - - - - L N Y N Q - T V W L H R L G T P Q S A D Q P V F A T - P E L P K R G H G A S V S S D G R W V V I T S S E G T D P V N T V H V A R - - - - V T N G K I - G P V T A L I P - D L K A Q W D F V D G V G D Q L W F V S G D G A P L K K I V R V D L S G S T P R - - - F D T V V P E S K - - - - - - - - - D N L E S V G I A G - N R L F A S Y I H D A K S Q V L A F D L D - G K P A G A V S L P G - I G S A S G L S G - R P G D R H A Y L S F S S F T Q P A T V L A L D P A - - - T A K T T P W E P V H L T - F D P
- - - - - Y P A T R A E Q - V V D T L H - - - - - G V Q V A D P Y R W L E - - D E K A P E V Q T W M T A Q N A H A R E A L A K F - P G R E A L A A R F K E L F Y T D S V S T P S R R N - G R F F Y V R T H K D K E K A I L Y W R Q G E - - - - - - - - - S G Q E K V L L D P N G W S K D G - T V S L G T W A V S W D G K K V A F A Q K P N - A A D E A V L H V I D V D S G E - - - - - - - - - - - W S K V D V I E G G K Y A T P K W T P D S K G F Y Y E W L P T D P - - - S I K V D E R P G Y T - T I R Y H T L G T E P S K D T V V H E - R T G D P T T F L Q S D L S R D G K Y L F V Y I L R G W S - E N D V Y W K R P G E K - - - - - - - - D F R L L V K - G V G A K Y E V H A W K - D R F Y V L T D E G A P R Q R V F E V D P A - - K P A R A S W K E I V P E D S - - - - - - - - S A S L L S V S I V G G - H L S L E Y L K D A T S E V R V A T L K - G K P V R T V Q L P G - V G A A S N L M G - L E D L D D A Y Y V F T S F T T P R Q I Y K T S V S - - - T G K S E L W A K V D V P - M N P
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - F S I V R D V E R L I A - - - V E K Y S L Q G V V D G D K L L V V G F S E G - - S V N A Y L Y D G G - - - - - - - - - - - E T V K L N R - - - - - - - - - E P I N S V L D P H Y G V G R V I L V R D V S K G A E Q H A L F K V N T S - - - - - - - - R P G E E Q R L E A V K P M R I L - - S G V D T G - - E A V V F T G A T E - - - - - - - - - - - - - - D R V A L Y A L D G G - - - - - - G L R E L A L P - - - G F G F V S D I R G - - D L I A G L G F F G G - G R V S L F T S N L S - - - - - - - - S G G L R V F D S G - E G S F S S A S I S P G M K V T A G L E T - - - A A R L V T V D P R - - - - - - - D G S V E D L E L P S K D F S S Y R P T A I T W L G Y L P D G R L A V V A R R E G - - R S A V F I D - - G E R V E A P - - - - - Q G N H G R V V L W R - - - G K L V T S H T S L S T P P R I V S L P - - - - - S G E - - P L L E G G - - - - - -
- - - L H Y P V T R Q G E - Q V D H Y F - - - - - G Q A V A D P Y R W L E - - D D R S P E T E A W V K A Q N A V T Q D Y L A Q I - P Y R A A I K E K L A A S W N Y A K E G A P F R E G - R Y H Y F F K N D G L Q N Q N V L W R Q Q E - - - - - - - - - - G K P A E V F L D P N T L S P D G - T T A L D Q L S F S R D G R I L A Y S L S L A - G S D W R E I H L - D V E S K Q - - - - - - - - - - - P L E - T P L K D V K F S G I S W L G - N E G F F Y S S Y D K P D G S E L - - - S A R T D Q H - K V Y F H R L G T A Q E D D R L V F G A I P A Q H H R Y V G A T V T E D D R F L L I S A A N S T S - G N R L Y V K D L S Q E - - - - - - N A P L L T V Q G - D L D A D V S L V D N K G S T L Y L L T N R D A P N R R L V T V D A A - - N P G P A H W R D L I P E R Q - - - - - - - - - Q V L - T V H S G S G - Y L F A E Y - V D A T A R V E Q F D Y E - G K R V R E V A L P G - L G S V S G F N G - K H D D P A L Y F G F E N Y A Q P P T L Y R F E P K - - - S G A I S L Y R A S A A P - F K P
M L S F Q Y P D V Y R D E T A I Q D Y H - - - - - G H K V C D P Y A W L E - - D P D S E Q T K A F V E A Q N K I T V P F L E Q C - P I R G L Y K E R M T E L Y D Y P K Y S C H F K K G - K R Y F Y F Y N T G L Q N Q R V L Y V Q D S L - - - - - - - - - E G E A R V F L D P N I L S D D G - T V A L R G Y A F S E D G E Y F A Y G L S A S - G S D W V T I K F M K V D G A K - - - - - - - - - - - E L P - D V L E R V K F S C M A W T H D G K G M F Y N A Y P Q Q D G K S D G T E T S T N L H Q - K L Y Y H V L G T D Q S E D I L C A E F - P D E P K W M G G A E L S D D G R Y V L L S I R E G C D P V N R L W Y C D L Q Q E S N G I T G I L K W V K L I D - N F E G E Y D Y V T N E G T V F T F K T N R H S P N Y R L I N I D F T - - D P E E S K W K V L V P E H E - - - - - - - - K D V L E W V A C V R S N F L V L C Y L H D V K N T L Q L H D L A T G A L L K I F P L - E - V G S V V G Y S G - Q K K D T E I F Y Q F T S F L S P G I I Y H C D L T K - E E L E P R V F R E V T V K - G I -
A P G - N Y P S T R R S - D H V D T Y Q S A S K G E V P V P D P Y Q W L E E S - - - T D E V D K W T T A Q A D L A Q S Y L D Q N - A D I Q K L A E K F R A S R N Y A K F S A P T L L D D G H W Y W F Y N R G L Q S Q S V L Y R S K E P A L P D F S K G D D N V G D V F F D P N V L A A D G - S A G M V L C K F S P D G K F F A Y A V S H L - G G D Y S T I Y V R S T S S P L S Q A S V A Q G V D G R L S - D E V K W F K F S T I I W T K D S K G F L Y Q R Y P A R - - - - - - - - - - S D R N A - M M C Y H K V G T T Q E E D I I V Y Q D - N E H P E W I Y G A D T S E D G K Y L Y L Y Q F K D T S K K N L L W V A E - - - - L D G V K S G I H W R K V V N - E Y A A D Y N I I T N H G S L V Y I K T N L N A P Q Y K V I T I D L S K D E P E - - - I R D F I P E E K - - - - - - - - D A K L A Q V N C A N E E Y F V A I Y K R N V K D E I Y L Y S K A - G V Q L T R L A - P D - F V G A A S I A N - R Q K Q T H F F L T L S G F N T P G T I A R Y D F T A P E T Q R F S I L R T T K V N E L D P
- - - M T P P K A E K R P - Y P I T T H - - - - - G D T R V D D Y Y W L R D D E R T D P Q V L D Y L Q A E N A F T D A A L K P Q Q A L R E T L Y E E M V A R E N L Y F Q S V P Y V R H - G Y R Y Q T R F E P G N E Y A I Y V R Q P Q A E S - - - - - - - - E H W D T L I D G N Q R A E Q R E F Y T L G G L E V S P D N Q K L A V A E D F L - S R R Q Y D I R F K N L S D D - - - - - - - - - - - S W T D - E V L E N T S G - S F E W A N D S A T V Y Y V R K H A - - - - - - - - - - - K T L L P Y Q V Y R H V V G T D P Q L D E L I Y E E - - Q D D T F Y V G L E K T T S D R F I L I H L S S - T - T T S E I L L L D A D R A - - - - - - D S T P Q M F V P R R K D H E Y G I D H Y H - Q H F Y I R S N K D G K N F G L Y Q S E - - - - Q A D E A Q W Q T L I A P R I - - - - - - - - E V M L E G F S L F R - D W L V V E E R S E G L T Q L R Q I H W Q S G - E V K R I A F D D P T Y T T W L A Y N P E P E T E L L R Y G Y S S M T T P T T L Y E L N L D - - - S D E R V M L K Q Q E V K N F T P

 

 

 

 

 

Member Chain UniProtKB GO term
d2hu7a1 A Q9YBQ2 GO:0004252
d2hu7a1 A Q9YBQ2 GO:0005737
d2hu7a1 A Q9YBQ2 GO:0006508
d2hu7a1 A Q9YBQ2 GO:0008236
d2hu7a1 A Q9YBQ2 GO:0008242
d2hu7a1 A Q9YBQ2 GO:0016787
d2hu7a1 A Q9YBQ2 GO:0004252
d2hu7a1 A Q9YBQ2 GO:0005737
d2hu7a1 A Q9YBQ2 GO:0006508
d2hu7a1 A Q9YBQ2 GO:0008236
d2hu7a1 A Q9YBQ2 GO:0008242
d2hu7a1 A Q9YBQ2 GO:0016787
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in