Superfamily : 48350 [ GTPase activation domain, GAP ]
Class : All alpha proteins
Fold : GTPase activation domain, GAP
# of Members : 13
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1f7ca-  ( 191 )                         aqld----siGfsIIkkCihAVetrGine
d1pbwa-  ( 115 )                   lpdLaeqfapp---diAPplLikLVeAIekkGlec
d1tx4a-  (  39 )            plpnqqFgvsLqhLqeknpeqepipiVLreTVayLqahAltt
d1wera-  ( 718 )    mpeeeYseFkeLILqkeLhVVyaLshVCgqdrtlLAsILLrIFlhek---
d2osaa-  ( 264 )                kVYscdLttLvkaht--tkrPmVVdmCIreIesrGlns
d2ovja1  ( 348 )                   egmLadfvs--qtspmIPsIVvhCVneIeqrGlte
d3byia1  ( 262 )    rpsltlqegikdqiFgshLh-VCeren--stvPwFVkqCieaVekrGldv
d3iuga1  ( 367 )               erVFgcdLgeHLlnsg--feVPqVLqsCTaFIeryGi-v
d3msxb-  ( 360 )               gqlFgisLpniCe---ndn-LpkpVldMLffLnqkGPlt
d5c5sa1  ( 110 )    p-------gvepghFgvcvdslts--d--asvPiVLekLLehVemhGlyt
d5irca1  (1242 )             wesnyFgvpLttvvtp----epiPiFIerCIeyIeatGlst
d5my3a1  (  21 )                 tFgvpLesliee----dmVPaIVrqCiyVIdkfGldq
d6v6fb-  (1206 )         erlv-lVTmgdgLpiAmaLavVpcsqwdeLArvLVtlFdsrh---
                                                     aaaaaaaaaaaaa    

                             60        70        80        90        100 
d1f7ca-  ( 216 )    qGLYrivGvnsrVqkLLsilmdpteIca------eweikTITSALktYLr
d1pbwa-  ( 147 )    stLYrtqsssn-laeLrqlLdcdtpsv-dlem---idvhvLAdAFkrYLl
d1tx4a-  (  81 )    egIFrrsantqvvreVqqkYn-mgl-pVdFd--qynalhLPAvILkTFLr
d1wera-  ( 765 )    -------leslLLctLNdreIsmedeattLfra----ttlAStLMeqYMk
d2osaa-  ( 300 )    eGLYrvsGfsdliedVkmaFdrd-gekAdIsvnmYedinIITgALklYFr
d2ovja1  ( 381 )    tgLYrisGc-rtv-el--kflrvkt-vplLs---vddIhAICslLkdFLr
d3byia1  ( 313 )    dgIYv-sGnlatIqkLrfivNqe---klnLddsqW-dIhVVTgALkmFFr
d3iuga1  ( 403 )    dGIYrlsGvasniq-LrheFd-seh-vPdLt--pyvdihSVGsLCklYF-
d3msxb-  ( 395 )    kgIFrqsAnvkscreLkekLn-sgv-evhLd--ce-sifVIAsVLkdFLr
d5c5sa1  ( 150 )    egLYrksgaanrtreLrqaLqtd-PaavkLe--nf-pihAITgVLkqWLr
d5irca1  (1280 )    egIYrvsGnksemesLQrqFddh---nldLae-kdftvnTVAgAMksFFs
d5my3a1  (  56 )    egIYrksanvldvsklkeeIddpanismIlpspsdsdiylVGsLLktFFa
d6v6fb-  (1252 )    -------llyqLLwnMF-seVelad--mtLFrg----nslaSkIMtfCFk
                             aaaaaaaaaaa                 aaaaaaaaaaaaa

                             110       120       130       140       150 
d1f7ca-  ( 267 )    mLpgPLMmyqfqrsFiaAkl-n---------------------------e
d1pbwa-  ( 192 )    dLpnpVIpaaVyseMislapevqs------------------------se
d1tx4a-  ( 127 )    eLpePLLtfdLyphVvgFln-id-------------------------es
d1wera-  ( 804 )    atAtqFVhhALkdsIlkImes----kqsCeLspskleknedvntNlthLl
d2osaa-  ( 349 )    dLpiPLITydAypkFieSAk-imd------------------------pd
d2ovja1  ( 428 )    nLkepLLTfrlNraFMeAAe-it-------------------------dd
d3byia1  ( 361 )    eLpePLFPysff-qFveAik-k-d------------------------nn
d3iuga1  ( 452 )    eLpnPLLTyqlyekFsdAvs-aat------------------------de
d3msxb-  ( 440 )    nIpgSIFssdlYdhWvsVmd-qgn------------------------de
d5c5sa1  ( 196 )    eLpePLMTfaqygdFLrAVe-lpe------------------------kq
d5irca1  (1327 )    eLpdPLVpysmQidLveahk-i-d------------------------re
d5my3a1  ( 109 )    sLpdsVLpkalsseIkvClq-i-d------------------------pt
d6v6fb-  (1291 )    vyGatyLqklLdplLrivitssdwqhvSFeVdptrlepsesl-eNqrnLl
                               aaaaaaa                                

                             160       170       180       190       200 
d1f7ca-  ( 292 )    srvseIHsLVh----rLpeknrqMLhlLMnHLakVAdnhkqNlMtvanLG
d1pbwa-  ( 218 )    eyIqlLkklIr--spsiphqYwlTLqyLLkHFfkLsqtsskNlLnarvLS
d1tx4a-  ( 151 )    qrvpaTlqvLq----tLpeeNyqVLrfLTaFLvqIsahsdqNkMtntnLA
d1wera-  ( 850 )    niLseLVekIfmAseiLpptLryIYgcLQksVqhkwpt--nttMrtrVVS
d2osaa-  ( 374 )    eqletLheALk----lLppaHceTLryLMaHLkrVtlhekeNlMnAenLG
d2ovja1  ( 453 )    nSiaaMyqaVg----eLpqanrDTLAfLMiHLqrVaq-sphT-mdvanLA
d3byia1  ( 386 )    trieaVksLVq----kLpppNrdTMkvLFgHLtkIvakas-NlmstqsLG
d3iuga1  ( 477 )    erlikIhdvIq----qLpppHyrTLefLMrHLslLadycsiTnMhaknLA
d3msxb-  ( 465 )    ekintVqrLld----qLprAnvvLLryLFgVLhnIeqhsssNqMtAfnLA
d5c5sa1  ( 221 )    eqlaaIyavle----hLpeAnhnSLerLIfHLVkVAlledvNrMspgaLA
d5irca1  (1352 )    qklhaLkevLk----kFpkenheVFkyVIsHLnrVshnnkvNlMtSenLS
d5my3a1  ( 134 )    tr-nfMhglIy----nLpdAqywTLrALVfHLkrVlaheaqN-MnlraLC
d6v6fb-  (1341 )    qmTekFFhaIisssseFppqLrsVChCLyqVVsqrfp----qnS-IgaVG
                    aaaaaaaaaa        aaaaaaaaaaaaaaaaaa         aaaaa

                             210       220       230       240       250 
d1f7ca-  ( 338 )    vvFGpTLLrpt------vaaim--dikfQniVIeiLIenhekIFntvp  
d1pbwa-  ( 266 )    eiFSpmLFrfs------aassd--ntenLikVIeiLIstew         
d1tx4a-  ( 197 )    vvFGpnLLwak----daaitlk--ainpIntFTkfLLdhqgeLF      
d1wera-  ( 898 )    gFVFlrLICpAIlnPrmfnIisdspspiAarTLiLVAkSVqnLAnlveFg
d2osaa-  ( 420 )    ivFGptLMrs-pel-damaaln--diryQrlVVelLIknediLf      
d2ovja1  ( 498 )    kvFGpTIVahavpnpdpvtmlD--i--rQpkVVerLLsLpleyWs---qf
d3byia1  ( 432 )    ivFGpTLLrAenet-g--nmai--hmvyQnqIAelMLseysIFg      
d3iuga1  ( 523 )    ivWapnLlrs-------------------svvVefILnhVdvLFs     
d3msxb-  ( 511 )    vcVApSILwPp-assspelene--ftkkVslLIqfLIenClrIf      
d5c5sa1  ( 267 )    iiFApCLLrc-ps--dpltsmk--dvlkIttCVemLIkeqmrkykvkmee
d5irca1  (1398 )    icFWptLMrPdfs---smdalt--atrsyqtIIelFIqq-pfFfy-n   
d5my3a1  ( 180 )    iiWGptIAPanpd-----dan---dvnfqimAMevLLevSdqAFe-pe  
d6v6fb-  (1386 )    SAMFlrFInpaIvsPyeagILdkkPpprIerGLkLMskILqsIAnhvlft
                    aaaaaaa                   aaaaaaaaaaaa  aaa       

                             260       270       280       290       300 
d1f7ca-                                                               
d1pbwa-                                                               
d1tx4a-                                                               
d1wera-  ( 948 )    akepyMegVnpfIksnkhrMimfLdeLGnvpelpdttehsrtdLsrdLaa
d2osaa-                                                               
d2ovja1  ( 543 )    mmv-----------------------------------------------
d3byia1                                                               
d3iuga1                                                               
d3msxb-                                                               
d5c5sa1  ( 314 )    isq-----------------------------------------------
d5irca1                                                               
d5my3a1                                                               
d6v6fb-  (1436 )    -keehMrpFndfVksnfdaArrFFldIAsdf--------------sgnvl
                                                                      

                             310       320       330       340  
d1f7ca-                                                         
d1pbwa-                                                         
d1tx4a-                                                         
d1wera-  ( 998 )    LHeiCvahsdeLrtlSnergaqqhvLkkLlaitelLqqkqnqyt
d2osaa-                                                         
d2ovja1  ( 546 )    -------------------------------------------e
d3byia1                                                         
d3iuga1                                                         
d3msxb-                                                         
d5c5sa1  ( 317 )    -------------------------------------------l
d5irca1                                                         
d5my3a1                                                         
d6v6fb-  (1485 )    alhlLwnnq-kigqyl--------rpdkmat-Laylgpp
 

 

Domain IDNameFamilySourceDomainSTRING-DB
GrafBCR-homology GTPase activation domain (BH-domain)Chicken (Gallus gallus) [TaxId: 9031]view
p85 alpha subunit RhoGAP domainBCR-homology GTPase activation domain (BH-domain)Human (Homo sapiens) [TaxId: 9606]view
p50 RhoGAP domainBCR-homology GTPase activation domain (BH-domain)Human (Homo sapiens) [TaxId: 9606]view
p120GAP domainp120GAP domain-likeHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesNorway rat (Rattus norvegicus) [TaxId: 10116]view
automated matchesautomated matchesBaker's yeast (Saccharomyces cerevisiae) [TaxId: 559292]view
automated matchesp120GAP domain-likeHuman (Homo sapiens) [TaxId: 9606]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340
- - - - - - - - - - - - - - - - - - - - - A Q L D - - - - S I G F S I I K K C I H A V E T R G I N E Q G L Y R I V G V N S R V Q K L L S I L M D P T E I C A - - - - - - E W E I K T I T S A L K T Y L R M L P G P L M M Y Q F Q R S F I A A K L - N - - - - - - - - - - - - - - - - - - - - - - - - - - - E S R V S E I H S L V H - - - - R L P E K N R Q M L H L L M N H L A K V A D N H K Q N L M T V A N L G V V F G P T L L R P T - - - - - - V A A I M - - D I K F Q N I V I E I L I E N H E K I F N T V P - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - L P D L A E Q F A P P - - - D I A P P L L I K L V E A I E K K G L E C S T L Y R T Q S S S N - L A E L R Q L L D C D T P S V - D L E M - - - I D V H V L A D A F K R Y L L D L P N P V I P A A V Y S E M I S L A P E V Q S - - - - - - - - - - - - - - - - - - - - - - - - S E E Y I Q L L K K L I R - - S P S I P H Q Y W L T L Q Y L L K H F F K L S Q T S S K N L L N A R V L S E I F S P M L F R F S - - - - - - A A S S D - - N T E N L I K V I E I L I S T E W - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - P L P N Q Q F G V S L Q H L Q E K N P E Q E P I P I V L R E T V A Y L Q A H A L T T E G I F R R S A N T Q V V R E V Q Q K Y N - M G L - P V D F D - - Q Y N A L H L P A V I L K T F L R E L P E P L L T F D L Y P H V V G F L N - I D - - - - - - - - - - - - - - - - - - - - - - - - - E S Q R V P A T L Q V L Q - - - - T L P E E N Y Q V L R F L T A F L V Q I S A H S D Q N K M T N T N L A V V F G P N L L W A K - - - - D A A I T L K - - A I N P I N T F T K F L L D H Q G E L F - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
M P E E E Y S E F K E L I L Q K E L H V V Y A L S H V C G Q D R T L L A S I L L R I F L H E K - - - - - - - - - - L E S L L L C T L N D R E I S M E D E A T T L F R A - - - - T T L A S T L M E Q Y M K A T A T Q F V H H A L K D S I L K I M E S - - - - K Q S C E L S P S K L E K N E D V N T N L T H L L N I L S E L V E K I F M A S E I L P P T L R Y I Y G C L Q K S V Q H K W P T - - N T T M R T R V V S G F V F L R L I C P A I L N P R M F N I I S D S P S P I A A R T L I L V A K S V Q N L A N L V E F G A K E P Y M E G V N P F I K S N K H R M I M F L D E L G N V P E L P D T T E H S R T D L S R D L A A L H E I C V A H S D E L R T L S N E R G A Q Q H V L K K L L A I T E L L Q Q K Q N Q Y T
- - - - - - - - - - - - K V Y S C D L T T L V K A H T - - T K R P M V V D M C I R E I E S R G L N S E G L Y R V S G F S D L I E D V K M A F D R D - G E K A D I S V N M Y E D I N I I T G A L K L Y F R D L P I P L I T Y D A Y P K F I E S A K - I M D - - - - - - - - - - - - - - - - - - - - - - - - P D E Q L E T L H E A L K - - - - L L P P A H C E T L R Y L M A H L K R V T L H E K E N L M N A E N L G I V F G P T L M R S - P E L - D A M A A L N - - D I R Y Q R L V V E L L I K N E D I L F - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - E G M L A D F V S - - Q T S P M I P S I V V H C V N E I E Q R G L T E T G L Y R I S G C - R T V - E L - - K F L R V K T - V P L L S - - - V D D I H A I C S L L K D F L R N L K E P L L T F R L N R A F M E A A E - I T - - - - - - - - - - - - - - - - - - - - - - - - - D D N S I A A M Y Q A V G - - - - E L P Q A N R D T L A F L M I H L Q R V A Q - S P H T - M D V A N L A K V F G P T I V A H A V P N P D P V T M L D - - I - - R Q P K V V E R L L S L P L E Y W S - - - Q F M M V - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - E
R P S L T L Q E G I K D Q I F G S H L H - V C E R E N - - S T V P W F V K Q C I E A V E K R G L D V D G I Y V - S G N L A T I Q K L R F I V N Q E - - - K L N L D D S Q W - D I H V V T G A L K M F F R E L P E P L F P Y S F F - Q F V E A I K - K - D - - - - - - - - - - - - - - - - - - - - - - - - N N T R I E A V K S L V Q - - - - K L P P P N R D T M K V L F G H L T K I V A K A S - N L M S T Q S L G I V F G P T L L R A E N E T - G - - N M A I - - H M V Y Q N Q I A E L M L S E Y S I F G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - E R V F G C D L G E H L L N S G - - F E V P Q V L Q S C T A F I E R Y G I - V D G I Y R L S G V A S N I Q - L R H E F D - S E H - V P D L T - - P Y V D I H S V G S L C K L Y F - E L P N P L L T Y Q L Y E K F S D A V S - A A T - - - - - - - - - - - - - - - - - - - - - - - - D E E R L I K I H D V I Q - - - - Q L P P P H Y R T L E F L M R H L S L L A D Y C S I T N M H A K N L A I V W A P N L L R S - - - - - - - - - - - - - - - - - - - S V V V E F I L N H V D V L F S - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - G Q L F G I S L P N I C E - - - N D N - L P K P V L D M L F F L N Q K G P L T K G I F R Q S A N V K S C R E L K E K L N - S G V - E V H L D - - C E - S I F V I A S V L K D F L R N I P G S I F S S D L Y D H W V S V M D - Q G N - - - - - - - - - - - - - - - - - - - - - - - - D E E K I N T V Q R L L D - - - - Q L P R A N V V L L R Y L F G V L H N I E Q H S S S N Q M T A F N L A V C V A P S I L W P P - A S S S P E L E N E - - F T K K V S L L I Q F L I E N C L R I F - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
P - - - - - - - G V E P G H F G V C V D S L T S - - D - - A S V P I V L E K L L E H V E M H G L Y T E G L Y R K S G A A N R T R E L R Q A L Q T D - P A A V K L E - - N F - P I H A I T G V L K Q W L R E L P E P L M T F A Q Y G D F L R A V E - L P E - - - - - - - - - - - - - - - - - - - - - - - - K Q E Q L A A I Y A V L E - - - - H L P E A N H N S L E R L I F H L V K V A L L E D V N R M S P G A L A I I F A P C L L R C - P S - - D P L T S M K - - D V L K I T T C V E M L I K E Q M R K Y K V K M E E I S Q - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - L
- - - - - - - - - W E S N Y F G V P L T T V V T P - - - - E P I P I F I E R C I E Y I E A T G L S T E G I Y R V S G N K S E M E S L Q R Q F D D H - - - N L D L A E - K D F T V N T V A G A M K S F F S E L P D P L V P Y S M Q I D L V E A H K - I - D - - - - - - - - - - - - - - - - - - - - - - - - R E Q K L H A L K E V L K - - - - K F P K E N H E V F K Y V I S H L N R V S H N N K V N L M T S E N L S I C F W P T L M R P D F S - - - S M D A L T - - A T R S Y Q T I I E L F I Q Q - P F F F Y - N - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - T F G V P L E S L I E E - - - - D M V P A I V R Q C I Y V I D K F G L D Q E G I Y R K S A N V L D V S K L K E E I D D P A N I S M I L P S P S D S D I Y L V G S L L K T F F A S L P D S V L P K A L S S E I K V C L Q - I - D - - - - - - - - - - - - - - - - - - - - - - - - P T T R - N F M H G L I Y - - - - N L P D A Q Y W T L R A L V F H L K R V L A H E A Q N - M N L R A L C I I W G P T I A P A N P D - - - - - D A N - - - D V N F Q I M A M E V L L E V S D Q A F E - P E - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - E R L V - L V T M G D G L P I A M A L A V V P C S Q W D E L A R V L V T L F D S R H - - - - - - - - - - L L Y Q L L W N M F - S E V E L A D - - M T L F R G - - - - N S L A S K I M T F C F K V Y G A T Y L Q K L L D P L L R I V I T S S D W Q H V S F E V D P T R L E P S E S L - E N Q R N L L Q M T E K F F H A I I S S S S E F P P Q L R S V C H C L Y Q V V S Q R F P - - - - Q N S - I G A V G S A M F L R F I N P A I V S P Y E A G I L D K K P P P R I E R G L K L M S K I L Q S I A N H V L F T - K E E H M R P F N D F V K S N F D A A R R F F L D I A S D F - - - - - - - - - - - - - - S G N V L A L H L L W N N Q - K I G Q Y L - - - - - - - - R P D K M A T - L A Y L G P P - - - - -

 

 

 

 

 

Member Chain UniProtKB GO term
d1f7ca_ A Q5ZMW5 GO:0005096
d1f7ca_ A Q5ZMW5 GO:0007165
d1pbwa_ A P27986 GO:0007165
d1tx4a_ A Q07960 GO:0007165
d1tx4a_ A P61586 GO:0007165
d1wera_ A P20936 GO:0043087
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in