Superfamily : 48230 [ Chondroitin AC/alginate lyase ]
Class : All alpha proteins
Fold : alpha/alpha toroid
# of Members : 6
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1cb8a1  (  26 )                    gtaelIMkrVmldlkk---------------plr
d1egua1  ( 171 )                   kdtytdrLddWngiIaGnqyYdskndqMa--klnq
d1hn0a1  ( 235 )    epeIqfhnvkpqlpvtpeNlaaIdlIrqrLineFvggeketnLaleenis
d1rwaa1  (   4 )                 pgaaeFaaLrnrWvdqiTGrnviqagdpdFa--kAit
d1x1ia1  (  26 )                   sdefdaLrikWatlLtGgpaLdpadsdIa--arTd
d3evha1  (   6 )            hpfdqavVkdptaSYvdvkarrtfLqsg--qld-----drLk
                                      aaaaaaaaaaaa                  aa

                             60        70        80        90        100 
d1cb8a1  (  45 )    nmdkvAeknLntLqp---------dgSWdVpykdd---------------
d1egua1  ( 204 )    elegkVadSlssissqa-----driyLWekfsnyk---------------
d1hn0a1  ( 285 )    kLksdfdaL--nIhtlanggTqGrhLITdkqiiiyqpenlnsqdkqlfdn
d1rwaa1  (  39 )    alnnkAadSlakldaaa-----grtsVFtdls-La---------------
d1x1ia1  (  59 )    kLaqdAndywedMdlss-----srtyIWyalrgng---------------
d3evha1  (  41 )    aalpkeydÇtteatp---npqqgeMvIpr-----rylsgnhgpvnpdyep
                    aaaaaaa                                           

                             110       120       130       140       150 
d1cb8a1  (  72 )    --amtnWlPnnHLlqLetIIQAYIekdShyygddkVfdqIs-AFkyWyds
d1egua1  ( 234 )    --tS--anLTaTYrkLeeMAkQVtNpsSryyqdetVvrtVrdSMewMhkh
d1hn0a1  ( 333 )    yviL--gnYTtlMFNISrayvl--ekdptqk--aqLkqMYllMTkHLLdq
d1rwaa1  (  68 )    --kd--aeMvtTYtrLsqLAtAwaTptAavfgdaavlaaIkaGLadAntl
d1x1ia1  (  89 )    --tS--dnVnaVYerLrtMalAAtTvgSslygnadLkedILdAldwLyvn
d3evha1  (  83 )    v--v--tlYrdFEkiSAtLGNLYVat-----gkpvYAtçLLnMLdkWAka
                          aaaaaaaaaaaaaaaaa          aaaaaaaaaaaaaaaa 

                             160       170       180       190       200 
d1cb8a1  ( 120 )    dPkSr------nwwhneIatPqaLGeMLILMry--GkpLdlvhkLTerMk
d1egua1  ( 280 )    vYnseksi-vgnwwdYEIGTPrAINnTLSLMke--yFsdeeIkkYTdVIe
d1hn0a1  ( 377 )    gFvkgsalvtThhWgySSrWWYISTLLMsdALk--e--anlqtqVYdSLl
d1rwaa1  ( 114 )    cYndrkeE-vgnwwSWEIGVPraLAdAMVLLha--eLsaaertaYcaAId
d1x1ia1  ( 135 )    SYnstrsrsaynwwhWqLGIPmsLNdA-VLLyd--dIsaarmatYMdTId
d3evha1  ( 124 )    daLlnYdpks-qSWyqVEwSAATAAFALSTMmaepnVdtaqrerVvkWLn
                                aaaaa aaaaaaaaa a            aaaaaaaaa

                             210       220       230       240       250 
d1cb8a1  ( 165 )    -------rGePek-------ktGAnkTdIALHyFYrALLtsd----ealL
d1egua1  ( 327 )    kFVpdpehFrkttdnpf--kAlgGnLVDMGrVKVIAGLLrkd----dqEi
d1hn0a1  ( 423 )    wYSrefk--ssFdMkvsadSSdLdYFntlSRQHLALLLLepddqkrInlV
d1rwaa1  ( 161 )    hFVpdPwlqfppkrgki--tSvGAnRVDLCqGIIIrSLAged----ptkL
d1x1ia1  ( 183 )    yFTpsIg-------------ltGAarAwQAiVVGVrAVIvkd----avkL
d3evha1  ( 173 )    rVArhQTsfpgg-----dtsccnnaSYWRGQEATIIGVIskd----deLF
                    aa                    aaaaaaaaaaaaaaaaa       aaaa

                             260       270       280       290       300 
d1cb8a1  ( 197 )    sfAvkELfy--pVqfvhy-eegLQydysYlQhgpql--QiSsyGavFItG
d1egua1  ( 371 )    ssTIrSIeq--VFklvdq-gegFyqdGsYiDhtnva--YTGayGNvLIdG
d1hn0a1  ( 471 )    nTFshYItgA-LtqvPpggkdGLrpdGtAwrhe-gn--yPg-ySFpAFkn
d1rwaa1  ( 205 )    nhAvaGLsq--VWqyvts-gdgIfrdgsFiQhsttp--YTGsyGVvLLtg
d1x1ia1  ( 216 )    aaArnGLsgtGIFpyatg-gdGFyadgsFvQhttfa--YTGGyGssVLeT
d3evha1  ( 214 )    rwGLgrYvq--AMg-------lInedGSFvhEMtr-heqSLHyQNyAMLP
                    aaaaaaa              bb     bb            aaaaaaaa

                             310       320       330       340       350 
d1cb8a1  ( 242 )    VLkLAnYVrdTpyaLstekla--iFSkYYrdsYLkaIrgsyMdfnVEgrg
d1egua1  ( 416 )    LSqLLpVIqktknpIdkdkmq--tMyhWIdkSFaplLvnGeLmdmsRgrs
d1hn0a1  ( 516 )    ASQLIyLLrdTpFsVgesGwn--nLkkAMv-sAwiySn-peVglplAgrh
d1rwaa1  ( 250 )    LSkLfsLLggtaFeVsdptrs--iFfdAVegSFapvMinGaMadavRgrS
d1x1ia1  ( 263 )    TAnLMyLLsgstwsVsdpnqs--nVWqWIyeAYrplLykGaMmdmvRgre
d3evha1  ( 254 )    LTMIAETAsrQgidLYaykengrdIhsArkFVFaAvkn-----pdlIkky
                    aaaaaaaa               aaaaaaaa            333    

                             360       370       380       390       400 
d1cb8a1  ( 290 )    vsrp-----dilnkkaEkrLlvAkmiDl-khteeWadAiarTdstvaagy
d1egua1  ( 464 )    isra-nseGhvaAVeVLrGIHrIAdmsegetkqrLqslVKtIvqsdsyyd
d1hn0a1  ( 562 )    pf------nspsLksVaqGYyWLAmSaksspdktLAsIYLaIsd------
d1rwaa1  ( 298 )    isre-antgydlGasAIeAILlLAramdpataarWrGlCaGWiardtyrp
d1x1ia1  ( 311 )    isrs-yaqdhavGHgIVaSIVRLAqfApaphaaaFkqIAkrVIqeDtfss
d3evha1  ( 299 )    asepQdtrAFkpgrgdLNWIEYQrarf--------gfadeLgfMtvpIfd
                                     aaaaaaa        aaaaaaaaaa        

                             410       420      
d1cb8a1  ( 335 )    k                           
d1egua1  ( 513 )    vfknLktYkdIslMqsLlsdagvasvpr
d1hn0a1  ( 600 )    -----ktqneStaiFg----etitpasl
d1rwaa1  ( 347 )    ilnsAs-VprTaLvkqLeatg-vapvae
d1x1ia1  ( 360 )    FygdVs-TDTIrlAkaIvddpsiapaaa
d3evha1  ( 341 )    prTGGsATLLaykpqg            
                           aaa
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Chondroitinase ACHyaluronate lyase-like catalytic, N-terminal domainPedobacter heparinus (Flavobacterium heparinum) [TaxId: 984]view
Hyaluronate lyaseHyaluronate lyase-like catalytic, N-terminal domainPneumococcus (Streptococcus pneumoniae) [TaxId: 1313]view
Chondroitin ABC lyase IHyaluronate lyase-like catalytic, N-terminal domainProteus vulgaris [TaxId: 585]view
Chondroitinase ACHyaluronate lyase-like catalytic, N-terminal domainArthrobacter aurescens [TaxId: 43663]view
automated matchesHyaluronate lyase-like catalytic, N-terminal domainBacillus sp. [TaxId: 84635]view
Alginate lyase A1-IIIAlginate lyase A1-IIISphingomonas sp., A1 [TaxId: 28214]view

 

No outliers

Created with Raphaëld3evha1d1hn0a1d1cb8a1d1egua1d1x1ia1d1rwaa1
FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420
- - - - - - - - - - - - - - - - G T A E L I M K R V M L D L K K - - - - - - - - - - - - - - - P L R N M D K V A E K N L N T L Q P - - - - - - - - - D G S W D V P Y K D D - - - - - - - - - - - - - - - - - A M T N W L P N N H L L Q L E T I I Q A Y I E K D S H Y Y G D D K V F D Q I S - A F K Y W Y D S D P K S R - - - - - - N W W H N E I A T P Q A L G E M L I L M R Y - - G K P L D L V H K L T E R M K - - - - - - - R G E P E K - - - - - - - K T G A N K T D I A L H Y F Y R A L L T S D - - - - E A L L S F A V K E L F Y - - P V Q F V H Y - E E G L Q Y D Y S Y L Q H G P Q L - - Q I S S Y G A V F I T G V L K L A N Y V R D T P Y A L S T E K L A - - I F S K Y Y R D S Y L K A I R G S Y M D F N V E G R G V S R P - - - - - D I L N K K A E K R L L V A K M I D L - K H T E E W A D A I A R T D S T V A A G Y K - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - K D T Y T D R L D D W N G I I A G N Q Y Y D S K N D Q M A - - K L N Q E L E G K V A D S L S S I S S Q A - - - - - D R I Y L W E K F S N Y K - - - - - - - - - - - - - - - - - T S - - A N L T A T Y R K L E E M A K Q V T N P S S R Y Y Q D E T V V R T V R D S M E W M H K H V Y N S E K S I - V G N W W D Y E I G T P R A I N N T L S L M K E - - Y F S D E E I K K Y T D V I E K F V P D P E H F R K T T D N P F - - K A L G G N L V D M G R V K V I A G L L R K D - - - - D Q E I S S T I R S I E Q - - V F K L V D Q - G E G F Y Q D G S Y I D H T N V A - - Y T G A Y G N V L I D G L S Q L L P V I Q K T K N P I D K D K M Q - - T M Y H W I D K S F A P L L V N G E L M D M S R G R S I S R A - N S E G H V A A V E V L R G I H R I A D M S E G E T K Q R L Q S L V K T I V Q S D S Y Y D V F K N L K T Y K D I S L M Q S L L S D A G V A S V P R
E P E I Q F H N V K P Q L P V T P E N L A A I D L I R Q R L I N E F V G G E K E T N L A L E E N I S K L K S D F D A L - - N I H T L A N G G T Q G R H L I T D K Q I I I Y Q P E N L N S Q D K Q L F D N Y V I L - - G N Y T T L M F N I S R A Y V L - - E K D P T Q K - - A Q L K Q M Y L L M T K H L L D Q G F V K G S A L V T T H H W G Y S S R W W Y I S T L L M S D A L K - - E - - A N L Q T Q V Y D S L L W Y S R E F K - - S S F D M K V S A D S S D L D Y F N T L S R Q H L A L L L L E P D D Q K R I N L V N T F S H Y I T G A - L T Q V P P G G K D G L R P D G T A W R H E - G N - - Y P G - Y S F P A F K N A S Q L I Y L L R D T P F S V G E S G W N - - N L K K A M V - S A W I Y S N - P E V G L P L A G R H P F - - - - - - N S P S L K S V A Q G Y Y W L A M S A K S S P D K T L A S I Y L A I S D - - - - - - - - - - - K T Q N E S T A I F G - - - - E T I T P A S L
- - - - - - - - - - - - - P G A A E F A A L R N R W V D Q I T G R N V I Q A G D P D F A - - K A I T A L N N K A A D S L A K L D A A A - - - - - G R T S V F T D L S - L A - - - - - - - - - - - - - - - - - K D - - A E M V T T Y T R L S Q L A T A W A T P T A A V F G D A A V L A A I K A G L A D A N T L C Y N D R K E E - V G N W W S W E I G V P R A L A D A M V L L H A - - E L S A A E R T A Y C A A I D H F V P D P W L Q F P P K R G K I - - T S V G A N R V D L C Q G I I I R S L A G E D - - - - P T K L N H A V A G L S Q - - V W Q Y V T S - G D G I F R D G S F I Q H S T T P - - Y T G S Y G V V L L T G L S K L F S L L G G T A F E V S D P T R S - - I F F D A V E G S F A P V M I N G A M A D A V R G R S I S R E - A N T G Y D L G A S A I E A I L L L A R A M D P A T A A R W R G L C A G W I A R D T Y R P I L N S A S - V P R T A L V K Q L E A T G - V A P V A E
- - - - - - - - - - - - - - - S D E F D A L R I K W A T L L T G G P A L D P A D S D I A - - A R T D K L A Q D A N D Y W E D M D L S S - - - - - S R T Y I W Y A L R G N G - - - - - - - - - - - - - - - - - T S - - D N V N A V Y E R L R T M A L A A T T V G S S L Y G N A D L K E D I L D A L D W L Y V N S Y N S T R S R S A Y N W W H W Q L G I P M S L N D A - V L L Y D - - D I S A A R M A T Y M D T I D Y F T P S I G - - - - - - - - - - - - - L T G A A R A W Q A I V V G V R A V I V K D - - - - A V K L A A A R N G L S G T G I F P Y A T G - G D G F Y A D G S F V Q H T T F A - - Y T G G Y G S S V L E T T A N L M Y L L S G S T W S V S D P N Q S - - N V W Q W I Y E A Y R P L L Y K G A M M D M V R G R E I S R S - Y A Q D H A V G H G I V A S I V R L A Q F A P A P H A A A F K Q I A K R V I Q E D T F S S F Y G D V S - T D T I R L A K A I V D D P S I A P A A A
- - - - - - - - H P F D Q A V V K D P T A S Y V D V K A R R T F L Q S G - - Q L D - - - - - D R L K A A L P K E Y D C T T E A T P - - - N P Q Q G E M V I P R - - - - - R Y L S G N H G P V N P D Y E P V - - V - - T L Y R D F E K I S A T L G N L Y V A T - - - - - G K P V Y A T C L L N M L D K W A K A D A L L N Y D P K S - Q S W Y Q V E W S A A T A A F A L S T M M A E P N V D T A Q R E R V V K W L N R V A R H Q T S F P G G - - - - - D T S C C N N A S Y W R G Q E A T I I G V I S K D - - - - D E L F R W G L G R Y V Q - - A M G - - - - - - - L I N E D G S F V H E M T R - H E Q S L H Y Q N Y A M L P L T M I A E T A S R Q G I D L Y A Y K E N G R D I H S A R K F V F A A V K N - - - - - P D L I K K Y A S E P Q D T R A F K P G R G D L N W I E Y Q R A R F - - - - - - - - G F A D E L G F M T V P I F D P R T G G S A T L L A Y K P Q G - - - - - - - - - - - -

 

 

 

 

 

 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in