Superfamily : 48097 [ Regulator of G-protein signaling, RGS ]
Class : All alpha proteins
Fold : Regulator of G-protein signaling, RGS
# of Members : 8
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1dk8a-  ( 111 )    gsa-sp-----tppylkWae----sLhsLLddqdGislFrtfLkq--egc
d1fqia-  ( 283 )    klvdip-----tkrverWaf----nFseLIrdpkGrqsFqhFLrk--efs
d1htjf-  ( 306 )                 esdiiFq----dlekLksrpAHLgVFLrYIFs--qad
d1iapa-  (  44 )                    sqFq----sleqVkrrPAHLMALLqHVAl--qfe
d2ihda-  (  46 )               steAtrWad----sFdvLLs-hyGvaaFrafLkt--efs
d2jnua1  (   3 )             teeqpvasWal----sFerllqdplGlayFteflkk--efs
d3v5wa1  (  30 )    kkillpepsirsvMqkyLedrgevtFekIfsqklGyllFrdfClnhleeA
d6am3a-  (  72 )    n---pt-----aeeVlsWsq----nFdkMMkapaGrnlFreFLrt--eys
                                             aaaaa  aaaaaaaaaaaaa     

                             60        70        80        90        100 
d1dk8a-  ( 149 )    adLLdFwfaCtgFrklepcdsneekRlklAraIyr-kyIldn-ngiVSrq
d1fqia-  ( 323 )    genLgFWeaCedLkygd-----qskvkekAeeiyk-lFLa-p-garrwin
d1htjf-  ( 337 )    pSPLLFyLCAevYqqas-----pkdsrslGkdIwn-iFLek--nApLrvk
d1iapa-  (  72 )    PgpLLCCLhAdmLgslg-----pkeakkaFldFyh-sFLek--tavLrVp
d2ihda-  (  80 )    eenLeFwlaCe-FkkTrs----taklvskAhriFe-eFVd-v-qApreVn
d2jnua1  (  38 )    aenvtFwkaCerFqqip--asdtqqlaqeArniyq-eflss--qAlspvn
d3v5wa1  (  80 )    rplVeFyeeIkkYekle----teeervarSreIfdsyiMkeLlacsh--p
d6am3a-  ( 108 )    eenLlFwlaCedLkkeqn----kkvieekArmIye-dyIs-i-lspkeVs
                     aaaaaaaaaaaa         aaaaaaaaaaaaa aa            

                             110       120       130       140       150 
d1dk8a-  ( 197 )    TkpatksfIkg-cImkql--IdpaMFdqAqteIqatMeentypsFlks--
d1fqia-  ( 365 )    idgkt-diTvk-glk--h--phryVLdaAQthIylk--kdsyarYlks--
d1htjf-  ( 379 )    Ipe-lqaeIds-rLrnsed--ArgVLceAQeaAp-eIq-eQIhdYrtkrt
d1iapa-  ( 114 )    VppnVafeldrtradlIsedvqrrFvqeVvqsQqvaVg-rqLedFrskrl
d2ihda-  ( 123 )    IdfqTreaTrk-nLq--e--psltCFdqAqgkVhslMekdSyprFlrs--
d2jnua1  (  83 )    idrqa-Wlgee-vla--e--PrpdmFraqqlqifnlmkfdSyarFvkS--
d3v5wa1  ( 124 )    FsksAtehVqg-hLgkkq--VppdLFqpYieeIcqnLrgdvFqkFies--
d6am3a-  ( 151 )    LdsrVrevInr-nll--d--PnphMYedAQlqIytlMhrdSFprFlns--
                         aaaaaa a             aaaaaaaaaaaa  aaaaaa    

                             160       170       180       190       200 
d1dk8a-  ( 242 )    -----diYleytrtgs-espkv                            
d1fqia-  ( 408 )    -----piYk-elakai-ep                               
d1htjf-  ( 425 )    lglgslYgendLldld--------gdplrerqVAekQlaaLgdilsay--
d1iapa-  ( 163 )    mgmT--pweqeLaqLeawvgrdrasYearErhvAerLLmhLeemqhtIst
d2ihda-  ( 166 )    -----kmyl-dll                                     
d2jnua1  ( 125 )    -----plYr-ecllaeae                                
d3v5wa1  ( 169 )    -----dkFtrFCqwknvelnih                            
d6am3a-  ( 194 )    -----qiyk-sfvest                                  
                           aa                                         

                             210       220 
d1dk8a-                                    
d1fqia-                                    
d1htjf-  ( 465 )    aadrsap-dfALntys-hagirl
d1iapa-  ( 211 )    deekSaaVvnaIglYMrhlgVrt
d2ihda-                                    
d2jnua1                                    
d3v5wa1                                    
d6am3a-
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Axin RGS-homologous domainRegulator of G-protein signaling, RGSHuman (Homo sapiens) [TaxId: 9606]view
RGS9, RGS domainRegulator of G-protein signaling, RGSCow (Bos taurus) [TaxId: 9913]view
Pdz-RhoGEF RGS-like domainRegulator of G-protein signaling, RGSHuman (Homo sapiens) [TaxId: 9606]view
p115RhoGEFRegulator of G-protein signaling, RGSHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view
automated matchesautomated matchesHuman (Homo sapiens) [TaxId: 9606]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220
G S A - S P - - - - - T P P Y L K W A E - - - - S L H S L L D D Q D G I S L F R T F L K Q - - E G C A D L L D F W F A C T G F R K L E P C D S N E E K R L K L A R A I Y R - K Y I L D N - N G I V S R Q T K P A T K S F I K G - C I M K Q L - - I D P A M F D Q A Q T E I Q A T M E E N T Y P S F L K S - - - - - - - D I Y L E Y T R T G S - E S P K V - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
K L V D I P - - - - - T K R V E R W A F - - - - N F S E L I R D P K G R Q S F Q H F L R K - - E F S G E N L G F W E A C E D L K Y G D - - - - - Q S K V K E K A E E I Y K - L F L A - P - G A R R W I N I D G K T - D I T V K - G L K - - H - - P H R Y V L D A A Q T H I Y L K - - K D S Y A R Y L K S - - - - - - - P I Y K - E L A K A I - E P - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - E S D I I F Q - - - - D L E K L K S R P A H L G V F L R Y I F S - - Q A D P S P L L F Y L C A E V Y Q Q A S - - - - - P K D S R S L G K D I W N - I F L E K - - N A P L R V K I P E - L Q A E I D S - R L R N S E D - - A R G V L C E A Q E A A P - E I Q - E Q I H D Y R T K R T L G L G S L Y G E N D L L D L D - - - - - - - - G D P L R E R Q V A E K Q L A A L G D I L S A Y - - A A D R S A P - D F A L N T Y S - H A G I R L
- - - - - - - - - - - - - - - - S Q F Q - - - - S L E Q V K R R P A H L M A L L Q H V A L - - Q F E P G P L L C C L H A D M L G S L G - - - - - P K E A K K A F L D F Y H - S F L E K - - T A V L R V P V P P N V A F E L D R T R A D L I S E D V Q R R F V Q E V V Q S Q Q V A V G - R Q L E D F R S K R L M G M T - - P W E Q E L A Q L E A W V G R D R A S Y E A R E R H V A E R L L M H L E E M Q H T I S T D E E K S A A V V N A I G L Y M R H L G V R T
- - - - - - - - - - - S T E A T R W A D - - - - S F D V L L S - H Y G V A A F R A F L K T - - E F S E E N L E F W L A C E - F K K T R S - - - - T A K L V S K A H R I F E - E F V D - V - Q A P R E V N I D F Q T R E A T R K - N L Q - - E - - P S L T C F D Q A Q G K V H S L M E K D S Y P R F L R S - - - - - - - K M Y L - D L L - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - T E E Q P V A S W A L - - - - S F E R L L Q D P L G L A Y F T E F L K K - - E F S A E N V T F W K A C E R F Q Q I P - - A S D T Q Q L A Q E A R N I Y Q - E F L S S - - Q A L S P V N I D R Q A - W L G E E - V L A - - E - - P R P D M F R A Q Q L Q I F N L M K F D S Y A R F V K S - - - - - - - P L Y R - E C L L A E A E - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
K K I L L P E P S I R S V M Q K Y L E D R G E V T F E K I F S Q K L G Y L L F R D F C L N H L E E A R P L V E F Y E E I K K Y E K L E - - - - T E E E R V A R S R E I F D S Y I M K E L L A C S H - - P F S K S A T E H V Q G - H L G K K Q - - V P P D L F Q P Y I E E I C Q N L R G D V F Q K F I E S - - - - - - - D K F T R F C Q W K N V E L N I H - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
N - - - P T - - - - - A E E V L S W S Q - - - - N F D K M M K A P A G R N L F R E F L R T - - E Y S E E N L L F W L A C E D L K K E Q N - - - - K K V I E E K A R M I Y E - D Y I S - I - L S P K E V S L D S R V R E V I N R - N L L - - D - - P N P H M Y E D A Q L Q I Y T L M H R D S F P R F L N S - - - - - - - Q I Y K - S F V E S T - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

 

 

 

 

 

Member Chain UniProtKB GO term
d1dk8a_ A O15169 GO:0090090
d1fqia_ A O46469 GO:0008277
d1htjf_ F O15085 GO:0001664
d1htjf_ F O15085 GO:0005085
d1htjf_ F O15085 GO:0005737
d1htjf_ F O15085 GO:0007186
d1iapa_ A Q92888 GO:0005085
d1iapa_ A Q92888 GO:0005737
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in