Superfamily : 47226 [ Histidine-containing phosphotransfer domain, HPT domain ]
Class : All alpha proteins
Fold : Four-helical up-and-down bundle
# of Members : 9
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d1c02a-  (   2 )                 stIpseiInwtiLneiismdd----------------
d1i5na-  (   5 )                                                      
d1sr2a-  ( 775 )                                        mqeavlqlievqla
d1tqga1  (   4 )                                                      
d1wn0a1  (   9 )          qlnallssMfasglVd-eqFqqLQmlqedg--------------
d1y6da-  (   1 )                                                      
d2a0ba-  ( 658 )                   ksealLdipmLeqylel------------------
d2ooca1  (   8 )                                                      
d4g78a1  (   1 )    mdhlhrklrdheaaMfqqgyLd-dqFsqlqkl--qd--------------
                                                                      

                             60        70        80        90        100 
d1c02a-  (  23 )    ----------dds-dfSk--glIiqFi-----dqAqtTFaqMqrQLdg--
d1i5na-  (   5 )                      isdfyqtFf-----deAdellad-eqhLldL-
d1sr2a-  ( 789 )    qeevtesplggdenaqlhasgyyalFv-----dtvpdDvkrlyteaa---
d1tqga1  (   4 )                        eylgvFv-----detkeylqnlndtllele
d1wn0a1  (  38 )    ----------gtp-gfVa--evVtlFc-----ddAdrIIseLaalLdqp-
d1y6da-  (   1 )                mntdvlnqqkieelSaeiGsdnvpvlldiflgemdsyi
d2a0ba-  ( 675 )    -----------vgpklIt--dgLavFe-----kmMpgyVsvLesnlt---
d2ooca1  (   8 )                   gaVdfayLegfAa-gdfavVdevLalFreqAalwa
d4g78a1  (  34 )    ----------dtspdfVi--evMtmFf-----ddSekllnnMsraLeqv-
                                         aaaaaa     aaaaaaaaaaaaaaa   

                             110       120       130       140       150 
d1c02a-  (  53 )    -------eknlteLdnlGhfL-kgsSaalGLqRIa-wVCerIQnLGrkmq
d1i5na-  (  31 )    -vpespdaeqLnaifraahsI-kggAgtfgftilq-eTth-lenLldear
d1sr2a-  ( 831 )    -------tsdfaalaqtAhrl-kgvFamlnlvpGk-qlCetlehlir---
d1tqga1  (  29 )    knpe--dmelineAfralhtl-kgmAgtmgfssMa-klChtlEnildkAr
d1wn0a1  (  69 )    -------iVdfdkVdayVhqL-kgsSasVgAqkVk-ftCmqFrqlCq---
d1y6da-  (  39 )    gtltelqgSeqllylkEishAlksSAasFGadrlceraiaidkkakAnql
d2a0ba-  ( 704 )    -------aqdkkgIveEGhkI-kgaAgsvGLrhLq-qLGqqIqsp---dl
d2ooca1  (  42 )    pLdpthp-----gwkdAVhtV-kgaArgvGAfnLG--vCrCeag------
d4g78a1  (  66 )    -------pvnfkqIdahAhqQ-kgsSasVGAarVk-nvCgtFrnfCe---
                              aaaaaaaaaaa aaaaaa   aaaa aaaa a aaa    

                             160       170       180       190       200 
d1c02a-  (  94 )    hfFpnkteLvntLsdksiinginideddeeikIqvddkdenSiyLilIak
d1i5na-  (  78 )    rge-----------------------------------qLntdiinlfle
d1sr2a-  ( 869 )    -----------------------------------------ekdvpgiek
d1tqga1  (  75 )    nsei----------------------------------kitsdlldkifa
d1wn0a1  ( 107 )    -----------------------------------------dknrdgCim
d1y6da-  (  89 )    qe--------------------------------------qgmetsEMla
d2a0ba-  ( 742 )    p-----------------------------------------aWednVge
d2ooca1  (  81 )    -----------------------------------------qeslegVrt
d4g78a1  ( 104 )    -----------------------------------------aqnleGCvr
                                                                aaaaaa

                             210       220       230     
d1c02a-  ( 144 )    ALnQSrLEfkLAri-----eLskyyntnl        
d1i5na-  (  94 )    tkd-iqeQLdayknseePdaasfeyICnaLrqlalea
d1sr2a-  ( 878 )    yisdidsyvksll                        
d1tqga1  (  91 )    Gvdmitrmvdkivs                       
d1wn0a1  ( 116 )    aLavVrneFydLrn-----kFqtMlqleq        
d1y6da-  ( 101 )    llhitrdaYrswtn                       
d2a0ba-  ( 751 )    wIeeMkeeWrhDVe-----vLkawVakat        
d2ooca1  (  90 )    aLdaAlldIaayah-----eqalslk           
d4g78a1  ( 113 )    clqqLqqeyslLkn-----nLkyLfkLqqeiktagrs
                    aaaaaaaaaaaa
 

 

Domain IDNameFamilySourceDomainSTRING-DB
Phosphorelay protein ypd1Phosphorelay protein-likeBaker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]view
Chemotaxis protein CheA P1 domainChemotaxis protein CheA P1 domainSalmonella typhimurium [TaxId: 90371]view
Sensor-like histidine kinase YojN, C-terminal domainSensor-like histidine kinase YojN, C-terminal domainEscherichia coli [TaxId: 562]view
Chemotaxis protein CheA P1 domainChemotaxis protein CheA P1 domainThermotoga maritima [TaxId: 2336]view
Histidine-containing phosphotransfer protein HP2Phosphorelay protein-likeMaize (Zea mays) [TaxId: 4577]view
Phosphorelay protein luxUPhosphorelay protein luxUVibrio harveyi [TaxId: 669]view
Aerobic respiration control sensor protein, ArcBAerobic respiration control sensor protein, ArcBEscherichia coli [TaxId: 562]view
Histidine phosphotransferase ShpASphA-likeCaulobacter crescentus [TaxId: 155892]view
automated matchesautomated matchesMedicago truncatula [TaxId: 3880]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230
- - - - - - - - - - - - - S T I P S E I I N W T I L N E I I S M D D - - - - - - - - - - - - - - - - - - - - - - - - - - D D S - D F S K - - G L I I Q F I - - - - - D Q A Q T T F A Q M Q R Q L D G - - - - - - - - - E K N L T E L D N L G H F L - K G S S A A L G L Q R I A - W V C E R I Q N L G R K M Q H F F P N K T E L V N T L S D K S I I N G I N I D E D D E E I K I Q V D D K D E N S I Y L I L I A K A L N Q S R L E F K L A R I - - - - - E L S K Y Y N T N L - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - I S D F Y Q T F F - - - - - D E A D E L L A D - E Q H L L D L - - V P E S P D A E Q L N A I F R A A H S I - K G G A G T F G F T I L Q - E T T H - L E N L L D E A R R G E - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Q L N T D I I N L F L E T K D - I Q E Q L D A Y K N S E E P D A A S F E Y I C N A L R Q L A L E A
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M Q E A V L Q L I E V Q L A Q E E V T E S P L G G D E N A Q L H A S G Y Y A L F V - - - - - D T V P D D V K R L Y T E A A - - - - - - - - - - T S D F A A L A Q T A H R L - K G V F A M L N L V P G K - Q L C E T L E H L I R - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - E K D V P G I E K Y I S D I D S Y V K S L L - - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - E Y L G V F V - - - - - D E T K E Y L Q N L N D T L L E L E K N P E - - D M E L I N E A F R A L H T L - K G M A G T M G F S S M A - K L C H T L E N I L D K A R N S E I - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - K I T S D L L D K I F A G V D M I T R M V D K I V S - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - Q L N A L L S S M F A S G L V D - E Q F Q Q L Q M L Q E D G - - - - - - - - - - - - - - - - - - - - - - - - G T P - G F V A - - E V V T L F C - - - - - D D A D R I I S E L A A L L D Q P - - - - - - - - I V D F D K V D A Y V H Q L - K G S S A S V G A Q K V K - F T C M Q F R Q L C Q - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - D K N R D G C I M A L A V V R N E F Y D L R N - - - - - K F Q T M L Q L E Q - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M N T D V L N Q Q K I E E L S A E I G S D N V P V L L D I F L G E M D S Y I G T L T E L Q G S E Q L L Y L K E I S H A L K S S A A S F G A D R L C E R A I A I D K K A K A N Q L Q E - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Q G M E T S E M L A L L H I T R D A Y R S W T N - - - - - - - - - - - - - - - - - - - - - - -
- - - - - - - - - - - - - - - K S E A L L D I P M L E Q Y L E L - - - - - - - - - - - - - - - - - - - - - - - - - - - - - V G P K L I T - - D G L A V F E - - - - - K M M P G Y V S V L E S N L T - - - - - - - - - - A Q D K K G I V E E G H K I - K G A A G S V G L R H L Q - Q L G Q Q I Q S P - - - D L P - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A W E D N V G E W I E E M K E E W R H D V E - - - - - V L K A W V A K A T - - - - - - - -
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - G A V D F A Y L E G F A A - G D F A V V D E V L A L F R E Q A A L W A P L D P T H P - - - - - G W K D A V H T V - K G A A R G V G A F N L G - - V C R C E A G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Q E S L E G V R T A L D A A L L D I A A Y A H - - - - - E Q A L S L K - - - - - - - - - - -
M D H L H R K L R D H E A A M F Q Q G Y L D - D Q F S Q L Q K L - - Q D - - - - - - - - - - - - - - - - - - - - - - - - D T S P D F V I - - E V M T M F F - - - - - D D S E K L L N N M S R A L E Q V - - - - - - - - P V N F K Q I D A H A H Q Q - K G S S A S V G A A R V K - N V C G T F R N F C E - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A Q N L E G C V R C L Q Q L Q Q E Y S L L K N - - - - - N L K Y L F K L Q Q E I K T A G R S

 

 

 

 

 

Member Chain UniProtKB GO term
d1c02a_ A Q07688 GO:0000160
d1c02a_ A Q07688 GO:0005515
d1c02a_ A Q07688 GO:0005634
d1c02a_ A Q07688 GO:0005737
d1c02a_ A Q07688 GO:0007234
d1c02a_ A Q07688 GO:0009927
d1c02a_ A Q07688 GO:0016772
d1c02a_ A Q07688 GO:0043424
d1i5na_ A P09384 GO:0000160
d1sr2a_ A P39838 GO:0000160
d1wn0a1 A Q9SLX1 GO:0000160
d1wn0a1 A Q9SLX1 GO:0005515
d1wn0a1 A Q9SLX1 GO:0005634
d1wn0a1 A Q9SLX1 GO:0005737
d1wn0a1 A Q9SLX1 GO:0005829
d1wn0a1 A Q9SLX1 GO:0009736
d1wn0a1 A Q9SLX1 GO:0009927
d1wn0a1 A Q9SLX1 GO:0043424
d1wn0a1 A Q9SLX1 GO:0080038
d1y6da_ A P0C5S4 GO:0000160
d2a0ba_ A P0AEC3 GO:0000160
d2ooca1 A Q9A980 GO:0000160
d2ooca1 A Q9A980 GO:0016740
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in