Superfamily : 345923 [ CRISPR-associated endonuclease Cas9/Csn1, Target recognition (REC) lobe ]
Class : Alpha and beta proteins (a+b)
Fold : CRISPR-associated endonuclease Cas9/Csn1, Target recognition (REC) lobe
# of Members : 3
Superposed Structure
solvent inaccessible: UPPER CASE X
solvent accesible: lower case x
alpha helix: red x
beta strand: blue x
3 - 10 helix: maroon x
hydrogen bond to main chain amide: bold x
hydrogen bond to mainchain carbonyl: underline x
disulphide bond: cedilla
positive phi: italic x
 
                             10        20        30        40        50  
d4ogca3  ( 253 )                                                      
d4oo8a3  (  59 )       aeatrlkrtarrrytrrknrilyLqiFsneMakvddsFfhRleesfl
d5axwa3  (  41 )    vennegrrskrgarrlkrrrrhriqrVklLf-dynlltd-----------
                                                                      

                             60        70        80        90        100 
d4ogca3  ( 253 )                                                      
d4oo8a3  ( 107 )    veedkherhpifgnivdevayheyptiYhLRkkLvdstdkadLrlIYlAL
d5axwa3  (  80 )    --hsls-----------------ginpyeARvkGLs---qLseeeFSaAL
                                                                      

                             110       120       130       140       150 
d4ogca3  ( 253 )                                                      
d4oo8a3  ( 159 )    ahMIkfrghfligdlnpdnsdVdlFiLVqtynqlfnpInAsgVdAkaiLs
d5axwa3  ( 110 )    lhLAkrrgvhnvv--------------------------------eedtg
                                                                      

                             160       170       180       190       200 
d4ogca3  ( 253 )                                                      
d4oo8a3  ( 214 )    alsksrlenLiaqLpgeglFgnLIALSLgltpnFsnfdladakLqlskdt
d5axwa3  ( 131 )    elstEQIsrNskaLk-yVAelQlerlkdg---eVr----gsiNrFk---t
                                                                      

                             210       220       230       240       250 
d4ogca3  ( 253 )                                                      
d4oo8a3  ( 271 )    ydddldnLlaqIgdqyadLFlaAnLsdAIllsdilApLSasMirydehhq
d5axwa3  ( 174 )    sdYvkEAkqLLkvQayh-ldqsFidtYidlLetrrt--yyegpge-----
                                                                      

                             260       270       280       290       300 
d4ogca3  ( 253 )                                                      
d4oo8a3  ( 331 )    dltlLkalVrqlpyeiFfdqsnGyaGYidggasqeeFyfIpiLeMdgTll
d5axwa3  ( 218 )    --------------------------------------------------
                                                                      

                             310       320       330       340       350 
d4ogca3  ( 253 )                                                      
d4oo8a3  ( 391 )    vklnedLLRkqrtfdngsiPhqihlgELhaIlrQdfypfLnkIkILtfri
d5axwa3  ( 218 )    --------------------------------------------------
                                                                      

                             360       370       380       390       400 
d4ogca3  ( 253 )                                          gsavsr-vapDp
d4oo8a3  ( 449 )    pyyVgplargnsrfawMtrksetItpwnFevVdkgaSaqsfiermtnfDk
d5axwa3  ( 218 )    ---------------------------gspfGwk--dikewyemlmghCt
                                                                      

                             410       420       430       440       450 
d4ogca3  ( 264 )    LpgqgsfrrAPkCDpefQrfrIisiVAnLrIsetgnrpLtadeRrhVvtf
d4oo8a3  ( 501 )    --nlpnekVlPkhSlLyeyFtVYneLtkVkyvTg--mpafLsgqkaIVdl
d5axwa3  ( 239 )    --yfpeelrsVkyAynADlynALndLNnLvItrdenekLeyyEKfqIIen
                                  aaaaaaaaaaaa   bb              aaaaa

                             460       470       480       490       500 
d4ogca3  ( 316 )    LtedSqadltWvdVAekLgvhrrdLrgtr----saarP-PidaTdrirqt
d4oo8a3  ( 552 )    LFKtnrVtvqLkedyF-eef---dsVeIsgvd----rFnasLgTYhdLlk
d5axwa3  ( 287 )    vFkqkk-kPtlkqIAe-ilvneedIkgyrvtstgkpeF-tnLkVyhdIkd
                                                              aaaa    

                             510       520       530       540       550 
d4ogca3  ( 370 )    kIsslktwweeadseqrGaI-rylyedptdsecaiialp-----eedqak
d4oo8a3  ( 600 )    iIdkfLdnee--nediLEdIVltLTlfe--dmiLtyahlfkvmLkryt--
d5axwa3  ( 335 )    ita-rkeIie--naelLdqIAkiLTIyqssedIqeeLtnlnseLtqeeIq
                                 aaaaa   aaaa                         

                             560       570       580       590       600 
d4ogca3  ( 417 )    ldslhlpagrAaYSreSLt--------aLSdhlat----tddlhearkrl
d4oo8a3  ( 658 )    --------gwGrlSrkLInGirDqsgkTILdFLksdgfaNrnfmqLihdd
d5axwa3  ( 383 )    ISnlkgYtgthnLSlkAInl--------IldeLwh---tndnqiaIFnrl
                                  aaaaa          aa           aaaaaa  

                             610 
d4ogca3  ( 456 )    f-gvddswappae
d4oo8a3  ( 701 )    sltFkdiqaqv  
d5axwa3  ( 423 )    lvpv------d
 

 

Domain IDNameFamilySourceDomainSTRING-DB
CRISPR-associated endonuclease Cas9/Csn1, REC lobeCRISPR-associated endonuclease Cas9/Csn1, Target recognition (REC) lobeActinomyces naeslundii [TaxId: 1115803]view
CRISPR-associated endonuclease Cas9/Csn1, REC lobeCRISPR-associated endonuclease Cas9/Csn1, Target recognition (REC) lobeStreptococcus pyogenes [TaxId: 301447]view
CRISPR-associated endonuclease Cas9/Csn1, REC lobeCRISPR-associated endonuclease Cas9/Csn1, Target recognition (REC) lobeStaphylococcus aureus subsp. aureus [TaxId: 46170]view

 

No outliers

FeatureDownload
Superfamily
Distance Matrix
Conserved Interactions
Cusp Results
Alistat - Alignment Statistics
SMotif - Conserved Structural Motifs
MeanRMS
PCSSE Details
Absolutely Conserved Residues
Highly Conserved Residues

 

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- - - A E A T R L K R T A R R R Y T R R K N R I L Y L Q I F S N E M A K V D D S F F H R L E E S F L V E E D K H E R H P I F G N I V D E V A Y H E Y P T I Y H L R K K L V D S T D K A D L R L I Y L A L A H M I K F R G H F L I G D L N P D N S D V D L F I L V Q T Y N Q L F N P I N A S G V D A K A I L S A L S K S R L E N L I A Q L P G E G L F G N L I A L S L G L T P N F S N F D L A D A K L Q L S K D T Y D D D L D N L L A Q I G D Q Y A D L F L A A N L S D A I L L S D I L A P L S A S M I R Y D E H H Q D L T L L K A L V R Q L P Y E I F F D Q S N G Y A G Y I D G G A S Q E E F Y F I P I L E M D G T L L V K L N E D L L R K Q R T F D N G S I P H Q I H L G E L H A I L R Q D F Y P F L N K I K I L T F R I P Y Y V G P L A R G N S R F A W M T R K S E T I T P W N F E V V D K G A S A Q S F I E R M T N F D K - - N L P N E K V L P K H S L L Y E Y F T V Y N E L T K V K Y V T G - - M P A F L S G Q K A I V D L L F K T N R V T V Q L K E D Y F - E E F - - - D S V E I S G V D - - - - R F N A S L G T Y H D L L K I I D K F L D N E E - - N E D I L E D I V L T L T L F E - - D M I L T Y A H L F K V M L K R Y T - - - - - - - - - - G W G R L S R K L I N G I R D Q S G K T I L D F L K S D G F A N R N F M Q L I H D D S L T F K D I Q A Q V - -
V E N N E G R R S K R G A R R L K R R R R H R I Q R V K L L F - D Y N L L T D - - - - - - - - - - - - - H S L S - - - - - - - - - - - - - - - - - G I N P Y E A R V K G L S - - - Q L S E E E F S A A L L H L A K R R G V H N V V - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - E E D T G E L S T E Q I S R N S K A L K - Y V A E L Q L E R L K D G - - - E V R - - - - G S I N R F K - - - T S D Y V K E A K Q L L K V Q A Y H - L D Q S F I D T Y I D L L E T R R T - - Y Y E G P G E - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - G S P F G W K - - D I K E W Y E M L M G H C T - - Y F P E E L R S V K Y A Y N A D L Y N A L N D L N N L V I T R D E N E K L E Y Y E K F Q I I E N V F K Q K K - K P T L K Q I A E - I L V N E E D I K G Y R V T S T G K P E F - T N L K V Y H D I K D I T A - R K E I I E - - N A E L L D Q I A K I L T I Y Q S S E D I Q E E L T N L N S E L T Q E E I Q I S N L K G Y T G T H N L S L K A I N L - - - - - - - - I L D E L W H - - - T N D N Q I A I F N R L L V P V - - - - - - D - -

 

 

 

 

 

Member Chain UniProtKB GO term
 
Contact: Prof. R. Sowdhamini - mini@ncbs.res.in