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Multi member superfamilies

Superfamily codeNo of membersAverage sizeSuperfamily name
46458    26         144     Globin-like
46548    3         151     alpha-helical ferredoxin
46565    4         86     Chaperone J-domain
46579    2         118     Prefoldin
46589    2         94     tRNA-binding arm
46604    2         47     Epsilon subunit of F1F0-ATP synthase C-terminal domain
46609    4         88     Fe,Mn superoxide dismutase (SOD), N-terminal domain
46626    22         101     Cytochrome c
46689    32         64     Homeodomain-like
46767    2         82     Methylated DNA-protein cysteine methyltransferase, C-terminal domain
46774    2         117     ARID-like
46785    18         88     "Winged helix" DNA-binding domain
46894    6         92     C-terminal effector domain of the bipartite response regulators
46929    2         48     DNA helicase RuvA subunit, C-terminal domain
46934    3         56     UBA-like
46955    5         90     Putative DNA-binding domain
46966    7         147     Spectrin repeat
46977    4         145     Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
46997    2         58     Bacterial immunoglobulin/albumin-binding domains
47005    2         39     Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
47014    3         39     Protozoan pheromone proteins
47027    2         290     Acyl-CoA binding protein
47031    2         108     Second domain of FERM
47060    3         70     S15/NS1 RNA-binding domain
47082    2         134     Fertilization protein
47090    2         80     PGBD-like
47095    6         83     HMG-box
47113    12         88     Histone-fold
47175    6         123     Cytochromes
47195    2         159     TMV-like viral coat proteins
47203    2         152     Acyl-CoA dehydrogenase C-terminal domain-like
47220    4         150     alpha-catenin/vinculin
47226    3         136     Histidine-containing phosphotransfer domain, HPT domain
47233    3         126     Bacterial GAP domain
47240    12         259     Ferritin-like
47266    16         142     4-helical cytokines
47323    7         185     Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
47336    4         78     ACP-like
47353    3         76     Retrovirus capsid protein C-terminal domain
47364    3         258     Domain of the SRP/SRP receptor G-proteins
47370    4         120     Bromodomain
47384    2         64     Homodimeric domain of signal transducing histidine kinase
47396    2         48     Transcription factor IIA (TFIIA), N-terminal domain
47406    3         32     SinR repressor dimerisation domain-like
47413    10         70     lambda repressor-like DNA-binding domains
47446    2         90     Signal peptide-binding domain
47459    5         71     Helix-loop-helix DNA-binding domain
47473    30         125     EF-hand
47565    2         122     Insect pheromon/odorant-binding proteins
47571    2         149     Cloroperoxidase
47576    5         114     Calponin-homology domain, CH-domain
47598    5         75     Met repressor-like
47610    2         64     Disulphide-bond formation facilitator (DSBA), insertion domain
47616    16         133     Glutathione S-transferase (GST), C-terminal domain
47661    3         137     t-snare proteins
47699    5         100     Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
47729    6         76     IHF-like DNA-binding proteins
47741    3         88     CO dehydrogenase ISP C-domain like
47769    3         80     SAM/Pointed domain
47781    3         110     RuvA domain 2-like
47789    2         75     C-terminal domain of RNA polymerase alpha subunit
47802    2         88     DNA polymerase beta, N-terminal domain-like
47807    4         113     5' to 3' exonuclease, C-terminal subdomain
47819    2         94     HRDC-like
47823    3         108     lambda integrase-like, N-terminal domain
47836    4         112     Retroviral matrix proteins
47857    2         159     Apolipophorin-III
47862    2         77     Saposin
47874    3         237     Annexin
47895    2         118     Transducin (alpha subunit), insertion domain
47917    2         124     C-terminal domain of alpha and beta subunits of F1 ATP synthase
47923    2         157     Ypt/Rab-GAP domain of gyp1p
47943    3         141     Retrovirus capsid protein, N-terminal core domain
47954    16         122     Cyclin-like
47973    2         153     Ribosomal protein S7
47986    10         102     DEATH domain
48013    2         135     Antitermination factor NusB
48019    4         116     DNA polymerase III clamp loader subunits, C-terminal domain
48034    2         97     Guanido kinase N-terminal domain
48050    2         115     Hemocyanin, N-terminal domain
48056    4         284     Di-copper centre-containing domain
48065    4         205     DBL homology domain (DH-domain)
48081    2         265     Methyl-coenzyme M reductase alpha and beta chain C-terminal domain
48097    5         155     Regulator of G-protein signalling, RGS
48113    4         296     Heme-dependent peroxidases
48150    5         204     DNA-glycosylase
48173    2         258     Cryptochrome/photolyase FAD-binding domain
48179    6         191     6-phosphogluconate dehydrogenase C-terminal domain-like
48208    8         468     Six-hairpin glycosyltransferases
48225    3         480     Seven-hairpin glycosyltransferases
48230    3         343     Chondroitin AC/alginate lyase
48239    6         308     Terpenoid cylases/Protein prenyltransferases
48256    3         394     Citrate synthase
48264    8         417     Cytochrome P450
48283    2         82     FIS-like
48310    2         398     Aldehyde ferredoxin oxidoreductase, C-terminal domains
48317    4         486     Acid phosphatase/Vanadium-dependent haloperoxidase
48334    2         282     DNA repair protein MutS, domain III
48345    2         214     A virus capsid protein alpha-helical domain
48350    4         205     GTPase activation domain, GAP
48371    9         369     ARM repeat
48403    8         176     Ankyrin repeat
48439    2         327     Protein prenylyltransferase
48452    9         202     TPR-like
48464    4         147     ENTH/VHS domain
48484    2         613     Lipoxigenase
48498    2         123     Tetracyclin repressor-like, C-terminal domain
48503    2         48     Skp1-Skp2 dimerisation domains
48508    8         250     Nuclear receptor ligand-binding domain
48537    3         252     Phospholipase C/P1 nuclease
48552    6         169     Serum albumin-like
48557    6         446     L-aspartase-like
48576    6         323     Terpenoid synthases
48592    2         248     GroEL equatorial domain-like chaperone equatorial domain
48600    2         170     Chorismate mutase II
48613    2         206     Heme oxygenase
48619    4         125     Phospholipase A2, PLA2
48670    2         61     Transducin (heterotrimeric G protein), gamma chain
49265    35         97     Fibronectin type III
49303    3         107     beta-Galactosidase/glucuronidase domain
49309    4         105     Transglutaminase, two C-terminal domains
49313    2         107     Cadherin
49319    2         113     Actinoxanthin-like
49329    3         147     Cu,Zn superoxide dismutase-like
49344    2         189     CBD9-like
49348    2         126     Clathrin adaptor appendage domain
49354    3         120     PapD-like
49367    2         106     Superoxide reductase-like
49373    6         94     Invasin/intimin cell-adhesion fragments
49384    7         136     Carbohydrate-binding domain
49401    5         154     Bacterial adhesins
49417    7         184     p53-like transcription factors
49452    3         105     Starch-binding domain
49478    2         93     B repeat unit of collagen binding surface protein (cna)
49482    3         249     Aromatic compound dioxygenase
49493    2         85     HSP40/DnaJ peptide-binding domain
49503    31         146     Cupredoxins
49562    10         133     C2 domain (Calcium/lipid-binding domain, CaLB)
49584    2         85     Periplasmic chaperone C-domain
49599    2         171     TRAF domain-like
49611    31         227     Viral coat and capsid proteins
49695    9         88     gamma-Crystallin-like
49723    4         117     Lipase/lipooxygenase domain (PLAT/LH2 domain)
49742    4         154     PHM/PNGase F
49749    4         313     Viral proteins
49764    3         125     HSP20-like chaperones
49777    3         164     PEBP-like
49785    11         159     Galactose-binding domain-like
49818    6         206     Viral protein domain
49835    3         149     Virus attachment protein
49842    7         145     TNF-like
49854    2         111     Spermadhesin, CUB domain
49863    3         80     Hyaluronate lyase-like, C-terminal domain
49879    3         162     SMAD/FHA domain
49899    26         197     Concanavalin A-like lectins/glucanases
49998    4         428     Copper amine oxidase, domain 3 (catalytic)
50005    2         269     Hyaluronate lyase-like, central domain
50022    5         130     ISP domain
50037    4         65     C-terminal domain of transcriptional repressors
50044    14         71     SH3-domain
50084    3         45     Myosin S1 fragment, N-terminal domain
50090    4         103     Electron transport accessory proteins
50104    5         100     Translation proteins SH3-like domain
50122    2         50     DNA-binding domain of retroviral integrase
50129    6         166     GroES-like
50156    10         99     PDZ domain-like
50176    2         95     N-terminal domains of the minor coat protein g3p
50182    5         75     Sm-like ribonucleoproteins
50193    2         127     Ribosomal protein L14
50203    13         99     Bacterial enterotoxins
50242    3         145     TIMP-like
50249    23         112     Nucleic acid-binding proteins
50324    2         229     Inorganic pyrophosphatase
50331    7         68     MOP-like
50341    2         141     CheW-like
50346    2         208     Photosynthetic reaction centre, H-chain, cytoplasmic domain
50353    5         141     Cytokine
50370    4         131     Ricin B-like lectins
50382    2         149     Agglutinin
50386    6         192     STI-like
50405    5         118     Actin-crosslinking proteins
50447    6         105     Translation proteins
50465    2         100     EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
50475    4         167     FMN-binding split barrel
50486    2         154     FMT C-terminal domain-like
50494    30         225     Trypsin-like serine proteases
50615    2         74     N-terminal domain of alpha and beta subunits of F1 ATP synthase
50621    2         153     Alanine racemase-like, C-terminal domain
50630    9         324     Acid proteases
50677    3         178     ValRS/IleRS/LeuRS editing domain
50685    2         165     Barwin-like endoglucanases
50692    7         119     ADC-like
50715    3         159     Ribosomal protein L25-like
50729    20         121     PH domain-like
50784    2         48     Transcription factor IIA (TFIIA), N-terminal domain
50789    3         205     Herpes virus serine proteinase, assemblin
50800    5         127     PK beta-barrel domain-like
50814    19         152     Lipocalins
50876    2         119     Avidin/streptavidin
50882    2         102     Metalloprotease inhibitor
50886    2         92     D-aminopeptidase, middle and C-terminal domains
50891    2         164     Cyclophilin (peptidylprolyl isomerase)
50904    2         108     Oncogene products
50911    2         140     Mannose 6-phosphate receptor domain
50916    2         128     Rap30/74 interaction domains
50923    4         197     Hemopexin-like domain
50939    7         402     Sialidases (neuraminidases)
50969    4         349     YVTN repeat-like/Quinoprotein amine dehydrogenase
50978    3         348     WD40-repeat
50985    2         337     RCC1/BLIP-II
50998    3         575     Quinoprotein alcohol dehydrogenase-like
51011    12         78     alpha-Amylases, C-terminal beta-sheet domain
51045    6         38     WW domain
51055    3         53     Carbohydrate binding domain
51069    4         247     Carbonic anhydrase
51096    3         209     delta-Endotoxin (insectocide), middle domain
51101    2         147     Mannose-binding lectins
51126    12         398     Pectin lyase-like
51161    7         224     Trimeric LpxA-like enzymes
51182    8         243     RmlC-like cupins
51197    3         318     Clavaminate synthase-like
51206    5         135     cAMP-binding domain-like
51225    2         110     Fibre shaft of virus attachment proteins
51230    8         90     Single hybrid motif
51246    5         85     Rudiment single hybrid motif
51283    2         127     Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)
51294    4         173     Hedgehog/intein (Hint) domain
51306    4         142     LexA/Signal peptidase
51316    2         137     Mss4-like
51332    2         172     E2 regulatory, transactivation domain
51338    2         141     Composite domain of metallo-dependent hydrolases
51344    2         85     Epsilon subunit of F1F0-ATP synthase N-terminal domain
51351    3         243     Triosephosphate isomerase (TIM)
51366    12         239     Ribulose-phoshate binding barrel
51395    10         390     FMN-linked oxidoreductases
51412    3         343     Inosine monophosphate dehydrogenase (IMPDH)
51419    3         229     PLP-binding barrel
51430    3         299     NAD(P)-linked oxidoreductase
51445    32         360     (Trans)glycosidases
51556    5         326     Metallo-dependent hydrolases
51569    13         297     Aldolase
51604    8         245     Enolase C-terminal domain-like
51621    5         341     Phosphoenolpyruvate/pyruvate domain
51649    3         311     RuBisCo, C-terminal domain
51658    4         375     Xylose isomerase-like
51679    4         305     Bacterial luciferase-like
51695    3         285     Phosphatidylinositol-specific phospholipase C (PI-PLC)
51703    3         500     Cobalamin (vitamin B12)-dependent enzymes
51717    3         259     Dihydropteroate synthetase-like
51726    2         350     Uroporphyrinogen decarboxylase, UROD
51735    49         183     NAD(P)-binding Rossmann-fold domains
51971    6         245     Nucleotide-binding domain
51989    3         330     Cellulases
51998    3         605     PFL-like glycyl radical enzymes
52009    2         128     Phosphohistidine domain
52029    2         172     GroEL apical domain-like
52047    3         363     RNI-like
52058    8         194     L domain-like
52080    2         130     Ribosomal proteins L15p and L18e
52091    2         113     Anti-sigma factor antagonist SpoIIaa
52096    10         263     ClpP/crotonase
52113    5         94     BRCT domain
52121    3         156     Lumazine synthase
52129    5         264     Caspase-like
52141    2         195     DNA glycosylase
52166    2         209     Ribosomal protein L4
52172    13         131     CheY-like
52210    2         161     Succinyl-CoA synthetase domains
52218    7         172     Flavoproteins
52242    4         156     Cobalamin (vitamin B12)-binding domain
52259    2         202     Cutinase-like
52266    4         254     Esterase/acetylhydrolase
52283    8         162     Formate/glycerate dehydrogenase catalytic domain-like
52317    6         196     Class I glutamine amidotransferase-like
52335    3         160     Methylglyoxal synthase-like
52343    10         148     Ferredoxin reductase-like, C-terminal NADP-linked domain
52374    13         305     Nucleotidylyl transferase
52402    6         240     Adenine nucleotide alpha hydrolases-like
52425    3         191     Cryptochrome/photolyase, N-terminal domain
52431    5         181     ETFP adenine nucleotide-binding domain-like
52440    10         101     PreATP-grasp domain
52467    10         208     DHS-like NAD/FAD-binding domain
52490    2         227     Tubulin, GTPase domain
52499    3         212     Cysteine hydrolase
52507    2         179     DFP DNA/pantothenate metabolism flavoprotein
52518    15         228     Thiamin diphosphate-binding fold (THDP-binding)
52540    40         221     P-loop containing nucleotide triphosphate hydrolases
52743    3         305     Subtilisin-like
52768    2         340     Arginase/deacetylase
52777    3         228     CoA-dependent acyltransferases
52788    2         144     Phosphotyrosine protein phosphatases I
52799    12         234     (Phosphotyrosine protein) phosphatases II
52821    7         142     Rhodanese/Cell cycle control phosphatase
52833    42         109     Thioredoxin-like
52922    3         142     TK C-terminal domain-like
52935    4         130     Pyruvate kinase, C-terminal domain
52943    2         241     ATP syntase (F1-ATPase), gamma subunit
52954    7         108     Anticodon-binding domain of Class II aaRS
52972    2         184     Maf/Ham1
53041    4         170     Resolvase-like
53056    4         208     beta-carbonic anhydrase, cab
53067    7         205     Actin-like ATPase domain
53092    2         165     Creatinase/prolidase N-terminal domain
53098    7         201     Ribonuclease H-like
53137    3         146     Translational machinery components
53150    2         146     DNA repair protein MutS, domain II
53155    3         83     Methylated DNA-protein cysteine methyltransferase domain
53163    2         241     HybD-like
53167    6         254     Purine and uridine phosphorylases
53182    2         215     Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)
53187    8         299     Zn-dependent exopeptidases
53218    3         167     Molybdenum cofactor biosynthesis proteins
53223    7         153     Aminoacid dehydrogenase-like, N-terminal domain
53244    4         135     MurD-like peptide ligases, peptide-binding domain
53254    4         252     Phosphoglycerate mutase-like
53271    14         194     PRTase-like
53300    6         197     vWA-like
53316    2         288     CoA transferase
53328    2         204     Formyltransferase
53335    21         238     S-adenosyl-L-methionine-dependent methyltransferases
53383    31         399     PLP-dependent transferases
53448    13         251     Nucleotide-diphospho-sugar transferases
53474    39         354     alpha/beta-Hydrolases
53590    2         314     Nucleoside hydrolase
53597    8         173     Dihydrofolate reductases
53613    6         324     Ribokinase-like
53623    4         238     MurD-like peptide ligases, catalytic domain
53639    2         214     AraD-like aldolase/epimerase
53649    5         440     Alkaline phosphatase-like
53659    2         392     Isocitrate/Isopropylmalate dehydrogenases
53671    3         153     Aspartate/ornithine carbamoyltransferase
53681    2         126     Aspartate/glutamate racemase
53686    6         358     Tryptophan synthase beta subunit-like PLP-dependent enzymes
53697    4         384     SIS domain
53706    4         612     Formate dehydrogenase/DMSO reductase, domains 1-3
53720    6         474     ALDH-like
53738    6         130     Phosphoglucomutase, first 3 domains
53748    2         415     Phosphoglycerate kinase
53756    3         366     UDP-Glycosyltransferase/glycogen phosphorylase
53795    3         271     PEP carboxykinase-like
53800    3         308     Chelatase
53807    7         400     "Helical backbone" metal receptor
53822    13         376     Periplasmic binding protein-like I
53850    15         255     Periplasmic binding protein-like II
53901    12         193     Thiolase-like
53927    2         147     Cytidine deaminase-like
53933    5         112     Microbial ribonucleases
53955    9         187     Lysozyme-like
54001    9         278     Cysteine proteinases
54060    4         159     His-Me finger endonucleases
54076    4         121     RNase A-like
54098    2         107     Prion-like
54117    10         70     Interleukin 8-like chemokines
54160    5         67     Chromo domain-like
54171    4         75     DNA-binding domain
54184    2         59     Penicillin-binding protein 2x (pbp-2x), c-terminal domain
54189    2         137     Ribosomal proteins L23 and L15e
54197    4         145     HIT-like
54211    11         134     Ribosomal protein S5 domain 2-like
54236    12         94     Ubiquitin-like
54277    4         98     CAD & PB1 domains
54285    3         72     MoaD/ThiS
54292    12         103     2Fe-2S ferredoxin-like
54328    4         114     Staphylokinase/streptokinase
54334    7         111     Superantigen toxins, C-terminal domain
54358    2         64     Immunoglobulin-binding domains
54373    11         101     FAD-linked reductases, C-terminal domain
54403    4         100     Cystatin/monellin
54416    8         104     Copper amine oxidase, domains 1 and 2
54427    7         149     NTF2-like
54452    13         143     MHC antigen-recognition domain
54495    7         151     UBC-like
54506    2         137     Diaminopimelate epimerase
54511    3         225     GFP-like
54523    3         135     Pilin
54534    5         119     FKBP-like
54556    4         73     Chitinase insertion domain
54585    4         97     Cdc48 domain 2-like
54593    7         155     Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
54631    2         56     CBS-domain
54637    4         148     Thioesterase/thiol ester dehydrase-isomerase
54654    3         65     CI-2 family of serine protease inhibitors
54665    4         133     CO dehydrogenase molybdoprotein N-domain-like
54675    2         118     Quinolinic acid phosphoribosyltransferase, N-terminal domain
54680    2         104     Pyrimidine nucleoside phosphorylase C-terminal domain
54695    6         95     POZ domain
54713    3         123     Elongation factor Ts (EF-Ts), dimerisation domain
54719    3         117     Fe,Mn superoxide dismutase (SOD), C-terminal domain
54762    2         74     Signal recognition particle alu RNA binding heterodimer, SRP9/14
54768    5         78     dsRNA-binding domain-like
54791    5         84     Eukaryotic type KH-domain (eKH-domain)
54806    2         75     Alpha-lytic protease prodomain
54814    4         91     Prokaryotic type KH domain (pKH-domain)
54826    8         124     Enolase N-terminal domain-like
54843    2         129     Ribosomal protein L22
54849    2         101     GroEL-intermediate domain like
54862    8         95     4Fe-4S ferredoxins
54897    4         128     Protease propeptides/inhibitors
54928    17         87     RNA-binding domain, RBD
54957    3         101     Viral DNA-binding domain
54966    3         130     RuBisCO, large subunit, small (N-terminal) domain
54980    2         84     EF-G/eEF-2 domains III and V
54984    2         89     eEF-1beta-like
55003    2         137     Poly(A) polymerase, C-terminal domain
55008    8         70     Metal-binding domain
55021    4         86     Regulatory domain in the aminoacid metabolism
55035    2         113     NAD-binding domain of HMG-CoA reductase
55060    2         165     GHMP Kinase
55073    3         204     Adenylyl and guanylyl cyclase catalytic domain
55088    3         233     Methyl-coenzyme M reductase subunits
55103    4         281     FAD-linked oxidases, C-terminal domain
55112    2         148     Formylmethanofuran:tetrahydromethanopterin formyltransferase
55116    2         159     Formiminotransferase domain of formiminotransferase-cyclodeaminase.
55120    3         142     Pseudouridine synthase
55124    2         70     Sulfite reductase, domains 1 and 3
55129    2         107     Ribosomal protein L30p/L7e
55136    2         156     Probable bacterial effector-binding domain
55159    2         104     eIF1-like
55166    2         143     Hedgehog/DD-pepidase
55174    3         124     Alpha-L RNA-binding motif
55190    2         115     Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
55194    2         184     Ribosome recycling factor, RRF
55205    3         361     EPT/RTPC-like
55221    2         122     Yest killer toxins
55239    2         131     RuBisCO, small subunit
55252    2         71     C-terminal domain of arginine repressor
55257    3         118     RBP11-like subunits of RNA polymerase
55261    2         126     Prokaryotic AspRS, insert domain
55271    2         113     DNA repair protein MutS, domain I
55282    2         159     Ribosomal protein L5
55287    2         78     RPB5-like RNA polymerase subunit
55298    3         126     YjgF-like
55307    3         168     Tubulin, C-terminal domain
55315    4         118     L30e-like
55331    5         106     Tautomerase/MIF
55347    5         137     Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
55387    2         112     Frataxin-like
55394    2         228     Bactericidal permeability-increasing protein, BPI
55405    3         126     RNA bacteriophage capsid protein
55418    2         195     Translation initiation factor eIF4e
55424    8         115     FAD/NAD-linked reductases, dimerisation (C-terminal) domain
55447    3         114     CO dehydrogenase flavoprotein C-terminal domain-like
55455    2         78     SRF-like
55464    2         141     Origin of replication-binding domain, RBD-like
55469    4         218     NADH oxidase/flavin reductase
55486    6         233     Metalloproteases ("zincins"), catalytic domain
55545    2         140     beta-N-acetylhexosaminidase-like domain
55550    13         107     SH2 domain
55594    3         86     HPr-like
55608    7         104     Homing endonucleases
55620    7         155     Tetrahydrobiopterin biosynthesis enzymes-like
55658    2         51     L9 N-domain-like
55666    2         99     Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
55681    14         295     Class II aaRS and biotin synthetases
55711    2         113     Clathrin adaptor appendage domain
55718    2         119     Sterol carrier protein, SCP
55729    10         194     Acyl-CoA N-acyltransferases (Nat)
55753    11         126     Actin depolymerizing proteins
55770    3         130     Profilin (actin-binding protein)
55785    4         117     PYP-like sensor domain (PAS domain)
55797    2         172     PR-1-like
55804    3         196     Phoshotransferase/anion transport protein
55811    4         162     Nudix
55821    2         194     YrdC/RibB
55831    3         259     Thymidylate synthase/dCMP hydroxymethylase
55856    4         86     Cytochrome b5
55874    8         187     ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
55895    4         205     Ribonuclease Rh-like
55909    5         282     Pentein
55920    5         254     Creatinase/aminopeptidase
55931    2         323     Glutamine synthase/guanido kinase
55945    5         99     TATA-box binding protein-like
55961    4         233     Bet v1-like
55973    3         125     S-adenosylmethionine synthetase
55979    12         124     DNA clamp
56003    3         632     Molybdemum cofactor-binding domain
56014    2         158     Sulfite reductase hemoprotein (SiRHP), domains 2 and 4
56024    5         215     Phospholipase D/nuclease
56029    3         111     Monooxygenase (hydroxylase) regulatory protein
56047    2         128     Ribosomal protein S8
56053    4         84     Ribosomal protein L6
56059    14         229     Glutathione synthetase ATP-binding domain-like
56091    4         238     DNA ligase/mRNA capping enzyme, catalytic domain
56104    2         312     SAICAR synthase-like
56112    17         307     Protein kinase-like (PK-like)
56176    8         213     FAD-binding domain
56194    2         125     Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
56214    3         115     4'-phosphopantetheinyl transferase
56219    4         279     DNase I-like
56235    16         237     N-terminal nucleophile aminohydrolases (Ntn hydrolases)
56281    6         239     Metallo-hydrolase/oxidoreductase
56300    3         297     Metallo-dependent phosphatases
56317    3         281     Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase
56322    3         450     ADC synthase
56327    11         167     Lactate & malate dehydrogenases, C-terminal domain
56349    7         210     DNA breaking-rejoining enzymes
56371    7         253     Ribosome inactivating proteins (RIP)
56399    3         205     ADP-ribosylation
56425    4         132     Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
56436    22         120     C-type lectin-like
56496    3         225     Fibrinogen C-terminal domain-like
56529    3         239     FAH
56542    2         303     Substrate-binding domain of HMG-CoA reductase
56553    2         126     Insert subdomain of RNA polymerase alpha subunit
56568    2         88     Non-globular alpha+beta subunits of globular proteins
56574    9         367     Serpins
56601    12         298     beta-Lactamase/D-ala carboxypeptidase
56634    2         534     Heme-linked catalases
56645    4         232     Acyl-CoA dehydrogenase NM domain-like
56655    6         315     Sugar phosphatases
56712    3         465     Prokaryotic type I DNA topoisomerase
56719    2         578     Type II DNA topoisomerase
56752    4         298     D-aminoacid aminotransferase-like PLP-dependent enzymes
56762    2         510     Nickel-iron hydrogenase, large subunit
56784    6         213     HAD-like
56796    2         372     Dehydroquinate synthase-like
56801    2         516     Firefly luciferase-like
56808    2         215     Ribosomal protein L1
56821    2         592     Prismane protein-like
56837    2         185     Colicin
56849    3         237     delta-Endotoxin (insectocide), N-terminal domain
56854    3         176     Bcl-2 inhibitors of programmed cell death
56918    5         47     Light-harvesting complex subunits
56925    2         142     OMPA-like
56935    8         432     Porins
56959    2         292     Leukocidin (pore-forming toxin)
56994    3         49     Insulin-like
57016    3         39     Plant lectins/antimicrobial peptides
57027    3         32     Plant inhibitors of proteinases and amylases
57038    2         29     Cyclotides
57048    2         36     Gurmarin-like
57059    18         34     omega toxin-like
57095    14         57     Scorpion toxin-like
57184    2         98     Growth factor receptor domain
57190    4         41     Colipase-like
57196    22         44     EGF/Laminin
57243    2         26     Bromelain inhibitor VI (cysteine protease inhibitor)
57247    2         59     Bowman-Birk inhibitor, BBI
57262    2         50     Leech antihemostatic proteins
57283    2         33     PMP inhibitors
57288    2         51     Midkine
57302    9         73     Snake toxin-like
57362    9         58     BPTI-like
57392    9         40     Defensin-like
57414    2         90     Hairpin loop containing domain-like
57424    2         41     LDL receptor-like module
57429    2         45     Crambin-like
57440    6         74     Kringle-like
57467    9         53     Ovomucoid/PCI-1 like inhibitors
57492    2         52     Trefoil
57501    11         108     Cystine-knot cytokines
57535    12         63     Complement control module/SCR domain
57546    2         36     Sea anemone toxin k
57552    2         59     Blood coagulation inhibitor (disintegrin)
57567    4         67     Serine proterase inhibitors
57586    3         54     TNF receptor-like
57603    5         45     Fibronectin type I module
57630    2         46     GLA-domain
57652    4         72     HIPIP (high potential iron protein)
57667    19         32     C2H2 and C2HC zinc fingers
57701    5         44     Zn2/Cys6 DNA-binding domain
57716    13         47     Glucocorticoid receptor-like (DNA-binding domain)
57756    4         33     Retrovirus zinc finger-like domains
57774    3         34     Microbial and mitochondrial ADK, insert "zinc finger" domain
57783    5         56     Zinc beta-ribbon
57802    5         60     Rubredoxin-like
57829    3         73     Zn-binding ribosomal proteins
57850    8         79     RING finger domain, C3HC4
57868    7         39     Metallothionein
57889    4         52     Cysteine-rich domain
57903    4         76     FYVE/PHD zinc finger
57917    2         105     Zn-binding domains of ADDBP
57924    4         113     Inhibitor of apoptosis (IAP) repeat
63380    10         108     Riboflavin synthase domain-like
63393    4         56     RBP12 subunit of RNA polymerase II
63411    13         200     LuxS/MPP-like metallohydrolase
63418    2         81     MurE/MurF N-terminal domain
63451    3         55     LEM domain
63520    2         110     PTS-regulatory domain, PRD
63570    2         102     PABC (PABP) domain
63600    2         191     Telomeric repeat binding factor (TRF) dimerisation domain
63748    2         95     Tudor/PWWP
63862    2         90     Thiamin pyrophosphokinase, substrate-binding domain
63999    2         195     Thiamin pyrophosphokinase, catalytic domain
64005    2         213     Undecaprenyl diphosphate synthase
64268    2         136     PX domain
64307    2         89     SirA-like
64356    2         132     SNARE-like
64501    2         511     Ku heterodimer subunits
68906    2         43     SAP domain
68923    3         225     PEP carboxykinase N-terminal domain
69012    2         153     alpha-ketoacid dehydrogenase kinase, N-terminal domain
69125    2         53     Nuclear receptor coactivator interlocking domain
69179    4         155     Integrin domains
69279    2         174     Phage tail proteins
69287    2         72     Urease metallochaperone UreE, N-terminal domain
69298    2         113     Quinohemoprotein amine dehydrogenase A chain, domain 3
69349    2         189     Phage fibre proteins
69635    4         123     Type III secretory system chaperone
69645    3         150     Arp2/3 complex subunits
69705    2         115     Transcription factor NusA, N-terminal domain
69737    2         67     Urease metallochaperone UreE, C-terminal domain
74650    5         287     Galactose mutarotase-like
74653    2         107     TolA/TonB C-terminal domain
74877    2         126     Major surface antigen p30, SAG1
75217    2         174     alpha/beta knot
75399    2         213     Plakin repeat
75520    2         141     Clathrin coat assembly domain
75689    2         44     Zinc-binding domain of translation initiation factor 2 beta
81271    2         70     TGS-like
81273    2         46     H-NS histone-like proteins
81296    36         122     E set domains
81301    3         276     Nucleotidyltransferase
81383    2         70     F-box domain
81585    2         59     DNA polymerase beta-like, second domain
81593    2         128     Nucleotidyltransferase substrate binding subunit/domain
81624    4         260     N-terminal domain of MutM-like DNA repair proteins
81811    2         105     Helical domain of Sec23/24
81923    2         136     Double Clp-N motif
81986    2         106     Tp47 lipoprotein, middle and C-terminal domains
81995    2         174     beta-sandwich domain of Sec23/24
82057    2         80     GW domain
82153    2         148     FAS1 domain
82199    5         242     SET domain
82693    4         101     Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
82714    2         90     Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains
82754    2         127     C-terminal, gelsolin-like domain of Sec23/24
82919    2         78     Zn-finger domain of Sec23/24



Single member superfamilies

Superfamily codeNo of membersAverage sizeSuperfamily name
46557     1         78     GreA transcript cleavage protein, N-terminal domain
46561     1         65     Ribosomal protein L29 (L29p)
46575     1         76     Theta subunit of DNA polymerase III
46585     1         86     Effector domain of the protein kinase pkn/prk1
46596     1         72     Eukaryotic DNA topoisomerase I, dispensable insert domain
46600     1         56     C-terminal UvrC-binding domain of UvrB
46906     1         70     Ribosomal protein L11, C-terminal domain
46911     1         73     Ribosomal protein S18
46915     1         83     Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
46919     1         46     N-terminal Zn binding domain of HIV integrase
46924     1         65     RNA polymerase subunit RPB10
46938     1         93     N-terminal domain of phosphatidylinositol transfer protein sec14p
46942     1         114     Elongation factor TFIIS domain 2
46946     1         125     S13-like H2TH domain
46950     1         72     Hypothetical protein MTH1615
46973     1         102     Enzyme IIa from lactose specific PTS, IIa-lac
46984     1         157     Smac/diablo
46988     1         102     Tubulin chaperone cofactor A
46992     1         99     Ribosomal protein S20
47040     1         81     Kix domain of CBP (creb binding protein)
47045     1         81     alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
47050     1         36     Thermostable subdomain from chicken villin headpiece
47055     1         67     TAF(II)230 TBP-binding fragment
47072     1         68     p8-MTCP1
47077     1         137     T4 endonuclease V
47144     1         95     HSC20 (HSCB), C-terminal oligomerisation domain
47148     1         137     Diol dehydratase, gamma subunit
47152     1         162     Methane monooxygenase hydrolase, gamma subunit
47157     1         95     Mitochondrial import receptor subunit Tom20
47162     1         132     Apolipoprotein
47170     1         157     Aspartate receptor, ligand-binding domain
47188     1         118     Hemerythrin
47212     1         94     FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
47216     1         200     Proteasome activator reg(alpha)
47345     1         83     Colicin E immunity proteins
47380     1         59     ROP protein
47391     1         46     Dimerization-anchoring domain of cAMP-dependent type II PK regulatory subunit
47401     1         37     Ectatomin, A & B chains
47454     1         74     A DNA-binding domain in eukaryotic transcription factors
47587     1         135     Domain of poly(ADP-ribose) polymerase
47592     1         88     MDM2
47644     1         90     Methionine synthase domain
47648     1         70     Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
47655     1         177     STAT
47668     1         131     N-terminal domain of cbl (N-cbl)
47672     1         148     Transferrin receptor ectodomain, C-terminal domain
47676     1         77     Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
47681     1         91     C-terminal domain of B transposition protein
47686     1         65     Anaphylotoxins (complement system)
47694     1         79     Cytochrome c oxidase subunit h
47719     1         31     p53 tetramerization domain
47724     1         90     Domain of early E2A DNA-binding protein, ADDBP
47752     1         79     Protein HNS-dependent expression A; HdeA
47757     1         81     Chemotaxis receptor methyltransferase CheR, N-terminal domain
47762     1         89     PAH2 domain
47794     1         70     DNA repair protein Rad51, N-terminal domain
47798     1         87     Barrier-to-autointegration factor, BAF
47831     1         123     Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
47852     1         142     Hepatitis B viral capsid (hbcag)
47869     1         70     Bacteriocin AS-48
47912     1         107     Wiscott-Aldrich syndrome protein, WASP, C-terminal domain
47928     1         105     N-terminal domain of the delta subunit of the F1F0-ATP synthase
47933     1         106     Endoplasmic reticulum protein ERP29, C-domain
47938     1         149     Functional domain of the splicing factor Prp18
47979     1         80     Iron-dependent represor protein, dimerization domain
48008     1         152     Fatty acid responsive transcription factor FadR, C-terminal domain
48024     1         102     N-terminal domain of DnaB helicase
48029     1         101     FliG
48045     1         143     Scaffolding protein gpD of bacteriophage procapsid
48076     1         132     LigA subunit of an aromatic-ring-opening dioxygenase LigAB
48092     1         124     Transcription factor STAT-4 N-domain
48108     1         153     Carbamoyl phosphate synthetase, large subunit connection domain
48140     1         143     Ribosomal protein L19 (L19e)
48145     1         158     Influenza virus matrix protein M1
48163     1         163     An anticodon-binding domain of class I aminoacyl-tRNA synthetases
48168     1         212     R1 subunit of ribonucleotide reductase, N-terminal domain
48201     1         70     Uteroglobin-like
48295     1         101     TrpR-like
48300     1         57     Ribosomal protein L7/12, oligomerisation (N-terminal) domain
48305     1         75     MHC class II-associated invariant chain ectoplasmic trimerization domain
48329     1         305     RNA polymerase sigma subunit
48340     1         300     Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain
48366     1         439     Ras GEF
48425     1         195     Sec7 domain
48435     1         450     Bacterial muramidases
48445     1         228     14-3-3 protein
48473     1         263     Phosphoinositide-binding clathrin adaptor, N-terminal domain
48479     1         109     Cytochrome c oxidase subunit E
48493     1         217     gene 59 helicase assembly protein
48547     1         351     Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
48608     1         156     Peridinin-chlorophyll protein
48647     1         99     Fungal elicitin
48652     1         90     Tetraspanin
48657     1         152     Repressor of bacterial conjugation FinO
48662     1         46     Ribosomal protein L39e
48666     1         57     Methanol dehydrogenase subunit
48674     1         88     Fe-only hydrogenase smaller subunit
48678     1         87     Moesin tail domain
48682     1         32     Nuclear receptor coactivator Src-1
48686     1         29     Proteinase A inhibitor IA3
48690     1         47     Epsilon subunit of mitochondrial F1F0-ATP synthase
49299     1         80     PKD domain
49363     1         112     Purple acid phosphatase, N-terminal domain
49380     1         161     Diphtheria toxin, C-terminal domain
49410     1         130     Alpha-macroglobulin receptor domain
49441     1         187     Cytochrome f, large domain
49447     1         256     Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor
49464     1         79     Carboxypeptidase D, a regulatory domain
49468     1         142     VHL
49472     1         115     Transthyretin (prealbumin)
49498     1         74     alpha-Amylase inhibitor tendamistat
49590     1         94     PHL pollen allergen
49594     1         110     Rab geranylgeranyltransferase alpha-subunit, insert domain
49606     1         85     Neurophysin II
49758     1         142     Calpain large subunit, middle domain (domain III)
49772     1         131     Ecotin, trypsin inhibitor
49830     1         228     F-MuLV receptor-binding domain
49870     1         207     Osmotin, thaumatin-like protein
49889     1         224     Soluble secreted chemokine inhibitor, VCCI
49894     1         299     Paculovirus p35
49994     1         293     beta-Galactosidase, domain 5
50012     1         260     EV matrix protein
50017     1         288     gp9
50118     1         101     Cell growth inhibitor/plasmid maintainance toxic component
50151     1         55     SacY-like RNA-binding domain
50199     1         137     Staphylococcal nuclease
50443     1         236     L-fucose isomerase, C-terminal domain
50610     1         80     mu transposase, C-terminal domain
50723     1         125     Core binding factor beta, CBF
50809     1         113     XRCC4, N-terminal domain
50934     1         235     Tachylectin-2
50952     1         448     Soluble quinoprotein glucose dehydrogenase
50956     1         353     Thermostable phytase (3-phytase)
50960     1         263     TolB, C-terminal domain
50965     1         386     Galactose oxidase, central domain
50974     1         441     Nitrous oxide reductase, N-terminal domain
50989     1         328     Clathrin heavy-chain terminal domain
50993     1         426     Prolyl oligopeptidase, N-terminal domain
51004     1         432     C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
51064     1         59     Head domain of nucleotide exchange factor GrpE
51081     1         350     Bacteriochlorophyll A protein
51087     1         251     Outer surface protein A
51092     1         163     Vitelline membrane outer protein-I (VMO-I)
51110     1         119     alpha-D-mannose-specific plant lectins
51120     1         224     Serralysin-like metalloprotease, C-terminal domain
51156     1         82     Insect cysteine-rich antifreeze protein
51177     1         90     An insect antifreeze protein
51215     1         166     Regulatory protein AraC
51219     1         68     Trp RNA-binding attenuation protein (TRAP)
51261     1         158     Duplicated hybrid motif
51269     1         67     Type III antifreeze protein
51274     1         95     Head decoration protein D (gpD, major capsid protein D)
51278     1         122     Urease, beta-subunit
51289     1         102     ACMNPV telokin-like protein
51322     1         103     Cyanovirin-N
51327     1         104     Head-binding domain of phage P22 tailspike protein
51391     1         226     Thiamin phosphate synthase
51645     1         688     Malate synthase G
51690     1         169     Quinolinic acid phosphoribosyltransferase, C-terminal domain
51713     1         372     tRNA-guanine transglycosylase
51730     1         275     FAD-linked oxidoreductase
51984     1         93     MurCD N-terminal domain
52016     1         226     Aconitase
52021     1         151     Carbamoyl phosphate synthetase, small subunit N-terminal domain
52025     1         193     Transferrin receptor ectodomain, apical domain
52038     1         90     Barstar (barnase inhibitor)
52042     1         142     Ribosomal protein L32e
52075     1         198     Outer arm dynein light chain 1
52087     1         203     C-terminal domain of phosphatidylinositol transfer protein sec14p
52151     1         125     FabD/lysophospholipase-like
52156     1         131     Initiation factor IF2/eIF5b, domain 3
52161     1         142     Ribosomal protein L13
52200     1         159     Toll/Interleukin receptor TIR domain
52206     1         111     Hypothetical protein MTH538
52251     1         105     Ornithine decarboxylase N-terminal "wing" domain
52255     1         158     N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) mutase PurE
52279     1         215     Beta-D-glucan exohydrolase, C-terminal domain
52304     1         136     Type II 3-dehydroquinate dehydratase
52309     1         156     Nucleoside 2-deoxyribosyltransferase
52313     1         237     Ribosomal protein S2
52413     1         108     UDP-glucose dehydrogenase (UDPGDH), C-terminal (UDP-binding) domain
52418     1         260     Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
52512     1         266     Phosphosugar isomerase
52728     1         161     Fructose permease, subunit IIb
52733     1         346     Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT)
52738     1         198     Methylesterase CheB, C-terminal domain
52794     1         103     Enzyme IIB-cellobiose
52913     1         95     RNA 3'-terminal phosphate cyclase, RPTC, insert domain
52949     1         159     Leucine aminopeptidase (Aminopeptidase A), N-terminal domain
52964     1         134     TolB, N-terminal domain
52968     1         178     B12-dependend dehydatases associated subunit
53032     1         97     tRNA splicing endonuclease, C-terminal domain
53036     1         139     Eukaryotic RPB5 N-terminal domain
53062     1         129     IIA domain of mannose transporter, IIA-Man
53146     1         124     MTH1175-like
53178     1         193     Peptidyl-tRNA hydrolase
53213     1         298     LigB subunit of an aromatic-ring-opening dioxygenase LigAB
53323     1         253     Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
53633     1         313     Carbamate kinase-like
53644     1         504     Cytosolic phospholipase A2 catalytic
53732     1         527     Aconitase iron-sulfur domain
53743     1         355     L-fucose isomerase, N-terminal and second domains
53774     1         337     Glutaminase/Asparaginase
53784     1         320     Phosphofructokinase
53790     1         239     Cobalt precorrin-4 methyltransferase CbiF
53920     1         321     Fe-only hydrogenase
54106     1         48     LysM domain
54111     1         100     Urease, gamma-subunit
54364     1         76     Translation initiation factor IF3, N-terminal domain
54368     1         100     Glutamine synthetase, N-terminal domain
54423     1         60     Disulfide bond isomerase, DsbC, N-terminal domain
54441     1         85     Uracil-DNA glycosylase inhibitor protein
54447     1         66     ssDNA-binding transcriptional regulator domain
54518     1         265     Transcriptional factor tubby, C-terminal domain
54529     1         182     Acidic mitochondrial matrix protein p32
54552     1         84     Colicin E3 immunity protein
54565     1         83     Ribosomal protein S16
54570     1         84     Ribosomal protein S19
54575     1         82     Ribosomal protein L31e
54580     1         67     Allophycocyanin linker chain (domain)
54611     1         143     Bacterial protein-export protein SecB
54616     1         99     DNA-binding domain of Mlu1-box binding protein MBP1
54621     1         173     Heme-binding protein A (HasA)
54626     1         212     Chalcone isomerase
54648     1         85     Dynein light chain 8 (DLC8)
54686     1         156     Ribosomal protein L10e
54690     1         142     Molybdopterin synthase subunit MoaE
54736     1         68     ClpS-like
54742     1         53     Transcription-state regulator AbrB, the N-terminal DNA recognition domain
54747     1         63     Ribosomal protein L11, N-terminal domain
54752     1         60     RecA protein, C-terminal domain
54782     1         88     Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain
54786     1         79     PI-Pfui intein middle domain
54810     1         121     GMP synthetase C-terminal dimerisation domain
54821     1         101     Ribosomal protein S3 C-terminal domain
54857     1         81     DNA damage-inducible protein DinI
54893     1         100     Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain
54909     1         111     Dimeric alpha+beta barrel
54913     1         112     GlnB-like
54919     1         150     Nucleoside diphosphate kinases
54975     1         98     Acylphosphatase-like
54991     1         104     Anticodon-binding domain of PheRS
54995     1         97     Ribosomal protein S6
54999     1         98     Ribosomal protein S10
55031     1         113     Bacterial exopeptidase dimerisation domain
55040     1         143     Molybdenum cofactor biosynthesis protein C, MoaC
55044     1         158     TRADD, N-terminal domain
55048     1         70     Probable ACP-binding domain of malonyl-CoA ACP transacylase
55052     1         68     CheY-binding domain of CheA
55056     1         79     Killer toxin KP6 alpha-subunit
55064     1         122     Translational regulator protein regA
55068     1         189     Peptide methionine sulfoxide reductase
55083     1         158     6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
55144     1         181     tRNA splicing product Appr>p cyclic nucleotide phosphodiesterase
55149     1         127     Pepsin inhibitor-3
55154     1         288     mRNA triphosphatase CET1
55186     1         179     Threonyl-tRNA synthetase (ThrRS), second 'additional' domain
55200     1         88     Translation initiation factor IF3, C-terminal domain
55216     1         91     C-terminal domain of TolA
55229     1         58     Cell division protein MinE topological specificity domain
55234     1         68     Cyanase C-terminal domain
55248     1         99     Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
55267     1         74     tRNA splicing endonuclease EdnA, N-terminal domain
55277     1         62     GYF domain
55326     1         166     Aminoimidazole ribonucleotide synthetase (PurM) N-terminal domain
55383     1         86     Copper amine oxidase, domain N
55399     1         107     Subtilisin inhibitor
55481     1         138     N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
55604     1         78     Glucose permease domain IIB
55637     1         101     Cell cycle regulatory proteins
55648     1         165     beta-lactamase-inhibitor protein, BLIP
55653     1         94     Ribosomal protein L9 C-domain
55671     1         104     Regulatory factor Nef
55676     1         227     Mosquitocidal delta-endotoxin CytB
55724     1         189     Ran-binding protein mog1p
55781     1         176     GAF domain-like
55816     1         188     5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain
55826     1         150     Hypothetical protein HI1434 (YbaK homologue)
55846     1         146     N-acetylmuramoyl-L-alanine amidase-like
55869     1         77     DNA topoisomerase I domain
55890     1         168     Sporulation responce regulatory protein Spo0B
55904     1         161     Ornithine decarboxylase C-terminal domain
55957     1         141     Phosphoglucomutase, C-terminal domain
56019     1         197     The spindle assembly checkpoint protein mad2
56037     1         209     B3/B4 domain of PheRS, PheT
56042     1         175     Aminoimidazole ribonucleotide synthetase (PurM) C-terminal domain
56199     1         316     Methenyltetrahydromethanopterin cyclohydrolase
56204     1         350     Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
56209     1         192     Nitrile hydratase alpha chain
56228     1         210     Aldehyde ferredoxin oxidoreductase, N-terminal domain
56266     1         363     L-aminopeptidase D-Ala-esterase/amidase
56271     1         309     Histidine decarboxylase
56276     1         309     S-adenosylmethionine decarboxylase
56295     1         363     Protein serine/threonine phosphatase 2
56366     1         123     SMAD MH1 domain
56420     1         164     Peptide deformylase
56487     1         112     Scavenger receptor cysteine-rich (SRCR) domain
56491     1         96     A heparin-binding domain
56502     1         305     gp120 core
56507     1         327     Methionine synthase activation domain-like
56512     1         416     Nitric oxide (NO) synthase oxygenase domain
56519     1         82     Penicillin binding protein dimerisation domain
56524     1         250     Sulfite oxidase, middle catalytic domain
56534     1         308     Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
56548     1         311     Conserved core of transcriptional regulatory protein vp16
56558     1         208     Baseplate structural protein gp11
56563     1         280     Major capsid protein gp5
56596     1         305     Replication terminator protein (Tus)
56629     1         250     ADP ribosyl cyclase-like
56726     1         289     DNA topoisomerase IV, alpha subunit
56731     1         310     DNA primase DnaG catalytic core
56736     1         266     DNA repair protein MutM (Fpg)
56741     1         220     Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
56747     1         344     DNA primase
56770     1         267     Nickel-iron hydrogenase, small subunit
56778     1         215     Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment
56815     1         527     Sec1/munc18-like (SM) proteins
56826     1         249     Upper collar protein gp10 (connector protein)
56831     1         845     BTV inner layer core protein vp3
56845     1         181     Diphtheria toxin, middle domain
56864     1         143     Exotoxin A, middle domain
56931     1         253     Outer membrane phospholipase A (OMPLA)
56954     1         423     Integral outer membrane protein TolC, efflux pump component
56973     1         366     (Pro)aerolysin, pore-forming lobe
56978     1         471     Perfringolysin
56983     1         302     Viral glycoprotein, central and dimerisation domains
56988     1         665     Anthrax protective antigen
57007     1         48     Heat-stable enterotoxin B
57011     1         54     Neurotoxin B-IV
57055     1         46     Agouti-related protein
57180     1         36     Cellulose-binding domain
57256     1         47     Elafin-like
57277     1         30     Granulin repeat
57296     1         40     Amb V allergen
57419     1         27     Neurotoxin III (ATX III)
57561     1         125     Methylamine dehydrogenase, L chain
57581     1         74     TB module/8-cys domain
57593     1         55     Heparin-binding domain from vascular endothelial growth factor
57598     1         51     Antifungal protein (AGAFP)
57610     1         65     Thyroglobulin type-1 domain
57615     1         50     Type X cellulose binding domain, CBDX
57620     1         61     Carboxypeptidase inhibitor
57625     1         73     Tachycitin
57642     1         47     Cholecystokinin A receptor, N-domain
57647     1         45     HIV-1 VPU cytoplasmic domain
57662     1         109     Ferredoxin thioredoxin reductase (FTR), catalytic beta chain
57770     1         35     Methionyl-tRNA synthetase (MetRS), Zn-domain
57798     1         159     Casein kinase II beta subunit
57821     1         71     Hypothetical protein MTH1184
57825     1         53     Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain
57840     1         37     Ribosomal protein L36
57845     1         39     B-box zinc-binding domain
57863     1         122     Pyk2-associated protein beta ARF-GAP domain
57879     1         42     Zinc domain conserved in yeast copper-regulated transcription factors
57884     1         92     Ada DNA repair protein, N-terminal domain (N-Ada 10)
57933     1         87     TAZ domain
57938     1         79     Cysteine-rich domain of the chaperone protein DnaJ.
63433     1         118     Fumarylacetoacetate hydrolase, FAH, N-terminal domain
63446     1         71     Type I dockerin domain
63491     1         112     BAG domain
63501     1         122     Frizzled cystein-rich domain
63515     1         162     Outer surface protein C (OspC)
63562     1         98     RNA polymerase omega subunit
63592     1         98     Flagellar transcriptional activator FlhD
63697     1         157     Olfactory marker protein
63707     1         160     Ganglioside M2 (gm2) activator
63712     1         205     Nicotinic receptor ligand binding domain-like
63724     1         175     Equinatoxin II (eqtII, tenebrosin C)
63732     1         267     Lactobacillus maltose phosphorylase, N-terminal domain
63737     1         208     Leukotriene A4 hydrolase N-terminal domain
63763     1         95     SAND domain-like
63817     1         148     Sortase
63825     1         258     Low density lipoprotein (LDL) receptor YWTD domain
63829     1         312     Diisopropylfluorophosphatase (phosphotriesterase, DFP)
63840     1         96     Ribonuclease domain of colicin E3
63848     1         107     Cell-division inhibitor MinC, C-terminal domain
63867     1         83     Molybdenum cofactor biosynthesis protein MoeA, C-terminal domain
63877     1         188     Methuselah ectodomain
63882     1         171     Molybdenum cofactor biosynthesis protein MoeA, N-terminal and linker domains
63887     1         101     P-domain of calnexin/calreticulin
63892     1         235     Pyridoxine 5'-phosphate synthase
63965     1         209     Precorrin-8x methylmutase
63992     1         274     Dipeptide transport protein
64043     1         89     Cell-division inhibitor MinC, N-terminal domain
64076     1         111     Hypothetical protein MT938 (MTH938)
64153     1         240     YjeF N-terminal domain-like
64158     1         234     2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain
64167     1         247     SurE-like
64182     1         310     DHH phosphoesterases
64197     1         386     AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC
64210     1         58     Head-to-tail joining protein W, gpW
64234     1         138     Photosystem I subunit PsaD
64263     1         105     Prokaryotic ribosomal protein L17
64288     1         164     Chorismate lyase
64325     1         73     Dimeric C-terminal domain of membrane protein TonB
64376     1         98     YlxR-like
64383     1         139     Cell-division protein ZipA, C-terminal domain
64397     1         229     Hsp33 domain
64438     1         295     Type 1 cytotoxic necrotizing factor, catalytic domain
64449     1         123     YopH tyrosine phosphatase N-terminal domain
64465     1         365     Outer capsid protein sigma 3
64496     1         96     DNA-binding domain of intron endonuclease I-TevI
64518     1         395     F41 fragment of flagellin
64546     1         41     Satiety factor CART (cocaine and amphetamine regulated transcript)
64571     1         46     Cellulose docking domain, dockering
64586     1         74     C-terminal domain of ProRS
68912     1         44     Rho termination factor, N-terminal domain
68918     1         57     Recombination endonuclease VII, C-terminal and dimerization domains
68930     1         104     Protein-L-isoaspartyl O-methyltransferase, C-terminal domain
68989     1         72     Hemolysin expression modulating protein HHA
68993     1         142     FAT domain of focal adhesion kinase
69000     1         105     Thiol oxidase Erv2p
69008     1         99     RecG, N-terminal domain
69025     1         84     Hypothetical protein MTH865
69036     1         64     Bcr-Abl oncoprotein oligomerization domain
69047     1         69     Hypothetical protein YjbJ
69055     1         98     1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
69060     1         174     Arp2/3 complex 21 kDa subunit ARPC3
69065     1         148     RNase III endonuclease catalytic domain
69070     1         90     Anti-sigma factor AsiA
69075     1         104     Glutamyl tRNA-reductase dimerization domain
69099     1         156     Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain
69103     1         139     Arp2/3 complex 16 kDa subunit ARPC5
69118     1         174     Antioxidant defence protein AhpD
69131     1         76     Quinohemoprotein amine dehydrogenase C chain
69189     1         94     Penicillin-binding protein 5, C-terminal domain
69203     1         94     Nucleoplasmin core
69255     1         124     Tail-associated lysozyme gp5, N-terminal domain
69304     1         281     Tricorn protease N-terminal domain
69318     1         438     Integrin alpha N-terminal domain
69322     1         360     Tricorn protease N-terminal domain
69336     1         270     Alpha subunit of glutamate synthase, C-terminal domain
69340     1         156     C-terminal domain of adenylylcyclase associated protein
69360     1         92     Choline binding domain of autolysin C-LytA
69369     1         232     Colicin E3 translocation domain
69500     1         145     D-Tyr tRNAtyr deacylase
69572     1         240     Molybdenum cofactor biosynthesis protein MoeB
69593     1         363     Glycerol-3-phosphate (1)-acyltransferase
69618     1         260     Uroporphyrinogen III synthase (U3S, HemD)
69652     1         108     DNA-binding C-terminal domain of the transcription factor MotA
69687     1         85     Integrin beta tail domain
69695     1         114     SRP19
69721     1         111     DsrC, the gamma subunit of dissimilatory sulfite reductase
69732     1         80     Lrp/AsnC-like transcriptional regulator C-terminal domain
69742     1         148     Glutamyl tRNA-reductase catalytic, N-terminal domain
69754     1         107     Ribosome binding protein Y (YfiA homologue)
69761     1         83     GTP cyclohydrolase I feedback regulatory protein, GFRP
69765     1         155     2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF
69786     1         104     YggU-like
69796     1         199     Thymidylate synthase-complementing protein Thy1
69819     1         140     MTH1598-like
69848     1         100     LCCL domain
69864     1         256     Argininosuccinate synthetase, C-terminal domain
69898     1         988     Golgi alpha-mannosidase II
69903     1         154     NSP3 homodimer
69908     1         641     Membrane penetration protein mu1
69917     1         297     OMPT-like
69922     1         266     Head and neck region of the ectodomain of NDV fusion glycoprotein
69959     1         55     Serine proteinase inhibitor lekti, domain one
69964     1         51     Pheromone ER-23
74731     1         60     Ribosomal protein L20
74748     1         269     Variable surface antigen VlsE
74778     1         160     Aconitase B, N-terminal domain
74784     1         212     Testis/brain RNA-binding protein (TB-RBP)
74788     1         359     Culin repeat
74800     1         51     C-terminal activation domain (CTAD) of HIF-1alpha
74853     1         113     Lamin A/C globular tail domain
74863     1         121     Thiol:disulfide interchange protein DsbD, N-terminal domain
74914     1         370     V-region of surface antigen I/II (SA I/II, PAC)
74924     1         95     Cap-Gly domain
74942     1         74     YhbC-like, C-terminal domain
74982     1         133     Small protein B (SmpB)
75001     1         119     Dipeptidyl peptidase I (cathepsin C), exclusion domain
75005     1         318     alpha-L-arabinanase
75011     1         355     3-carboxy-cis,cis-mucoante lactonizing enzyme
75098     1         457     Monomethylamine methyltransferase MtmB
75138     1         129     HPr kinase/phoshatase HprK N-terminal domain
75169     1         108     YchN-like
75181     1         148     Hypothetical protein MTH777 (MT0777)
75304     1         412     Amidase signature (AS) enzymes
75347     1         170     Rotavirus NSP2 fragment, C-terminal domain
75404     1         163     VSV matrix protein
75412     1         88     Hypothetical protein MTH1880
75420     1         90     YhbC-like, N-terminal domain
75445     1         69     D-ribose-5-phosphate isomerase (RpiA), lid domain
75471     1         98     YhbY-like
75500     1         103     Putative transcriptional regulator TM1602, C-terminal domain
75516     1         167     Pheromone-binding domain of LuxR-like quorum-sensing transcription factors
75553     1         161     Smc hinge domain
75569     1         202     Hypothetical protein MTH1020
75574     1         143     Rotavirus NSP2 fragment, N-terminal domain
75604     1         222     Archaeosine tRNA-guanine transglycosylase, C-terminal additional domains
75615     1         120     Bifunctional dehydrogenase/ferrochelatase Met8p, dimerisation and C-terminal domains
75620     1         354     Polypeptide chain release factor 2 (RF2)
75625     1         241     YebC-like
75632     1         276     Culin homology domain
75704     1         87     Mitotic arrest deficient-like 1, Mad1
75708     1         177     Chemotaxis phosphatase CheZ
75712     1         103     Rad50 coiled-coil Zn hook
81277     1         101     C-terminal domain of octopus hemocyanin
81382     1         55     Skp1 dimerisation domain-like
81601     1         68     Protein serine/threonine phosphatase 2C, C-terminal domain
81606     1         295     Protein serine/threonine phosphatase 2C, catalytic domain
81631     1         260     Poly(A) polymerase, middle domain
81653     1         870     Calcium ATPase, transduction domain A
81660     1         634     Calcium ATPase, ATP-binding domain N
81698     1         69     FF domain
81710     1         87     Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
81730     1         65     beta-catenin-interacting protein ICAT
81736     1         104     Pollen allergen Phl P 6
81761     1         763     X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain
81767     1         576     Pre-protein croslinking domain of SecA
81778     1         78     Crustacean CHH/MIH/GIH neurohormone
81783     1         62     C-terminal domain of DFF45/ICAD (DFF-C domain)
81790     1         85     Myosin phosphatase inhibitor 17kDa protein, CPI-17
81799     1         178     Putative methyltransferase TM0872, insert domain
81822     1         176     RuBisCo LSMT C-terminal, substrate-binding domain
81827     1         173     Porin chaperone SurA, peptide-binding domain
81832     1         165     GEF domain of SopE toxin
81837     1         300     BEACH domain
81853     1         324     Family 10 polysaccharide lyase
81872     1         591     BRCA2 helical domain
81878     1         250     BRCA2 tower domain
81886     1         232     Helical scaffold and wing domains of SecA
81891     1         259     tRNA CCA-adding enzyme, C-terminal domains
81901     1         133     Cysteine rich protein B (HcpB)
81930     1         316     Orange carotenoid protein, N-terminal domain
81935     1         514     N-terminal domain of bifunctional PutA protein
81982     1         131     Antigen MPT63/MPB63 (immunoprotective extracellular protein)
82004     1         136     N-utilization substance G protein NusG, insert domain
82026     1         120     Fucose-binding lectin II (PA-IIL)
82046     1         371     Viral chemokine binding protein m3
82051     1         332     Obg GTP-binding protein N-terminal domain
82061     1         203     BAH domain
82093     1         100     Heme chaperone CcmE
82109     1         292     IP3 receptor type 1 binding core, domain 1
82114     1         154     Riboflavin kinase
82171     1         726     Dipeptidyl peptidase IV/CD26, N-terminal domain
82185     1         293     Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
82215     1         158     C-terminal autoproteolytic domain of nucleoporin nup98
82220     1         408     Tp47 lipoprotein, N-terminal domain
82282     1         348     Betaine-homocysteine S-methyltransferase
82317     1         516     Swiveling domain of the glycerol dehydratase reactivase alpha subunit
82544     1         414     Putative glycerate kinase (hypothetical protein TM1585)
82549     1         270     DegV-like
82602     1         143     Nuclease A inhibitor (NuiA)
82607     1         85     YbaB-like
82615     1         75     Polo domain
82649     1         140     SufE (YhnA)
82653     1         81     Probable GTPase Der, C-terminal domain
82657     1         113     BolA-like
82671     1         132     SEA domain
82679     1         101     N-utilization substance G protein NusG, N-terminal domain
82689     1         101     Mechanosensitive channel protein MscS (YggB), C-terminal domain
82697     1         76     PurS subunit of FGAM synthetase
82704     1         89     DNA-binding protein Sso10b (AlbA)
82708     1         62     R3H domain
82771     1         97     GIY-YIG endonuclease
82784     1         142     Ohr/OsmC resistance proteins
82808     1         118     Replication modulator SeqA, C-terminal DNA-binding domain
82829     1         203     Putative cell cycle protein MesJ, middle and C-terminal domain
82895     1         113     TSP-1 type 1 repeat
82910     1         110     Apical membrane antigen 1
82927     1         52     Cysteine-rich DNA binding domain, (DM domain)
82931     1         105     Tumor suppressor gene product Apc
82936     1         74     Apolipoprotein A-II



Contact:

Dr. R. Sowdhamini (mini@ncbs.res.in)

Dr. Saikat Chakrabarti

Dr. PN. Suganthan

G. Pugalenthi