Pfam Domains mapped on to the structure: 5ICD
No.
Chain ID
Pfam ID
Pfam Description
Linkout - Pfam
Linkout - CDD
1
A
PF00180
Isocitrate/isopropylmalate dehydrogenase
PF00180
PF00180
Conserved Domain Database Superfamily Annotations: 5ICD
Structural Details of PDB entry 5ICD
Structural Details of PDB entry 5ICD
PDBid Chains Hinge Swapped Domain
5ICD
A,B
A:187-201,B:187-201
A:3-186,B:3-186
Swapped-domain interface residues and interactions:
Chains Residues
A
110 , 111 , 112 , 113 , 116 , 123 , 139 , 140 , 141 , 142 , 156 , 157 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 171 , 174 , 175 , 178 , 179 , 182 , 183 , 185 , 187 , 188 , 189 , 233 , 236 , 290 , 291 ,
B
110 , 111 , 112 , 113 , 116 , 123 , 139 , 140 , 141 , 142 , 156 , 157 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 171 , 174 , 175 , 178 , 179 , 182 , 183 , 185 , 187 , 188 , 189 , 233 , 236 , 290 , 291 ,
Non-swapped-domain interface residues and interactions:
Chains Residues
A
190 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 204 , 205 , 208 , 230 , 234 , 235 , 237 , 244 , 282 , 283 , 286 , 287 , 304 , 305 , 307 , 308 , 311 , 312 , 315 , 320 , 416 ,
B
190 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 204 , 205 , 208 , 230 , 234 , 235 , 237 , 244 , 282 , 283 , 286 , 287 , 304 , 305 , 307 , 308 , 311 , 312 , 315 , 320 ,
Mutations in critical regions:
Chains
Hinge
Domain swapped interface Non-swapped interface Swapped Domain
A No mutation No mutation No mutation No mutation B No mutation No mutation No mutation No mutation
HIDE output:
JMOL Visualization:
2D-plot:
JOY Structural annotation for hinge hinge and swapped domain:
JOY output:
