Pfam Domains mapped on to the structure: 2HM7

No.	Chain ID	Pfam ID	Pfam Description	Linkout - Pfam	Linkout - CDD
1	A	PF00135	Carboxylesterase family	PF00135	PF00135
2	A	PF07859	alpha/beta hydrolase fold	PF07859	PF07859

Gene Ontology Annotations: 2HM7

No.	GO ID	GO Description	Linkout - AmiGO
1	GO:0008152	metabolic process	GO:0008152

Conserved Domain Database Superfamily Annotations: 2HM7

No.	PDB ID	PSSM ID	CDD Accession	Superfamily Short Name	Linkout - CDD
1	2HM7	211462	Esterase_lipase	superfamily	C -
2	2HM7	211462	Esterase_lipase	superfamily	C -

Structural Details of PDB entry 2HM7 PDBid Chains Hinge Swapped Domain 2HM7 A,B A:290-303,B:290-303 A:304-310,B:304-310 Swapped-domain interface residues and interactions: Chains Residues A 310, Non-swapped-domain interface residues and interactions: Chains Residues A 3, 4, 5, 6, 7, 9, 10, 11, 14, 15, 19, 22, 25, 27, 30, 31, 34, 36, 37, 38, 39, 40, 83, 86, 87, 88, 92, 117, 118, 203, 204, 205, 207, 209, 210, 212, 213, 214, 251, 279, 280, 281, 286, 287, 290, 291, 292, 293, B 3, 4, 5, 6, 7, 9, 10, 11, 14, 15, 19, 22, 25, 27, 30, 31, 34, 36, 37, 38, 39, 40, 83, 86, 87, 88, 92, 117, 118, 203, 204, 205, 207, 209, 210, 212, 213, 214, 251, 279, 280, 281, 286, 287, 290, 291, 292, 293,

Swapped domains are represented using trasperent spheres. Non-swapped part is represented using light color and cartoon representation. Hinge region is shown in yellow color.

Mutations in critical regions:

Chains	Hinge	Domain swapped interface	Non-swapped interface	Swapped Domain
A	No mutation	No mutation	No mutation	No mutation
B	No mutation	No mutation	No mutation	No mutation

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:2HM7

B:2HM7

JOY Structural annotation for hinge hinge and swapped domain:

Hinge	Swapped domain

JOY output:

ali file:	2HM7.ali
atm file:	2HM7.atm
cof file:	2HM7.cof
hbd file:	2HM7.hbd
html file:	2HM7.html
pdb file:	2HM7.pdb
ps file:	2HM7.ps
psa file:	2HM7.psa
rtf file:	2HM7.rtf
sst file:	2HM7.sst
tem file:	2HM7.tem