3DSwap | Knowledgebase of 3D Domain Swapping in Proteins

Pfam Domains mapped on to the structure: 1SHN

No. Chain ID Pfam ID Pfam Description Linkout - Pfam Linkout - CDD

1 A PF00245 Alkaline phosphatase PF00245 PF00245

Gene Ontology Annotations: 1SHN

No. GO ID GO Description Linkout - AmiGO

1 GO:0008152 metabolic process GO:0008152

Conserved Domain Database Superfamily Annotations: 1SHN

No. PDB ID PSSM ID CDD Accession Superfamily Short Name Linkout - CDD

1 1SHN 73179 cd00016 alkPPc - cl15837

2 1SHN 210237 cl15837 alkPPc superfamily - -

3 1SHN 210237 cl15837 alkPPc superfamily - -

Structural Details of PDB entry 1SHN

Structural Details of PDB entry 1SHN

PDBid Chains Hinge Swapped Domain

1SHN A,B A:21-28,B:21-28 A:1-20,B:1-20

Swapped-domain interface residues and interactions:

Chains Residues
A 1, 2, 3, 4, 7, 8, 10, 11, 12, 14, 15, 16, 18, 19, 79, 97, 98, 107, 108, 109, 448, 456, 457, 460, 461,

B 1, 2, 3, 4, 7, 8, 10, 11, 12, 14, 15, 16, 18, 19, 79, 97, 98, 107, 108, 109, 448, 456, 457, 460, 461,

Non-swapped-domain interface residues and interactions:

Chains Residues
A 23, 41, 42, 45, 48, 49, 59, 60, 62, 66, 69, 70, 71, 73, 75, 77, 78, 80, 81, 82, 83, 101, 122, 124, 125, 360, 362, 363, 364, 365, 366, 367, 368, 369, 380, 381, 382, 387, 391, 393, 394, 396, 398, 400, 404, 406, 422, 423, 424, 425, 426, 427, 428, 431, 432, 433, 434, 435, 436, 440, 450, 451, 452, 453, 454, 464, 471, 472, 476,

B 23, 41, 42, 45, 48, 49, 59, 60, 62, 66, 69, 70, 71, 73, 75, 77, 78, 80, 81, 82, 83, 101, 122, 124, 125, 360, 362, 363, 364, 365, 366, 367, 368, 369, 380, 381, 382, 383, 387, 391, 393, 394, 396, 398, 400, 404, 406, 422, 423, 424, 425, 426, 427, 428, 431, 432, 433, 434, 435, 436, 440, 450, 451, 452, 453, 454, 464, 471, 472,

Swapped domains are represented using trasperent spheres.
Non-swapped part is represented using light color and cartoon representation.
Hinge region is shown in yellow color.

Mutations in critical regions:

Chains Hinge Domain swapped interface Non-swapped interface Swapped Domain

A No mutation GLU(1)-, GLU(2)-, ASP(3)-, No mutation GLU(1)-, GLU(2)-, ASP(3)-,

B No mutation GLU(1)-, GLU(2)-, ASP(3)-, No mutation GLU(1)-, GLU(2)-, ASP(3)-,

HIDE output:

Homologues found through HIDE algorithm

JMOL Visualization:

2D-plot:

A:1SHN B:1SHN

JOY Structural annotation for hinge hinge and swapped domain:

Hinge Swapped domain

JOY output:

ali file: 1SHN.ali
atm file: 1SHN.atm
cof file: 1SHN.cof
hbd file: 1SHN.hbd
html file: 1SHN.html
pdb file: 1SHN.pdb
ps file: 1SHN.ps
psa file: 1SHN.psa
rtf file: 1SHN.rtf
sst file: 1SHN.sst
tem file: 1SHN.tem