RNA-binding proteins (RBPs) stabilise, protect, package, transport and mediate interactions with or act catalytically on RNA (cutting, unwinding, replicating, modifying, etc.) (Dreyfuss et al., 2002). The association of this class of proteins with their RNA partners is dynamic and defines the cellular localisation, lifetime and processing of different kinds of RNA, as well as the rate of translation of mRNA (Lunde et al., 2007). hRBPome reports a comprehensive comparative analysis of RBPs reported by six independent studies. Each of these studies had adopted different techniques and workflows for the identification of RBPs. Hence, for a comparative analysis, the gene names of the RBPs identified in each of these studies, have been considered.

        hRBPome assigns confidence scores to putative RBPs based on their occurence in the datasets from different studies. The datasets considered in this program are as follows: our own genome-wide survey (GWS) of the human proteome (Ghosh and Sowdhamini, 2016), the census of human RBPs (Gerstberger et al., 2014), the unexplored human RBP atlas (Zhao et al., 2014), the mRNA-bound proteome (Baltz et al., 2012), the HeLa mRNA interactome (Castello et al., 2012) and the RBPDB (Cook et al., 2010). A putative RBP is assigned a confidence score of 6, if it occurs in all of the six datasets mentioned, that of 5 if it occurs in five datasets and so on.