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D-Aspartic Acid

PubChem CID: 83887

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Compound Synonyms D-Aspartic acid, 1783-96-6, (R)-2-aminosuccinic acid, D-Aspartate, (-)-Aspartic acid, H-D-Asp-OH, (2R)-2-aminobutanedioic acid, (R)-Aspartic acid, Aspartic acid D-form, D-(-)-Aspartic acid, Aspartic acid, D-, D-Asparaginsaeure, NSC 97922, (R)-(-)-Aminosuccinic acid, BRN 1723529, EINECS 217-234-6, MFCD00063081, (R)-2-aminobutanedioic acid, DTXSID2045650, CHEBI:17364, Tocris-0213, C4H7NO4, 4SR0Q8YD1X, CHEMBL29757, D-ASPARTIC ACID [MI], DTXCID0025650, D-ASPARTIC ACID [WHO-DD], 4-04-00-02998 (Beilstein Handbook Reference), NSC-97922, NCGC00024498-02, (2R)-2-aminobutanedioate, d aspartic acid, D-Aminosuccinic acid, [3H]-D-aspartate, [3H]D-aspartic acid, 1-Amino-1,2-carboxyethane, [3H]-D-aspartic acid, UNII-4SR0Q8YD1X, delta-aspartate, D-Asparaginic Acid, delta-aspartic acid, D-Asp, delta-asparaginsaeure, Lopac-alpha-9256, [3h]-d-asp, (R)-Aminosuccinic Acid, (R)-2-aminosuccinicacid, (R)-2-Aminobutanedioate, Lopac-A-9256, 3-hydroxy-N-(2-methyl-1-oxo-2-propenyl)-, delta-(-)-Aspartic acid, Biomol-NT_000167, bmse000273, SCHEMBL145539, BPBio1_001126, GTPL4698, GTPL6511, BDBM31174, Tox21_110904, HB0230, PDSP1_001545, PDSP2_001529, s5129, AKOS015854091, DB02655, FA12669, D-Aspartic acid, ReagentPlus(R), 99%, NCGC00015104-01, NCGC00024498-01, NCGC00024498-03, NCGC00024498-04, AC-22382, AS-12792, BP-12717, HY-42068, SY009812, CAS-1783-96-6, (2R)-2-azaniumyl-4-hydroxy-4-oxobutanoate, A0545, CS-0020434, NS00074115, EN300-67412, C00402, D-Aspartic acid, Vetec(TM) reagent grade, 99%, SR-01000597731, SR-01000597731-1, Q27076990, 0BBACB33-ED80-42B3-9F05-75E0E3E41D6D, F1905-7153, Z1079451886, 27881-01-2
Topological Polar Surface Area 101.0
Hydrogen Bond Donor Count 3.0
Heavy Atom Count 9.0
Pathway Kegg Map Id map00250
Description D-Aspartic acid is the D-isomer of aspartic acid. Since its discovery in invertebrates, free D-aspartate (D-Asp) has been identified in a variety of organisms, including microorganisms, plants, and lower animals, mammals and humans. D-Asp in mammalian tissues is present in specific cells, indicating the existence of specific molecular components that regulate D-Asp levels and localization in tissues. In the rat adrenal medulla, D-Asp is closely associated with adrenaline-cells (A-cells), which account for approximately 80% of the total number of chromaffin cells in the tissue, and which make and store adrenaline. D-Asp appears to be absent from noradrenaline-cells (NA-cells), which comprise approximately 20% of the total number of chromaffin cells in the adrenal medulla, and which make and store noradrenaline. D-aspartate oxidase (EC 1.4.3.1, D-AspO), which catalyzes oxidative deamination of D-Asp, appears to be present only in NA-cells, suggesting that the lack of D-Asp in these cells is due to D-Asp oxidase-mediated metabolism of D-Aspecies In the rat adrenal cortex, the distribution of D-Asp changes during development. It has been suggested that developmental changes in the localization of D-Asp reflects the participation of D-Asp in the development and maturation of steroidogenesis in rat adrenal cortical cells. D-Asp is involved in steroid hormone synthesis and secretion in mammals as well. D-Asp is synthesized intracellularly, most likely by Asp racemase (EC 5.1.1.13). Endogenous D-Asp apparently has two different intracellular localization patterns: cytoplasmic and vesicular. D-Asp release can occur through three distinct pathways: 1) spontaneous, continuous release of cytoplasmic D-Asp, which is not associated with a specific stimulus, 2) release of cytoplasmic D-Asp via a volume-sensitive organic anion channel that connects the cytoplasm and extracellular space, 3) exocytotic discharge of vesicular D-Aspecies D-Asp can be released via a mechanism that involves the L-Glu transporter. D-Asp is thus apparently in dynamic flux at the cellular level to carry out its physiological function(s) in mammals. (PMID: 16755369) [HMDB]
Isotope Atom Count 0.0
Molecular Complexity 133.0
Database Name cmaup_ingredients;fooddb_chem_all;hmdb_chem_all;npass_chem_all;pubchem
Defined Atom Stereocenter Count 1.0
Uniprot Id Q99489, Q13255, Q14416, O15303, Q9R1M7, O59010, P16473, Q9F4F7, Q9NUW8, P27695, P10275
Iupac Name (2R)-2-aminobutanedioic acid
Prediction Hob 1.0
Class Carboxylic acids and derivatives
Target Id NPT210
Xlogp -2.8
Superclass Organic acids and derivatives
Subclass Amino acids, peptides, and analogues
Molecular Formula C4H7NO4
Prediction Swissadme 0.0
Inchi Key CKLJMWTZIZZHCS-UWTATZPHSA-N
Fcsp3 0.5
Logs -1.137
Rotatable Bond Count 3.0
State Solid
Logd -0.79
Synonyms (-)-Aspartic acid, (2R)-2-Aminobutanedioate, (2R)-2-Aminobutanedioic acid, (R)-2-Aminobutanedioate, (R)-2-Aminobutanedioic acid, (R)-2-Aminosuccinic acid, (R)-Aspartic acid, 1-Amino-1,2-carboxyethane, Aspartate D-form, aspartic acid, Aspartic acid D-form, D-(-)-Aspartic acid, D-Asparaginsaeure, D-aspartate, D-aspartic acid, delta-(-)-Aspartic acid, delta-asparaginsaeure, delta-aspartate, delta-aspartic acid, Lopac-alpha-9256, Tocris-0213, DAS, (R)-2-Aminosuccinate, D-Aspartate, D Aspartate, D Aspartic acid, 1-amino-1,2-Carboxyethane, Aspartic acid, delta-Asparaginsaeure, delta-Aspartate, delta-Aspartic acid
Compound Name D-Aspartic Acid
Kingdom Organic compounds
Prediction Hob Swissadme 0.0
Exact Mass 133.038
Formal Charge 0.0
Monoisotopic Mass 133.038
Hydrogen Bond Acceptor Count 5.0
Molecular Weight 133.1
Covalent Unit Count 1.0
Total Atom Stereocenter Count 1.0
Total Bond Stereocenter Count 0.0
Molecular Framework Aliphatic acyclic compounds
Esol 1.9834614000000002
Inchi InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m1/s1
Smiles C([C@H](C(=O)O)N)C(=O)O
Nring 0.0
Defined Bond Stereocenter Count 0.0
Taxonomy Direct Parent Aspartic acid and derivatives

  • 1. Outgoing r'ship FOUND_IN to/from Acorus Gramineus (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 2. Outgoing r'ship FOUND_IN to/from Acorus Tatarinowii (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 3. Outgoing r'ship FOUND_IN to/from Allium Sativum (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 4. Outgoing r'ship FOUND_IN to/from Aloe Africana (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 5. Outgoing r'ship FOUND_IN to/from Aloe Barbadensis (Plant) Rel Props:Source_db:npass_chem_all
  • 6. Outgoing r'ship FOUND_IN to/from Aloe Ferox (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 7. Outgoing r'ship FOUND_IN to/from Aloe Spicata (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 8. Outgoing r'ship FOUND_IN to/from Aloe Vera (Plant) Rel Props:Source_db:cmaup_ingredients
  • 9. Outgoing r'ship FOUND_IN to/from Amomum Melegueta (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 10. Outgoing r'ship FOUND_IN to/from Anacyclus Monanthos (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 11. Outgoing r'ship FOUND_IN to/from Arabidopsis Thaliana (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 12. Outgoing r'ship FOUND_IN to/from Arachis Hypogaea (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 13. Outgoing r'ship FOUND_IN to/from Arum Palaestinum (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 14. Outgoing r'ship FOUND_IN to/from Astragalus Siculus (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 15. Outgoing r'ship FOUND_IN to/from Brassica Juncea (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 16. Outgoing r'ship FOUND_IN to/from Bupleurum Chinense (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 17. Outgoing r'ship FOUND_IN to/from Bupleurum Falcatum (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 18. Outgoing r'ship FOUND_IN to/from Bupleurum Scorzonerifolium (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 19. Outgoing r'ship FOUND_IN to/from Corydalis Tashiroi (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 20. Outgoing r'ship FOUND_IN to/from Euphorbia Cuneata (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 21. Outgoing r'ship FOUND_IN to/from Fagopyrum Esculentum (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 22. Outgoing r'ship FOUND_IN to/from Foeniculum Vulgare (Plant) Rel Props:Source_db:npass_chem_all
  • 23. Outgoing r'ship FOUND_IN to/from Ginkgo Biloba (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 24. Outgoing r'ship FOUND_IN to/from Glycyrrhiza Glabra (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 25. Outgoing r'ship FOUND_IN to/from Guizotia Scabra (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 26. Outgoing r'ship FOUND_IN to/from Hakea Trifurcata (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 27. Outgoing r'ship FOUND_IN to/from Juglans Nigra (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 28. Outgoing r'ship FOUND_IN to/from Leontice Robustum (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 29. Outgoing r'ship FOUND_IN to/from Lycopersicon Esculentum (Plant) Rel Props:Source_db:npass_chem_all
  • 30. Outgoing r'ship FOUND_IN to/from Malus Pumila (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 31. Outgoing r'ship FOUND_IN to/from Mikania Cordifolia (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 32. Outgoing r'ship FOUND_IN to/from Oryza Sativa (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 33. Outgoing r'ship FOUND_IN to/from Otholobium Glandulosum (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 34. Outgoing r'ship FOUND_IN to/from Pinellia Ternata (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 35. Outgoing r'ship FOUND_IN to/from Pogostemon Cablin (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 36. Outgoing r'ship FOUND_IN to/from Prunus Speciosa (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 37. Outgoing r'ship FOUND_IN to/from Raoulia Australis (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 38. Outgoing r'ship FOUND_IN to/from Senecio Chionophilus (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 39. Outgoing r'ship FOUND_IN to/from Sinapis Alba (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 40. Outgoing r'ship FOUND_IN to/from Solanum Lycopersicum (Plant) Rel Props:Source_db:cmaup_ingredients
  • 41. Outgoing r'ship FOUND_IN to/from Solanum Tuberosum (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 42. Outgoing r'ship FOUND_IN to/from Terminalia Brachystemma (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 43. Outgoing r'ship FOUND_IN to/from Tussilago Farfara (Plant) Rel Props:Source_db:npass_chem_all
  • 44. Outgoing r'ship FOUND_IN to/from Zea Mays (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
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