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Parthenolide

PubChem CID: 7251185

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Compound Synonyms parthenolide, 20554-84-1, (-)-Parthenolide, MFCD00134592, CHEBI:7939, PARTHENOLIDE [MI], 2RDB26I5ZB, PARTHENOLIDE [USP-RS], PARTHENOLIDE [WHO-DD], CHEMBL465158, UNII-2RDB26I5ZB, NSC-157035, (1aR,4E,7aS,10aS,10bR)-1a,5-dimethyl-8-methylidene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, (1S,2R,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one, PARTHENOLIDE (USP-RS), PARTHENOLIDE (CONSTITUENT OF FEVERFEW) [DSC], NSC 157035, (1AR,4E,7AS,10AS,10BS)-2,3,6,7,7A,8,10A,10B-OCTAHYDRO-1A,5-DIMETHYL-8-METHYLENEOXIRENO(9,10)CYCLODECA(1,2-B)FURAN-9(1AH)-ONE, 4,5.ALPHA.-EPOXY-6.BETA.-HYDROXY-GERMACRA-1(10),11(13)-DIEN-12-OIC ACID .GAMMA.-LACTONE, 4,5-alpha-Epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-oic acid gamma-lactone, DTXCID0020579, DTXSID2040579, partenolide, Parthenolide?, NSC157035, (1aR,4E,7aS,10aS,10bR)-1a,5-dimethyl-8-methylidene-2,3,6,7,7a,8,10a,10b-octahydrooxireno(9,10)cyclodeca(1,2-b)furan-9(1aH)-one, Parthenolide (Standard), Prestwick2_000550, Prestwick3_000550, Epitope ID:115014, PARTHENOLIDE [INCI], SCHEMBL8220, BSPBio_000599, BSPBio_001308, MLS002153872, BPBio1_000659, parthenolide-(alternate-stereo), SCHEMBL13367522, BCBcMAP01_000041, GTPL12428, HY-N0141R, Parthenolide, >=98% (HPLC), KTEXNACQROZXEV-PVLRGYAZSA-N, GLXC-02572, HMS1361B10, HMS1569N21, HMS1791B10, HMS1989B10, HMS2096N21, HMS3402B10, HMS3713N21, parthenolide, (1aR-(1aR*,4E,7aS*,10aS*,10bR*))-isomer, (1S,2S,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo(9.3.0.02,4)tetradec-7-en-13-one, (1S,2S,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one, (3aS,9aR,10aR,10bS,E)-6,9a-dimethyl-3-methylene-3a,4,5,8,9,9a,10a,10b-octahydrooxireno[2',3':9,10]cyclodeca[1,2-b]furan-2(3H)-one, BCP10404, EX-A5460, Germacra-1(10),11(13)-dien-12-oic acid, 4,5-.alpha.-epoxy-6-.beta.-hydroxy-, .gamma.-lactone, HY-N0141, Oxireno(9,10)cyclodeca(1,2-b)furan-9(1aH)-one, 2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylene-, (1aR,4E,7aS,10aS,10bS)-, PTL, BDBM50552137, AKOS016010226, CCG-208244, CS-1919, FP65646, 4,5alpha-epoxy-6beta-hydroxy-germacra-1(10),11(13)-dien-12-oic acid gamma-lactone, IDI1_033778, NCGC00163415-01, NCGC00163415-04, AS-17479, SMR001233226, AB00513860, PARTHENOLIDE (CONSTITUENT OF FEVERFEW), EN300-21037378, BRD-K28120222-001-08-4, 4,5-Epoxy-germacra-1(10)E,11(13)-dien-12,6alpha-olide, (-)-Parthenolide, NSC-157035, NSC 157035, NSC157035, Parthenolide, United States Pharmacopeia (USP) Reference Standard, 4,5-a-Epoxy-6-b-hydroxygermacra-1(10),11(13)-dien-12-Oate g-lactone, 4,5-a-Epoxy-6-b-hydroxygermacra-1(10),11(13)-dien-12-Oic acid g-lactone, 4,5-alpha-Epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-Oate gamma-lactone, (1S,2R,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.0,2,4]tetradec-7-en-13-one
Ghose Rule True
Classyfire Kingdom Organic compounds
Topological Polar Surface Area 38.8
Hydrogen Bond Donor Count 0.0
Pfizer 3 75 Rule False
Scaffold Graph Level CC1CC2C3CC3CCCCCCC2C1C
Np Classifier Class Germacrane sesquiterpenoids
Deep Smiles C/C=CCC[C@@]C)O[C@@H]3[C@@H][C@@H]CC%11))C=C)C=O)O5
Heavy Atom Count 18.0
Classyfire Class Prenol lipids
Scaffold Graph Node Level CC1C(O)OC2C1CCCCCCC1OC12
Classyfire Subclass Terpene lactones
Isotope Atom Count 0.0
Molecular Complexity 437.0
Database Name cmaup_ingredients;imppat_phytochem;pubchem
Defined Atom Stereocenter Count 4.0
Iupac Name (1S,2R,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one
Prediction Hob 1.0
Veber Rule True
Classyfire Superclass Lipids and lipid-like molecules
Target Id NPT94
Xlogp 2.3
Gsk 4 400 Rule True
Molecular Formula C15H20O3
Scaffold Graph Node Bond Level C=C1C(=O)OC2C1CCC=CCCC1OC12
Prediction Swissadme 0.0
Inchi Key KTEXNACQROZXEV-PVLRGYAZSA-N
Silicos It Class Soluble
Fcsp3 0.6666666666666666
Logs -4.223
Rotatable Bond Count 0.0
Logd 2.822
Synonyms parthenolide
Esol Class Soluble
Functional Groups C/C=C(/C)C, C=C1CCOC1=O, C[C@@]1(C)O[C@@H]1C
Compound Name Parthenolide
Prediction Hob Swissadme 0.0
Exact Mass 248.141
Formal Charge 0.0
Monoisotopic Mass 248.141
Hydrogen Bond Acceptor Count 3.0
Molecular Weight 248.32
Gi Absorption True
Covalent Unit Count 1.0
Total Atom Stereocenter Count 4.0
Total Bond Stereocenter Count 1.0
Lipinski Rule Of 5 True
Esol -2.8537963999999993
Inchi InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1
Smiles C/C/1=C\CC[C@@]2([C@H](O2)[C@@H]3[C@@H](CC1)C(=C)C(=O)O3)C
Nring 3.0
Np Classifier Biosynthetic Pathway Terpenoids
Defined Bond Stereocenter Count 1.0
Egan Rule True
Np Classifier Superclass Sesquiterpenoids

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  • 2. Outgoing r'ship FOUND_IN to/from Chrysanthemum Indicum (Plant) Rel Props:Reference:ISBN:9780387706375
  • 3. Outgoing r'ship FOUND_IN to/from Cyathocline Purpurea (Plant) Rel Props:Reference:ISBN:9770972795006
  • 4. Outgoing r'ship FOUND_IN to/from Magnolia Champaca (Plant) Rel Props:Reference:ISBN:9788172363130
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  • 6. Outgoing r'ship FOUND_IN to/from Magnolia Lanuginosa (Plant) Rel Props:Reference:ISBN:9770972795006
  • 7. Outgoing r'ship FOUND_IN to/from Mollugo Pentaphylla (Plant) Rel Props:Source_db:cmaup_ingredients
  • 8. Outgoing r'ship FOUND_IN to/from Tanacetum Parthenium (Plant) Rel Props:Reference:ISBN:9780896038776
  • 9. Outgoing r'ship FOUND_IN to/from Tanacetum Vulgare (Plant) Rel Props:Reference:ISBN:9788172363093