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Maytanbutine

PubChem CID: 6438456

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Compound Synonyms Maytanbutine, UGX4BO6MOQ, UNII-UGX4BO6MOQ, 38997-10-3, NSC 165014, NSC-165014, MAYTANSINE, N2'-DEACETYL-N2'-(2-METHYL-1-OXOPROPYL)-, Maytansine, N(2')-deacetyl-N(2')-(2-methyl-1-oxopropyl)-, ((1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo(19.3.1.110,14.03,5)hexacosa-10,12,14(26),16,18-pentaen-6-yl) 2-(methyl(2-methylpropanoyl)amino)propanoate, [(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] 2-[methyl(2-methylpropanoyl)amino]propanoate, CHEMBL502675, Maytansine, N(2')-deacetyl-N(2')-(2-methyl-1-oxopropyl)-(9CI)
Ghose Rule False
Classyfire Kingdom Organic compounds
Topological Polar Surface Area 156.0
Hydrogen Bond Donor Count 2.0
Pfizer 3 75 Rule False
Scaffold Graph Level CC1CCC2CC2CC2CC(C)CC(CCCCCCC3CCCC(C1)C3)C2
Np Classifier Class Ansa macrolides
Deep Smiles CO[C@@H]/C=C/C=CC)/CcccOC))ccc6)NC=O)C[C@@H][C@][C@H][C@@H][C@@H]C[C@@]%21O)NC=O)O6))))))C))O3))C))OC=O)CNC=O)CC)C)))C))C)))))))C)))Cl
Heavy Atom Count 50.0
Classyfire Class Macrolactams
Scaffold Graph Node Level OC1CCC2OC2CC2CC(CCCCCCC3CCCC(C3)N1)NC(O)O2
Isotope Atom Count 0.0
Molecular Complexity 1340.0
Database Name imppat_phytochem;pubchem
Defined Atom Stereocenter Count 7.0
Iupac Name [(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] 2-[methyl(2-methylpropanoyl)amino]propanoate
Veber Rule True
Classyfire Superclass Phenylpropanoids and polyketides
Xlogp 3.0
Gsk 4 400 Rule False
Molecular Formula C36H50ClN3O10
Scaffold Graph Node Bond Level O=C1CCC2OC2CC2CC(CC=CC=CCc3cccc(c3)N1)NC(=O)O2
Inchi Key RJIVUFYDGYNSNE-BGOHZRNNSA-N
Silicos It Class Moderately soluble
Rotatable Bond Count 7.0
Synonyms maytanbutine
Esol Class Moderately soluble
Functional Groups C/C(C)=C/C=C/C, CC(=O)N(C)C, CC(=O)OC, COC, C[C@@]1(C)O[C@H]1C, C[C@@]1(O)CCOC(=O)N1, cCl, cN(C)C(C)=O, cOC
Compound Name Maytanbutine
Exact Mass 719.318
Formal Charge 0.0
Monoisotopic Mass 719.318
Hydrogen Bond Acceptor Count 10.0
Molecular Weight 720.2
Gi Absorption False
Covalent Unit Count 1.0
Total Atom Stereocenter Count 8.0
Total Bond Stereocenter Count 2.0
Lipinski Rule Of 5 True
Inchi InChI=1S/C36H50ClN3O10/c1-19(2)32(42)39(7)22(5)33(43)49-28-17-29(41)40(8)24-15-23(16-25(46-9)30(24)37)14-20(3)12-11-13-27(47-10)36(45)18-26(48-34(44)38-36)21(4)31-35(28,6)50-31/h11-13,15-16,19,21-22,26-28,31,45H,14,17-18H2,1-10H3,(H,38,44)/b13-11+,20-12+/t21-,22?,26+,27-,28+,31+,35+,36+/m1/s1
Smiles C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)C(C)N(C)C(=O)C(C)C)C)\C)OC)(NC(=O)O2)O
Np Classifier Biosynthetic Pathway Polyketides
Defined Bond Stereocenter Count 2.0
Egan Rule False
Np Classifier Superclass Macrolides