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Thebaine

PubChem CID: 5324289

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Compound Synonyms THEBAINE, Paramorphine, 115-37-7, Thebain, 3-O-Methyl-oripavin, EINECS 204-084-1, 2P9MKG8GX7, 4,5alpha-Epoxy-3,6-dimethoxy-17-methyl-6,8-morphinadien, CHEBI:9519, DTXSID7046099, (5R,9R,13S)-4,5-Epoxy-3,6-dimethoxy-9alpha-methyl-6,8-morphinadien, THEBAINE [MI], codeine methyl enol ether, THEBAINE [WHO-DD], IDS-NT-002, (4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline, DTXCID5026099, NCGC00160239-01, 3,6-dimethoxy-17-methyl-6,7,8,14-tetradehydro-4,5alpha-epoxymorphinan, (5alpha)-6,7,8,14-tetradehydro-4,5-epoxy-3,6-dimethoxy-17-methylmorphinan, Morphinan, 6,7,8,14-tetradehydro-4,5-alpha-epoxy-3,6-dimethoxy-17-methyl-, Tebain, CODEINE MONOHYDRATE IMPURITY G [EP IMPURITY], OXYCODONE HYDROCHLORIDE IMPURITY F [EP IMPURITY], CODEINE PHOSPHATE HEMIHYDRATE IMPURITY G [EP IMPURITY], CODEINE HYDROCHLORIDE DIHYDRATE IMPURITY G [EP IMPURITY], CODEINE PHOSPHATE SESQUIHYDRATE IMPURITY G [EP IMPURITY], HYDROCODONE HYDROGEN TARTRATE 2.5-HYDRATE IMPURITY I [EP IMPURITY], Thebaine (1.0mg/ml in Acetonitrile), (5.ALPHA.)-6,7,8,14-TETRADEHYDRO-4,5-EPOXY-3,6-DIMETHOXY-17-METHYLMORPHINAN, CAS-115-37-7, CODEINE MONOHYDRATE IMPURITY G (EP IMPURITY), UNII-2P9MKG8GX7, OXYCODONE HYDROCHLORIDE IMPURITY F (EP IMPURITY), tebaine, CODEINE HYDROCHLORIDE DIHYDRATE IMPURITY G (EP IMPURITY), CODEINE PHOSPHATE HEMIHYDRATE IMPURITY G (EP IMPURITY), CODEINE PHOSPHATE SESQUIHYDRATE IMPURITY G (EP IMPURITY), Kodein, DEA No. 9333, HYDROCODONE HYDROGEN TARTRATE 2.5-HYDRATE IMPURITY I (EP IMPURITY), Thebaine, powder, NCGC00247709-01, Codeine Impurity G, (4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro(3,2-e)isoquinoline, SCHEMBL37580, Thebaine, 1mg/ml in Methanol, CHEMBL403893, SCHEMBL19880976, GTPL13146, Thebaine 0.1 mg/ml in Methanol, Morphinan, 6,7,8,14-tetradehydro-4,5.alpha.-epoxy-3,6-dimethoxy-17-methyl-, BDBM224032, Tox21_111751, Tox21_112863, NS00005833, C06173, T-0020, Q63392872, Thebaine, European Pharmacopoeia (EP) Reference Standard, 6,7,8,14-tetradehydro-4,5-epoxy-3,6-dimethoxy-17-methylmorphinan, Morphinan, 6,7,8,14-tetradehydro-4,5alpha-epoxy-3,6-dimethoxy-17-methyl-, Morphinan, 6,7,8,14-tetradehydro-4,5-epoxy-3,6-dimethoxy-17-methyl-,(5.alpha.)-, 204-084-1, D4R
Ghose Rule True
Classyfire Kingdom Organic compounds
Topological Polar Surface Area 30.9
Hydrogen Bond Donor Count 0.0
Pfizer 3 75 Rule False
Scaffold Graph Level C1CC2CC3CCCC45C(CCCC34)CC(C1)C25
Np Classifier Class Isoquinoline alkaloids, Morphinan alkaloids
Deep Smiles COC=CC=C[C@][C@H]6Occ5cC[C@H]9NCC%11))C))))ccc6OC
Heavy Atom Count 23.0
Classyfire Class Morphinans
Scaffold Graph Node Level C1CC2CC3NCCC45C(CCCC34)OC(C1)C25
Isotope Atom Count 0.0
Molecular Complexity 585.0
Database Name cmaup_ingredients;imppat_phytochem;npass_chem_all;pubchem
Defined Atom Stereocenter Count 3.0
Uniprot Id P35372, P10275
Iupac Name (4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline
Prediction Hob 1.0
Veber Rule True
Classyfire Superclass Alkaloids and derivatives
Target Id NPT145
Xlogp 2.2
Gsk 4 400 Rule True
Molecular Formula C19H21NO3
Scaffold Graph Node Bond Level C1=CC2Oc3cccc4c3C23CCNC(C4)C3=C1
Prediction Swissadme 1.0
Inchi Key FQXXSQDCDRQNQE-VMDGZTHMSA-N
Silicos It Class Soluble
Fcsp3 0.4736842105263157
Logs -3.056
Rotatable Bond Count 2.0
Logd 2.036
Synonyms paramorphine, thebain, thebaine
Esol Class Soluble
Functional Groups CN(C)C, COC1=CC=C(C)CC1, cOC
Compound Name Thebaine
Prediction Hob Swissadme 1.0
Exact Mass 311.152
Formal Charge 0.0
Monoisotopic Mass 311.152
Hydrogen Bond Acceptor Count 4.0
Molecular Weight 311.4
Gi Absorption True
Covalent Unit Count 1.0
Total Atom Stereocenter Count 3.0
Total Bond Stereocenter Count 0.0
Lipinski Rule Of 5 True
Esol -3.2176056782608695
Inchi InChI=1S/C19H21NO3/c1-20-9-8-19-12-5-7-15(22-3)18(19)23-17-14(21-2)6-4-11(16(17)19)10-13(12)20/h4-7,13,18H,8-10H2,1-3H3/t13-,18+,19+/m1/s1
Smiles CN1CC[C@]23[C@@H]4C(=CC=C2[C@H]1CC5=C3C(=C(C=C5)OC)O4)OC
Nring 5.0
Np Classifier Biosynthetic Pathway Alkaloids
Defined Bond Stereocenter Count 0.0
Egan Rule True
Np Classifier Superclass Tyrosine alkaloids

  • 1. Outgoing r'ship FOUND_IN to/from Aloe Microstigma (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 2. Outgoing r'ship FOUND_IN to/from Chrozophora Prostrata (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 3. Outgoing r'ship FOUND_IN to/from Papaver Orientale (Plant) Rel Props:Reference:https://www.ncbi.nlm.nih.gov/pubmed/886446
  • 4. Outgoing r'ship FOUND_IN to/from Papaver Rhoeas (Plant) Rel Props:Reference:ISBN:9788172361266
  • 5. Outgoing r'ship FOUND_IN to/from Papaver Somniferum (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 6. Outgoing r'ship FOUND_IN to/from Rauvolfia Serpentina (Plant) Rel Props:Reference:https://doi.org/10.1186/s12906-015-0683-7