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Propranolol

PubChem CID: 4946

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Compound Synonyms propranolol, 525-66-6, Propanolol, beta-Propranolol, Betalong, Euprovasin, Proprasylyt, Reducor, Propanalol, Anapriline, Propanix, propranololo, Corpendol, Sawatal, dl-propranolol, Sumial, Inderal, Racemic propranolol, Propranololum, D,L-Propranolol, (+-)-Propranolol, 1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol, racemic-Propranolol, .beta.-Propranolol, CCRIS 3082, 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol, 1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol, Propanolol [INN-Spanish], UNII-9Y8NXQ24VQ, Propranololum [INN-Latin], 1-Isopropylamino-3-(naphthalen-1-yloxy)-propan-2-ol, EINECS 208-378-0, EINECS 235-867-6, 9Y8NXQ24VQ, hemangiol, 1-Isopropylamino-3-(1-naphthyloxy)-2-propanol, Bedranol, CHEBI:8499, 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+/-)-propranolol, 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)-, CHEMBL27, rac-Propanolol, AY-64043-, Betadren, DTXSID6023525, 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)-, (+-)-, 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, Inderex, Inderol, Pranolol, Propranolol (INN), (1)-1-(Isopropylamino)-3-(naphthyloxy)propan-2-ol, 13013-17-7, 1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-ol, PROPRANOLOL [INN], 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)-, Inderal hydrochloride, Propanolol (INN-Spanish), Propranololum (INN-Latin), Propranololo [DCIT], 3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol, Propranalol, 1-(naphthalen-1-yloxy)-3-[(propan-2-yl)amino]propan-2-ol, Propranolol [INN:BAN], AY 20694, b-Propranolol, Propranolol (TN), Dociton (Salt/Mix), Inderal (Salt/Mix), Obsidan (Salt/Mix), Propanolol,(+/-), PROPRANOLOL, d, Avlocardyl (Salt/Mix), beta-Propranolol, Dociton, PROPANOLOL(-), PROPRANOLOL [MI], Prestwick0_000952, Prestwick1_000952, Prestwick2_000952, Prestwick3_000952, PROPRANOLOL,(+), PROPRANOLOL,(-), Spectrum2_001301, Spectrum2_001699, Spectrum3_000883, Spectrum3_001071, Spectrum4_000974, Spectrum4_001222, Spectrum5_000751, (.+/-.)-Propranolol, PROPRANOLOL [VANDF], SCHEMBL3955, (S)-1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol, 3-[(methylethyl)amino]-1-naphthyloxypropan-2-ol, Lopac0_000896, Oprea1_304193, BSPBio_000944, BSPBio_002682, CBDivE_006180, GTPL564, KBioGR_001347, KBioGR_001684, KBioGR_002515, KBioSS_002523, PROPRANOLOL [WHO-DD], DivK1c_000023, SPBio_001361, SPBio_001658, SPBio_003093, (+)-Propranolol hydrochloride, (R)-(+)-Propranolol hydrochloride, 1-(Isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol, BPBio1_001040, DTXCID903525, ICI 45520 (Salt/Mix), NSC 91523 (Salt/Mix), SCHEMBL12264958, BDBM25761, HY-B0573B, KBio1_000023, KBio2_002515, KBio2_005083, KBio2_007651, KBio3_001766, KBio3_001902, KBio3_002993, C07AA05, cMAP_000071, NINDS_000023, (A+/-)-Propranolol hydrochloride, [2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine, Bio1_000367, Bio1_000856, Bio1_001345, HMS2090L21, HMS3428G03, ALBB-023324, BCP26001, BCP31343, YDA89723, BBL023437, PDSP1_000767, PDSP1_001607, PDSP1_001608, PDSP2_000755, PDSP2_001591, PDSP2_001592, STK735510, AKOS000588816, AKOS016050338, CCG-103643, DB00571, FE-0204, FP27655, SDCCGSBI-0050871.P004, IDI1_000023, NCGC00015798-04, NCGC00015798-05, NCGC00015798-06, NCGC00015798-07, NCGC00015798-08, NCGC00015798-09, NCGC00015798-15, NCGC00015798-19, NCGC00024690-02, NCGC00024690-03, DA-57114, SBI-0050871.P003, AB00053537, CS-0069968, NS00000196, EN300-40731, C07407, D08443, G60902, AB00053537-10, AB00053537_11, AB00053537_12, 1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol, L000679, Q423364, 1(-alpha-naphthoxy)-3-(iso-propylamino)-2-propanol, 1-(alpha-naphthoxy)-3-(iso-propylamino)-2-propanol, 1-(alpha-naphthoxy)-3-(isopropylamino)-2-propanol, 1-(isopropylamino)-3-naphthalen-1-yloxy-propan-2-ol, BRD-A10070317-003-06-9, BRD-A10070317-003-17-6, BRD-A10070317-003-28-3, BRD-A10070317-003-29-1, BRD-A10070317-003-30-9, 1-((1-Methylethyl)amino)-3-(1-naphthyloxy)-2-propanol, 1-(1-Naphthyloxy)-2-hydroxy-3-(isopropylamino)propane, F0001-3681, 1-[(1-methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-ol, 1[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol hydrochloride, Angilol, Apsolol, (+/-)-Propranolol hydrochloride, 208-378-0
Topological Polar Surface Area 41.5
Hydrogen Bond Donor Count 2.0
Heavy Atom Count 19.0
Description A widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety. --PubChem, Propranolol is a highly lipophilic drug achieving high concentrations in the brain. The duration of action of a single oral dose is longer than the half-life indicates and may be up to 12 hours, if the single dose is high enough (e.g. 80 mg). Effective plasma concentrations are between 10-100 ng/mL. -- Wikipedia, It was the first successful beta blocker developed. Propranolol is commonly marketed by Wyeth under the trade name Inderal. [HMDB]
Isotope Atom Count 0.0
Molecular Complexity 257.0
Database Name cmaup_ingredients;fooddb_chem_all;npass_chem_all;pubchem
Defined Atom Stereocenter Count 0.0
Enzyme Uniprot Id P07741, Q01432, Q01433, P23109, P08588, P07550, P28222, P08908
Uniprot Id P02768, P07550, P08588, P54833, P13945, P26255, P19327, P28564, B0FL73, Q8K4Z4, P18089, P18090, P10608, P28222, P43140, P61169, Q28998, Q28997, P19020, P08183, P10635, n.a., Q92887, O15245, B9W4V6, Q96KQ7, O15296, P21728, Q99700, O89049, P22309, O60656, P36537, P06133, P16662, P05177, P28223, P41595, P28335, P50406, P31645, Q99720, Q14973, O94956, Q9NPD5, Q9Y6L6, Q9NUW8, P15289, Q14524, O35505, Q12809, Q13936, P20813, P10632, O70127, P51589, P11712, O95342, Q06278, P33261, P08684, P08908, P34969, P29274, P0DMS8, P35348, P08913, P18825, P30556, P37288, P32238, P20309, P11229, P08172, P14416, P25101, P41143, P41145, P35372, O15438, O15439, P34913, P34971, P0DTD1
Iupac Name 1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol
Prediction Hob 1.0
Class Naphthalenes
Target Id NPT225, NPT668, NPT110, NPT613, NPT226, NPT227, NPT208, NPT290, NPT291, NPT292, NPT294, NPT295, NPT296, NPT748, NPT2856, NPT98, NPT2691, NPT92
Xlogp 3.0
Superclass Benzenoids
Molecular Formula C16H21NO2
Prediction Swissadme 1.0
Inchi Key AQHHHDLHHXJYJD-UHFFFAOYSA-N
Fcsp3 0.375
Logs -3.301
Rotatable Bond Count 6.0
State Solid
Logd 3.143
Synonyms 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol, 1-(Isopropylamino)-3-(1-naphthyloxy)propan-2-ol, b-Propranolol, beta-Propranolol, Dociton, Euprovasin, Propanalol, Propanix, Propanolol, Propranololo, Propranololum, β-propranolol
Substituent Name Naphthalene, Alkyl aryl ether, Secondary alcohol, 1,2-aminoalcohol, Secondary amine, Ether, Secondary aliphatic amine, Hydrocarbon derivative, Organooxygen compound, Organonitrogen compound, Amine, Alcohol, Aromatic homopolycyclic compound
Compound Name Propranolol
Kingdom Organic compounds
Prediction Hob Swissadme 1.0
Exact Mass 259.157
Formal Charge 0.0
Monoisotopic Mass 259.157
Hydrogen Bond Acceptor Count 3.0
Molecular Weight 259.339
Covalent Unit Count 1.0
Total Atom Stereocenter Count 1.0
Total Bond Stereocenter Count 0.0
Esol -3.318837484210526
Inchi InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
Smiles CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O
Nring 2.0
Defined Bond Stereocenter Count 0.0

  • 1. Outgoing r'ship FOUND_IN to/from Asimina Triloba (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 2. Outgoing r'ship FOUND_IN to/from Myristica Fragrans (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all