Pulegone
PubChem CID: 442495
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| Compound Synonyms | Pulegone, (+)-Pulegone, 89-82-7, (R)-Pulegone, d-Pulegone, (R)-(+)-Pulegone, Pulegon, (+)-(R)-Pulegone, (1R)-(+)-p-Menth-4(8)-en-3-one, Pulegone, d-, Pulegone (natural), Cyclohexanone, 5-methyl-2-(1-methylethylidene)-, (R)-, R-(+)-Pulegone, Cyclohexanone, 5-methyl-2-(1-methylethylidene)-, (5R)-, NSC 15334, FEMA No. 2963, 3-Methyl-6-isopropylidenecyclohexanone, CCRIS 5746, p-MENTH-4(8)-EN-3-ONE, (R)-(+)-, 4(8)-p-Menthen-3-one, delta-, (5R)-5-methyl-2-(propan-2-ylidene)cyclohexan-1-one, EINECS 201-943-2, UNII-4LF2673R3G, CHEBI:35596, 5-Methyl-2-(1-methylethylidene)cyclohexanone, (R)-, AI3-11218, HSDB 8146, (R)-2-Isopropylidene-5-methylcyclohexanone, 1beta-p-menth-4(8)-en-3-one, 4LF2673R3G, (1R)-PULEGONE, (5R)-2-isopropylidene-5-methylcyclohexanone, DTXSID2025975, 1-Isopropylidene-4-methyl-2-cyclohexanone, 1-Methyl-4-isopropylidene-3-cyclohexanone, (R)-5-methyl-2-(propan-2-ylidene)cyclohexanone, (+)-4(8)-Para-menthen-3-one, (5R)-5-methyl-2-propan-2-ylidenecyclohexan-1-one, NSC-15334, Cyclohexanone, 5-methyl-2-(1-methylethylidene)-, (theta)-, PULEGONE (IARC), PULEGONE [IARC], (R)-(+)-Pulegone 1000 microg/mL in Hexane, (R)-(+)-P-MENTH-4(8)-EN-3-ONE, (R)-p-Menth-4(8)-en-3-one, PULEGONE, (D), (5R)-5-methyl-2-(propan-2-ylidene)cyclohexanone, DTXSID3051757, Pulegone,(S), Pulegone (Standard), (+)-1-Methyl-4-isopropylidene-3-cyclohexanone, PULEGONE [FHFI], PULEGONE [MI], bmse000839, (R)-Pulegone - 90%, (R)-Pulegone - 95%, SCHEMBL38305, DTXCID405975, CHEMBL2924219, DTXCID6030312, FEMA 2963, HY-N1500R, (R)-(+)-Pulegone, 97%, (+)-Pulegone, analytical standard, HY-N1500, (R)-(+)-Pulegone, >=90%, Tox21_200206, BBL033995, s9140, STK801810, AKOS005622693, CCG-266234, FP27262, LMPR0102090025, CAS-89-82-7, NCGC00257760-01, AS-18103, XP164793, 4(8)-p-Menthen-3-one, (R)-(+)-, (R)-(+)-Pulegone, 85%, technical grade, CS-0017045, NS00114091, P2331, (5R)-2-isopropylidene-5-methyl-cyclohexanone, C09893, EN300-220670, 10.14272/NZGWDASTMWDZIW-MRVPVSSYSA-N.1, Q413816, doi:10.14272/NZGWDASTMWDZIW-MRVPVSSYSA-N.1, (+)-Pulegone, primary pharmaceutical reference standard, Z1255364872, (5R)-5-Methyl-2-(1-methylethylidene)cyclohexanone, (R)-(+)-p-Menth-4(8)-en-3-one, Pulegon, (+)-Pulegone |
|---|---|
| Ghose Rule | False |
| Classyfire Kingdom | Organic compounds |
| Topological Polar Surface Area | 17.1 |
| Hydrogen Bond Donor Count | 0.0 |
| Pfizer 3 75 Rule | False |
| Scaffold Graph Level | CC1CCCCC1C |
| Np Classifier Class | Menthane monoterpenoids, Monocyclic monoterpenoids |
| Deep Smiles | C[C@@H]CCC=CC)C))C=O)C6 |
| Heavy Atom Count | 11.0 |
| Classyfire Class | Prenol lipids |
| Description | Pulegone, also known as (+)-(R)-pulegone or (1r)-(+)-P-menth-4(8)-en-3-one, is a member of the class of compounds known as menthane monoterpenoids. Menthane monoterpenoids are monoterpenoids with a structure based on the o-, m-, or p-menthane backbone. P-menthane consists of the cyclohexane ring with a methyl group and a (2-methyl)-propyl group at the 1 and 4 ring position, respectively. The o- and m- menthanes are much rarer, and presumably arise by alkyl migration of p-menthanes. Thus, pulegone is considered to be an isoprenoid lipid molecule. Pulegone is slightly soluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). Pulegone can be found in a number of food items such as globe artichoke, sacred lotus, garden onion, and rubus (blackberry, raspberry), which makes pulegone a potential biomarker for the consumption of these food products. Pulegone can be found primarily in saliva. Pulegone is a naturally occurring organic compound obtained from the essential oils of a variety of plants such as Nepeta cataria (catnip), Mentha piperita, and pennyroyal. It is classified as a monoterpene . |
| Scaffold Graph Node Level | CC1CCCCC1O |
| Classyfire Subclass | Monoterpenoids |
| Isotope Atom Count | 0.0 |
| Molecular Complexity | 197.0 |
| Database Name | cmaup_ingredients;fooddb_chem_all;hmdb_chem_all;imppat_phytochem;npass_chem_all;pubchem |
| Defined Atom Stereocenter Count | 1.0 |
| Uniprot Id | Q75NA5, P10275, P19838 |
| Iupac Name | (5R)-5-methyl-2-propan-2-ylidenecyclohexan-1-one |
| Prediction Hob | 1.0 |
| Class | Prenol lipids |
| Veber Rule | True |
| Classyfire Superclass | Lipids and lipid-like molecules |
| Xlogp | 2.8 |
| Superclass | Lipids and lipid-like molecules |
| Subclass | Monoterpenoids |
| Gsk 4 400 Rule | True |
| Molecular Formula | C10H16O |
| Scaffold Graph Node Bond Level | C=C1CCCCC1=O |
| Prediction Swissadme | 0.0 |
| Inchi Key | NZGWDASTMWDZIW-MRVPVSSYSA-N |
| Silicos It Class | Soluble |
| Fcsp3 | 0.7 |
| Logs | -2.659 |
| Rotatable Bond Count | 0.0 |
| State | Solid |
| Logd | 3.096 |
| Synonyms | (+)-(R)-Pulegone, (1R)-(+)-p-Menth-4(8)-en-3-one, (5R)-2-Isopropylidene-5-methylcyclohexanone, (R)-Pulegone, D-Pulegone, (+)-Pulegone, Pulegone, (R)-isomer, (R)-(+)-p-Menth-4(8)-en-3-one, (R)-p-Menth-4(8)-en-3-one, p-Menth-4(8)-en-3-one, (R)-5-Methyl-2-(1-methylethylidene)cyclohexanone, (R)-(+)-Pulegone, (1R)-Pulegone, L-Pulegone, NSC 15334, Pulegon, FEMA 2963, (+)-4(8)-Para-menthen-3-one, 5-Methyl-2-(1-methylethylidene)cyclohexanone, Pulegone, (5R)-5-Methyl-2-(1-methylethylidene)cyclohexanone, cis-Isopulegone, Isopulegone, Pulegone, (S)-isomer, (+) pulegone, (+)-pulegone, (r)-(+)-pulegone, +-pulegone, d-pulegone, pulegon, pulegone, pulegone c, pulegoneb |
| Esol Class | Soluble |
| Functional Groups | CC(=O)C(C)=C(C)C |
| Compound Name | Pulegone |
| Kingdom | Organic compounds |
| Prediction Hob Swissadme | 0.0 |
| Exact Mass | 152.12 |
| Formal Charge | 0.0 |
| Monoisotopic Mass | 152.12 |
| Hydrogen Bond Acceptor Count | 1.0 |
| Molecular Weight | 152.23 |
| Gi Absorption | True |
| Covalent Unit Count | 1.0 |
| Total Atom Stereocenter Count | 1.0 |
| Total Bond Stereocenter Count | 0.0 |
| Molecular Framework | Aliphatic homomonocyclic compounds |
| Lipinski Rule Of 5 | True |
| Esol | -2.7242694 |
| Inchi | InChI=1S/C10H16O/c1-7(2)9-5-4-8(3)6-10(9)11/h8H,4-6H2,1-3H3/t8-/m1/s1 |
| Smiles | C[C@@H]1CCC(=C(C)C)C(=O)C1 |
| Nring | 1.0 |
| Np Classifier Biosynthetic Pathway | Terpenoids |
| Defined Bond Stereocenter Count | 0.0 |
| Egan Rule | True |
| Taxonomy Direct Parent | Menthane monoterpenoids |
| Np Classifier Superclass | Monoterpenoids |
- 1. Outgoing r'ship
FOUND_INto/from Acacia Aroma (Plant) Rel Props:Reference:https://doi.org/10.1002/(sici)1099-1026(1998070)13:4<266::aid-ffj739>3.0.co;2-5 - 2. Outgoing r'ship
FOUND_INto/from Acacia Caven (Plant) Rel Props:Reference:https://doi.org/10.1002/(sici)1099-1026(1998070)13:4<266::aid-ffj739>3.0.co;2-5 - 3. Outgoing r'ship
FOUND_INto/from Achillea Millefolium (Plant) Rel Props:Reference:https://doi.org/10.1002/ffj.1074 - 4. Outgoing r'ship
FOUND_INto/from Acinos Alpinus (Plant) Rel Props:Reference:https://doi.org/10.1002/(sici)1099-1026(199901/02)14:1<55::aid-ffj784>3.0.co;2-q - 5. Outgoing r'ship
FOUND_INto/from Acorus Calamus (Plant) Rel Props:Reference:ISBN:9770976605004 - 6. Outgoing r'ship
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FOUND_INto/from Mentha Rotundifolia (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.2016.1185471 - 109. Outgoing r'ship
FOUND_INto/from Mentha Spicata (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.2016.1185471 - 110. Outgoing r'ship
FOUND_INto/from Micromeria Douglasii (Plant) Rel Props:Reference:ISBN:9770976605004 - 111. Outgoing r'ship
FOUND_INto/from Minthostachys Mollis (Plant) Rel Props:Reference:https://doi.org/10.1002/ffj.1262 - 112. Outgoing r'ship
FOUND_INto/from Minthostachys Verticillata (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.2007.9699257 - 113. Outgoing r'ship
FOUND_INto/from Murraya Euchrestifolia (Plant) Rel Props:Reference:ISBN:9770976605004 - 114. Outgoing r'ship
FOUND_INto/from Murraya Koenigii (Plant) Rel Props:Reference:ISBN:9770972795006 - 115. Outgoing r'ship
FOUND_INto/from Nasturtium Officinale (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.2008.9700076 - 116. Outgoing r'ship
FOUND_INto/from Nepeta Cataria (Plant) Rel Props:Reference:https://doi.org/10.1080/0972060x.2016.1211965 - 117. Outgoing r'ship
FOUND_INto/from Nepeta Multifida (Plant) Rel Props:Reference:https://doi.org/10.1080/0972-060x.2003.10643356 - 118. Outgoing r'ship
FOUND_INto/from Nepeta Nuda (Plant) Rel Props:Reference:https://doi.org/10.1080/0972060x.2017.1407678 - 119. Outgoing r'ship
FOUND_INto/from Nepeta Persica (Plant) Rel Props:Reference:https://doi.org/10.1002/ffj.1023 - 120. Outgoing r'ship
FOUND_INto/from Nicotiana Tabacum (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.2002.9699832 - 121. Outgoing r'ship
FOUND_INto/from Nigella Damascena (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.2003.9712267 - 122. Outgoing r'ship
FOUND_INto/from Nigella Sativa (Plant) Rel Props:Reference:https://doi.org/10.1080/0972-060x.2003.10643354 - 123. Outgoing r'ship
FOUND_INto/from Ocimum Basilicum (Plant) Rel Props:Reference:https://doi.org/10.1080/0972060x.2018.1425640 - 124. Outgoing r'ship
FOUND_INto/from Ocimum Gratissimum (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.2018.1487343 - 125. Outgoing r'ship
FOUND_INto/from Ophiorrhiza Mungos (Plant) Rel Props:Reference:ISBN:9770972795006; ISBN:9770976605004 - 126. Outgoing r'ship
FOUND_INto/from Origanum Majorana (Plant) Rel Props:Reference:https://doi.org/10.1080/0972060x.2012.10644030 - 127. Outgoing r'ship
FOUND_INto/from Origanum Vulgare (Plant) Rel Props:Reference:https://doi.org/10.1080/0972060x.2007.10643545 - 128. Outgoing r'ship
FOUND_INto/from Perilla Frutescens (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 129. Outgoing r'ship
FOUND_INto/from Petroselinum Crispum (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.2000.9712206 - 130. Outgoing r'ship
FOUND_INto/from Peucedanum Officinale (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.2009.9700128 - 131. Outgoing r'ship
FOUND_INto/from Pimenta Racemosa (Plant) Rel Props:Reference:https://doi.org/10.1080/0972060x.2012.10644030 - 132. Outgoing r'ship
FOUND_INto/from Pinellia Ternata (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 133. Outgoing r'ship
FOUND_INto/from Pinus Sylvestris (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.2001.9699652 - 134. Outgoing r'ship
FOUND_INto/from Pistacia Terebinthus (Plant) Rel Props:Reference:https://doi.org/10.1080/0972060x.2012.10644092 - 135. Outgoing r'ship
FOUND_INto/from Poliomintha Incana (Plant) Rel Props:Reference:ISBN:9770976605004 - 136. Outgoing r'ship
FOUND_INto/from Polygala Senega (Plant) Rel Props:Reference:https://doi.org/10.1002/ffj.2730100408 - 137. Outgoing r'ship
FOUND_INto/from Pulicaria Dysenterica (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.2007.9699296 - 138. Outgoing r'ship
FOUND_INto/from Pycnanthemum Flexuosum (Plant) Rel Props:Reference:ISBN:9770976605004 - 139. Outgoing r'ship
FOUND_INto/from Pycnanthemum Virginianum (Plant) Rel Props:Reference:ISBN:9770976605004 - 140. Outgoing r'ship
FOUND_INto/from Ribes Nigrum (Plant) Rel Props:Reference:ISBN:9770976605004 - 141. Outgoing r'ship
FOUND_INto/from Rosa Canina (Plant) Rel Props:Reference:https://doi.org/10.1080/0972-060x.2004.10643360 - 142. Outgoing r'ship
FOUND_INto/from Rosa Centifolia (Plant) Rel Props:Reference:https://doi.org/10.1080/0972-060x.2004.10643360 - 143. Outgoing r'ship
FOUND_INto/from Rosa Damascena (Plant) Rel Props:Reference:https://doi.org/10.1080/0972060x.2013.813229 - 144. Outgoing r'ship
FOUND_INto/from Rosa Gallica (Plant) Rel Props:Reference:https://doi.org/10.1080/0972060x.2010.10643794 - 145. Outgoing r'ship
FOUND_INto/from Rosmarinus Officinalis (Plant) Rel Props:Reference:https://www.ncbi.nlm.nih.gov/pubmed/10460442 - 146. Outgoing r'ship
FOUND_INto/from Ruta Chalepensis (Plant) Rel Props:Reference:ISBN:9770976605004 - 147. Outgoing r'ship
FOUND_INto/from Ruta Graveolens (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.1997.10554263 - 148. Outgoing r'ship
FOUND_INto/from Salvia Nemorosa (Plant) Rel Props:Reference:ISBN:9770976605004 - 149. Outgoing r'ship
FOUND_INto/from Salvia Officinalis (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.1997.9699464 - 150. Outgoing r'ship
FOUND_INto/from Salvia Palaestina (Plant) Rel Props:Reference:https://doi.org/10.1002/ffj.1448 - 151. Outgoing r'ship
FOUND_INto/from Salvia Sclarea (Plant) Rel Props:Reference:https://doi.org/10.1080/0972060x.2012.10644030 - 152. Outgoing r'ship
FOUND_INto/from Salvia Virgata (Plant) Rel Props:Reference:https://doi.org/10.1080/0972060x.2014.958560 - 153. Outgoing r'ship
FOUND_INto/from Satureja Hortensis (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.2000.9712206 - 154. Outgoing r'ship
FOUND_INto/from Satureja Thymbra (Plant) Rel Props:Reference:ISBN:9770976605004 - 155. Outgoing r'ship
FOUND_INto/from Schinus Molle (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.2014.947387 - 156. Outgoing r'ship
FOUND_INto/from Schizonepeta Tenuifolia (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 157. Outgoing r'ship
FOUND_INto/from Schizonepeta Tenuisfolia (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 158. Outgoing r'ship
FOUND_INto/from Senna Alexandrina (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 159. Outgoing r'ship
FOUND_INto/from Serenoa Repens (Plant) Rel Props:Reference:ISBN:9770976605004 - 160. Outgoing r'ship
FOUND_INto/from Stachys Byzantina (Plant) Rel Props:Reference:https://doi.org/10.1080/0972060x.2012.10644064 - 161. Outgoing r'ship
FOUND_INto/from Symphyotrichum Lanceolatum (Plant) Rel Props:Reference:ISBN:9770976605004 - 162. Outgoing r'ship
FOUND_INto/from Syzygium Aromaticum (Plant) Rel Props:Reference:https://doi.org/10.1080/0972060x.2005.10643444 - 163. Outgoing r'ship
FOUND_INto/from Tagetes Terniflora (Plant) Rel Props:Reference:https://doi.org/10.1002/ffj.1379 - 164. Outgoing r'ship
FOUND_INto/from Tetradium Glabrifolium (Plant) Rel Props:Reference:https://doi.org/10.1080/0972060x.2014.894893 - 165. Outgoing r'ship
FOUND_INto/from Teucrium Scordium (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.2010.9700303 - 166. Outgoing r'ship
FOUND_INto/from Thymbra Capitata (Plant) Rel Props:Reference:ISBN:9770976605004 - 167. Outgoing r'ship
FOUND_INto/from Thymus Fedtschenkoi (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.2002.9699808 - 168. Outgoing r'ship
FOUND_INto/from Thymus Kotschyanus (Plant) Rel Props:Reference:https://doi.org/10.1080/0972060x.2013.854498 - 169. Outgoing r'ship
FOUND_INto/from Thymus Migricus (Plant) Rel Props:Reference:https://doi.org/10.1002/ffj.1036 - 170. Outgoing r'ship
FOUND_INto/from Thymus Pulegioides (Plant) Rel Props:Reference:https://doi.org/10.1080/0972-060x.2003.10643346 - 171. Outgoing r'ship
FOUND_INto/from Thymus Quinquecostatus (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 172. Outgoing r'ship
FOUND_INto/from Thymus Vulgaris (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 173. Outgoing r'ship
FOUND_INto/from Tilia Cordata (Plant) Rel Props:Reference:https://doi.org/10.1080/0972060x.2017.1359681 - 174. Outgoing r'ship
FOUND_INto/from Uvaria Grandiflora (Plant) Rel Props:Reference:https://doi.org/10.1080/0972060x.2017.1321503 - 175. Outgoing r'ship
FOUND_INto/from Vaccinium Myrtillus (Plant) Rel Props:Reference:https://doi.org/10.1080/0972060x.2017.1417060 - 176. Outgoing r'ship
FOUND_INto/from Valeriana Officinalis (Plant) Rel Props:Reference:ISBN:9770976605004 - 177. Outgoing r'ship
FOUND_INto/from Viscum Album (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.1996.9701029 - 178. Outgoing r'ship
FOUND_INto/from Xanthium Orientale (Plant) Rel Props:Reference:https://doi.org/10.1002/ffj.3084 - 179. Outgoing r'ship
FOUND_INto/from Zingiber Officinale (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.2018.1487343 - 180. Outgoing r'ship
FOUND_INto/from Ziziphora Capitata (Plant) Rel Props:Reference:ISBN:9770976605004 - 181. Outgoing r'ship
FOUND_INto/from Ziziphora Clinopodioides (Plant) Rel Props:Reference:https://doi.org/10.1080/10412905.1991.9697899 - 182. Outgoing r'ship
FOUND_INto/from Ziziphora Taurica (Plant) Rel Props:Reference:ISBN:9770976605004