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Narcotoline

PubChem CID: 442330

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Compound Synonyms Narcotoline, 521-40-4, desmethylnarcotine, UNII-M5V1K1QE3F, EINECS 208-313-6, M5V1K1QE3F, (3S)-3-[(5R)-4-hydroxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6,7-dimethoxy-3H-2-benzofuran-1-one, NARCOTOLINE [MI], (-)-NARCOTOLINE, DTXSID50200098, [S-(R*,R*)]-6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-hydroxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)phthalide, (3S)-6,7-DIMETHOXY-3-((5R)-5,6,7,8-TETRAHYDRO-4-HYDROXY-6-METHYL-1,3-DIOXOLO(4,5-G)ISOQUINOLIN-5-YL)-1(3H)-ISOBENZOFURANONE, 1(3H)-ISOBENZOFURANONE, 6,7-DIMETHOXY-3-((5R)-5,6,7,8-TETRAHYDRO-4-HYDROXY-6-METHYL-1,3-DIOXOLO(4,5-G)ISOQUINOLIN-5-YL)-, (3S)-, (3S)-3-((5R)-4-hydroxy-6-methyl-7,8-dihydro-5H-(1,3)dioxolo(4,5-g)isoquinolin-5-yl)-6,7-dimethoxy-3H-2-benzofuran-1-one, (S)-3-((R)-4-Hydroxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-6,7-dimethoxyisobenzofuran-1(3H)-one, (S-(R*,R*))-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-4-hydroxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)phthalide, C09593, SCHEMBL309428, CHEBI:7482, DTXCID50122589, LMGZCSKYOKDBES-AEFFLSMTSA-N, (3S)-3-((5R)-4-hydroxy-6-methyl-7,8-dihydro-5H-(1,3)dioxolo(4,5-g)isoquinolin-5-yl)-6,7-dimethoxy-3H-isobenzofuran-1-one, (3S)-3-[(5R)-4-hydroxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6,7-dimethoxy-3H-isobenzofuran-1-one, NS00032434, AE-562/12222669, Q6965699, 208-313-6, 3-(4-hydroxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-6,7-dimethoxy-2-benzofuran-1(3H)-one
Ghose Rule True
Classyfire Kingdom Organic compounds
Topological Polar Surface Area 86.7
Hydrogen Bond Donor Count 1.0
Pfizer 3 75 Rule True
Scaffold Graph Level CC1CC(C2CCCC3CC4CCCC4CC32)C2CCCCC12
Np Classifier Class Isoquinoline alkaloids, Tetrahydroisoquinoline alkaloids
Deep Smiles COccOC))cccc6C=O)O[C@@H]5[C@@H]NC)CCcc6cO)ccc6)OCO5
Heavy Atom Count 29.0
Classyfire Class Phthalide isoquinolines
Scaffold Graph Node Level OC1OC(C2NCCC3CC4OCOC4CC32)C2CCCCC12
Isotope Atom Count 0.0
Molecular Complexity 632.0
Database Name cmaup_ingredients;imppat_phytochem;npass_chem_all;pubchem
Defined Atom Stereocenter Count 2.0
Iupac Name (3S)-3-[(5R)-4-hydroxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6,7-dimethoxy-3H-2-benzofuran-1-one
Prediction Hob 1.0
Veber Rule True
Classyfire Superclass Alkaloids and derivatives
Xlogp 2.4
Gsk 4 400 Rule True
Molecular Formula C21H21NO7
Scaffold Graph Node Bond Level O=C1OC(C2NCCc3cc4c(cc32)OCO4)c2ccccc21
Prediction Swissadme 1.0
Inchi Key LMGZCSKYOKDBES-AEFFLSMTSA-N
Silicos It Class Moderately soluble
Fcsp3 0.3809523809523809
Logs -3.653
Rotatable Bond Count 3.0
Logd 1.972
Synonyms (-)-narcotoline, narcotoline
Esol Class Soluble
Functional Groups CN(C)C, c1cOCO1, cC(=O)OC, cO, cOC
Compound Name Narcotoline
Prediction Hob Swissadme 1.0
Exact Mass 399.132
Formal Charge 0.0
Monoisotopic Mass 399.132
Hydrogen Bond Acceptor Count 8.0
Molecular Weight 399.4
Gi Absorption True
Covalent Unit Count 1.0
Total Atom Stereocenter Count 2.0
Total Bond Stereocenter Count 0.0
Lipinski Rule Of 5 True
Esol -3.9238806965517252
Inchi InChI=1S/C21H21NO7/c1-22-7-6-10-8-13-20(28-9-27-13)17(23)14(10)16(22)18-11-4-5-12(25-2)19(26-3)15(11)21(24)29-18/h4-5,8,16,18,23H,6-7,9H2,1-3H3/t16-,18+/m1/s1
Smiles CN1CCC2=CC3=C(C(=C2[C@@H]1[C@@H]4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)O)OCO3
Nring 5.0
Np Classifier Biosynthetic Pathway Alkaloids
Defined Bond Stereocenter Count 0.0
Egan Rule True
Np Classifier Superclass Tyrosine alkaloids

  • 1. Outgoing r'ship FOUND_IN to/from Aloe Microstigma (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 2. Outgoing r'ship FOUND_IN to/from Chrozophora Prostrata (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 3. Outgoing r'ship FOUND_IN to/from Papaver Somniferum (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all