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Cephaeline

PubChem CID: 442195

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Compound Synonyms Cephaeline, 483-17-0, Cephaelin, Cepheline, Dihydropsychotrine, (-)-Cephaeline, 7',10,11-Trimethoxyemetan-6'-ol, CHEBI:3533, (1R)-1-[[(2S,3R,11bS)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol, UNII-QA971541A1, CEPHAELINE [MI], EINECS 207-591-6, DTXSID501016520, QA971541A1, 5483-17-0, Emetan-6'-ol, 7',10,11-trimethoxy-, GNF-Pf-307, (1R)-1-(((2S,3R,11BS)-3-ETHYL-1,3,4,6,7,11B-HEXAHYDRO-9,10-DIMETHOXY-2H-BENZO(A)QUINOLIZIN-2-YL)METHYL)-1,2,3,4-TETRAHYDRO-7-METHOXY-6-ISOQUINOLINOL, 6-ISOQUINOLINOL, 1-(((2S,3R,11BS)-3-ETHYL-1,3,4,6,7,11B-HEXAHYDRO-9,10-DIMETHOXY-2H-BENZO(A)QUINOLIZIN-2-YL)METHYL)-1,2,3,4-TETRAHYDRO-7-METHOXY-, (1R)-, NSC32944, Cephaelinel, (1R)-1-(((2S,3R,11bS)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo(a)quinolizin-2-yl)methyl)-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol, Prestwick0_000428, Prestwick1_000428, Prestwick2_000428, Prestwick3_000428, BSPBio_000416, SCHEMBL181711, SPBio_002355, BPBio1_000458, CHEMBL255708, MEGxp0_001992, ACon1_001325, DTGZHCFJNDAHEN-OZEXIGSWSA-N, DTXCID401474711, GLXC-20548, HY-N4118, BDBM50478475, AKOS030242139, FC19891, NCGC00180626-04, DA-62210, MS-28608, NCI60_002878, 1ST162321, CS-0032129, NS00041514, C09390, G60956, Q5063249, SR-02000000200-1, BRD-K80348542-001-01-4, BRD-K80348542-339-03-4, (1R)-1-[[(2S,3R,11bS)-3-Ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-2-yl]methyl]-1,2,3,4-tetrahydro-7-methoxy -6-isoquinolinol, 7',10,11-Trimethoxyemetan-6'-ol, Cepheline, 207-591-6
Ghose Rule False
Classyfire Kingdom Organic compounds
Topological Polar Surface Area 63.2
Hydrogen Bond Donor Count 2.0
Pfizer 3 75 Rule False
Scaffold Graph Level C1CCC2C(C1)CCCC2CC1CCC2CCC3CCCCC3C2C1
Np Classifier Class Isoquinoline alkaloids, Terpenoid tetrahydroisoquinoline alkaloids
Deep Smiles CC[C@H]CNCCcc[C@@H]6C[C@@H]%10C[C@H]NCCcc6ccOC))cc6)O))))))))))))))cccc6)OC)))OC
Heavy Atom Count 34.0
Classyfire Class Emetine alkaloids
Scaffold Graph Node Level C1CCC2C(C1)CCNC2CC1CCN2CCC3CCCCC3C2C1
Isotope Atom Count 0.0
Molecular Complexity 664.0
Database Name cmaup_ingredients;imppat_phytochem;npass_chem_all;pubchem
Defined Atom Stereocenter Count 4.0
Uniprot Id P20701, n.a.
Iupac Name (1R)-1-[[(2S,3R,11bS)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol
Prediction Hob 0.0
Veber Rule True
Classyfire Superclass Alkaloids and derivatives
Xlogp 4.4
Gsk 4 400 Rule False
Molecular Formula C28H38N2O4
Scaffold Graph Node Bond Level c1ccc2c(c1)CCNC2CC1CCN2CCc3ccccc3C2C1
Prediction Swissadme 1.0
Inchi Key DTGZHCFJNDAHEN-OZEXIGSWSA-N
Silicos It Class Poorly soluble
Fcsp3 0.5714285714285714
Logs -2.548
Rotatable Bond Count 6.0
Logd 3.926
Synonyms cephaeline
Esol Class Moderately soluble
Functional Groups CN(C)C, CNC, cO, cOC
Compound Name Cephaeline
Prediction Hob Swissadme 0.0
Exact Mass 466.283
Formal Charge 0.0
Monoisotopic Mass 466.283
Hydrogen Bond Acceptor Count 6.0
Molecular Weight 466.6
Gi Absorption True
Covalent Unit Count 1.0
Total Atom Stereocenter Count 4.0
Total Bond Stereocenter Count 0.0
Lipinski Rule Of 5 True
Esol -5.376532870588236
Inchi InChI=1S/C28H38N2O4/c1-5-17-16-30-9-7-19-13-27(33-3)28(34-4)15-22(19)24(30)11-20(17)10-23-21-14-26(32-2)25(31)12-18(21)6-8-29-23/h12-15,17,20,23-24,29,31H,5-11,16H2,1-4H3/t17-,20-,23+,24-/m0/s1
Smiles CC[C@H]1CN2CCC3=CC(=C(C=C3[C@@H]2C[C@@H]1C[C@@H]4C5=CC(=C(C=C5CCN4)O)OC)OC)OC
Nring 5.0
Np Classifier Biosynthetic Pathway Alkaloids
Defined Bond Stereocenter Count 0.0
Egan Rule True
Np Classifier Superclass Tyrosine alkaloids

  • 1. Outgoing r'ship FOUND_IN to/from Alangium Lamarckii (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 2. Outgoing r'ship FOUND_IN to/from Alangium Salviifolium (Plant) Rel Props:Source_db:npass_chem_all
  • 3. Outgoing r'ship FOUND_IN to/from Carapichea Ipecacuanha (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 4. Outgoing r'ship FOUND_IN to/from Cedrus Deodara (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 5. Outgoing r'ship FOUND_IN to/from Mentha Aquatica (Plant) Rel Props:Source_db:npass_chem_all
  • 6. Outgoing r'ship FOUND_IN to/from Psychotria Klugii (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 7. Outgoing r'ship FOUND_IN to/from Tragopogon Porrifolius (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all