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Hyperforin

PubChem CID: 441298

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Compound Synonyms hyperforin, 11079-53-1, hiperforina, hyperforine, CHEBI:5834, RM741E34FP, CHEMBL1237210, (1R,5S,6R,7S)-4-hydroxy-6-methyl-1,3,7-tris(3-methylbut-2-en-1-yl)-6-(4-methylpent-3-en-1-yl)-5-(2-methylpropanoyl)bicyclo[3.3.1]non-3-ene-2,9-dione, (+)-Hyperforin, (1R,5S,6R,7S)-4-hydroxy-5-isobutyryl-6-methyl-1,3,7-tris(3-methylbut-2-en-1-yl)-6-(4-methylpent-3-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione, Bicyclo[3.3.1]non-3-ene-2,9-dione, 4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-, (1R,5S,6R,7S)-, UNII-RM741E34FP, HSDB 7646, BICYCLO(3.3.1)NON-3-ENE-2,9-DIONE, 4-HYDROXY-6-METHYL-1,3,7-TRIS(3-METHYL-2-BUTEN-1-YL)-5-(2-METHYL-1-OXOPROPYL)-6-(4-METHYL-3-PENTEN-1-YL)-, (1R,5S,6R,7S)-, HYPERFORIN [MI], Spectrum5_002025, HYPERFORIN [HSDB], HYPERFORIN [WHO-DD], SCHEMBL98723, CHEMBL501711, GTPL2764, Hyperforin, >=85% (HPLC), SCHEMBL15557965, DTXSID90891409, Hyperforin - solution in methanol, IWBJJCOKGLUQIZ-HQKKAZOISA-N, BCP06690, BDBM50193079, MFCD01861497, PDSP2_001346, DB01892, FH64889, NCGC00163120-01, 4-Hydroxy-6-methyl-1,3,7-tris(3-methyl-2-butenyl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-pentenyl) bicyclo(3.3.1)non-3-ene-2,9-dione, HY-116330, CS-0065073, NS00011745, C07608, Q412742, HYPERFORIN (CONSTITUENT OF ST. JOHN'S WORT) [DSC], (1R,5R,7S,8R)-4-hydroxy-8-methyl-3,5,7-tris(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)-1-(2-methylpropanoyl)bicyclo[3.3.1]non-3-ene-2,9-dione, Bicyclo(3.3.1)(1,4)benzodiazepin-5-one, 4-Hydroxy-6-methyl-1,3,7-tris(3-methyl-2-butenyl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-pentenyl)-, (1R,5S,6R,7S)-
Ghose Rule False
Classyfire Kingdom Organic compounds
Topological Polar Surface Area 71.4
Hydrogen Bond Donor Count 1.0
Pfizer 3 75 Rule False
Scaffold Graph Level CC1CCC2CCCC1C2C
Np Classifier Class Polyprenylated cyclic polyketides (Hop meroterpenoids)
Deep Smiles CC=CCC[C@]C)[C@@H]CC=CC)C))))C[C@]C=O)[C@]6C=O)CC)C)))C=O)C=C6O))CC=CC)C))))))))CC=CC)C)))))))))))C
Heavy Atom Count 39.0
Classyfire Class Prenol lipids
Scaffold Graph Node Level OC1CCC2CCCC1C2O
Classyfire Subclass Monoterpenoids
Isotope Atom Count 0.0
Molecular Complexity 1140.0
Database Name cmaup_ingredients;imppat_phytochem;npass_chem_all;pubchem
Defined Atom Stereocenter Count 4.0
Uniprot Id P31652, O75469, P08684, Q16637, P10636, P97697, P02791, Q92830, Q96KQ7, P11473, P11021, n.a.
Iupac Name (1R,5R,7S,8R)-4-hydroxy-8-methyl-3,5,7-tris(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)-1-(2-methylpropanoyl)bicyclo[3.3.1]non-3-ene-2,9-dione
Prediction Hob 0.0
Veber Rule False
Classyfire Superclass Lipids and lipid-like molecules
Target Id NPT543, NPT109, NPT93, NPT51, NPT1158, NPT1046, NPT295, NPT228, NPT246, NPT956
Xlogp 9.6
Gsk 4 400 Rule False
Molecular Formula C35H52O4
Scaffold Graph Node Bond Level O=C1C=CC2CCCC1C2=O
Prediction Swissadme 0.0
Inchi Key KGSZHKRKHXOAMG-HQKKAZOISA-N
Silicos It Class Poorly soluble
Fcsp3 0.6285714285714286
Logs -5.16
Rotatable Bond Count 11.0
Logd 6.701
Synonyms hyperforin
Esol Class Poorly soluble
Functional Groups CC(C(C)=O)=C(C)O, CC(C)=O, CC=C(C)C
Compound Name Hyperforin
Prediction Hob Swissadme 0.0
Exact Mass 536.387
Formal Charge 0.0
Monoisotopic Mass 536.387
Hydrogen Bond Acceptor Count 4.0
Molecular Weight 536.8
Gi Absorption False
Covalent Unit Count 1.0
Total Atom Stereocenter Count 4.0
Total Bond Stereocenter Count 0.0
Lipinski Rule Of 5 False
Esol -8.509041400000001
Inchi InChI=1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,37H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1
Smiles CC(C)C(=O)[C@]12C(=O)C(=C([C@](C1=O)(C[C@@H]([C@@]2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C
Nring 2.0
Np Classifier Biosynthetic Pathway Polyketides, Terpenoids
Defined Bond Stereocenter Count 0.0
Egan Rule False
Np Classifier Superclass Meroterpenoids

  • 1. Outgoing r'ship FOUND_IN to/from Apocynum Venetum (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 2. Outgoing r'ship FOUND_IN to/from Hypericum Henryi (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 3. Outgoing r'ship FOUND_IN to/from Hypericum Perforatum (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all
  • 4. Outgoing r'ship FOUND_IN to/from Hypericum Scabrum (Plant) Rel Props:Source_db:cmaup_ingredients