Metformin
PubChem CID: 4091
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| Compound Synonyms | metformin, 657-24-9, 1,1-Dimethylbiguanide, N,N-dimethylimidodicarbonimidic diamide, Fluamine, Metformine, Metiguanide, Dimethylbiguanide, Imidodicarbonimidic diamide, N,N-dimethyl-, Flumamine, Gliguanid, Haurymelin, Melbin, N,N-Dimethylbiguanide, Metformina, Islotin, Dimethyldiguanide, N1,N1-Dimethylbiguanide, DMGG, NNDG, N,N-Dimethyldiguanide, Diabetosan, Metforminum, Glifage, Siofor, Metformine [INN-French], Metforminum [INN-Latin], 3-(diaminomethylidene)-1,1-dimethylguanidine, LA-6023, BIGUANIDE, 1,1-DIMETHYL-, Dimethylbiguanid, 1,1-Dimethyl biguanide, Metformin extended release, EINECS 211-517-8, CCRIS 9321, CHEBI:6801, DTXSID2023270, UNII-9100L32L2N, 9100L32L2N, CHEMBL1431, DTXCID803270, Imidodicarbonimidic diamide-, N,N-dimethyl-, Metformina [DCIT], Metformina [Spanish], Metformine (INN-French), Metforminum (INN-Latin), Dimethylguanylguanidine, Metformin [USAN:INN:BAN], C4H11N5, MLS000028493, [14C]metformin, [14C]-metformin, Metformin (USAN/INN), NCGC00016564-01, SMR000058277, CAS-1115-70-4, N,N-dimethylguanylguanidine, Dianben, Obimet, N-dimethylbiguanide, MF8, Metforminum (Latin), MFCD00242652, DMBG, Glucophage (Salt/Mix), METFORMIN [INN], n',n'-dimethylbiguanide, METFORMIN [MI], METFORMIN [USAN], Prestwick0_000004, Prestwick1_000004, Prestwick2_000004, Prestwick3_000004, METFORMIN [VANDF], N,N-Dimethylguanylguanidin, METFORMIN [WHO-DD], SCHEMBL8944, BSPBio_000007, BSPBio_002314, KBioGR_002310, KBioSS_002312, cid_14219, LA 6023 (Salt/Mix), BIDD:GT0697, SPBio_001928, N(1),N(1)-dimethylbiguanide, BPBio1_000009, GTPL4503, GTPL4779, SCHEMBL9913821, SCHEMBL10276396, BDBM57047, KBio2_002310, KBio2_004878, KBio2_007446, KBio3_002790, A10BA02, cMAP_000016, HMS2089D19, HY-B0627, Tox21_302370, BBL012337, BDBM50229665, HSCI1_000295, NSC813213, s5958, STK011633, STL483693, STL484070, N,N-Dimethyltriimidodicarbonic diamide, AKOS000121065, AKOS005206848, AKOS015966566, CCG-102605, DB00331, NSC-813213, 3-carbamimidoyl-1,1-dimethyl-guanidine, NCGC00016564-02, NCGC00016564-03, NCGC00016564-05, NCGC00016564-07, NCGC00188959-01, NCGC00255255-01, AC-32484, AS-65365, CAS-657-24-9, SBI-0206876.P001, 1-carbamimidamido-N,N-dimethylmethanimidamide, CS-0009563, NS00000333, EN300-23696, C07151, D04966, D72476, EN300-746417, Q19484, (E)-3-[Amino(dimethylamino)methylidene]guanidine, 1-[(E)-amino(dimethylamino)methylidene]guanidine, {[amino(dimethylamino)methylidene]amino}methanimidamide, BRD-K79602928-003-04-1, BRD-K79602928-003-08-2, BRD-K79602928-003-18-1, BRD-K79602928-003-19-9, 3-(diaminomethylene)-1,1-dimethyl-guanidine, hydrochloride, [(E)-[AMINO(DIMETHYLAMINO)METHYLIDENE]AMINO]METHANIMIDAMIDE, 3-[bis(azanyl)methylidene]-1,1-dimethyl-guanidine, hydrochloride, 211-517-8 |
|---|---|
| Topological Polar Surface Area | 91.5 |
| Hydrogen Bond Donor Count | 3.0 |
| Heavy Atom Count | 9.0 |
| Description | 1,1-Dimethylbiguanide or Metformin is a biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. Metformin is the most popular anti-diabetic drug in the United States and one of the most prescribed drugs in the country overall, with nearly 35 million prescriptions filled in 2006 for generic metformin alone. [HMDB] |
| Isotope Atom Count | 0.0 |
| Molecular Complexity | 132.0 |
| Database Name | cmaup_ingredients;fooddb_chem_all;npass_chem_all;pubchem |
| Defined Atom Stereocenter Count | 0.0 |
| Uniprot Id | P27487, O15245, n.a., P02545, P02791, Q92830, Q63089, O15244, O75496, O94956, Q9NPD5, Q9Y6L6, P20417, Q96FL8, Q7RTT9, O95342, Q92887, O15438, O15439, Q9UGI9, P00374, P19357, P19838 |
| Iupac Name | 3-(diaminomethylidene)-1,1-dimethylguanidine |
| Prediction Hob | 1.0 |
| Class | Guanidines |
| Target Id | NPT1592, NPT483, NPT1540, NPT613, NPT4037, NPT2818 |
| Xlogp | -1.3 |
| Superclass | Organonitrogen compounds |
| Subclass | Biguanides |
| Molecular Formula | C4H11N5 |
| Prediction Swissadme | 0.0 |
| Inchi Key | XZWYZXLIPXDOLR-UHFFFAOYSA-N |
| Fcsp3 | 0.5 |
| Logs | -1.053 |
| Rotatable Bond Count | 2.0 |
| State | Solid |
| Logd | -2.054 |
| Synonyms | 1,1-Dimethyl biguanide, Diabefagos, Diabex, Diaformin, Dianben, Dimethylbiguanide, DMBG, Fortamet, Glucophage, Glumetza, Meguan, Metformin, Metiguanide, N,N-Dimethylbiguanide, N1,N1-Dimethylbiguanide, Obimet, Riomet |
| Substituent Name | Biguanide, Tertiary amine, Carboximidamide, Hydrocarbon derivative, Imine, Amine, Aliphatic acyclic compound |
| Compound Name | Metformin |
| Kingdom | Organic compounds |
| Prediction Hob Swissadme | 0.0 |
| Exact Mass | 129.101 |
| Formal Charge | 0.0 |
| Monoisotopic Mass | 129.101 |
| Hydrogen Bond Acceptor Count | 1.0 |
| Molecular Weight | 129.16 |
| Covalent Unit Count | 1.0 |
| Total Atom Stereocenter Count | 0.0 |
| Total Bond Stereocenter Count | 0.0 |
| Esol | 0.22496460000000013 |
| Inchi | InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8) |
| Smiles | CN(C)C(=N)N=C(N)N |
| Nring | 0.0 |
| Defined Bond Stereocenter Count | 0.0 |
- 1. Outgoing r'ship
FOUND_INto/from Achyrocline Satureioides (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 2. Outgoing r'ship
FOUND_INto/from Artemisia Dracunculus (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 3. Outgoing r'ship
FOUND_INto/from Aster Bellidiastrum (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 4. Outgoing r'ship
FOUND_INto/from Dolomiaea Souliei (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 5. Outgoing r'ship
FOUND_INto/from Eucalyptus Camaldulensis (Plant) Rel Props:Source_db:npass_chem_all - 6. Outgoing r'ship
FOUND_INto/from Garcinia Mangostana (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 7. Outgoing r'ship
FOUND_INto/from Glycyrrhiza Uralensis (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 8. Outgoing r'ship
FOUND_INto/from Halimodendron Halodendron (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 9. Outgoing r'ship
FOUND_INto/from Lonicera Hypoleuca (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 10. Outgoing r'ship
FOUND_INto/from Murraya Koenigii (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 11. Outgoing r'ship
FOUND_INto/from Nicotiana Sylvestris (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 12. Outgoing r'ship
FOUND_INto/from Plantago Depressa (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 13. Outgoing r'ship
FOUND_INto/from Pterocarpus Marsupium (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 14. Outgoing r'ship
FOUND_INto/from Senecio Vellereus (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 15. Outgoing r'ship
FOUND_INto/from Serpocaulon Triseriale (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 16. Outgoing r'ship
FOUND_INto/from Tinospora Crispa (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all - 17. Outgoing r'ship
FOUND_INto/from Wibelia Divaricata (Plant) Rel Props:Source_db:cmaup_ingredients;npass_chem_all