DL-ornithine
PubChem CID: 389
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| Compound Synonyms | DL-Ornithine, 2,5-Diaminopentanoic acid, 616-07-9, Ornithine, DL-, Ornithine DL-form, L-Ornithine-[2,3-3H], (+/-)-Ornithine, 2,5-Diaminovaleric acid, 128551-39-3, UNII-2381769MQC, (RS)-ORNITHINE, EINECS 210-463-2, 2381769MQC, ORNITHINE DL-FORM [MI], CHEBI:18257, 2,5-Diaminopentanoate, NSC118360, DTXSID00860383, MFCD00242584, NCGC00183365-01, SCHEMBL8578, 2,5-Diamino-pentanoic acid, 5-amino-2-azaniumylpentanoate, CHEMBL2009502, HMS3264G21, ALBB-005910, LMFA01100057, NSC169844, STK503614, 2,5-diaminovaleric acid, hydrochloride, AKOS005171631, NSC-169844, NCGC00183365-02, (S)-.alpha.,.delta.-Diaminovaleric acid, NCI60_000440, SY256915, SBI-0053903.P002, DB-230289, NS00013927, EN300-34024, C01602, AB01563203_01, L001064, SR-01000872727, SR-01000872727-1, BRD-A13561534-003-02-0, Q27102952, C7601A40-40C3-4A94-97FF-26B2E32A816E |
|---|---|
| Topological Polar Surface Area | 89.3 |
| Hydrogen Bond Donor Count | 3.0 |
| Heavy Atom Count | 9.0 |
| Pathway Kegg Map Id | map00330, map00260 |
| Description | A non-essential and nonprotein amino acid, ornithine is critical for the production of the body's proteins, enzymes and muscle tissue. Ornithine plays a central role in the urea cycle and is important for the disposal of excess nitrogen (ammonia). Ornithine is the starting point for the synthesis of many polyamines such as putrescine and spermine. Ornithine supplements are claimed to enhance the release of growth hormone and to burn excess body fat. Ornithine is necessary for proper immune function and good liver function., AF112968, L-Ornithine is one of the products of the action of the enzyme arginase on L-arginine, creating urea. Therefore, ornithine is a central part of the urea cycle, which allows for the disposal of excess nitrogen. Ornithine is recycled and in a manner is a catalyst. First, ammonia is converted into carbamoyl phosphate (phosphate-CONH2), which creates one half of urea. Ornithine is converted into a urea derivative at the ? (terminal) nitrogen by carbamoyl phosphate. Another nitrogen is added from aspartate, producing the denitrogenated fumarate, and the resulting arginine (a guanidinium compound) is hydrolysed back to ornithine, producing urea. The nitrogens of urea come from the ammonia and aspartate, and the nitrogen in ornithine remains intact., ORNT1). Mutations in the mitochondrial ornithine transporter result in hyperammonemia, hyperornithinemia, homocitrullinuria (HHH) syndrome, a disorder of the urea cycle. (PMID 16256388) The pathophysiology of the disease may involve diminished ornithine transport into mitochondria, resulting in ornithine accumulation in the cytoplasm and reduced ability to clear carbamoyl phosphate and ammonia loads. (OMIM 838970), Ornithine is an amino acid produced in the urea cycle by the splitting off of urea from arginine. It is a central part of the urea cycle, which allows for the disposal of excess nitrogen. L-Ornithine is also a precursor of citrulline and arginine. In order for ornithine produced in the cytosol to be converted to citrulline, it must first cross the inner mitochondrial membrane into the mitochondrial matrix where it is carbamylated by ornithine transcarbamylase. This transfer is mediated by the mitochondrial ornithine transporter (SLC25A15, Ornithine is an amino acid which plays a role in the urea cycle. Ornithine is found in many foods, some of which are soft-necked garlic, orange bell pepper, sunburst squash (pattypan squash), and cucumber. |
| Isotope Atom Count | 0.0 |
| Molecular Complexity | 95.0 |
| Database Name | cmaup_ingredients;fooddb_chem_all;pubchem |
| Defined Atom Stereocenter Count | 0.0 |
| Enzyme Uniprot Id | P04181, P50440, P54886, P00480, P11926, O43246, Q9Y619, Q9BXI2, P30825, P52569, P54368, O95190, Q9UMX2, O14977 |
| Iupac Name | 2,5-diaminopentanoic acid |
| Prediction Hob | 1.0 |
| Class | Carboxylic acids and derivatives |
| Xlogp | -4.4 |
| Superclass | Organic acids and derivatives |
| Subclass | Amino acids, peptides, and analogues |
| Molecular Formula | C5H12N2O2 |
| Prediction Swissadme | 0.0 |
| Inchi Key | AHLPHDHHMVZTML-UHFFFAOYSA-N |
| Fcsp3 | 0.8 |
| Rotatable Bond Count | 4.0 |
| State | Solid |
| Synonyms | (+)-s-ornithine, (2S)-2,5-diaminopentanoic acid, (S)-2,5-Diaminopentanoate, (S)-2,5-Diaminopentanoic acid, (S)-2,5-Diaminovalerate, (S)-2,5-diaminovaleric acid, (s)-a,d-diaminovalerate, (s)-a,d-diaminovaleric acid, (S)-a,delta-Diaminovalerate, (S)-a,delta-Diaminovaleric acid, (S)-a,δ-diaminovalerate, (S)-a,δ-diaminovaleric acid, (S)-alpha,delta-Diaminovalerate, (s)-alpha,delta-diaminovaleric acid, (s)-ornithine, (S)-α,δ-diaminovalerate, (S)-α,δ-diaminovaleric acid, 2,5-diaminopentanoate, 2,5-diaminopentanoic acid, 2,5-diaminovaleric acid, 5-amino-L-Norvaline, Alpha, delta-diaminovaleric acid, L-(-)-ornithine, L-Norvaline, 5-amino-, L-Ornithine, L-Ornithine (9CI), Ornithine, L- (8CI), Pentanoic acid, 2,5-diamino-, (S)- |
| Substituent Name | L-alpha-amino acid, Amino fatty acid, Fatty acyl, Fatty acid, Monocarboxylic acid or derivatives, Carboxylic acid, Hydrocarbon derivative, Primary amine, Organooxygen compound, Organonitrogen compound, Primary aliphatic amine, Carbonyl group, Amine, Aliphatic acyclic compound |
| Compound Name | DL-ornithine |
| Kingdom | Organic compounds |
| Prediction Hob Swissadme | 0.0 |
| Exact Mass | 132.09 |
| Formal Charge | 0.0 |
| Monoisotopic Mass | 132.09 |
| Hydrogen Bond Acceptor Count | 4.0 |
| Molecular Weight | 132.16 |
| Covalent Unit Count | 1.0 |
| Total Atom Stereocenter Count | 1.0 |
| Total Bond Stereocenter Count | 0.0 |
| Esol | 2.3828894000000007 |
| Inchi | InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9) |
| Smiles | C(CC(C(=O)O)N)CN |
| Defined Bond Stereocenter Count | 0.0 |
- 1. Outgoing r'ship
FOUND_INto/from Allium Cepa (Plant) Rel Props:Source_db:cmaup_ingredients - 2. Outgoing r'ship
FOUND_INto/from Allium Sativum (Plant) Rel Props:Source_db:fooddb_chem_all - 3. Outgoing r'ship
FOUND_INto/from Annona Squamosa (Plant) Rel Props:Source_db:fooddb_chem_all - 4. Outgoing r'ship
FOUND_INto/from Beta Vulgaris (Plant) Rel Props:Source_db:fooddb_chem_all - 5. Outgoing r'ship
FOUND_INto/from Brassica Oleracea (Plant) Rel Props:Source_db:cmaup_ingredients - 6. Outgoing r'ship
FOUND_INto/from Capsicum Annuum (Plant) Rel Props:Source_db:cmaup_ingredients - 7. Outgoing r'ship
FOUND_INto/from Chlamydomonas Reinhardtii (Plant) Rel Props:Source_db:cmaup_ingredients - 8. Outgoing r'ship
FOUND_INto/from Cucumis Sativus (Plant) Rel Props:Source_db:cmaup_ingredients - 9. Outgoing r'ship
FOUND_INto/from Cucurbita Pepo (Plant) Rel Props:Source_db:cmaup_ingredients - 10. Outgoing r'ship
FOUND_INto/from Momordica Charantia (Plant) Rel Props:Source_db:fooddb_chem_all - 11. Outgoing r'ship
FOUND_INto/from Orobanche Coerulescens (Plant) Rel Props:Source_db:cmaup_ingredients - 12. Outgoing r'ship
FOUND_INto/from Rubus Idaeus (Plant) Rel Props:Source_db:cmaup_ingredients - 13. Outgoing r'ship
FOUND_INto/from Solanum Tuberosum (Plant) Rel Props:Source_db:cmaup_ingredients - 14. Outgoing r'ship
FOUND_INto/from Spinacia Oleracea (Plant) Rel Props:Source_db:cmaup_ingredients