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Isoniazid

PubChem CID: 3767

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Compound Synonyms isoniazid, 54-85-3, Isonicotinic acid hydrazide, Isonicotinohydrazide, pyridine-4-carbohydrazide, Isoniazide, Rimifon, Nydrazid, Cotinazin, Hydrazid, Iscotin, Mybasan, Isonicotinylhydrazine, Atcotibine, Hidrasonil, Isobicina, Isonicotan, Neumandin, Armazid, Armazide, Dinacrin, Ditubin, Eralon, Ertuban, Isidrina, Laniazid, Cedin, Hyzyd, Isonicotinic hydrazide, Andrazide, Neoteben, Nicizina, Niconyl, Nicotibina, Nicozide, Pycazide, Stanozide, Isolyn, Isohydrazide, Isonicotinhydrazid, Antimicina, Chemiazid, Chemidon, Fimalene, Hidranizil, Hidrulta, Ismazide, Isocidene, Isocotin, Isonerit, Isonicid, Isonicotil, Isonidrin, Isonikazid, Isonilex, Isonindon, Isonirit, Isoniton, Isonizide, Isotebezid, Nidrazid, Nyscozid, Pyricidin, Pyrizidin, Raumanon, Retozide, Rimitsid, Teebaconin, Tubazide, Azuren, Cemidon, Defonin, Diforin, Ebidene, Eutizon, Evalon, Hidrun, Hycozid, Idrazil, Inizid, Isocid, Isonex, Isonico, Isonide, Isonin, Isozide, Isozyd, Neoxin, Niadrin, Nicetal, Nidaton, Nikozid, Niplen, Nitadon, Pelazid, Rimicid, Tubazid, Antituberkulosum, Nevin, Inah, Ido-tebin, Isoniacid, Nicotibine, Nicotisan, Rimiphone, Tisiodrazida, Tubilysin, Isotebe, Isotinyl, Nicazide, Phthisen, Pyreazid, 4-Pyridinecarboxylic acid, hydrazide, Percin, Razide, Tyvid, Neo-Tizide, Isoniazid SA, Armacide, Cortinazine, Cotinizin, GINK, Isonicazide, Isotamine, Robisellin, Sauterazid, Tibinide, Unicozyde, Vazadrine, Zonazide, Dibutin, Hyozid, Isonicotinyl hydrazide, Tebecid, Tekazin, Tubeco, Tubicon, Tubomel, Vederon, Zinadon, Isonicotinoyl hydrazide, Dow-Isoniazid, 4-Pyridinecarboxylic acid hydrazide, Preparation 6424, TB-Razide, Sanohidrazina, Laniozid, Pyridicin, Robiselin, Sauterzid, Tibazide, Tibizide, Tuberian, Unicocyde, Niteban, Roxifen, Tebenic, Tebexin, Tebilon, Tibison, Tibivis, Tibusan, Tizide, Tebos, Tisin, Inh-Burgthal, TB-Vis, FSR 3, TB-Phlogin, Isoniazida, Isoniazidum, Tubizid, Zidafimia, Isozid, INH, Nitebannsc 9659, In-73, Cedin (Aerosol), RU-EF-Tb, bacillen, tebemid, tubercid, Isonizida, Isokin, Tibemid, Isonicotinoylhydrazine, 4-Pyridinecarbonylhydrazine, Isonicotinsaeurehydrazid, FSR-3, 4-(Hydrazinocarbonyl)pyridine, BP 5015, 4-Pyridylcarbonylhydrazide, isonicotinoylhydrazide, Dianicotyl, Ipcazide, NSC 9659, 4-pyridinecarbohydrazide, 4-Pyridinecarboxylic hydrazide, RP-5015, Isonicotinylhydrazide, Usaf cb-2, HIA, Isonicotinyl hydrazine, pyridine-4-carboxylic acid hydrazide, CCRIS 351, MFCD00006426, CHEBI:6030, 5015 RP, L 1945, HSDB 1647, Isoniazidum [INN-Latin], Isoniazida [INN-Spanish], 5015 R.P., UNII-V83O1VOZ8L, NSC-9659, EINECS 200-214-6, V83O1VOZ8L, RP 5015, I.A.I., DTXSID8020755, isonicotinate hydrazide, Idrazide dell'acido isonicotinico, AI3-23936, NSC9659, CHEMBL64, DTXCID20755, MLS000069444, Isoniazid [USP:INN:BAN:JAN], RIFATER COMPONENT ISONIAZID, RIFAMATE COMPONENT ISONIAZID, CAS-54-85-3, NCGC00016244-09, Continazine, Tubecotubercid, Abdizide, Anidrasona, SMR000059082, Tibiazide, Fetefu, Hydra, Isoniazidum (INN-Latin), Isoniazida (INN-Spanish), ISONIAZID (MART.), ISONIAZID [MART.], ISONIAZID (USP-RS), ISONIAZID [USP-RS], LANIZID, ISONIAZID (EP IMPURITY), ISONIAZID [EP IMPURITY], ISONIAZID (EP MONOGRAPH), ISONIAZID [EP MONOGRAPH], ISONIAZID (USP MONOGRAPH), Isoniazid (USP:INN:BAN:JAN), ISONIAZID [USP MONOGRAPH], RY-EF-Tb, [(4-Pyridinylcarbonyl)oxy]hydrazine, Isoniazid, pyridine-4-carbohydrazide, AZT + Isoniazid, FRS-3, Isoniazid & EEP, Laniazid (TN), ISONICOTINIC ACID HYDRAZIDE (IARC), ISONICOTINIC ACID HYDRAZIDE [IARC], ((4-PYRIDINYLCARBONYL)OXY)HYDRAZINE, Isoniazid & Propolis, Isonicotinsaeurehydrazid [German], INHd20, SR-01000003025, lsoniazid, Hydrazide, Isonicotinic Acid, Mayambutol, Dinocrin, Idrazide dell'acido isonicotinico [Italian], isoniazid (inh), isonicotinhydrazide, Soniazid,(S), NIZ, Prestwick_578, Isoniazid (Tubizid), Isoniazid 300 mg, Isoniazid(Tubizid)?, ISOZIN, Isoniazid (Standard), Rifater (Salt/Mix), Isonicotinsaurehydrazid, Isonicotinic acid hydrazide (Isoniazid), Isonicotinicacidhydrazide, Spectrum_000853, ISONIAZID [INN], ISONIAZID [JAN], Opera_ID_454, ISONIAZID [MI], isonicotinicacid hydrazide, ISONIAZID [HSDB], isonicotinic acid hydrazid, Prestwick0_000161, Prestwick1_000161, Prestwick2_000161, Prestwick3_000161, Spectrum2_000107, Spectrum3_000472, Spectrum4_000022, Spectrum5_000876, ISONIAZID [VANDF], T.B. RAZIDE, I0138, WLN: T6NJ DVMZ, isonicotinic acid hydrazone, SCHEMBL228, Biomol-NT_000288, Epitope ID:141801, 4-Pyridylcarbonyl hydrazide, ISONIAZID [WHO-DD], ISONIAZID [WHO-IP], Oprea1_396155, BSPBio_000021, BSPBio_002204, KBioGR_000423, KBioSS_001333, MLS001055327, BIDD:GT0140, DivK1c_000070, SPECTRUM1500355, SPBio_000094, SPBio_001942, Isoniazid (JP18/USP/INN), pyridine, 4-hydrazinocarbonyl-, BPBio1_000025, BPBio1_001322, SCHEMBL2998929, ISONIAZID [ORANGE BOOK], component of Niadox (Salt/Mix), GTPL12761, HMS500D12, HY-B0329R, KBio1_000070, KBio2_001333, KBio2_003901, KBio2_006469, KBio3_001424, NINDS_000070, 4-Pyridinecarboxamide, 2'-amino-, HMS1568B03, HMS1920H09, HMS2089I16, HMS2091N19, HMS2095B03, HMS2234G04, HMS3259E19, HMS3373O01, HMS3655L03, HMS3712B03, KUC109571N, Pharmakon1600-01500355, 4-pyridinecarbohydrazide(Isoniazid), ISONIAZIDUM [WHO-IP LATIN], BCP13791, HY-B0329, STR00210, Anti-TNF monoclonal antibody & INH, Tox21_113640, Tox21_201367, Tox21_300193, BBL008409, BDBM50336507, CCG-39710, NSC757078, s1937, STK086288, ISONIAZID COMPONENT OF RIFATER, (HBD) Human beta-defensin-1 & INH, AKOS000119062, ISONIAZID COMPONENT OF RIFAMATE, Isonicotinic acid hydrazide(Isoniazid), Tox21_113640_1, AI24685, DB00951, KSC-27-048, NC00513, NSC-757078, PS-4129, IDI1_000070, UPCMLD0ENAT5791176:001, NCGC00016244-01, NCGC00016244-02, NCGC00016244-03, NCGC00016244-04, NCGC00016244-05, NCGC00016244-06, NCGC00016244-07, NCGC00016244-08, NCGC00016244-10, NCGC00016244-11, NCGC00016244-12, NCGC00016244-14, NCGC00016244-15, NCGC00016244-17, NCGC00022648-03, NCGC00022648-04, NCGC00022648-05, NCGC00022648-06, NCGC00022648-07, NCGC00254094-01, NCGC00258919-01, SY010614, Isoniazid, Vetec(TM) reagent grade, 98%, SBI-0051419.P003, AB00052025, ISONICOTINIC ACID HYDRAZIDE [WHO-IP], NS00006598, SW196752-3, EN300-18498, ISONICOTINIC ACID HYDRAZIDE(ISONIAZIDE), C07054, D00346, D70582, Isoniazid, analytical standard, >=99% (TLC), AB00052025-20, AB00052025-21, AB00052025_22, AB00052025_23, AB00052025_24, AB00052025_25, AE-641/02310003, Q423169, 4-PYRIDINECARBOXYLIC ACID HYDRAZIDE [WHO-IP], SR-01000003025-2, SR-01000003025-3, BRD-K87202646-001-26-8, BRD-K87202646-001-32-6, BRD-K87202646-001-33-4, BRD-K87202646-061-04-9, BRD-K87202646-061-05-6, Isoniazid, certified reference material, TraceCERT(R), Z58981801, F0391-0007, Isoniazid, European Pharmacopoeia (EP) Reference Standard, Isoniazid, United States Pharmacopeia (USP) Reference Standard, 4-Pyridinecarboxylic acid hydrazide, Isonicotinic acid hydrazide, 4-(Hydrazinocarbonyl)pyridine, InChI=1/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10, Isoniazid, Pharmaceutical??Secondary??Standard, ??Certified??Reference??Material, 200-214-6
Topological Polar Surface Area 68.0
Hydrogen Bond Donor Count 2.0
Heavy Atom Count 10.0
Description Isoniazid (also called isonicotinyl hydrazine or INH, sold as Laniazid, Nydrazid) is an organic compound that is the first-line antituberculosis medication in prevention and treatment. First discovered in 1912 as an inhibitor of the MAO enzyme, it was first used as an antidepressant, but discontinued due to side effects. In 1951, it was later discovered that isoniazid was effective against TB. Isoniazid is never used on its own to treat active tuberculosis because resistance quickly develops., Isoniazid is a bactericidal agent active against organisms of the genus Mycobacterium, specifically <i>M. tuberculosis</i>, <i>M. bovis</i> and <i>M. kansasii</i>. It is a highly specific agent, ineffective against other microorganisms. Isoniazid is bactericidal to rapidly-dividing mycobacteria, but is bacteriostatic if the mycobacterium is slow-growing., Isoniazid is a prodrug and must be activated by bacterial catalase. It is activated by catalase-peroxidase enzyme KatG which couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to ketoenoylreductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of Isoniazid, including nitric oxide, that has also been shown to be important in the action of another antimycobacterial prodrug PA824. [HMDB]
Isotope Atom Count 0.0
Molecular Complexity 120.0
Database Name cmaup_ingredients;fooddb_chem_all;npass_chem_all;pubchem
Defined Atom Stereocenter Count 0.0
Uniprot Id P18088, n.a., Q92887, B2RXH2, P08659, Q9F4F7, P51450, P08684, P10635, P9WNX1, Q92830, Q96KQ7, Q9UIF8, P05177, P11509, P33261, P10632, Q12809, O94925, O75496, O94956, Q9NPD5, Q9Y6L6, P9WIL5, P27695, O70127, O95342, O42713, P11344, P9WG47, P05164, O15438, O15439, P9WGR1, P02768, I6X8D2, O15527, Q96FI4, P78549, P05523, P11712, P0AES4, C3TDZ2, P0DTD1, O42275, P10275, Q16236
Iupac Name pyridine-4-carbohydrazide
Prediction Hob 1.0
Target Id NPT48, NPT109, NPT110, NPT208, NPT240, NPT213, NPT628, NPT1634
Xlogp -0.7
Molecular Formula C6H7N3O
Prediction Swissadme 0.0
Inchi Key QRXWMOHMRWLFEY-UHFFFAOYSA-N
Fcsp3 0.0
Logs -0.495
Rotatable Bond Count 1.0
Logd -0.395
Synonyms (HBD) Human beta-defensin-1 & INH, 4-(Hydrazinocarbonyl)pyridine, 4-Pyridinecarbonylhydrazine, 4-Pyridinecarboxylic acid hydrazide, 4-Pyridinecarboxylic acid, hydrazide, 4-Pyridinecarboxylic hydrazide, 4-Pyridylcarbonyl hydrazide, 4-Pyridylcarbonylhydrazide, Abdizide, Amidon, Andrazide, Anidrasona, Antimicina, Antituberkulosum, Armacide, Armazid, Armazide, Atcotibine, Azt + isoniazid, Azuren, Bacillen, Bacillin, Cedin, Cedin (aerosol), Cemidon, Chemiazid, Chemidon, Continazine, Cortinazine, Cotinazin, Cotinizin, Defonin, Dibutin, Diforin, Dinacrin, Ditubin, Dom-Isoniazid 300mg Tablets, Dow-isoniazid, Ebidene, Eralon, Ertuban, Eutizon, Evalon, Fetefu, Fimalene, FRS-3, FSR 3, FSR-3, Ftivazide, GINK, HIA, Hid rasonil, Hidranizil, Hidrasonil, Hidrulta, Hidrun, Hycozid, Hydra, Hydrazid, Hydrazide, Hydrazide, isonicotinic acid, Hyozid, Hyzyd, I.a.I, I.a.I., I3377_FLUKA, I3377_SIGMA, Ido-tebin, Idrazide dell'acido isonicotinico [italian], Idrazil, INAH, INH, Inh-burgthal, INHd20, Inizid, Iscotin, Isidrina, Ismazide, Isobicina, Isocid, Isocidene, Isoco tin, Isocotin, Isohydrazide, Isokin, Isolyn, Isonerit, Isonex, Isoniacid, Isoniazid (JP15/USP/INN), Isoniazid [ban:inn:jan], Isoniazid [inn:ban:jan], Isoniazid & CRL8131, Isoniazid & eep, Isoniazid & propolis, Isoniazid daily for 9 months, Isoniazid sa, Isoniazid(isonicotinic acid), Isoniazida [inn-spanish], Isoniazide, Isoniazidum [inn-latin], Isonicazide, Isonicid, Isonico, Isonicotan, Isonicotil, Isonicotinate hydrazide, Isonicotinhydrazid, Isonicotinic acid hydrazide, Isonicotinic hydrazide, Isonicotinohydrazide, isonicotinohydrazide (ACD/Name 4.0), Isonicotinoyl hydrazide, Isonicotinoylhydrazide, Isonicotinoylhydrazine, Isonicotinsaeurehydrazid [german], Isonicotinyl hydrazide, Isonicotinyl hydrazine, Isonicotinylhydrazide, Isonicotinylhydrazine, Isonide, Isonidrin, Isonikazid, Isonilex, Isonin, Isonindon, Isonirit, Isoniton, Isonizida, Isonizide, Isopyrin, Isotamine, Isotamine powder, Isotamine Syr Pediatric 50mg/5ml, Isotamine-100, Isotamine-300, Isotebe, Isotebezid, Isotinyl, Isozid, Isozid e, Isozide, Isozyd, ISZ, Laniazid, Laniazid (TN), Laniozid, Lanizid, Mixture name, Mybasan, nchembio884-comp3, Neo-tizide, Neoteben, Neoxin, Neumandin, Nevin, Niadrin, Niazid, Nicazide, Nicetal, Nicizina, Niconyl, Nicotibina, Nicotibine, Nicotisan, Nicozide, Nidaton, Nidra zid, Nidrazid, Nikozid, Niplen, Nitadon, Niteban, Nitebannsc 9659, Nydrazid, Nyscozid, Pelazid, Percin, Phthisen, Phthivazide, Pms-Isoniazid 100mg/Tab, Pms-Isoniazid 300mg/Tab, Pms-Isoniazid Syrup 50mg/5ml, Pms-Isoniazid Tab 50mg, Preparation 6424, Prestwick_578, Pycazide, Pyreazid, Pyricidin, Pyridicin, pyridine-4-carbohydrazide, Pyrizidin, Raumanon, Razide, Retozide, Rifamate, Rifater, Rimicid, Rimif on, Rimifon, Rimiphone, Rimitsid, Robiselin, Robisellin, Roxifen, Ru-ef-TB, RY-ef-TB, Sanohidrazina, Sauterazid, Sauterzid, Stanozide, TB-phlogin, TB-razide, TB-vis, Tebecid, Tebemid, Tebenic, Tebexin, Tebilon, Tebos, Teebaconin, Tekazin, Tibazide, Tibemid, Tibiazide, Tibison, Tibivis, Tibusan, Tubazid, Tubazide, Tubeco, Tubecotubercid, Tubercid, Tuberian, Tubicon, Tubilysin, Tubizid, Tubomel, Tyvid, Unicocyde, Unicozyde, Usaf cb-2, Vazadrine, Vederon, WLN: T6NJ DVMZ, Zidafimia, Zinadon, Zonazide
Compound Name Isoniazid
Prediction Hob Swissadme 0.0
Exact Mass 137.059
Formal Charge 0.0
Monoisotopic Mass 137.059
Hydrogen Bond Acceptor Count 3.0
Molecular Weight 137.14
Covalent Unit Count 1.0
Total Atom Stereocenter Count 0.0
Total Bond Stereocenter Count 0.0
Esol -0.5612803999999998
Inchi InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
Smiles C1=CN=CC=C1C(=O)NN
Nring 1.0
Defined Bond Stereocenter Count 0.0

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